Edge and modular significance assessment in individual-specific networks.

Evidence of epistasis in regions of long-range linkage disequilibrium across five complex diseases in the UK Biobank and eMERGE datasets.

netANOVA: novel graph clustering technique with significance assessment via hierarchical ANOVA.

Capturing the dynamics of microbiomes using individual-specific networks

Fine-scale subpopulation detection via an SNP-based unsupervised method: A case study on the 1000 Genomes Project resources.

Targeted Methylation Profiling of Single Laser-Capture Microdissected Post-Mortem Brain Cells by Adapted Limiting Dilution Bisulfite Pyrosequencing (LDBSP).

Interpretable network-guided epistasis detection

Individual-specific networks for prediction modelling–A scoping review of methods

Correction: Confounding of linkage disequilibrium patterns in large scale DNA based gene-gene interaction studies

Discovery of new drug indications for COVID- 19: A drug repurposing approach

Polymorphisms in the mTOR-PI3K-Akt pathway, energy balance-related exposures and colorectal cancer risk in the Netherlands Cohort Study

Detecting gene–gene interactions from GWAS using diffusion kernel principal components

Performance of model-based multifactor dimensionality reduction methods for epistasis detection by controlling population structure

Are Volatile Organic Compounds Able to Identify Airflow Decline in Asthma?

Novel EDGE encoding method enhances ability to identify genetic interactions.

The AIMe registry for artificial intelligence in biomedical research

An Early Stage Researcher's Primer on Systems Medicine Terminology.

A different view on fine-scale population structure in Western African populations.

Network and systems medicine: position paper of the european collaboration on science and technology action on open multiscale systems medicine

Time to health-related quality of life improvement analysis was developed to enhance evaluation of modern anticancer therapies

Successful Infliximab Treatment is Associated With Reversal of Clotting Abnormalities in Inflammatory Bowel Disease Patients

Robust Genome-Wide Ancestry Inference for Heterogeneous Datasets and Ancestry Facial Imaging based on the 1000 Genomes Project

Mechanistic Modeling and Multiscale Applications for Precision Medicine: Theory and Practice

Confounding of linkage disequilibrium patterns in large scale DNA based gene-gene interaction studies

Modelling strategies to improve parameter estimates in prognostic factors analyses with patient-reported outcomes in oncology

Principals about principal components in statistical genetics

Epistasis Detection in Genome-Wide Screening for Complex Human Diseases in Structured Populations

IPCAPS: an R package for iterative pruning to capture population structure

Comparative performances of machine learning methods for classifying Crohn Disease patients using genome-wide genotyping data.

Exhaled Volatile Organic Compounds Are Able to Discriminate Between Neutrophilic and Eosinophilic Asthma

How to increase our belief in discovered statistical interactions via large-scale association studies?

Multiple Epistasis Interactions Within MHC Are Associated With Ulcerative Colitis

Statistical methods for genome-wide association studies.

Anti-infliximab antibody concentrations can guide treatment intensification in patients with Crohn's disease who lose clinical response

Male-specific epistasis between WWC1 and TLN2 genes is associated with Alzheimer's disease.

The search for gene-gene interactions in genome-wide association studies: challenges in abundance of methods, practical considerations, and biological interpretation

Integration of Gene Expression and Methylation to unravel Biological Networks in Glioblastoma Patients

Pit pattern analysis with high-definition chromoendoscopy and narrow-band imaging for optical diagnosis of dysplasia in patients with ulcerative colitis

The association between etanercept serum concentration and psoriasis severity is highly age-dependent

A systematic SNP selection approach to identify mechanisms underlying disease aetiology: Linking height to post-menopausal breast and colorectal cancer risk

Novel genetic loci associated with hippocampal volume.

Specific members of the predominant gut microbiota predict pouchitis following colectomy and IPAA in UC.

Integrative eQTL analysis of tumor and host omics data in individuals with bladder cancer

Practical aspects of gene regulatory inference via conditional inference forests from expression data

Novel genetic loci underlying human intracranial volume identified through genome-wide association.

A roadmap to multifactor dimensionality reduction methods.

Toward the integration of omics data in epidemiological studies: still a "long and winding road"

Integration Analysis of Three Omics Data Using Penalized Regression Methods: An Application to Bladder Cancer

gammaMAXT: a fast multiple-testing correction algorithm

Model-Based Multifactor Dimensionality Reduction for Rare Variant Association Analysis

A cautionary note on the impact of protocol changes for Genome-Wide Association SNP x SNP Interaction studies: an example on ankylosing spondylitis

High-density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis.

Short-term Effect of Infliximab Is Reflected in the Clot Lysis Profile of Patients with Inflammatory Bowel Disease: A Prospective Study.

Genome-Wide Copy Number Variation Scan Identifies Complement Component C4 as Novel Susceptibility Gene for Crohn's Disease.

Withdrawal of Immunomodulators After Co-treatment Does Not Reduce Trough Level of Infliximab in Patients With Crohn's Disease.

Filter-free exhaustive odds ratio-based genome-wide interaction approach pinpoints evidence for interaction in the HLA region in psoriasis.

Common genetic variants influence human subcortical brain structures.

Anti-Tumor Necrosis Factor Therapy Restores Peripheral Blood B-cell Subsets and CD40 Expression in Inflammatory Bowel Diseases.

Restoration of Foxp3+ Regulatory T-cell Subsets and Foxp3- Type 1 Regulatory-like T Cells in Inflammatory Bowel Diseases During Anti-tumor Necrosis Factor Therapy.

Statistical Analysis of High-Dimensional Genetic Data in Complex Traits.

Framework for the Integration of Genomics, Epigenomics and Transcriptomics in Complex Diseases.

Framework for the integration of genomics, epigenomics, and transcriptomics in complex diseases

Perspectives on Data Integration in Human Complex Disease Analysis

Trough concentrations of infliximab guide dosing for patients with inflammatory bowel disease.

Practical aspects of genome-wide association interaction analysis.

Genome-Wide Association Interaction Analysis for Alzheimer’s Disease

Risk of malignancies in patients with inflammatory bowel disease treated with thiopurines or anti-TNF alpha antibodies.

Active PAI-1 as marker for venous thromboembolism: case-control study using a comprehensive panel of PAI-1 and TAFI assays.

Letter to the Editor: On the term 'interaction' and related phrases in the literature on Random Forests.

Neutrophil gelatinase B-associated lipocalin and matrix metalloproteinase-9 complex as a surrogate serum marker of mucosal healing in ulcerative colitis.

Diagnosing and treating pediatric Crohn's disease patients: is there a difference between adult and pediatric gastroenterologist's practices ? Results of the BELCRO cohort.

Discovering main genetic interactions with LABNet LAsso-based network inference.

A comparison of multivariate genome-wide association methods.

Association of IL33-IL-1 receptor-like 1 (IL1RL1) pathway polymorphisms with wheezing phenotypes and asthma in childhood.

The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data.

An efficient algorithm to perform multiple testing in epistasis screening

Therapeutic Strategy and Patient Outcome during the First 2 Years of Pediatric Crohn’s Disease

Unique gene expression and MR T2 relaxometry patterns define chronic murine dextran sodium sulphate colitis as a model for connective tissue changes in human Crohn's disease.

Genetic and microbial factors modulating the ubiquitin proteasome system in inflammatory bowel disease.

Profile of pediatric Crohn's disease in Belgium.

Genetic variations in toll-like receptor pathway and lung function decline in Cystic fibrosis patients.

Genetic association and functional role of Crohn disease risk alleles involved in microbial sensing, autophagy, and endoplasmic reticulum (ER) stress.

A robustness study to investigate the performance of parametric and non-parametric tests used in Model-Based Multifactor Dimensionality Reduction Epistasis Detection

Molecular reclassification of Crohn's disease: a cautionary note on population stratification.

EU Pancreas: An Integrated European Platform for Pancreas Cancer Research - from Basic Science to Clinical and Public Health Interventions for a Rare Disease.

Esophageal impedance baseline is age dependent.

Behind the (impedance) baseline in children.

Large Sample Size, Wide Variant Spectrum, and Advanced Machine-Learning Technique Boost Risk Prediction for Inflammatory Bowel Disease.

Lower-Order Effects Adjustment in Quantitative Traits Model-Based Multifactor Dimensionality Reduction

Challenges and opportunities in genome-wide environmental interaction (GWEI) studies.

Specific IgE against Staphylococcus aureus enterotoxins: An independent risk factor for asthma

Safety and cost of infliximab for the treatment of Belgian pediatric patients with Crohn's disease.

A family-based association test to detect gene-gene interactions in the presence of linkage

Polymorphisms in the lectin pathway genes as a possible cause of early chronic Pseudomonas aeruginosa colonization in cystic fibrosis patients.

Does pet ownership in infancy lead to asthma or allergy at school age? Pooled analysis of individual participant data from 11 European birth cohorts.

Clustering of Crohn’s disease patients: Identification of sub-phenotypes and population stratification

Heterogeneous nuclear ribonucleoproteins as targets of autoantibodies in systemic rheumatic diseases.

Identification of common variants associated with human hippocampal and intracranial volumes.

Effects of domperidone on QTc interval in infants

Comparison of genetic association strategies in the presence of rare alleles

Mucosal gene expression of cell adhesion molecules, chemokines, and chemokine receptors in patients with inflammatory bowel disease before and after infliximab treatment.

Mucosal gene expression profiling differentiates early from late ileal Crohn's disease

Tolerability of shortened infliximab infusion times in patients with inflammatory bowel diseases: a single-center cohort study.

Model-Based Multifactor Dimensionality Reduction for detecting epistasis in case-control data in the presence of noise

Mepolizumab, a humanized anti-IL-5 mAb, as a treatment option for severe nasal polyposis.

Genetic variation in the autophagy gene ULK1 and risk of Crohn's disease

High-throughput method for comparative analysis of denaturing gradient gel electrophoresis profiles from human fecal samples reveals significant increases in two bifidobacterial species after inulin-type prebiotic intake.

Levels of C-reactive protein are associated with response to infliximab therapy in patients with Crohn's disease.

Model-Based Multifactor Dimensionality Reduction to detect epistasis for quantitative traits in the presence of error-free and noisy data.

Effects of haptoglobin polymorphisms and deficiency on susceptibility to inflammatory bowel disease and on severity of murine colitis.

Sequencing of DISC1 pathway genes reveals increased burden of rare missense variants in schizophrenia patients from a northern Swedish population.

Outcome of pregnancy in women with inflammatory bowel disease treated with antitumor necrosis factor therapy.

Perspectives on genome-wide multi-stage family-based association studies.

Travelling the world of gene-gene interactions

A report of the first biennial meeting on Capita Selecta in Complex Disease Analysis (CSCDA2010), Leuven, Belgium, August 25-27, 2010.

Identification of a novel autoantigen in inflammatory bowel disease by protein microarray.

Investigating Hardy-Weinberg equilibrium in case-control or cohort studies or meta-analysis.

The impact of infliximab therapy on intestinal mucosal gene expression of endothelial cell adhesion molecules in patients with inflammatory bowel disease

Intestinal mucosal expression of matrix metalloproteinase and ADAM genes in patients with inflammatory bowel disease and the impact of infliximab therapy

Intestinal mucosal gene expression of endothelial cell adhesion molecules in patients with inflammatory bowel disease and the impact of infliximab therapy.

Intestinal mucosal gene expression of endothelial cell adhesion molecules in patients with inflammatory bowel disease before and after first infliximab treatment.

Predictive value of epithelial gene expression profiles for response to infliximab in Crohn’s disease

Presence of IL-5 and Ige-antibodies to staphylococcal enterotoxins in nasal polyps is associated with co-morbid asthma

Tolerability of shortened infliximab infusion times in patients with inflammatory bowel disease: a single center cohort study

mbmdr: an R package for exploring gene-gene interactions associated with binary or quantitative traits

FAM-MDR: A Flexible Family-Based Multifactor Dimensionality Reduction Technique to Detect Epistasis Using Related Individuals

Molecular Reclassification of Crohn's Disease by Cluster Analysis of Genetic Variants

Molecular Reclassification of Crohn’s Disease by cluster analysis of genetic variants.

In utero smoke exposure and impaired response to inhaled corticosteroids in children with asthma

A screening methodology based on Random Forests to improve the detection of gene-gene interactions

Immortal time bias and infliximab-related mortality and malignancy incidence

Reanalysis of death risk in long-term follow-up in infliximab patients versus controls

Familial aggregation and antimicrobial response dose-dependently affect the risk for Crohn's disease.

Kinetics of C-Reactive Protein (CRP) following maintenance infliximab treatment in Crohn's disease identifies profiles of patients with better outcome

Kinetics of C-reactive Protein (CRP) Following Maintenance Infliximab Treatment in Crohn’s disease identifies profiles of patients with better outcome

Analysis of the high affinity IgE receptor genes reveals epistatic effects of FCER1A variants on eczema risk

Multicollinearity

Mucosal Gene Expression of Antimicrobial Peptides in Inflammatory Bowel Disease Before and After First Infliximab Treatment

The impact of infliximab therapy on intestinal mucosal expression of matrix metalloproteinase and ADAM genes in patients with inflammatory bowel disease.

Mucosal gene signatures to predict response to infliximab in patients with ulcerative colitis

The impact of infliximab therapy on colonic mucosal expression of barrier genes in patients with inflammatory bowel disease

The impact of infliximab therapy on colonic mucosal expression of barrier genes in patients with inflammatory bowel disease.

Colonic mucosal expression of barrier genes in patients with inflammatory bowel disease before and after first infliximab treatmen

TECK and MADCAM-1 mucosal expression in active IBD: the effect of infliximab therapy

Colonic mucosal expression of barrier genes in patients with inflammatory bowel disease before and after first infliximab treatment.

Small effect of the androgen receptor gene GGN repeat polymorphism on serum testosterone levels in healthy men

Molecular Reclassification of Crohn’s Disease by cluster analysis of genetic variants

Cluster analysis of genetic variants enables reclassification of Crohn’s disease at the molecular level

A Family-Based Association Test to Detect Gene-Gene Interactions in the Presence of Linkage

Polymorphisms in innate immunity genes predispose to bacteremia and death in the medical intensive care unit

Genetic risk profiling and prediction of disease course in Crohn's disease patients.

Predictive Value of C-Reactive Protein Level Changes On the Long Term Outcome of Infliximab in Crohn's Disease

Predictive Value of C-Reactive Protein Level Changes On the Long Term Outcome of Infliximab in Crohn's Disease

Importin-13 genetic variation is associated with improved airway responsiveness in childhood asthma

GENESTAT: an information portal for design and analysis of genetic association studies

Long-term outcome of treatment with infliximab in 614 patients with Crohn's disease: results from a single-centre cohort

Mucosal Healing Predicts Long-term Outcome of Maintenance Therapy with Infliximab in Crohn's Disease

Polymorphisms of the SHBG gene contribute to the interindividual variation of sex steroid hormone blood levels in young, middle-aged and elderly men

Gene expression of antimicrobial peptides in colonic mucosa of patients with inflammatory bowel disease before and after first infliximab treatment.

Effect of infliximab treatment on colonic mucosal gene expression profiles in patients with inflammatory bowel disease

Mucosal gene signatures to predict response to infliximab in patients with inflammatory bowel disease.

Mucosal gene signatures to predict response to infliximab in patients with inflammatory bowel disease

Mucosal gene signatures to predict response to infliximab in patients with inflammatory bowel disease

Microarray study of mucosal antimicrobial peptides in patients with inflammatory bowel disease before and after infliximab treatment.

Microarray study of mucosal antimicrobial peptides in patients with inflammatory bowel disease before and after first infliximab treatment

Heritability of blood concentrations of sex-steroids in relation to body composition in young adult male siblings.

Improving strategies for detecting genetic patterns of disease susceptibility in association studies

TNFA-3086 > A in two international population-based cohorts and risk of asthma

A Family-based Association Test for Quantitative Traits to Detect Gene-Gene Interactions

Long-term outcome after infliximab for refractory ulcerative colitis

Long-term efficacy of infliximab and colectomy-free survival in outpatients with refractory ulcerative colitis.

Genetic markers and the risk of complicated disease behaviour in Crohn's disease patients

Stability of gut microbiota over time in Crohn's disease patients compared to healthy relatives

Stability Of Gut Microbiota Over Time In Crohn's Disease Patients Compared To Healthy Relatives

Long term stability of gut microbiota in Crohn’s disease patients compared to healthy relatives

Gene expression profiling to predict the response of infliximab in patients with UC

Gene expression profiling to predict the response of infliximab in patients with UC

Gene expression profiling to predict the response of infliximab in patients with UC

Does a patient's self-reported health-related quality of life predict survival beyond key biomedical data in advanced colorectal cancer? (vol 42, pg 42, 2006)

New serological markers in inflammatory bowel disease are associated with complicated disease behavior

Genetic markers and the risk of complicated disease behaviour in Crohn’s disease patients

Genetic markers and the risk of complicated disease behaviour in Crohn's disease patients

Genetic markers and the risk of complicated disease behaviour in Crohn's disease patients

Faecal bacterial molecular profiles of Crohn’s disease patients differ from their healthy relatives and matched healthy controls.

Faecal bacterial dgge profiles of Crohn's disease patients are different from those of their healthy first degree relatives and matched healthy controls

Faecal bacterial dgge profiles of Crohn's disease patients are different from those of their healthy first degree relatives and matched healthy controls

Faecal bacterial DGGE profiles of Crohn’s disease patients are different from those of their healthy first degree relatives and matched healthy controls

Analysis of incomplete data

Mixed IBD families: A distinct entity within IBD

Pet ownership in eight European birth cohorts - results of a GA(2)LEN initiative

Approaches to handling incomplete data in family-based association testing

Does a patient's self-reported health-related quality of life predict survival beyond key biomedical data in advanced colorectal cancer?

Toll-like receptor-1,-2, and-6 polymorphisms influence disease extension in inflammatory bowel diseases

T-bet polymorphisms are associated with asthma and airway hyperresponsiveness

Eotaxin polymorphisms and serum total IgE levels in children with asthma

A bootstrap model averaging technique to investigate the prognostic value for survival of quality of life information.

Non-small cell lung cancer and health-related quality of life (HRQOL): Is baseline HRQOL of prognostic value for survival?

Predicting survival using health related quality of life scores in glioblastoma cancers: Findings from an international phase III randomised controlled trial.

The value of patient-reported symptoms as prognostic factors for survival in advanced colorectal cancer.

The prognostic value of health related quality of life in colorectal cancer patients: A multivariate analysis using a bootstrap model-averaging approach

Testing for association in genetic studies

Combined analysis from eleven linkage studies of bipolar disorder provides strong evidence of susceptibility loci on chromosomes 6q and 8q

Comparison of linkage and association strategies for quantitative traits using the COGA dataset.

Permutation based methods for comparing quality of life between observed treatments

Analysis of incomplete data

Genomic screening in family-based association testing

Paternal history of asthma and airway responsiveness in children with asthma

Crohn's disease and month of birth.

PBAT: a comprehensive software package for genome-wide association analysis of complex family-based studies

Genomic screening and replication using the same data set in family-based association testing

Genomic screening in family-based association testing and the multiple testing problem

An equivalence test for comparing DNA sequences

Baseline health-related quality-of-life data as prognostic factors in a phase III multicentre study of women with metastatic breast cancer

Health-related quality of life parameters as prognostic factors in a nonmetastatic breast cancer population: An international multicenter study

Transmission of CARD15 (NOD2) variants within families of patients with inflammatory bowel disease.

Deficient host-bacteria interactions in inflammatory bowel disease? The toll-like receptor (TLR)-4 Asp299gly polymorphism is associated with Crohn's disease and ulcerative colitis

Interassay and interobserver variability in the detection of anti-neutrophil cytoplasmic antibodies in patients with ulcerative colitis.

Pancreatic autoantibodies in inflammatory bowel disease

A family-based association test for repeatedly measured quantitative traits adjusting for unknown environmental and/or polygenic effects

Tumour necrosis factor- receptor 1 and 2 polymorhpisms in inflammatory bowel disease and their association with response to infliximab

Genomic screening in family-based association testing

Multicollinearity

Introducing the multivariate dale model in population-based genetic association studies

Genome wide scan in a Flemish inflammatory bowel disease population: support for the IBD4 locus, population heterogeneity, and epistasis

Guidelines for the use of epoetin: have quality-of-life benefits been proven?

A local influence approach applied to binary data from a psychiatric study.

The value of serologic markers in indeterminate colitis: A prospective follow-up study - Reply

Multivariate and multidimensional analysis

Transmission of CARD15 (NOD2) variants in families with Crohns disease

Autoimmunity associated with anti-tumor necrosis factor alpha treatment in Crohn's disease: A prospective cohort study

Erythropoietin improves quality of life--a response.

Human recombinant erythropoietin and quality of life: a wonder drug or something to wonder about?

Using word frequencies for testing equivalence between two DNA sequences

The value of serologic markers in indeterminate colitis: A prospective follow-up study

Multicollinearity in prognostic factor analyses using the EORTC QLQ-C30: identification and impact on model selection

Merits of the multivariate Dale model in genetic association studies

The multivariate Dale model and genetic associations