Article (Scientific journals)
Pancreatic autoantibodies in inflammatory bowel disease
Joossens, S.; Vermeire, S.; Van Steen, Kristel et al.
2004In Inflammatory Bowel Diseases, 10 (6), p. 771-777
Peer Reviewed verified by ORBi
 

Files


Full Text
Joossens_2004_pancreatic.pdf
Publisher postprint (119.38 kB)
Request a copy

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
crohn's disease; inflammatory bowel disease; pancreatic autoantibodies; ulcerative colitis; islet-cell antibodies; crohns-disease; ulcerative-colitis; antineutrophil; prevalence; subgroup; antigen; markers; family
Abstract :
[en] Background: Autoantibodies against exocrine pancreas (PABs) have been reported to be specific for Crohn's disease (CD), albeit at a low prevalence (30%). We studied PABs in patients with inflammatory bowel disease (IBD), unaffected family members, and control subjects. Methods: A Belgian study cohort of 575 subjects, including 289 IBD patients (CD, 169 patients; ulcerative colitis [UC], 120 patients), 108 unaffected first-degree relatives, 78 subjects with non-IBD gastrointestinal disorders (gastrointestinal control subjects [GIcos]), and 100 healthy control subjects (Hcos), were tested for PAB by a standardized indirect immunofluorescence method. Results: The prevalence of PABs in this study cohort was 32% for CD, 23.3% for UC, and 22.2% for their unaffected family members (all P < 0.001), compared with 1.3% for GIcos and 0% for Hcos. Two staining patterns could be observed: an intracellular pattern (IC); and an extracellular pattern (EC). The EC was significantly more prevalent in CD patients compared with UC patients (P = 0.014), and higher titers of this pattern were found in CD patients (P = 0.01). Both PAB patterns were negatively associated with stricturing disease behavior of CD (P = 0.021). The IC was associated with familial CD (P = 0.0009) and familial UC (P = 0.0003). Conclusions: The prevalence of PAB found in CD patients in this study was similar to that cited in previous reports. In contrast to these reports, we also found an increased prevalence of PABs in patients with UC and in unaffected first-degree relatives of IBD patients. We observed two main staining patterns, both of which were present in IBD and were associated with specific phenotypes of the disease.
Disciplines :
Gastroenterology & hepatology
Author, co-author :
Joossens, S.
Vermeire, S.
Van Steen, Kristel  ;  Université de Liège - ULiège > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Bioinformatique
Godefridis, G.
Claessens, G.
Pierik, M.
Hietinck, R.
Aerts, R.
Rutgeerts, P.
Bossuyt, X.
Language :
English
Title :
Pancreatic autoantibodies in inflammatory bowel disease
Publication date :
2004
Journal title :
Inflammatory Bowel Diseases
ISSN :
1078-0998
eISSN :
1536-4844
Publisher :
Lippincott Williams & Wilkins, Hagerstown, United States - Maryland
Volume :
10
Issue :
6
Pages :
771-777
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 23 May 2010

Statistics


Number of views
40 (4 by ULiège)
Number of downloads
0 (0 by ULiège)

Scopus citations®
 
61
Scopus citations®
without self-citations
55
OpenCitations
 
43

Bibliography


Similar publications



Contact ORBi