Article (Scientific journals)
PBAT: a comprehensive software package for genome-wide association analysis of complex family-based studies
Van Steen, Kristel; Lange, C.
2005In Human Genomics, 2 (1), p. 67-9
Peer Reviewed verified by ORBi
 

Files


Full Text
PBAT-human genomics online version.pdf
Author preprint (42.59 kB)
Request a copy

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
Family; *Genome, Human; Genomics/instrumentation/*methods; Humans; Models, Genetic; Polymorphism, Single Nucleotide; *Software
Abstract :
[en] The PBAT software package (v2.5) provides a unique set of tools for complex family-based association analysis at a genome-wide level. PBAT can handle nuclear families with missing parental genotypes, extended pedigrees with missing genotypic information, analysis of single nucleotide polymorphisms (SNPs), haplotype analysis, quantitative traits, multivariate/longitudinal data and time to onset phenotypes. The data analysis can be adjusted for covariates and gene/environment interactions. Haplotype-based features include sliding windows and the reconstruction of the haplotypes of the probands. PBAT's screening tools allow the user successfully to handle the multiple comparisons problem at a genome-wide level, even for 100,000 SNPs and more. Moreover, PBAT is computationally fast. A genome scan of 300,000 SNPs in 2,000 trios takes 4 central processing unit (CPU)-days. PBAT is available for Linux, Sun Solaris and Windows XP.
Disciplines :
Physical, chemical, mathematical & earth Sciences: Multidisciplinary, general & others
Author, co-author :
Van Steen, Kristel  ;  Université de Liège - ULiège > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Bioinformatique
Lange, C.
Language :
English
Title :
PBAT: a comprehensive software package for genome-wide association analysis of complex family-based studies
Publication date :
2005
Journal title :
Human Genomics
ISSN :
1473-9542
eISSN :
1479-7364
Publisher :
Henry Stewart Publications LLP
Volume :
2
Issue :
1
Pages :
67-9
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
2005/04/09
Available on ORBi :
since 24 May 2010

Statistics


Number of views
57 (2 by ULiège)
Number of downloads
2 (0 by ULiège)

Scopus citations®
 
61
Scopus citations®
without self-citations
52
OpenCitations
 
60

Bibliography


Similar publications



Contact ORBi