Reference : Approaches to handling incomplete data in family-based association testing
Scientific journals : Article
Life sciences : Genetics & genetic processes
http://hdl.handle.net/2268/38805
Approaches to handling incomplete data in family-based association testing
English
Van Steen, Kristel mailto [Université de Liège - ULg > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Bioinformatique >]
Laird, N. M. [> > > >]
Markel, P. [> > > >]
Molenberghs, G. [> > > >]
2007
Annals of Human Genetics
Cambridge University Press
71
Pt 2
141-51
International
0003-4800
Cambridge
United Kingdom
[en] Data Interpretation, Statistical ; Family ; Female ; Genetics, Medical/*statistics & numerical data ; Genotype ; Haplotypes ; Humans ; Male ; Models, Statistical
[en] The high throughput of data arising from the complete sequence of the human genome has left statistical geneticists with a rich and extensive information source. The wide availability of software and the increase in computing power has improved the possibilities to access and process such data. One problem is incompleteness of the data: unobserved or partially observed data points due to technical reasons or reasons associated with the patient's status or erroneous measurements of phenotype or genotype, to name a few. When not properly accounted for, these sources of incompleteness may seriously jeopardize the credibility of results from analyses. In this paper we provide some perspectives on the occurrence and analysis of different forms of incomplete data in family-based genetic association testing.
http://hdl.handle.net/2268/38805
2006/11/14

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