Article (Scientific journals)
Health-related quality of life parameters as prognostic factors in a nonmetastatic breast cancer population: An international multicenter study
Efficace, F.; Therasse, P.; Piccart, M. J. et al.
2004In Journal of Clinical Oncology, 22 (16), p. 3381-3388
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Keywords :
cox regression; eortc qlq-c30; chemotherapy; scores; survival; oncology; model; women; trial; identification
Abstract :
[en] Purpose The purpose of this research was to evaluate whether baseline health-related quality of life (HRQOL) parameters are prognostic factors for survival in locally advanced breast cancer patients. Although the literature highlights the important role of HRQOL parameters in predicting survival in advanced metastatic disease, little evidence exists for earlier stages. Patients and Methods The overall sample consisted of 448 patients randomly assigned to receive cyclophosphamide, epirubicin, and fluorouracil versus epirubicin, cyclophosphamide, and granulocyte colony-stimulating factor. Patients were enrolled in 12 countries. HRQOL baseline scores were assessed using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire C30. The Cox proportional hazards regression model was used for both univariate and multivariate analyses of survival. In addition, a bootstrap resampling technique was used to assess the stability of the outcomes. Bootstrap results were then applied for model averaging purposes as a means to account for the observed model selection uncertainty. Results The final multivariate model retained inflammatory breast cancer (T4d) as the only factor predicting overall survival (OS) with a hazard ratio of 1.375 (95% CI, 1.027 to 1.840; P = .03). The presence of inflammatory breast cancer lowers the median survival time from 6.6 to 4.2 years (36% reduction). None of the preselected HRQOL variables were prognostic for OS or disease-free survival, in either the univariate or multivariate analysis. Conclusion Our findings suggest that baseline HBQOL parameters have no prognostic value in a nonmetastatic breast cancer population.
Disciplines :
Oncology
Author, co-author :
Efficace, F.
Therasse, P.
Piccart, M. J.
Coens, C.
Van Steen, Kristel  ;  Université de Liège - ULiège > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Bioinformatique
Welnicka-Jaskiewicz, M.
Cufer, T.
Dyczka, J.
Lichinitser, M.
Shepherd, L.
de Haes, H.
Sprangers, M. A.
Bottomley, A.
More authors (3 more) Less
Language :
English
Title :
Health-related quality of life parameters as prognostic factors in a nonmetastatic breast cancer population: An international multicenter study
Publication date :
2004
Journal title :
Journal of Clinical Oncology
ISSN :
0732-183X
eISSN :
1527-7755
Publisher :
American Society of Clinical Oncology, Alexandria, United States - Virginia
Volume :
22
Issue :
16
Pages :
3381-3388
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 22 May 2010

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