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| Reference : Specific IgE against Staphylococcus aureus enterotoxins: An independent risk factor for ... |
| Scientific journals : Article | |||
| Human health sciences : Immunology & infectious disease | |||
| http://hdl.handle.net/2268/129630 | |||
| Specific IgE against Staphylococcus aureus enterotoxins: An independent risk factor for asthma | |
| English | |
| Bachert, C. [Upper Airway Research Laboratory (URL), Ghent University Hospital, Ghent, Belgium] | |
Van Steen, Kristel  [Université de Liège - ULg > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Bioinformatique >] | |
| Zhang, N. [Upper Airway Research Laboratory (URL), Ghent University Hospital, Ghent, Belgium] | |
| Holtappels, G. [Upper Airway Research Laboratory (URL), Ghent University Hospital, Ghent, Belgium] | |
| Cattaert, Tom [Université de Liège - ULg > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Bioinformatique >] | |
| Maus, Bärbel [Université de Liège - ULg > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Bioinformatique >] | |
| Buhl, R. [Pulmonary Department, Mainz University Hospital, Mainz, Germany] | |
| Taube, C. [Pulmonary Department, Mainz University Hospital, Mainz, Germany, Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands] | |
| Korn, S. [Pulmonary Department, Mainz University Hospital, Mainz, Germany] | |
| Kowalski, M. [Department of Allergy, Immunology and Rheumatology, Medical University of Lodz, Lódź, Poland] | |
| Bousquet, J. [University Hospital and INSERM 1080, Montpellier, Montpellier, France] | |
| Howarth, P. [Clinical and Experimental Sciences, Faculty of Medicine, Southampton University and National Institute of Health Respiratory Biomedical Research Unit, Southampton General Hospital, Southampton, United Kingdom] | |
| 2012 | |
| Journal of Allergy and Clinical Immunology (The) | |
| 130 | |
| 2 | |
| 376-381.e8 | |
| 0091-6749 | |
| [en] Asthma ; FEV 1 ; IgE ; Staphylococcus aureus | |
| [en] Background: The role of IgE in patients with severe asthma is not fully understood. Objective: We sought to investigate whether IgE to Staphylococcus aureus enterotoxins might be relevant to disease severity in adult asthmatic patients. Methods: Specific IgE antibody concentrations in serum against enterotoxins, grass pollen (GP), and house dust mite allergens and total IgE levels were measured in adult cohorts of 69 control subjects, 152 patients with nonsevere asthma, and 166 patients with severe asthma. Severe asthma was defined as inadequately controlled disease despite high-dose inhaled corticosteroids plus at least 2 other controller therapies, including oral steroids. Results: Enterotoxin IgE positivity was significantly greater in patients with severe asthma (59.6%) than in healthy control subjects (13%, P < .001). Twenty-one percent of patients with severe asthma with enterotoxin IgE were considered nonatopic. Logistic regression analyses demonstrated significantly increased risks for enterotoxin IgE-positive subjects to have any asthma (OR, 7.25; 95% CI, 2.7-19.1) or severe asthma (OR, 11.09; 95% CI, 4.1-29.6) versus enterotoxin IgE-negative subjects. The presence of GP or house dust mite IgE antibodies was not associated with either significantly increased risk for asthma or severity. Oral steroid use and hospitalizations were significantly increased in patients with enterotoxin IgE and nonatopic asthma. GP IgE was associated with a higher FEV
1 percent predicted value, and enterotoxin IgE was associated with a lower FEV 1 percent predicted value. Conclusions: Staphylococcal enterotoxin IgE antibodies, but not IgE against inhalant allergens, are risk factors for asthma severity. We hypothesize that the presence of enterotoxin IgE in serum indicates the involvement of staphylococcal superantigens in the pathophysiology of patients with severe asthma. © 2012 American Academy of Allergy, Asthma & Immunology. | |
| http://hdl.handle.net/2268/129630 | |
| 10.1016/j.jaci.2012.05.012 |
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