Reference : Plasminogen activator inhibitor-1 protects endothelial cells from FasL-mediated apoptosis.
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/9665
Plasminogen activator inhibitor-1 protects endothelial cells from FasL-mediated apoptosis.
English
Bajou, Khalid mailto [Université de Liège - ULg > Département des sciences de la vie > Biologie et génétique moléculaire >]
Peng, H. [ > > ]
Laug, W. E. [ > > ]
Maillard, Catherine [Université de Liège - ULg > Département des sciences cliniques > Labo de biologie des tumeurs et du développement >]
Noël, Agnès mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biologie cellulaire et moléculaire appliquée à l'homme >]
Foidart, Jean-Michel mailto [Université de Liège - ULg > Département des sciences cliniques > Gynécologie - Obstétrique - Labo de biologie des tumeurs et du développement >]
Martial, Joseph mailto [Université de Liège - ULg > Département des sciences de la vie > Biologie et génétique moléculaire >]
Declerck, Y. A. [ > > ]
2008
Cancer Cell
Elsevier Science
14
4
324-34
Yes (verified by ORBi)
International
1535-6108
[en] CELLCYCLE ; CELLBIO
[en] Plasminogen activator inhibitor-1 (PAI-1) paradoxically enhances tumor progression and angiogenesis; however, the mechanism supporting this role is not known. Here we provide evidence that PAI-1 is essential to protect endothelial cells (ECs) from FasL-mediated apoptosis. In the absence of host-derived PAI-1, human neuroblastoma cells implanted in PAI-1-deficient mice form smaller and poorly vascularized tumors containing an increased number of apoptotic ECs. We observed that knockdown of PAI-1 in ECs enhances cell-associated plasmin activity and increases spontaneous apoptosis in vitro. We further demonstrate that plasmin cleaves FasL at Arg144-Lys145, releasing a soluble proapoptotic FasL fragment from the surface of ECs. The data provide a mechanism explaining the proangiogenic activity of PAI-1.
Giga-Cancer
http://hdl.handle.net/2268/9665
10.1016/j.ccr.2008.08.012

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Open access
Bajou Cancer Cell 2008.pdfAuthor postprint673.36 kBView/Open

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.