Reference : Application of new methodologies based on design of experiments, independent componen...
Scientific journals : Article
Physical, chemical, mathematical & earth Sciences : Multidisciplinary, general & others
Human health sciences : Pharmacy, pharmacology & toxicology
http://hdl.handle.net/2268/88084
Application of new methodologies based on design of experiments, independent component analysis and design space for robust optimization in liquid chromatography
English
Debrus, Benjamin mailto [Université de Liège - ULg > Département de pharmacie > Chimie analytique >]
Lebrun, Pierre mailto [Université de Liège - ULg > Département de pharmacie > Chimie analytique >]
Ceccato, Attilio [Université de Liège - ULg > Département de pharmacie > Analyse des médicaments >]
Caliaro, Gabriel [ > > ]
Rozet, Eric [Université de Liège - ULg > Département de pharmacie > Chimie analytique >]
Nistor, Iolanda [Université de Liège - ULg > > > Form. doc. sc. bioméd. & pharma.]
Oprean, Radu [ > > ]
Rupérez, Fransico J. [ > > ]
Barbas, Coral [ > > ]
Boulanger, Bruno [Université de Liège - ULg > Département de pharmacie > Analyse des médicaments >]
Hubert, Philippe mailto [Université de Liège - ULg > Département de pharmacie > Chimie analytique >]
2011
Analytica Chimica Acta
Elsevier
691
33-42
Yes (verified by ORBi)
International
0003-2670
1873-4324
Amsterdam
The Netherlands
[en] High-performance liquid chromatography ; Method development ; Separation optimization ; Experimental design ; Design space ; Independent component analysis ; Quality by design
[en] HPLC separations of an unknown sample mixture and a pharmaceutical formulation have been optimized using a recently developed chemometric methodology proposed by W. Dewé et al. in 2004 and improved by P. Lebrun et al. in 2008. This methodology is based on experimental designs which are used to model retention times of compounds of interest. Then, the prediction accuracy and the optimal separation robustness, including the uncertainty study, were evaluated. Finally, the design space (ICH Q8(R2) guideline) was computed as the probability for a criterion to lie in a selected range of acceptance. Furthermore, the chromatograms were automatically read. Peak detection and peak matching were carried out with a previously developed methodology using independent component analysis published by B. Debrus et al. in 2009. The present successful applications strengthen the high potential of these methodologies for the automated development of chromatographic methods.
Région wallonne : Direction générale des Technologies, de la Recherche et de l'Energie - DGTRE ; Arlenda S.A.
ADAM & Optimal-DS
Researchers ; Professionals
http://hdl.handle.net/2268/88084
10.1016/j.aca.2011.02.035
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TF4-527PRR0-1&_user=532038&_coverDate=04%2F08%2F2011&_rdoc=5&_fmt=high&_orig=browse&_origin=browse&_zone=rslt_list_item&_srch=doc-info%28%23toc%235216%232011%23993089998%233059746%23FLA%23display%23Volume%29&_cdi=5216&_sort=d&_docanchor=&view=c&_ct=17&_acct=C000026659&_version=1&_urlVersion=0&_userid=532038&md5=76cf5ef2b38e8863ffc3d9b51375d7d6&searchtype=a

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Restricted access
ACA_DoE-ICA-DS_2011_published.pdfPublisher postprint864.92 kBRequest copy

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.