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Debrus Benjamin

Département de pharmacie > Chimie analytique

See author's contact details
Main Referenced Co-authors
Hubert, Philippe  (67)
Lebrun, Pierre  (54)
Boulanger, Bruno  (28)
Rozet, Eric  (22)
Marini Djang'Eing'A, Roland  (17)
Main Referenced Keywords
Design Space (12); HPLC (11); Design of experiments (9); Design space (7); design space (6);
Main Referenced Unit & Research Centers
CIRM - Centre Interdisciplinaire de Recherche sur le Médicament - ULiège [BE] (5)
Centre Interfacultaire de Recherche du Médicament (3)
C.I.R.M. (2)
CRIM (2)
CIRM - Service d'Analyse des Médicaments - Service de Chimie Analytique (1)
Main Referenced Disciplines
Pharmacy, pharmacology & toxicology (60)
Physical, chemical, mathematical & earth Sciences: Multidisciplinary, general & others (8)
Mathematics (5)
Chemistry (4)

Publications (total 69)

The most downloaded
2642 downloads
Dispas, A., Lebrun, P., Mbinze Kindenge, J., Debrus, B., Mavar Tayer Mbay, J., Boulanger, B., Marini Djang'Eing'A, R., & Hubert, P. (December 2011). Application d'une nouvelle méthode de développement de méthodes chromatographiques pour lutter contre la contrefaçon des médicaments anti-inflammatoires [Paper presentation]. Chimiométrie 2011, Marseille, France. https://hdl.handle.net/2268/104112

The most cited

225 citations (Scopus®)

De Backer, B., Debrus, B., Lebrun, P., Theunis, L., Dubois, N., Decock, L., Verstraete, A., Hubert, P., & Charlier, C. (08 December 2009). Innovative development and validation of an HPLC/DAD method for the qualitative and quantitative determination of major cannabinoids in cannabis plant material. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 877 (32), 4115-4124. doi:10.1016/j.jchromb.2009.11.004 https://hdl.handle.net/2268/4442

Avohou, T. H., Hubert, C., Debrus, B., Lebrun, P., Rudaz, S., Boulanger, B., & Hubert, P. (2018). Statistical methods in Quality by Design approach to Liquid Chromatography method development. In S. Fekete & I. Molnar, Software-Assisted Method Development for Modeling High Performance Liquid Chromatography (pp. 109-150). London, United Kingdom: World Scientific Publishing. doi:10.1142/q0161
Peer reviewed

Rozet, E., Debrus, B., Lebrun, P., Boulanger, B., Hubert, C., & Hubert, P. (22 January 2015). Design Space for Analytical Methods: Why ? What ? How ? [Paper presentation]. AFSEP - Innovation en développements de méthodes, Lyon, France.

Debrus, B., Lebrun, P., Rozet, E., Schofield, T., Mbinze Kindenge, J., Marini Djang'Eing'A, R., Rudaz, S., Boulanger, B., & Hubert, P. (2013). A New Method for Quality by Design Robust Optimization in Liquid Chromatography. LC-GC Europe.
Peer Reviewed verified by ORBi

Lebrun, P., Boulanger, B., Debrus, B., Lambert, P., & Hubert, P. (2013). A Bayesian Design Space for analytical methods based on multivariate models and predictions. Journal of Biopharmaceutical Statistics, 23, 1330–1351. doi:10.1080/10543406.2013.834922
Peer Reviewed verified by ORBi

Rozet, E., Lebrun, P., Debrus, B., Boulanger, B., & Hubert, P. (2013). Design Spaces for Analytical Methods. TrAC: Trends in Analytical Chemistry, 42, 157-167. doi:10.1016/j.trac.2012.09.007
Peer Reviewed verified by ORBi

Mbinze Kindenge, J., Lebrun, P., Debrus, B., Dispas, A., Kalenda Tshilombo, N., Mavar Tayey Mbay, J., Schofield, T., Boulanger, B., Rozet, E., Hubert, P., & Marini Djang'Eing'A, R. (12 September 2012). APPLICATION OF AN INNOVATIVE DESIGN SPACE OPTIMIZATION STRATEGY TO THE DEVELOPMENT OF LC METHODS TO COMBAT POTENTIALLY COUNTERFEIT NONSTEROIDAL ANTIINFLAMMATORY DRUGS. Journal of Chromatography. A, 1263, 113-124. doi:10.1016/j.chroma.2012.09.038
Peer Reviewed verified by ORBi

Lamalle, C., Marini Djang'Eing'A, R., Debrus, B., Lebrun, P., Crommen, J., Hubert, P., Servais, A.-C., & Fillet, M. (07 August 2012). Development of a generic micellar electrokinetic chromatography method for the separation of 15 antimalarial drugs as a tool to detect medicine counterfeiting. Electrophoresis, 33, 1669-1678. doi:10.1002/elps.201100621
Peer Reviewed verified by ORBi

Mbinze Kindenge, J., Lebrun, P., Debrus, B., Dispas, A., Hubert, C., Rozet, E., Marini Djang'Eing'A, R., & Hubert, P. (June 2012). APPLICATION OF AN INNOVATIVE DESIGN SPACE OPTIMIZATION STRATEGY TO THE DEVELOPMENT OF LC METHODS TO COMBAT POTENTIALLY COUNTERFEIT NSAIDS [Poster presentation]. HPLC 2012, Anaheim, California, United States.

Mbinze Kindenge, J., Lebrun, P., Debrus, B., Dispas, A., Hubert, P., & Marini Djang'Eing'A, R. (May 2012). THE DEVELOPMENT OF LC GENERIC ANALYTICAL METHODS TO FIGHT COUNTERFEIT NSAIDS USING DESIGN SPACE OPTIMISATION STRATEGY [Paper presentation]. 16ème FORUM DES SCIENCES PHARMACEUTIQUES, Blankenberge, Belgium.

Rozet, E., Debrus, B., Lebrun, P., Boulanger, B., & Hubert, P. (February 2012). COMBINATION OF INDEPENDENT COMPONENT ANALYSIS, DESIGN OF EXPERIMENTS AND DESIGN SPACE FOR A NOVEL METHODOLOGY TO DEVELOP CHROMATOGRAPHIC METHODS [Poster presentation]. 12th International Symposium on Hyphenated Techniques for Chromatography (HTC-12), Bruges, Belgium.

Tyteca, E., Liekens, A., Clicq, D., Fanigliulo, A., Debrus, B., Rudaz, S., Guillarme, D., & Desmet, G. (2012). Predictive elution window stretching and shifting as a generic search strategy for automated method development for liquid chromatography. Analytical Chemistry, 84 (18), 7823-7830. doi:10.1021/ac301331g
Peer Reviewed verified by ORBi

Rozet, E., Lebrun, P., Debrus, B., & Hubert, P. (2012). New Methodology for the development of chromatographic methods with bioanalytical application. Bioanalysis, 4 (7), 755-758. doi:10.4155/bio.12.47
Peer Reviewed verified by ORBi

Debrus, B., Rozet, E., Hubert, P., Veuthey, J.-L., Rudaz, S., & Guillarme, D. (2012). Chapter 3 Method Transfer Between Conventional HPLC and UHPLC. In D. Guillarme & J.-L. Veuthey (Eds.), UHPLC in Life Sciences (pp. 67-101). Royal Society of Chemistry. doi:10.1039/9781849735490-00067
Peer reviewed

Rafamantanana, M. H., Debrus, B., Raoelison, G., Rozet, E., Lebrun, P., Uverg-Ratsimamanga, S., Hubert, P., & Quetin-Leclercq, J. (2012). APPLICATION OF DESIGN OF EXPERIMENTS AND DESIGN SPACE METHODOLOGY FOR THE HPLC-UV SEPARATION OPTIMIZATION OF APORPHINE ALKALOIDS FROM LEAVES OF Spirospermum penduliflorum THOUARS. Journal of Pharmaceutical and Biomedical Analysis, 62, 23-32. doi:10.1016/j.jpba.2011.12.028
Peer Reviewed verified by ORBi

Houbart, V., COBRAIVILLE, G., Lecomte, F., Debrus, B., Hubert, P., & Fillet, M. (16 December 2011). Development of a nano-liquid chromatography on chip tandem mass spectrometry method for high-sensitivity hepcidin quantitation. Journal of Chromatography. A, 1218 (50), 9046-9054. doi:10.1016/j.chroma.2011.10.030
Peer Reviewed verified by ORBi

Dispas, A., Lebrun, P., Mbinze Kindenge, J., Debrus, B., Mavar Tayer Mbay, J., Boulanger, B., Marini Djang'Eing'A, R., & Hubert, P. (December 2011). Application d'une nouvelle méthode de développement de méthodes chromatographiques pour lutter contre la contrefaçon des médicaments anti-inflammatoires [Paper presentation]. Chimiométrie 2011, Marseille, France.

Rozet, E., Debrus, B., Lebrun, P., Boulanger, B., & Hubert, P. (08 September 2011). New Methodology for the Development of Chromatographic Methods [Paper presentation]. 17th International Symposium on Separation Sciences – ISSS 2011, Cluj, Romania.

Marini Djang'Eing'A, R., Mbinze Kindenge, J., Debrus, B., Lebrun, P., Mantanus, J., Ziemons, E., Lamalle, C., Fillet, M., Rudaz, S., & Hubert, P. (September 2011). IMPLEMENTATION OF GENERIC ANALYTICAL METHODS TO FIGHT AGAINST COUNTERFEIT MEDICINES [Paper presentation]. Recent Development in Pharmaceutical Analysis (RDPA), Pavia, Italy.

Lamalle, C., Marini Djang'Eing'A, R., Debrus, B., Lebrun, P., Crommen, J., Hubert, P., Servais, A.-C., & Fillet, M. (September 2011). GENERIC MEKC METHOD FOR THE SEPARATION OF 15 ANTIMALARIAL DRUGS [Poster presentation]. Recent Development in Pharmaceutical Analysis (RDPA), Pavia, Italy.

Lamalle, C., Marini Djang'Eing'A, R., Debrus, B., Lebrun, P., Servais, A.-C., Crommen, J., Hubert, P., & Fillet, M. (June 2011). Development of a Generic MEKC Method for the Separation of 15 Antimalarial Drugs by a Design Space Approach [Poster presentation]. 36th International symposium on HPLC and Related Techniques, Budapest, Hungary.

Debrus, B. (2011). Nouvelle méthodologie pour le développement de méthodes chromatographiques [Doctoral thesis, Université de Liège]. ORBi-University of Liège. https://orbi.uliege.be/handle/2268/315366

Lebrun, P., Boulanger, B., Hubert, P., Mbinze Kindenge, J., & Debrus, B. (02 March 2011). Design Space and desirability index. A Bayesian predictive risk-based approach to flexibly achieve multi-criteria decision methods [Paper presentation]. The Second International Symposium on Biopharmaceutical Statistics, Berlin, Germany.

Debrus, B., Broséus, J., Guillarme, D., Lebrun, P., Hubert, P., Veuthey, J.-L., Esseiva, P., & Rudaz, S. (March 2011). Innovative methodology to transfer conventional GC-MS heroin profiling to UHPLC-MS/MS. Analytical and Bioanalytical Chemistry, 399 (8), 2719-2730. doi:10.1007/s00216-010-4282-7
Peer Reviewed verified by ORBi

Nistor, I., Cao, M., Debrus, B., Lebrun, P., Lecomte, F., Rozet, E., Angenot, L., Frederich, M., Oprean, R., & Hubert, P. (2011). Application of a new optimization strategy for the separation of tertiary alkaloids extracted from Strychnos usambarensis leaves. Journal of Pharmaceutical and Biomedical Analysis, 56, 30-37. doi:10.1016/j.jpba.2011.04.027
Peer Reviewed verified by ORBi

Debrus, B., Lebrun, P., Mbinze Kindenge, J., Lecomte, F., Ceccato, A., Caliaro, G., Mavar Tayey Mbay, J., Boulanger, B., Marini Djang'Eing'A, R., Rozet, E., & Hubert, P. (2011). Innovative high-performance liquid chromatography method development for the screening of 19 antimalarial drugs based on a generic approach, using design of experiments, independent component analysis and design space. Journal of Chromatography. A, 1218, 5205-5215. doi:10.1016/j.chroma.2011.05.102
Peer Reviewed verified by ORBi

Krier, F., Brion, M., Debrus, B., Lebrun, P., Driesen, A., Ziemons, E., Evrard, B., & Hubert, P. (2011). Optimisation and validation of a fast HPLC method for the quantification of sulindac and its related impurities. Journal of Pharmaceutical and Biomedical Analysis, 54, 694-700. doi:10.1016/j.jpba.2010.10.022
Peer Reviewed verified by ORBi

ZIME DIAWARA, H., GBAGUIDI, F., Evrard, B., Quetin-Leclercq, J., MOUDACHIROU, M., Debrus, B., Hubert, P., & Rozet, E. (2011). Validation, transfer and measurement uncertainty estimation of an HPLC-UV method for the quantification of artemisinin in hydro alcoholic extracts of Artemisia annua L. Journal of Pharmaceutical and Biomedical Analysis, 56, 7-15. doi:10.1016/j.jpba.2011.04.012
Peer Reviewed verified by ORBi

Debrus, B., & Hubert, P. (2011). Introduction à la chromatographie liquide. (ULiège - Université de Liège).

Debrus, B., Lebrun, P., Ceccato, A., Caliaro, G., Rozet, E., Nistor, I., Oprean, R., Rupérez, F. J., Barbas, C., Boulanger, B., & Hubert, P. (2011). Application of new methodologies based on design of experiments, independent component analysis and design space for robust optimization in liquid chromatography. Analytica Chimica Acta, 691, 33-42. doi:10.1016/j.aca.2011.02.035
Peer Reviewed verified by ORBi

Lebrun, P., Lambert, P., Debrus, B., Hubert, P., Marini Djang'Eing'A, R., Moonen, F., & Boulanger, B. (December 2010). Developing and optimizing analytical chromatographic method in a Quality by Design environment. Bayesian multi-criteria risk-based Design Space to guarantee future quality [Poster presentation]. Chimiométrie 2010, Paris, France.

Krier, F., Brion, M., Debrus, B., Lebrun, P., Driesen, A., Ziemons, E., Evrard, B., & Hubert, P. (15 November 2010). Optimisation and validation of a fast HPLC method for the quantification of sulindac and its related impurities [Poster presentation]. The FIP Pharmaceutical Sciences World Congress 2010 in association with the AAPS Annual Meeting & Exposition, new orléans, United States.

Nistor, I., Debrus, B., Lebrun, P., Cao, M., Frederich, M., Angenot, L., Oprean, R., & Hubert, P. (September 2010). Application of experimental design and design space for the separation of compounds extracted from the leaves of Strychnos usambarensis [Paper presentation]. Drug Analysis 2010, Antwerpen, Belgium.

Dubois, N., Debrus, B., Hubert, P., & Charlier, C. (September 2010). Validated quantitative simultaneous determination of cocaine, opiates and amphetamines in serum by UHPLC-MS/MS [Poster presentation]. Drug Analysis 2010, Antwerp, Belgium.

Krier, F., Brion, M., Debrus, B., Lebrun, P., Driesen, A., Evrard, B., & Hubert, P. (September 2010). Optimisation and validation of a fast HPLC method for the quantitation of sulindac and its impurities [Poster presentation]. Drug Analysis 2010, Anvers (Antwerp), Belgium.

Marini Djang'Eing'A, R., Mbinze Kindenge, J., Montes, M. L. A., Debrus, B., Lebrun, P., Mantanus, J., Ziemons, E., Rohrbasser, C., Rudaz, S., & Hubert, P. (September 2010). Analytical tools to fight against counterfeit medicines. Chimica Oggi, 28 (5), 10-14.
Peer Reviewed verified by ORBi

Marini Djang'Eing'A, R., Mbinze Kindenge, J., Montes, M. L. A., Debrus, B., Lebrun, P., Mantanus, J., Ziemons, E., Rudaz, S., & Hubert, P. (September 2010). Contribution to fight against counterfeit medecines applying several analytical tools [Poster presentation]. International Symposium on Drug Analysis 2010, Anvers, Belgium.

Nistor, I., Lecomte, F., Mbinze Kindenge, J., Debrus, B., Lebrun, P., Marini Djang'Eing'A, R., Oprean, R., & Hubert, P. (September 2010). Transfer of a conventional LC method for the screening of conterfeit antimalarial medicines to UHPLC [Poster presentation]. Drug analysis 2010, Antwerpen, Belgium.

Debrus, B., Lebrun, P., Boulanger, B., Rozet, E., Caliaro, G., Ceccato, A., & Hubert, P. (September 2010). Implementation of design space concept for the development of robust analytical methods [Poster presentation]. Drug Analysis 2010, Anvers (Antwerp), Belgium.

Rafamantanana, M. H., Debrus, B., Raoelison, G. E., Uverg-Ratsimamanga, S., Hubert, P., & Quetin-Leclercq, J. (September 2010). Application of experimental design for the HPLC-UV-MS separation of aporphine alkaloids from leaves of Spirospermum Penduliflorum thouars [Poster presentation]. Drug Analysis 2010, Antwerp, Belgium.

Lamalle, C., Marini Djang'Eing'A, R., Debrus, B., Servais, A.-C., Crommen, J., Hubert, P., & Fillet, M. (September 2010). A DESIGN SPACE APPROACH TO DEVELOP A GENERIC CE METHOD FOR THE SEPARATION OF 19 ANTIMALARIAL DRUGS [Poster presentation]. International Symposium on Drug Analysis, Anvers, Belgium.

Nistor, I., Debrus, B., Lebrun, P., Lecomte, F., Cao, M., Frederich, M., Angenot, L., Boulanger, B., Oprean, R., & Hubert, P. (September 2010). Application of experimental design and design for the separation of compounds extracted from the leaves of Strychnos Usambarensis [Poster presentation]. Drug analysis 2010, Antwerpen, Belgium.

Marini Djang'Eing'A, R., Mbinze Kindende, J., Lecomte, F., Debrus, B., Lebrun, P., Rozet, E., Mantanus, J., Ziemons, E., & Hubert, P. (31 July 2010). La contrefaçon des médicaments : outils pour lutter contre ce fléau [Paper presentation]. Conférence Scientifique, Kisangani, Province Orientale, Congo - Kinshasa.

Nistor, I., Debrus, B., Lebrun, P., Lecomte, F., Martine, C., Frederich, M., Angenot, L., Boulanger, B., Oprean, R., & Hubert, P. (26 January 2010). Optimisation de la séparation des alcaloïdes extraits des feuilles de Strychnos usambarensis au moyen du design space [Paper presentation]. Assemblée générale du CIRM et forum des jeunes chercheurs, Liège, Belgium.

Debrus, B., Lebrun, P., Boulanger, B., Rozet, E., Caliaro, G., Ceccato, A., & Hubert, P. (2010). Development of robust analytical methods using design space methodology [Poster presentation]. Chimiométrie 2010, Paris, France.

Dubois, N., Debrus, B., Hubert, P., & Charlier, C. (2010). Validated quantitative simultaneous determination of cocaine opiates and amphetamines in serum by U-HPLC coupled to tandem mass spectrometry. Acta Clinica Belgica, 65 (1), 75-84. doi:10.1179/acb.2010.113
Peer Reviewed verified by ORBi

De Backer, B., Debrus, B., Lebrun, P., Theunis, L., Dubois, N., Decock, L., Verstraete, A., Hubert, P., & Charlier, C. (08 December 2009). Innovative development and validation of an HPLC/DAD method for the qualitative and quantitative determination of major cannabinoids in cannabis plant material. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 877 (32), 4115-4124. doi:10.1016/j.jchromb.2009.11.004
Peer Reviewed verified by ORBi

Mbinze Kindenge, J., Marini Djang'Eing'A, R., Debrus, B., Lebrun, P., Lecomte, F., Boulanger, B., & Hubert, P. (December 2009). Développement d’une méthode pour la séparation de 19 antipaludéens par HPLC au moyen de la planification expérimentale et du Design Space [Poster presentation]. 7ème congrès francophone de l'AfSep sur les sciences séparatives et les couplages (SEP'09), Marseille, France.

Nistor, I., Debrus, B., Lebrun, P., Lecomte, F., Cao, M., Frederich, M., Angenot, L., Boulanger, B., Oprean, R., & Hubert, P. (December 2009). Application de la planification expérimentale et du design space pour la séparation des composés extraits des feuilles de Strychnos usambarensis [Poster presentation]. 7ème congrès francophone de l'AfSep sur les sciences séparatives et les couplages (SEP'09), Marseille, France.

De Backer, B., Debrus, B., Lebrun, P., Dubois, N., Hubert, P., & Charlier, C. (October 2009). Innovative development and validation of an HPLC/DAD method for the qualitative and quantitative determination of major cannabinoids in cannabis plant material [Paper presentation]. 4èmes journées internationales de Toxicologie, Liège, Belgium.

Debrus, B., Broséus, J., Guillarme, D., Hubert, P., Veuthey, J.-L., Esseiva, P., & Rudaz, S. (October 2009). Implementation of new Fast-GC-MS and UHPLC-MS/MS data in a conventional GC-MS database for heroin profiling [Paper presentation]. 4èmes journées internationales de toxicologie hospitalière, Liège, Belgium.

De Backer, B., Debrus, B., Lebrun, P., Dubois, N., Hubert, P., & Charlier, C. (October 2009). Innovative development and validation of an HPLC/DAD method for the qualitative and quantitative determination of major cannabinoids in cannabis plant material [Poster presentation]. 4èmes journées internationales de Toxicologie, Liège, Belgium.

Debrus, B., Broséus, J., Guillarme, D., Hubert, P., Veuthey, J.-L., Esseiva, P., & Rudaz, S. (August 2009). Transfer of heroin profiling method from conventional GC-MS to Fast-GC-MS and UHPLC-MS/MS [Paper presentation]. TIAFT 2009, Genève, Switzerland.

De Backer, B., Debrus, B., Lebrun, P., Dubois, N., Hubert, P., & Charlier, C. (August 2009). Innovative development and validation of an HPLC/DAD method for the qualitative and quantitative determination of major cannabinoïds in cannabis plant material [Poster presentation]. 47ème meeting de l'International Association of Forensic Toxicologists (TIAFT), Genève, Switzerland.

Debrus, B., Lebrun, P., Ceccato, A., Caliaro, G., Govaerts, B., Olsen, B. A., Rozet, E., Boulanger, B., & Hubert, P. (30 June 2009). A new statistical method for the automated detection of peaks in UV-DAD chromatograms of a sample mixture. Talanta, 79, 77-85. doi:10.1016/j.talanta.2009.03.009
Peer Reviewed verified by ORBi

Nistor, I., Debrus, B., Lebrun, P., Rozet, E., Ceccato, A., Caliaro, G., Oprean, R., Boulanger, B., & Hubert, P. (27 April 2009). Nouvelle méthodologie pour le développement automatisé de méthodes analytiques en chromatographie liquide pour l'analyse de mélanges de composés inconnus [Paper presentation]. Assemblée générale du CIRM et forum des jeunes chercheurs, Liège, Belgium.

Debrus, B., Lebrun, P., Rozet, E., Nistor, I., Ceccato, A., Caliaro, G., Oprean, R., Boulanger, B., & Hubert, P. (2009). Nouvelle méthodologie pour le développement automatisé de méthodes analytiques en chromatographie liquide pour l’analyse de mélanges de composés inconnus. Spectra Analyse, 268, 28-33.
Peer reviewed

Martin, G., Mansion, F., Servais, A.-C., Debrus, B., Rozet, E., Hubert, P., Crommen, J., & Fillet, M. (2009). CE-MS method development for peptides analysis, especially hepcidin, an iron metabolism marker. Electrophoresis, 30 (15), 2624-31. doi:10.1002/elps.200800794
Peer Reviewed verified by ORBi

Lebrun, P., Boulanger, B., Jullion, A., Govaerts, B., Debrus, B., & Hubert, P. (September 2008). Design Space for analytical methods. A Bayesian perspective based on multivariate models and prediction [Paper presentation]. Non-clinical statistics 2008 (NCS2008), Leuven, Belgium.

Debrus, B., Lebrun, P., Ceccato, A., Caliaro, G., Rozet, E., Rupérez, J., Barbas, C., Boulanger, B., & Hubert, P. (July 2008). Chromatographic separation of a pharmaceutical formulation using Design of Experiment and Design Space [Poster presentation]. 11th conference on Chemometrics in Analytical Chemistry (CAC'2008), Montpellier, France.

Lebrun, P., Boulanger, B., Debrus, B., Govaerts, B., & Hubert, P. (June 2008). The Expected Design Space for analytical methods: a new perspective based on modeling and prediction [Paper presentation]. International symposium on biopharmaceutical statistics, Shanghai, China.

Debrus, B., Lebrun, P., Ceccato, A., Caliaro, G., Jupérez, J., Barbas, C., Boulanger, B., & Hubert, P. (June 2008). Usefulness of design space for the optimization of chromatographic separations [Paper presentation]. 19th International Symposium on Pharmaceutical and Biomedical Analysis (PBA 2008), Gdansk, Poland.

Lebrun, P., Debrus, B., Boulanger, B., Govaerts, B., & Hubert, P. (May 2008). Use of Independent Component Analysis and clustering methods to find and identify relevant components in a matrix of UV-spectral data.

Lebrun, P., Govaerts, B., Debrus, B., Ceccato, A., Caliaro, G., Hubert, P., & Boulanger, B. (2008). Development of a new predictive modelling technique to find with confidence equivalence zone and design space of chromatographic analytical methods. Chemometrics and Intelligent Laboratory Systems, 91, 4-16. doi:10.1016/j.chemolab.2007.05.010
Peer Reviewed verified by ORBi

Lebrun, P., Debrus, B., Boulanger, B., Caliaro, G., Ceccato, A., & Hubert, P. (June 2007). Numerical separation in HPLC-UV-DAD with Independent Component Analysis (ICA) using high order statistics for the automated identification of peaks [Poster presentation]. HPLC 2007, Gent, Belgium.

Debrus, B., Lebrun, P., Boulanger, B., Dewé, W., Ceccato, A., & Hubert, P. (20 March 2007). Séparation numérique et quantification automatique de pics en CLHP-UV grâce à l’utilisation de l’analyse en composantes indépendantes (ICA) [Paper presentation]. SEP 2007, Grenoble, France.

Debrus, B., Lebrun, P., Boulanger, B., Dewé, W., Ceccato, A., & Hubert, P. (20 March 2007). Evaluation d'une nouvelle méthode pour le développement entièrement automatisé de méthodes analytiques en chromatographie liquide [Poster presentation]. SEP 2007, Grenoble, France.

Ziemons, E., Dive, G., Debrus, B., Barillaro, V., Frederich, M., Lejeune, R., Angenot, L., Delattre, L., Thunus, L., & Hubert, P. (February 2007). Study of the physicochemical properties in aqueous medium and molecular modeling of tagitinin C/cyclodextrin complexes. Journal of Pharmaceutical and Biomedical Analysis, 43 (3), 910-919. doi:10.1016/j.jpba.2006.09.011
Peer Reviewed verified by ORBi

Lebrun, P., Boulanger, B., Hubert, P., Debrus, B., & Govaerts, B. (December 2006). Statistical Models and Multi-Criteria Optimization Techniques in Chromatography [Paper presentation]. Chimiométrie 2006, Paris, France.

Boulanger, B., Dewé, W., Ceccato, A., Debrus, B., Lebrun, P., & Hubert, P. (December 2006). Utilisation de l’Analyse en Composantes Indépendantes (ICA) pour la séparation numérique des pics et la quantification automatique en CLHP-UV [Paper presentation]. Chimiométrie 2006, Paris, France.

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