Reference : Modulating skeletal muscle mass by postnatal, muscle-specific inactivation of the myosta...
Scientific journals : Article
Life sciences : Veterinary medicine & animal health
Life sciences : Genetics & genetic processes
http://hdl.handle.net/2268/4433
Modulating skeletal muscle mass by postnatal, muscle-specific inactivation of the myostatin gene.
English
Grobet, Luc mailto [Université de Liège - ULg > Département de productions animales > Génétique > >]
Pirottin, Dimitri mailto [Université de Liège - ULg > Département de productions animales > Génétique > >]
Farnir, Frédéric mailto [Université de Liège - ULg > Département de productions animales > Biostatistique, économie, sélection animale >]
Poncelet, Dominique [Université de Liège - ULG > Département de productions animales > Génétique > >]
Royo, Luis Jose [Université de Liège - ULG > Département de productions animales > Génétique > >]
Brouwers, Benoît mailto [Université de Liège - ULg > Département de productions animales > Génétique > >]
Christians, Elisabeth [Université de Liège - ULG > Département de morphologie et pathologie > Histologie et embryologie > >]
Desmecht, Daniel mailto [Université de Liège - ULg > Département de morphologie et pathologie > Pathologie spéciale et autopsies >]
Coignoul, Freddy mailto [Université de Liège - ULg > Département de morphologie et pathologie > Pathologie générale et autopsies >]
Kahn, Ronald [Harvard Medical School > Department of Medicine > Joslin Diabetes Center > >]
Georges, Michel mailto [Université de Liège - ULg > Département de productions animales > Génétique > >]
2003
Genesis
Wiley
35
4
227-38
Yes
International
1526-954X
1526-968X
New York
United States
[en] Animals ; Crosses, Genetic ; conditional knockout ; cre-lox ; muscular hypertrophy ; myostatin ; Integrases/genetics/metabolism ; Mice ; Mice, Transgenic ; Muscle, Skeletal/metabolism ; Transforming Growth Factor beta/genetics/metabolism ; Viral Proteins/genetics/metabolism
[en] By using a conditional gene targeting approach exploiting the cre-lox system, we show that postnatal inactivation of the myostatin gene in striated muscle is sufficient to cause a generalized muscular hypertrophy of the same magnitude as that observed for constitutive myostatin knockout mice. This formally demonstrates that striated muscle is the production site of functional myostatin and that this member of the TGFbeta family of growth and differentiation factors regulates muscle mass not only during early embryogenesis but throughout development. It indicates that myostatin antagonist could be used to treat muscle wasting and to promote muscle growth in man and animals.
Researchers ; Professionals
http://hdl.handle.net/2268/4433
also: http://hdl.handle.net/2268/94432 ; http://hdl.handle.net/2268/101936
10.1002/gene.10188
Copyright 2003 Wiley-Liss, Inc.

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Restricted access
Grobet_genesis.pdfPublisher postprint496.7 kBRequest copy

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.