Reference : Mice without uPA, tPA, or plasminogen genes are resistant to experimental choroidal n...
Scientific journals : Article
Human health sciences : Ophthalmology
http://hdl.handle.net/2268/3842
Mice without uPA, tPA, or plasminogen genes are resistant to experimental choroidal neovascularization
English
Rakic, Jean-Marie mailto [Université de Liège - ULg > Département des sciences cliniques > Ophtalmologie >]
Lambert, Vincent mailto [Centre Hospitalier Universitaire de Liège - CHU > > Ophtalmologie >]
Munaut, Carine mailto [Université de Liège - ULg > Département des sciences cliniques > Labo de biologie des tumeurs et du développement >]
Bajou, Khalid mailto [Université de Liège - ULg > Département des sciences de la vie > Biologie et génétique moléculaire >]
Peyrollier, Karine [> > > >]
Alvarez Gonzalez, Maria-Luz mailto [Université de Liège - ULg > Département des sciences cliniques > Labo de biologie des tumeurs et du développement >]
Carmeliet, Peter [> > > >]
Foidart, Jean-Michel mailto [Université de Liège - ULg > Département des sciences cliniques > Gynécologie - Obstétrique >]
Noël, Agnès mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biologie cellulaire et moléculaire appliquée à l'homme >]
Apr-2003
Investigative Ophthalmology & Visual Science
Assoc Research Vision Ophthalmology Inc
44
4
1732-1739
Yes (verified by ORBi)
International
0146-0404
Bethesda
[en] plasminogen ; age-related macular degeneration ; angiogenesis
[en] PURPOSE. To evaluate the presence and potential involvement of members of the plasminogen/plasminogen activator (Plg/PA) system in the exudative form of age-related macular degeneration (AMD). METHODS. The expression of PA members mRNA was evaluated in human and experimental choroidal neovascularization (CNV) by RT-PCR. The presence and activity of PA was studied by immunofluorescence and in situ zymography. The influence of endogenous plasminogen (Plg), urokinase (uPA), tissue type plasminogen activator (tPA), and uPA receptor (uPAR) was explored in single-gene-deficient mice in a model of laser-induced CNV. RESULTS. Members of the Plg/PA system were present both in human and murine CNV. The absence of Pig, uPA, or tPA significantly decreased the development of experimental CNV compared with wild-type or uPAR-deficient mice. This effect could be attributable, partly to a modulation of matrix metalloproteinase activity, but also to an accumulation of fibrinogen-fibrin in the laser-induced wounds. CONCLUSIONS. Together with previous work done by the authors, this study indicates that choroidal neovascularization is extremely sensitive to the modulation of Plg/PA system activity. This may provide a new strategy for the treatment of exudative AMD.
http://hdl.handle.net/2268/3842
http://www.iovs.org/cgi/content/full/44/4/1732

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Open access
Rakic JM Mice IOVS2003.pdf.pdfAuthor postprint508.06 kBView/Open
Restricted access
Rakic JM Mice IOVS2003.pdfPublisher postprint789.82 kBRequest copy

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.