Reference : GSK3-Mediated BCL-3 phosphorylation modulates its degradation and its oncogenicity
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/3640
GSK3-Mediated BCL-3 phosphorylation modulates its degradation and its oncogenicity
English
Viatour, Patrick [Université de Liège - ULg > > Chimie médicale >]
Dejardin, Emmanuel mailto [Université de Liège - ULg > > Virologie - Immunologie >]
Warnier, Michael [> > > >]
Lair, Florence [> > > >]
Claudio, Estefania [> > > >]
Bureau, Fabrice mailto [Université de Liège - ULg > Département de sciences fonctionnelles > Biochimie et biologie moléculaire >]
Marine, Jean Christophe [> > > >]
Merville, Marie-Paule mailto [Université de Liège - ULg > Département de pharmacie > Chimie médicale >]
Maurer, Ulrich [> > > >]
Green, Douglas [> > > >]
Piette, Jacques mailto [Université de Liège - ULg > Département des sciences de la vie > Virologie - Immunologie >]
Siebenlist, Ulrich [> > > >]
Bours, Vincent mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Génétique générale et humaine]
Chariot, Alain mailto [Université de Liège - ULg > Département de pharmacie > Chimie médicale >]
8-Oct-2004
Molecular Cell
Cell Press
16
1
35-45
Yes (verified by ORBi)
International
1097-2765
Cambridge
[en] The oncoprotein BCL-3 is a nuclear transcription factor that activates NF-kappaB target genes through formation of heterocomplexes with p50 or p52. BCL-3 is phosphorylated in vivo, but specific BCL-3 kinases have not been identified so far. In this report, we show that BCL-3 is a substrate for the protein kinase GSK3 and that GSK3-mediated BCL-3 phosphorylation, which is inhibited by Akt activation, targets its degradation through the proteasome pathway. This phosphorylation modulates its association with HDAC1, -3, and -6 and attenuates its oncogenicity by selectively controlling the expression of a subset of newly identified target genes such as SLPI and CxcI1. Our results therefore suggest that constitutive BCL-3 phosphorylation by GSK3 regulates BCL-3 turnover and transcriptional activity.
GIGA-R
FNRS, TELEVIE, FBC, ARC ULG
Insight into the oncogenic potential of BCL-3
http://hdl.handle.net/2268/3640
10.1016/j.molcel.2004.09.004

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