Article (Scientific journals)
GSK3-Mediated BCL-3 phosphorylation modulates its degradation and its oncogenicity
Viatour, Patrick; Dejardin, Emmanuel; Warnier, Michael et al.
2004In Molecular Cell, 16 (1), p. 35-45
Peer Reviewed verified by ORBi
 

Files


Full Text
PDF Mol. Cell BCL-3.pdf
Publisher postprint (504.31 kB)
Download

All documents in ORBi are protected by a user license.

Send to



Details



Abstract :
[en] The oncoprotein BCL-3 is a nuclear transcription factor that activates NF-kappaB target genes through formation of heterocomplexes with p50 or p52. BCL-3 is phosphorylated in vivo, but specific BCL-3 kinases have not been identified so far. In this report, we show that BCL-3 is a substrate for the protein kinase GSK3 and that GSK3-mediated BCL-3 phosphorylation, which is inhibited by Akt activation, targets its degradation through the proteasome pathway. This phosphorylation modulates its association with HDAC1, -3, and -6 and attenuates its oncogenicity by selectively controlling the expression of a subset of newly identified target genes such as SLPI and CxcI1. Our results therefore suggest that constitutive BCL-3 phosphorylation by GSK3 regulates BCL-3 turnover and transcriptional activity.
Research center :
GIGA‐R - Giga‐Research - ULiège
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Viatour, Patrick ;  Université de Liège - ULiège > Chimie médicale
Dejardin, Emmanuel ;  Université de Liège - ULiège > Virologie - Immunologie
Warnier, Michael
Lair, Florence
Claudio, Estefania
Bureau, Fabrice ;  Université de Liège - ULiège > Département de sciences fonctionnelles > Biochimie et biologie moléculaire
Marine, Jean Christophe
Merville, Marie-Paule ;  Université de Liège - ULiège > Département de pharmacie > Chimie médicale
Maurer, Ulrich
Green, Douglas
Piette, Jacques ;  Université de Liège - ULiège > Département des sciences de la vie > Virologie - Immunologie
Siebenlist, Ulrich
Bours, Vincent ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Génétique générale et humaine
Chariot, Alain ;  Université de Liège - ULiège > Département de pharmacie > Chimie médicale
More authors (4 more) Less
Language :
English
Title :
GSK3-Mediated BCL-3 phosphorylation modulates its degradation and its oncogenicity
Publication date :
08 October 2004
Journal title :
Molecular Cell
ISSN :
1097-2765
eISSN :
1097-4164
Publisher :
Cell Press, Cambridge, United Kingdom
Volume :
16
Issue :
1
Pages :
35-45
Peer reviewed :
Peer Reviewed verified by ORBi
Name of the research project :
Insight into the oncogenic potential of BCL-3
Funders :
FNRS, TELEVIE, FBC, ARC ULG
Available on ORBi :
since 06 January 2009

Statistics


Number of views
120 (13 by ULiège)
Number of downloads
238 (5 by ULiège)

Scopus citations®
 
109
Scopus citations®
without self-citations
95
OpenCitations
 
104

Bibliography


Similar publications



Contact ORBi