Reference : The lymphotoxin-beta receptor induces different patterns of gene expression via two N...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
The lymphotoxin-beta receptor induces different patterns of gene expression via two NF-kappaB pathways.
Dejardin, Emmanuel mailto [Université de Liège - ULg > > GIGA-R : Virologie - Immunologie >]
Droin, Nathalie [ > > ]
Delhase, Mireille [ > > ]
Haas, Elvira [ > > ]
Cao, Yixue [ > > ]
Makris, Constantin [ > > ]
Li, Zhi-Wei [ > > ]
Karin, Michael [ > > ]
Ware, Carl [ > > ]
Green, Douglas [ > > ]
Cell Press
Yes (verified by ORBi)
[en] NF-kB, lymphotoxin
[en] The lymphotoxin-beta receptor (LTbetaR) plays critical roles in inflammation and lymphoid organogenesis through activation of NF-kappaB. In addition to activation of the classical NF-kappaB, ligation of this receptor induces the processing of the cytosolic NF-kappaB2/p100 precursor to yield the mature p52 subunit, followed by translocation of p52 to the nucleus. This activation of NF-kappaB2 requires NIK and IKKalpha, while NEMO/IKKgamma is dispensable for p100 processing. IKKbeta-dependent activation of canonical NF-kappaB is required for the expression but not processing of p100 and for the expression of proinflammatory molecules including VCAM-1, MIP-1beta, and MIP-2 in response to LTbetaR ligation. In contrast, IKKalpha controls the induction by LTbetaR ligation of chemokines and cytokines involved in lymphoid organogenesis, including SLC, BLC, ELC, SDF1, and BAFF.

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