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See detailComparison of Platelet Rich Plasma (PRP) versus Hyaluronic Acid (HA) injections to treat patellar tendinopathies
Kaux, Jean-François ULiege; Roberjot, Mathieu; SAMSON, Antoine ULiege

in British Journal of Sports Medicine (in press)

Introduction: The treatment of patellar tendinopathies could be difficult. Recent systematic review concluded that PRP could be recommend as a treatment in such indication. Recently, the viscoelastic ... [more ▼]

Introduction: The treatment of patellar tendinopathies could be difficult. Recent systematic review concluded that PRP could be recommend as a treatment in such indication. Recently, the viscoelastic properties of hyaluronic acid (HA) on liquid connective tissue have been proposed for the treatment of tendinopathies. Some observations also support its use in a clinical setting to improve pain and function. We aimed to compare the effect of PRP injection versus two injections of HA after three months on patients who have a proximal patellar tendinopathy. Methods: Thirty-three sportsmen with proximal patellar tendinopathies being not relieved after minimum three months of normal physiotherapy treatments where included. Eighteen of them (group 1) have received a leukocyte poor PRP injection (obtained using an aphaeresis machine (3)) and the other fifteen (group 2) two HA injections, all of them have benefited of standardized rehabilitation. Concerning the evaluation of the pathology, algo-functional tests (visual analogic scale (VAS), pressure algometer, IKDC score, VISA-P score), isokinetic (associated to VAS) along with the patellar tendon ultrasonography (US) have been realized over three times (pre-injection, after 6 weeks, after 3 months post-injections). Results: The results of VAS (p<0,01), algometric scores (p<0,01), IKDC scores (p<0,01) and VISA-P (p<0,01) show a considerable improvement in the two groups, but not for the US findings. For the group 1, isokinetic tests show significative results for the hamstrings in C60°/s with an improvement of maximum peak torque (p=0,01) for the pathological member, a diminution (p>0,05) for the healthy limb and during the analysis of the bilateral difference (p=0,0002). For the group 2, the improvement of quadriceps maximum peak torque in C240°/s is significant (p>0,01) for the pathological knee after 6 weeks post-injections only. The VAS associated with isokinetic tests decreases significantly for all contraction modes after three months of study. Conclusion: Both PRP and HA can improve the symptoms of proximal patellar tendinopathy, even if the results are slightly better in the PRP group. [less ▲]

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See detailFrench Translation and validation of the Exercise-Induced Leg Pain
Kaux, Jean-François ULiege; Hagelstein, Thibaut; Van Beveren, Julien et al

in British Journal of Sports Medicine (in press)

Objective: The « Exercise-Induced Leg Pain » (EILP) questionnaire has been developed (in German) to evaluate the severity of symptoms and sports ability in individuals with exercise-induced leg pain. The ... [more ▼]

Objective: The « Exercise-Induced Leg Pain » (EILP) questionnaire has been developed (in German) to evaluate the severity of symptoms and sports ability in individuals with exercise-induced leg pain. The purpose of the present study was to translate and cross-culturally adapt this questionnaire into French and to study the reliability and validity of the French-translated version (EILP-F). Methods: Translation and cross-culturally adaptation of the original EILP (EILP-G) was performed according to established guidelines. The translation part was articulated in six stages: (i) two initial translations from German to French; (ii) synthesis of the two translations; (iii) backward translations; (iv) expert committee to compare the backward translations with the original questionnaire; (v) pre-test; and (vi) approval of the final version of the EILP-F. To validate the EILP-F questionnaire, 84 subjects were recruited (28 pathological patients with a confirmed diagnosis of chronic leg pain, 28 asymptomatic sport students, 28 athletes healthy control). Discriminative power of the questionnaire was tested as well as reliability (internal consistency, test–retest reliability after a 7-10-day interval), construct validity and floor/ceiling effects. Results: the EILP-F version of the questionnaire has been generated without any major difficulties. The ability of the questionnaire to discriminate the three groups of subjects has been showed with a total score of 61.0 ± 18.5 for the pathologic group; 93.9 ± 7.57 for the asymptomatic group and 94.1 ± 9.79 for the control group (p-value adjusted on age = 0.008). A high internal consistency (Cronbach's alpha of 0.93) and an excellent test-retest radiality (ICC of 0.98 (95% CI 0.97-0.99, p<0.001)) indicated that the EILP-F is reliable. The EILP-F also demonstrated a good construct validity against different subscales of the Short Form-36 questionnaire, a generic quality of life questionnaire, with more than 87 % of prespecified hypotheses confirmed. Finally, no floor or ceiling effects were observed. Conclusion: The EILP-F questionnaire, a French version adapted from the original EILP-G, was successfully translated and cross-culturally adapted. The EILP-F questionnaire is consistent, valid and reliable for evaluating the French-speaking patients with chronic exercise-induced leg pain. [less ▲]

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See detailFrench translation and validation of the AKPS questionnaire
Buckinx, Fanny ULiege; Remy, Gaël; Bornheim, Stephen ULiege et al

in British Journal of Sports Medicine (in press)

Introduction: The Anterior Knee Pain Scale (AKPS) is a questionnaire used to examine the subjective symptoms, such as the functional limitations and the anterior knee pain. First developed in English ... [more ▼]

Introduction: The Anterior Knee Pain Scale (AKPS) is a questionnaire used to examine the subjective symptoms, such as the functional limitations and the anterior knee pain. First developed in English, this questionnaire has since been translated and validated into several languages. The aims of the study were to translate and cross-culturally adapt the AKPS into French and to evaluate the reliability and validity of this translated version of the questionnaire. Methods: The translation part was articulated in six stages, according to international guidelines: (i) two initial translations from english to french; (ii) synthesis of the two translations; (iii) backward translations into the original language; (iv) expert committee to compare the backward translations with the original questionnaire (v) pre-final version testing and (VI) expert committee appraisal. To validate the French AKPS questionnaire, we assessed its validity, reliability and floor/ceiling effects. To do this, volunteer patients from Belgium and France, with patellofemoral pain syndrome were asked to answer the french version of the AKPS questionnaire at baseline and after 7 days, as well as the generic SF-36 questionnaire. Results: The AKPS questionnaire was translated without any major difficulties. A total of 101 subjects aged 34.49 ± 11.38 years on average were included in this study. Among them, 58.4% were women. Results indicated an excellent test-retest reliability (intraclass coefficient correlation of 0.97, 95% CI 0.96 - 0.98), a high internal consistency (Cronbach’s alpha of 0.87), a consistent construct validity (high correlations with the SF-36 questionnaire were found with domains related to physical function (r = 0.80), physical role (r = 0.70), pain (r = 0.64)) and low or moderate correlations with domains related to mental health (r = 0.26), vitality (r = 0.32), social function (r = 0.41)). Moreover, no floor/ceiling has been found. Conclusion: A valid AKPS french questionnaire is now available and can be used with confidence to better assess the disease burden associated with femoropatellar syndrom. It was successfully cross-culturally adapted into French. [less ▲]

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See detailIsokinetic profile of subjects with proximal patellar tendinopathy
Kaux, Jean-François ULiege; Croisier, Jean-Louis ULiege; Libertiaux, Vincent ULiege

in British Journal of Sports Medicine (in press)

Introduction Patellar tendinopathy (PT) is commonly observed in jumping sports. Even if its biomechanic is somewhat explored, no information is known about the muscle strength profile of these patients ... [more ▼]

Introduction Patellar tendinopathy (PT) is commonly observed in jumping sports. Even if its biomechanic is somewhat explored, no information is known about the muscle strength profile of these patients. We aimed to determine if there exists a specific profile of patients suffering from a PT Methods 43 patients (42 males; 29 y.o +/- 9.8 y.o) suffering from PT were recruited. To be eligible, the patients must not have suffered from any other traumatic or micro-traumatic injury than the PT on the pathologic limb. After a physical examination, the tendon damage was assessed by ultrasounds examination. The patients were then tested on an isokinetic dynamometer and the peak torque per unit of mass (PTm) developed by the quadriceps and the hamstrings were recorded for various testing modalities. After each test, a visual analog scale (VAS) was used to estimate the pain felt by the patients. Results No significant correlation was found between the MTm and the demographic variables. The difference in MTm between the healthy and the pathological limbs was significant only in concentric 60°/s, for both the quadriceps and the hamstrings. Lastly, the VAS score showed that the most intense pain was experienced after the eccentric test. Conclusions There is no specific patient strength profile emerging from the isokinetic test. This stresses the importance for the clinicians to make testing and to apply a personalized treatment to each patient. On the other hand, the isokinetic eccentric testing of the quadriceps could be used to induce a mechanical stress on the tendon for a reliable pain assessment. [less ▲]

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See detailHybrid Fire Testing: Discussion on stability and implementation of a new method in a virtual environment
Sauca, Ana ULiege; Gernay, Thomas ULiege; Robert, Fabienne et al

in Journal of Structural Fire Engineering (in press)

Purpose – The purpose of this paper is to propose a method for Hybrid Fire Testing (HFT) which is unconditionally stable, ensures equilibrium and compatibility at the interface and captures the global ... [more ▼]

Purpose – The purpose of this paper is to propose a method for Hybrid Fire Testing (HFT) which is unconditionally stable, ensures equilibrium and compatibility at the interface and captures the global behavior of the analyzed structure. HFT is a technique that allows assessing experimentally the fire performance of a structural element under real boundary conditions that capture the effect of the surrounding structure. Design/methodology/approach – The paper starts with the analysis of the method used in the few previous HFT. Based on the analytical study of a simple one degree-of-freedom elastic system, it is shown that this previous method is fundamentally unstable in certain configurations that cannot be easily predicted in advance. Therefore, a new method is introduced to overcome the stability problem. The method is applied in a virtual hybrid test on a 2D reinforced concrete beam part of a moment resisting frame. Findings – It is shown through analytical developments and applicative examples that the stability of the method used in previous HFT depends on the stiffness ratio between the two substructures. The method is unstable when implemented in force control on a physical substructure that is less stiff than the surrounding structure. Conversely, the method is unstable when implemented in displacement control on a physical substructure stiffer than the remainder. In multi degrees-of-freedom tests where the temperature will affect the stiffness of the elements, it is generally not possible to ensure continuous stability throughout the test using this former method. Therefore, a new method is proposed where the stability is not dependent on the stiffness ratio between the two substructures. Application of the new method in a virtual HFT proved to be stable, to ensure compatibility and equilibrium at the interface and to reproduce accurately the global structural behavior. Originality/value – The paper provides a method to perform Hybrid Fire Tests which overcomes the stability problem lying in the former method. The efficiency of the new method is demonstrated in a virtual HFT with 3 degrees-of-freedom at the interface, the next step being its implementation in a real (laboratory) hybrid test. [less ▲]

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See detailEthylene/vinyl acetate-based macrocycles via organometallic-mediated radical polymerization and CuAAC ‘click’ reaction
Demarteau, Jérémy ULiege; De Winter, Julien; Detrembleur, Christophe ULiege et al

in Polymer Chemistry (in press)

Recent advances in organometallic-mediated radical polymerization led to unique α,ω-difunctional poly(vinyl acetate) (PVAc) and ethylene/vinyl acetate copolymers (EVA). A copper- catalyzed Huisgen dipolar ... [more ▼]

Recent advances in organometallic-mediated radical polymerization led to unique α,ω-difunctional poly(vinyl acetate) (PVAc) and ethylene/vinyl acetate copolymers (EVA). A copper- catalyzed Huisgen dipolar cycloaddition ring-closure reaction was applied to these difunctional precursors paving the way to unprecedented PVAc and/or EVA macrocycles, and to their PVOH- and EVOH-counterparts after hydrolysis. [less ▲]

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See detailStellar parameters for TRAPPIST-1
Van Grootel, Valérie ULiege; Silva Fernandes, Catarina ULiege; Gillon, Michaël ULiege et al

in Astrophysical Journal (in press)

TRAPPIST-1 is an ultracool dwarf star transited by seven Earth-sized planets, for which thorough characterization of atmospheric properties, surface conditions encompassing habitability and internal ... [more ▼]

TRAPPIST-1 is an ultracool dwarf star transited by seven Earth-sized planets, for which thorough characterization of atmospheric properties, surface conditions encompassing habitability and internal compositions is possible with current and next generation telescopes. Accurate modeling of the star is essential to achieve this goal. We aim to obtain updated stellar parameters for TRAPPIST- 1 based on new measurements and evolutionary models, compared to those used in discovery studies. We present a new measurement for the parallax of TRAPPIST-1, 82.4 $\pm$ 0.8 mas, based on 188 epochs of observations with the TRAPPIST and Liverpool Telescopes from 2013 to 2016. This revised parallax yields an updated luminosity of $L_*=(5.22\pm0.19)\times 10^{-4} L_{\odot}$, very close to the previous estimate but almost twice more precise. We next present an updated estimate for TRAPPIST-1 stellar mass, based on two approaches: mass from stellar evolution modeling, and empirical mass derived from dynamical masses of equivalently classified ultracool dwarfs in astrometric binaries. We combine them through a Monte-Carlo approach to derive a semi-empirical estimate for the mass of TRAPPIST-1. We also derive estimate for the radius by combining this mass with stellar density inferred from transits, as well as estimate for the effective temperature from our revised luminosity and radius. Our final results are $M_*=0.089 \pm 0.006 M_{\odot}$, $R_* = 0.121 \pm 0.003 R_{\odot}$, and $T_{\rm eff} =$ 2516 $\pm$ 41 K. Considering the degree to which TRAPPIST-1 system will be scrutinized in coming years, these revised and more precise stellar parameters should be considered when assessing the properties of TRAPPIST-1 planets. [less ▲]

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See detailNew observations and asteroseismic analysis of the subdwarf B pulsator PG 1219+534
Van Grootel, Valérie ULiege; Peters, Marie-Julie; Green, Elizabeth M. et al

in Open Astronomy (in press)

We present a new asteroseismic modeling of the hot B subdwarf (sdB) pulsator PG 1219+534, based on a 3-month campaign with the Mont4K/Kuiper combination at Mt Bigelow (Arizona) and on updated atmospheric ... [more ▼]

We present a new asteroseismic modeling of the hot B subdwarf (sdB) pulsator PG 1219+534, based on a 3-month campaign with the Mont4K/Kuiper combination at Mt Bigelow (Arizona) and on updated atmospheric parameters from high S/N low and medium resolution spectroscopy. On the basis of the nine independent pulsation periods extracted from the photometric light curve, we carried out an astroseismic analysis by applying the forward modeling approach using our latest (third and fourth generation) sdB models. Atmospheric parameters (Teff = 34 258±170 K, log g = 5.838±0.030) were used as independent constraints, as well as partial mode identification based on observed multiplet structures we ascribed to stellar rotation. The optimal model found is remarkably consistent between various analyses with third and fourth generation of sdB models, and also with previously published analysis with second generation sdB models. It corresponds to a sdB with a canonical mass (0.46 ± 0.02 M⊙), rather thin H-He envelope (log q(envl)= −3.75 ± 0.12), and close to He-burning exhaustion (Xcore(C + O) = 0.86 ± 0.05). We also investigate the internal rotation of the star. We find that PG 1219+534 rotates very slowly (Prot=34.91 ± 0.84 days) and that solid-body rotation is reached at least down to ∼60% of the radius. [less ▲]

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See detailNadeau
Lorent, Fanny ULiege

in Coste, Claude (Ed.) Dictionnaire Roland Barthes (in press)

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See detailRécit
Lorent, Fanny ULiege; Chassain, Adrien

in Coste, Claude (Ed.) Dictionnaire Roland Barthes (in press)

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See detailDynamic simulation of a post-combustion CO2 capture pilot with assessment of solvent degradation
Benkoussas, Hana ULiege; Léonard, Grégoire ULiege; Ioana Burca, Madalina et al

Conference (in press)

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See detailA Markov-switching Generalized additive model for compound Poisson processes, with applications to operational losses models
Hambuckers, julien ULiege; Kneib, Thomas; Langrock, Roland et al

in Quantitative Finance (in press)

This paper is concerned with modeling the behavior of random sums over time. Such models are particularly useful to describe the dynamics of operational losses, and to correctly estimate tail-related risk ... [more ▼]

This paper is concerned with modeling the behavior of random sums over time. Such models are particularly useful to describe the dynamics of operational losses, and to correctly estimate tail-related risk indicators. However, time-varying dependence structures make it a difficult task. To tackle these issues, we formulate a new Markov-switching generalized additive compound process combining Poisson and generalized Pareto distributions. This flexible model takes into account two important features: on the one hand, we allow all parameters of the compound loss distribution to depend on economic covariates in a flexible way. On the other hand, we allow this dependence to vary over time, via a hidden state process. A simulation study indicates that, even in the case of a short time series, this model is easily and well estimated with a standard maximum likelihood procedure. Relying on this approach, we analyze a novel dataset of 819 losses resulting from frauds at the Italian bank UniCredit. We show that our model improves the estimation of the total loss distribution over time, compared to standard alternatives. In particular, this model provides estimations of the 99.9% quantile that are never exceeded by the historical total losses, a feature particularly desirable for banking regulators. [less ▲]

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See detailSupercritical fluid chromatography: a promising alternative to current bioanalytical techniques
Dispas, Amandine ULiege; Jambo, Hugues ULiege; André, Sébastien ULiege et al

in Bioanalysis (in press)

During the last years, chemistry was involved in the worldwide effort toward environmental problems leading to the birth of green chemistry. In this context, green analytical tools were developed as ... [more ▼]

During the last years, chemistry was involved in the worldwide effort toward environmental problems leading to the birth of green chemistry. In this context, green analytical tools were developed as modern Supercritical Fluid Chromatography in the field of separative techniques. This chromatographic technique knew resurgence a few years ago, thanks to its high efficiency, fastness and robustness of new generation equipment. These advantages and its easy hyphenation to MS fulfill the requirements of bioanalysis regarding separation capacity and high throughput. In the present paper, the technical aspects focused on bioanalysis specifications will be detailed followed by a critical review of bioanalytical supercritical fluid chromatography methods published in the literature. [less ▲]

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See detailMacroporous poly(ionic liquid)/ionic liquid gels via CO2-based emulsion-templating polymerization
Mathieu, Kevin ULiege; Jérôme, Christine ULiege; Debuigne, Antoine ULiege

in Polymer Chemistry (in press)

Structuring poly(ionic liquid)s (PILs) into porous materials or swelling PILs with free ionic liquids (ILs) has received specific attention recently and contributed to improve the performances of these ... [more ▼]

Structuring poly(ionic liquid)s (PILs) into porous materials or swelling PILs with free ionic liquids (ILs) has received specific attention recently and contributed to improve the performances of these materials used in a wide range of applications. The present work aims to take benefit of both approaches and produce macroporous PIL/IL gels in a single step through an innovative emulsion-templated polymerization method based on supercritical carbon dioxide (scCO2). More precisely, ILs vinyl monomers and crosslinkers were polymerized in the presence of non polymerizable ILs within the outer phase of a CO2-in-ILs high internal phase emulsion (HIPE). Specific macromolecular surfactants were synthesized by controlled radical polymerization techniques and tested for the stabilization of the CO2-in-ILs emulsions. While optimizing the polymerization conditions, we found that adding a limited amount of water in the medium was beneficial for the emulsion stability. Overall, this straightforward process gave access to macroporous polyHIPEs composed of poly(vinyl imidazolium) networks swollen by ‘free’ vinyl imidazolium-based ILs having interesting properties such as switchable polarity upon simple anion exchange reaction. [less ▲]

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See detailCreative Economy and Development: International Institution’s Perspectives
De Beukelaer, Christiaan; Vlassis, Antonios ULiege

in Labadi, Sophia (Ed.) The cultural turn in international aid: impacts and challenges for heritage and the creative industries' (2018)

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See detailMededingingsrecht: do's and don'ts voor Belgische ondernemingen
Van Cleynenbreugel, Pieter ULiege

Book published by Intersentia (2018)

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See detailInfluence of urban pattern on inundation flow in floodplains of lowland rivers
Bruwier, Martin ULiege; Mustafa, Ahmed Mohamed El Saeid ULiege; Aliaga, Daniel G. et al

in Science of the Total Environment (2018), 622–623

The objective of this paper is to investigate the respective influence of various urban pattern characteristics on inundation flow. A set of 2,000 synthetic urban patterns were generated using an urban ... [more ▼]

The objective of this paper is to investigate the respective influence of various urban pattern characteristics on inundation flow. A set of 2,000 synthetic urban patterns were generated using an urban procedural model providing locations and shapes of streets and buildings over a square domain of 1 x 1 km². Steady two-dimensional hydraulic computations were performed over the 2,000 urban patterns with identical hydraulic boundary conditions. To run such a large amount of simulations, the computational efficiency of the hydraulic model was improved by using an anisotropic porosity model. This model computes on relatively coarse computational cells, but preserves information from the detailed topographic data through porosity parameters. Relationships between urban characteristics and the computed inundation water depths have been based on multiple linear regressions. Finally, a simple mechanistic model based on two district-scale porosity parameters, combining several urban characteristics, is shown to capture satisfactorily the influence of urban characteristics on inundation water depths. The findings of this study give guidelines for more flood-resilient urban planning. [less ▲]

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