Last 7 days
Bookmark and Share    
Full Text
Peer Reviewed
See detailBrain-heart interactions reveal consciousness in non-communicating patients
Raimondo, Federico; Rohaut, Benjamin; Demertzi, Athina ULiege et al

in Annals of Neurology (in press)

Objective: We here aimed at characterizing heart–brain interactions in patients with disorders of consciousness. We tested how this information impacts data-driven classification between unresponsive and ... [more ▼]

Objective: We here aimed at characterizing heart–brain interactions in patients with disorders of consciousness. We tested how this information impacts data-driven classification between unresponsive and minimally conscious patients. Methods: A cohort of 127 patients in vegetative state/unresponsive wakefulness syndrome (VS/UWS; n570) and minimally conscious state (MCS; n557) were presented with the local–global auditory oddball paradigm, which dis- tinguishes 2 levels of processing: short-term deviation of local auditory regularities and global long-term rule viola- tions. In addition to previously validated markers of consciousness extracted from electroencephalograms (EEG), we computed autonomic cardiac markers, such as heart rate (HR) and HR variability (HRV), and cardiac cycle phase shifts triggered by the processing of the auditory stimuli. Results: HR and HRV were similar in patients across groups. The cardiac cycle was not sensitive to the processing of local regularities in either the VS/UWS or MCS patients. In contrast, global regularities induced a phase shift of the cardiac cycle exclusively in the MCS group. The interval between the auditory stimulation and the following R peak was significantly shortened in MCS when the auditory rule was violated. When the information for the cardiac cycle modulations and other consciousness-related EEG markers were combined, single patient classification performance was enhanced compared to classification with solely EEG markers. Interpretation: Our work shows a link between residual cognitive processing and the modulation of autonomic somatic markers. These results open a new window to evaluate patients with disorders of consciousness via the embodied paradigm, according to which body–brain functions contribute to a holistic approach to conscious processing. [less ▲]

Detailed reference viewed: 22 (3 ULiège)
Peer Reviewed
See detailLogiques d'une entrée en poésie
Saint-Amand, Denis ULiege

in Gaden, Élodie; Claudel, Paul-André (Eds.) Valentine de Saint-Point à la croisée des avant-gardes (in press)

Personnage intrigant de la Belle-Époque, auteure prolifique et femme du monde active dans différents réseaux avant-gardistes, Valentine de Saint-Point compte aujourd’hui parmi ceux qu’on appelle les ... [more ▼]

Personnage intrigant de la Belle-Époque, auteure prolifique et femme du monde active dans différents réseaux avant-gardistes, Valentine de Saint-Point compte aujourd’hui parmi ceux qu’on appelle les minores, les laissés pour compte de l’histoire littéraire, les marginaux. Le présent article a pour objectif de revenir sur l’émergence littéraire de l’auteure ― du moins, sur la forme la plus visible de cette émergence. On s’y penche sur ce qui se joue et se donne à lire dans le recueil Poèmes de la mer et du soleil, publié en 1905 chez Albert Messein et qui va permettre à l’auteure d’entrer dans le jeu en se présentant comme poétesse et en se positionnant, par des revendications de filiation plus ou moins explicites, vis-à-vis de l’offre poétique de son temps. [less ▲]

Detailed reference viewed: 13 (0 ULiège)
Full Text
Peer Reviewed
See detailPD-L1 expression is regulated by both DNA methylation and NF-kB during EMT signaling in non-small cell lung carcinoma
Asgarova, Afag; Asgarov, Kamal; Godet, Yann et al

in Oncoimmunology (in press)

Detailed reference viewed: 27 (1 ULiège)
Peer Reviewed
See detailRenaissance(s), norme(s), classicisme
Miesse, Hélène ULiege

in Miesse, Hélène; Valenti, Gianluca (Eds.) « Modello, regola, ordine ». Parcours normatifs dans l’Italie du Cinquecento (in press)

Detailed reference viewed: 13 (0 ULiège)
Full Text
Peer Reviewed
See detailSurvival and consciousness recovery are better in the minimally conscious state than in the vegetative state
Faugeras, Frédéric; Rohaut, Benjamin; Valente, Melanie et al

in Brain Injury (in press)

BACKGROUND The prognosis value of early clinical diagnosis of consciousness impairment is documented by an extremely limited number of studies, whereas it may convey important information to guide medical ... [more ▼]

BACKGROUND The prognosis value of early clinical diagnosis of consciousness impairment is documented by an extremely limited number of studies, whereas it may convey important information to guide medical decisions. OBJECTIVE We aimed at determining if patients diagnosed at an early stage (<90 days after brain injury) as being in the minimally conscious state (MCS) have a better prognosis than patients in the vegetative state/Unresponsive Wakefulness syndrome (VS/UWS), independent of care limitations or withdrawal decisions. METHODS Patients hospitalized in ICUs of the Pitié-Salpêtrière Hospital (Paris, France) from November 2008 to January 2011 were included and evaluated behaviourally with standardized assessment and with the Coma Recovery Scale-Revised as being either in the VS/UWS or in the MCS. They were then prospectively followed until 1July 2011 to evaluate their outcome with the GOSE. We compared survival function and outcomes of these two groups. RESULTS Both survival function and outcomes, including consciousness recovery, were significantly better in the MCS group. This difference of outcome still holds when considering only patients still alive at the end of the study. CONCLUSIONS Early accurate clinical diagnosis of VS/UWS or MCS conveys a strong prognostic value of survival and of consciousness recovery. [less ▲]

Detailed reference viewed: 21 (3 ULiège)
Full Text
Peer Reviewed
See detailTyrannie du style et excès d'absurdités. La crack-fic comme art du "trop"
Lucca, Sian ULiege

in COnTEXTES (in press)

Detailed reference viewed: 23 (3 ULiège)
See detailPublic et privé dans les œuvres et la correspondance de Francesco Guicciardini
Miesse, Hélène ULiege

in Lucas-Fiorato, Corinne; Girotto, Carlo (Eds.) L’écriture épistolaire entre Renaissance et Âge baroque. Pratiques, enjeux, pistes de recherche (in press)

Detailed reference viewed: 15 (0 ULiège)
Full Text
Peer Reviewed
See detailDispersal and alternative breeding site fidelity strategies in an amphibian
Denoël, Mathieu ULiege; Dalleur, séverine; Langrand, Estelle et al

in Ecography (in press)

Dispersal (i.e., movement from a natal or breeding site to another breeding site) is a central process in ecology and evolution as it affects the eco-evolutionary dynamics of spatially structured ... [more ▼]

Dispersal (i.e., movement from a natal or breeding site to another breeding site) is a central process in ecology and evolution as it affects the eco-evolutionary dynamics of spatially structured populations. Dispersal evolution is regulated by the balance between costs and benefits, which is influenced by the individual phenotype (i.e., phenotype-dependent dispersal) and environmental factors (i.e., condition-dependent dispersal). Even though these processes have been extensively studied in species with simple life cycles, our knowledge about these mechanisms in organisms displaying complex life cycles remains fragmentary. In fact, little is specifically known about how the interplay between individual and environmental factors may lead to alternative dispersal strategies that, in turn, lead to the coexistence of contrasted site fidelity phenotypes. In this paper, we examined breeding dispersal in a pond-breeding amphibian, the great crested newt (Triturus cristatus), within usual walking distances for a newt. We took advantage of recent developments in multi-event capture-recapture models and used capture-recapture data (946 newts marked) collected in a spatially structured population occupying a large pond network (73 ponds). We showed a high rate of breeding site infidelity (i.e., pond use) and the coexistence of two dispersal phenotypes, namely, a highly pond faithful phenotype and a dispersing phenotype. Individuals that were site faithful at time t-1 were therefore more likely to remain site faithful at time t. Our results also demonstrated that the probability that individuals belong to one or the other dispersal phenotypes depended on environmental and individual factors. In particular, we highlighted the existence of a dispersal syndrome implying a covariation pattern among dispersal behavior, body size, and survival. Our work opens new research prospects in the evolution of dispersal in organisms displaying complex life cycles and raises interesting questions about the evolutionary pathways that contribute to the diversification of movement strategies in the wild. [less ▲]

Detailed reference viewed: 64 (22 ULiège)
Full Text
See detailRéécrire (avec) Kafka. Une paradoxale figure de l’exit, entre silence, mensonge et vérité
Lucca, Sian ULiege

E-print/Working paper (in press)

Detailed reference viewed: 27 (1 ULiège)
Full Text
Peer Reviewed
See detailTetrabutyl ammonium salts: cheap catalysts for the facile and selective synthesis of a-alkylidene cyclic carbonates from CO2 and alkynol
Méreau, Raphaël; Grignard, Bruno ULiege; Boyaval, Amélie ULiege et al

in ChemCatChem (in press)

n-tetrabutyl ammonium organic salts are used for the first time as catalysts for the coupling of CO2 with 2-methyl-3-butyn-2-ol to form α-methylene cyclic carbonate. The final yields could reach 98% in ... [more ▼]

n-tetrabutyl ammonium organic salts are used for the first time as catalysts for the coupling of CO2 with 2-methyl-3-butyn-2-ol to form α-methylene cyclic carbonate. The final yields could reach 98% in less than 10 hours at 353K and 3MPa under solvent free conditions. A particular synergistic effect between the cation and the anion of the organocatalyst is demonstrated through catalyst screening. Online kinetic studies by ATR-IR spectroscopy correlated to DFT calculations reveal a compelling evolution of the solvation of the catalyst during the reaction that provide an understanding of the underlying reason for the observed unique kinetics and selectivity. Such in-depth fundamental mechanistic and kinetic studies enable determining and comprehending the key parameters favouring the design of novel highly active and selective catalysts for the valorisation [less ▲]

Detailed reference viewed: 22 (3 ULiège)
Peer Reviewed
See detailKings or Soldiers? Changes in the Figurative Representation of Fighting Heroes by the End of the Early Bronze Age
Couturaud, Barbara ULiege

in Tales of Royalty. Notions of Kingship in Visual and Textual Narration in the Ancient Near East (in press)

Detailed reference viewed: 13 (0 ULiège)
Full Text
Peer Reviewed
See detailEfficacy of Basil-Cabbage intercropping to control insect pests in Benin, West Africa
Yarou, Boni Barthélémy ULiege; Assogba Komlan, Françoise; Tossou, Eric et al

in Communications in Agricultural and Applied Biological Sciences (in press)

Cabbage (Brassica oleracea L.) is a common vegetable whose production is severely limited by insect pest pressure in Western Africa. This study was conducted during the dry and rainy season in the south ... [more ▼]

Cabbage (Brassica oleracea L.) is a common vegetable whose production is severely limited by insect pest pressure in Western Africa. This study was conducted during the dry and rainy season in the south Benin to evaluate the potential of tropical basil (Ocimum gratissimum L.) for repelling cabbage pests (Hellula undalis Fabricius, Plutella xylostella L. and Spodoptera litto-ralis Boisduval). In a complete randomized block design with four replicates, the insect infestation were compared between three association modalities: (i) cabbage intercropped with tropical basil, (ii) cabbage plots surrounded by tropical basil and (iii) control (no basil in the cabbage area). The presence of tropical basil near cabbage plots significantly reduced insect pest abundance on cabbage. Damages were also less important on cabbage intercropped with tropical basil. Among both intercropping modalities, alternate rows showed the best results in terms of reducing pest populations and damages than compared to cabbage plots surrounded by tropical basil. [less ▲]

Detailed reference viewed: 96 (6 ULiège)
Full Text
Peer Reviewed
See detailThe current environmental levels of endocrine disruptors (mercury, cadmium, organochlorine pesticides and PCBs) in a Belgian adult population and their predictors of exposure
PIRARD, Catherine ULiege; Compere, Stéphanie; Firquet, Cathy et al

in International Journal of Hygiene and Environmental Health (in press)

A human biomonitoring study was carried out measuring the levels of endocrine disruptors in 252 participants (18-76 years old) recruited between February and May 2015 from the general population of Liege ... [more ▼]

A human biomonitoring study was carried out measuring the levels of endocrine disruptors in 252 participants (18-76 years old) recruited between February and May 2015 from the general population of Liege Province (Belgium). In this study, we reported the recent levels of cadmium and mercury in urine, some organochlorine pesticides and polychlorinated biphenyls (PCBs) in serum, and their relations to demographic characteristics, lifestyle behaviors and dietary habits. The median urinary levels of mercury and cadmium were 0.81 µg/l and <0.5µg/l respectively. The mercury levels were higher in participants having at least 3 dental amalgams, and consuming sea fish more than once a week. Although our mercury levels in most participants were lower than some health-based guidelines, they were higher than in our neighboring countries where ban or restrictions on the dental amalgams use were implemented. Urinary cadmium levels in current smokers were significantly higher than former or never smokers, as well as non-smokers for passively exposed vs non-exposed ones. Median PCB-153 and -180 serum levels were 53.8 and 41.1 ng/g lipid respectively, but PCB-138 was below the limit of quantification of 0.15 µg/l in 49% of the samples. Among the organochlorine pesticides, 4,4’-dichlorodiphenyldichloroethylene (4,4’-DDE), beta-hexachlorohexane and hexachlorobenzene were positively detected respectively in 48%, 49% and 37% of the serum samples. Eventhough, a dramatic decrease in organochlorines levels was observed, at least 1 pesticide or PCB was detected in 96% of our population, and more than 50% of our samples were contaminated by 4 or more organochlorines. Age, body mass index, and breastfeeding duration were the most predictive determinants of pesticide or PCB serum concentrations, but not dietary habits. [less ▲]

Detailed reference viewed: 23 (1 ULiège)
Full Text
Peer Reviewed
See detailMacroelement for Complete Shear Behaviour of Continuous Deep Girders
Liu, Jian ULiege; Mihaylov, Boyan ULiege

in ACI Structural and Materials Journals (in press)

Detailed reference viewed: 41 (21 ULiège)
Full Text
Peer Reviewed
See detail‘Quality by Design’ approach for the analysis of impurities in pharmaceutical drug products and drug substances
Dispas, Amandine ULiege; Avohou, Tonakpon Hermane ULiege; Lebrun, Pierre ULiege et al

in Trends in Analytical Chemistry (in press)

The pharmaceutical industry is highly regulated by quality policies. The concept of risk management is strongly integrated into the quality assurance system to ensure pharmaceuticals’ quality and ... [more ▼]

The pharmaceutical industry is highly regulated by quality policies. The concept of risk management is strongly integrated into the quality assurance system to ensure pharmaceuticals’ quality and patients’ safety. In the context of quality control, the detection of impurities in raw materials and finished products is a major concern. It can be challenging for analytical scientists to meet specificity/selectivity and sensitivity requirements. Obviously, separation techniques are widely used for the detection of impurities but the method development required to achieve Analytical Target Profile (ATP) concerns is often challenging. Therefore, to ensure pragmatic and systematic methods development and simultaneously manage the risk associated with analytical methods, the principles of Quality by Design (QbD) should be applied. This paper provides an overview of QbD principles and statistical strategies (mainly DoE-DS approach) which can be applied to impurity detection methods, as well as a review of the literature where QbD has been applied to these types of analytical methods. [less ▲]

Detailed reference viewed: 48 (14 ULiège)
Full Text
Peer Reviewed
See detailDynamic simulation of a post-combustion CO2 capture pilot with assessment of solvent degradation
Benkoussas, Hana ULiege; Léonard, Grégoire ULiege; Ioana Burca, Madalina et al

in European Symposium on Computer Aided Process Engineering (in press)

To predict solvent degradation in an industrial CO2 capture process and for a better understanding of the interactions between solvent degradation and performance of the capture process, an existing ... [more ▼]

To predict solvent degradation in an industrial CO2 capture process and for a better understanding of the interactions between solvent degradation and performance of the capture process, an existing dynamic model of an amine based pilot plant for carbon capture has been improved and adapted at the University of Babes-Bolyai on the basis of the kinetic model of solvent oxidative degradation proposed at the University of Liège. The developed dynamic model has been used to simulate the transient behavior of the CO2 capture process with assessment of solvent degradation. [less ▲]

Detailed reference viewed: 48 (10 ULiège)