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See detailAssociation between self-perception of aging, view of cancer and health of older patients in oncology: A one-year longitudinal study
Schroyen, Sarah ULg; Missotten, Pierre ULg; JERUSALEM, Guy ULg et al

in BMC Cancer (in press)

Background: Identifying older people affected by cancer who are more at risk of negative health outcomes is a major issue in health initiatives focusing on medical effectiveness. In this regard ... [more ▼]

Background: Identifying older people affected by cancer who are more at risk of negative health outcomes is a major issue in health initiatives focusing on medical effectiveness. In this regard, psychological risk factors such as patients’ perception of their own aging and cancer could be used as indicators to improve customization of cancer care. We hypothesize that more negative self-perception of aging (SPA) and view of cancer could be linked to worse physical and mental health outcomes in cancer patients. Methods: 101 patients diagnosed with cancer (breast, gynecological, lung or hematological) were followed for one year. They were evaluated on four occasions (baseline, 3, 6 and 12 months after the baseline). Their SPA, view of cancer and health (physical and mental) were assessed at each time of evaluation. Results: Negative SPA and/or view of cancer at baseline are associated with negative evolution of patients’ physical and mental health. Moreover, when the evolution of SPA and cancer view were taken into account, these two stigmas are still linked with the evolution of mental health. In comparison, only a negative evolution of SPA was linked to worse physical health outcomes. Conclusions: Such results indicate that SPA and view of cancer could be used as markers of vulnerability in older people with cancer. [less ▲]

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See detailPulse-Based Control Using Koopman Operator Under Parametric Uncertainty
Sootla, Aivar; Ernst, Damien ULg

in IEEE Transactions on Automatic Control (in press)

In applications, such as biomedicine and systems/synthetic biology, technical limitations in actuation complicate implementation of time-varying control signals. In order to alleviate some of these ... [more ▼]

In applications, such as biomedicine and systems/synthetic biology, technical limitations in actuation complicate implementation of time-varying control signals. In order to alleviate some of these limitations, it may be desirable to derive simple control policies, such as step functions with fixed magnitude and length (or temporal pulses). In this technical note, we further develop a recently proposed pulse-based solution to the convergence problem, i.e., minimizing the convergence time to the target exponentially stable equilibrium, for monotone systems. In particular, we extend this solution to monotone systems with parametric uncertainty. Our solutions also provide worst-case estimates on convergence times. Furthermore, we indicate how our tools can be used for a class of non-monotone systems, and more importantly how these tools can be extended to other control problems. We illustrate our approach on switching under parametric uncertainty and regulation around a saddle point problems in a genetic toggle switch system. [less ▲]

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See detailA discontinuous Galerkin method for non-linear electro-thermo-mechanical problems; Application to shape memory composite materials
Homsi, Lina ULg; Noels, Ludovic ULg

in Meccanica (in press)

A coupled Electro-Thermo-Mechanical Discontinuous Galerkin (DG) method is developed considering the non-linear interactions of electrical, thermal, and mechanical fields. In order to develop a stable ... [more ▼]

A coupled Electro-Thermo-Mechanical Discontinuous Galerkin (DG) method is developed considering the non-linear interactions of electrical, thermal, and mechanical fields. In order to develop a stable discontinuous Galerkin formulation the governing equations are expressed in terms of energetically conjugated fields gradients and fluxes. Moreover, the DG method is formulated in finite deformations and finite fields variations. The multi-physics DG formulation is shown to satisfy the consistency condition, and the uniqueness and optimal convergence rate properties are derived under the assumption of small deformation. First the numerical properties are verified on a simple numerical example, and then the framework is applied to simulate the response of smart composite materials in which the shape memory effect of the matrix is triggered by the Joule effect. [less ▲]

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See detailMultiple Gas-Phase Conformations of a Synthetic Linear Poly(acrylamide) Polymer Observed Using Ion Mobility-Mass Spectrometry
Haler, Jean ULg; Far, Johann ULg; Aqil, Abdelhafid ULg et al

in Journal of the American Society for Mass Spectrometry (in press)

Ion mobility-mass spectrometry (IM-MS) has emerged as a powerful separation and identification tool to characterize synthetic polymer mixtures and topologies (linear, cyclic, star-shaped ... [more ▼]

Ion mobility-mass spectrometry (IM-MS) has emerged as a powerful separation and identification tool to characterize synthetic polymer mixtures and topologies (linear, cyclic, star-shaped,...). Electrospray coupled to IM-MS already revealed the coexistence of several charge state-dependent conformations for a single charge state of biomolecules with strong intramolecular interactions, even when limited resolving power IM-MS instruments were used. For synthetic polymers, the sample's polydispersity allows the observation of several chain lengths. A unique collision cross-section (CCS) trend is usually observed when increasing the degree of polymerization (DP) at constant charge state, allowing the deciphering of different polymer topologies. In this paper, we report multiple coexisting CCS trends when increasing the DP at constant charge state for linear poly(acrylamide) PAAm in the gas phase. This is similar to observations on peptides and proteins. Biomolecules show in addition population changes when collisionally heating the ions. In the case of synthetic PAAm, fragmentation occurred before reaching the energy for conformation conversion. These observations, which were made on two different IM-MS instruments (SYNAPT G2 HDMS and high resolution multi-pass cyclic T-Wave prototype from Waters), limit the use of ion mobility for synthetic polymer topology interpretations to polymers where unique CCS values are observed for each DP at constant charge state. [less ▲]

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See detailA biased random key genetic algorithm applied to the electric distribution network reconfiguration problem
de Faria Jr., Haroldo; Resende, Mauricio; Ernst, Damien ULg

in Journal of Heuristics (in press)

This work presents a biased random-key genetic algorithm (BRKGA) to solve the electric distribution network reconfiguration problem (DNR). The DNR is one of the most studied combinatorial optimization ... [more ▼]

This work presents a biased random-key genetic algorithm (BRKGA) to solve the electric distribution network reconfiguration problem (DNR). The DNR is one of the most studied combinatorial optimization problems in power system analysis. Given a set of switches of an electric network that can be opened or closed, the objective is to select the best configuration of the switches to optimize a given network objective while at the same time satisfying a set of operational constraints. The good performance of BRKGAs on many combinatorial optimization problems and the fact that it has never been applied to solve DNR problems are the main motivation for this research. A BRKGA is a variant of random-key genetic algorithms, where one of the parents used for mating is biased to be of higher fitness than the other parent. Solutions are encoded by using random keys, which are represented as vectors of real numbers in the interval (0,1), thus enabling an indirect search of the solution inside a proprietary search space. The genetic operators do not need to be modified to generate only feasible solutions, which is an exclusive task of the decoder of the problem. Tests were performed on standard distribution systems used in DNR studies found in the technical literature and the performance and robustness of the BRKGA were compared with other GA implementations. [less ▲]

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See detailA damage to crack transition model accounting for stress triaxiality formulated in a hybrid non-local implicit discontinuous Galerkin - cohesive band model framework
Leclerc, Julien ULg; Wu, Ling ULg; Nguyen, Van Dung ULg et al

in International Journal for Numerical Methods in Engineering (in press)

Modelling the entire ductile fracture process remains a challenge. On the one hand, continuous damage models succeed in capturing the initial diffuse damage stage but are not able to represent ... [more ▼]

Modelling the entire ductile fracture process remains a challenge. On the one hand, continuous damage models succeed in capturing the initial diffuse damage stage but are not able to represent discontinuities or cracks. On the other hand, discontinuous methods, as the cohesive zones, which model the crack propagation behaviour, are suited to represent the localised damaging process. However, they are unable to represent diffuse damage. Moreover, most of the cohesive models do not capture triaxiality effect. In this paper, the advantages of the two approaches are combined in a single damage to crack transition framework. In a small deformation setting, a non-local elastic damage model is associated with a cohesive model in a discontinuous Galerkin finite element framework. A cohesive band model is used to naturally introduce a triaxiality-dependent behaviour inside the cohesive law. Practically, a numerical thickness is introduced to recover a 3D-state, mandatory to incorporate the in-plane stretch effects. This thickness is evaluated to ensure the energy consistency of the method and is not a new numerical parameter. The traction-separation law is then built from the underlying damage model. [less ▲]

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See detailStochastic Inventory Routing for Perishable Products
Crama, Yves ULg; Rezaei Sadrabadi, Mahmood ULg; Savelsbergh, Martin et al

in Transportation Science (in press)

Different solution methods are developed to solve an inventory routing problem for a perishable product with stochastic demands. The solution methods are compared empirically in terms of average profit ... [more ▼]

Different solution methods are developed to solve an inventory routing problem for a perishable product with stochastic demands. The solution methods are compared empirically in terms of average profit, service level, and actual freshness. The benefits of explicitly considering demand uncertainty are quantified. The computational study highlights that in certain situations a simple ordering policy can already reach a very good performance, but that statistically and economically significant improvements are achieved when using more advanced solution methods. Managerial insights concerning the impact of shelf life and store capacity on profit are also obtained. [less ▲]

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See detailPrévalence et risque de maltraitance des aînés à domicile en Wallonie : retour sur un dispositif d’enquête
Nisen, Laurent ULg

in "Vieillir aujourd'hui des mo(n)des recomposés" (in press)

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See detailDe automatische toekenning van rechten in de Belgische sociale bescherming. Stand van zaken en opties voor de toekomst
Buysse, Linde; Goedemé, Tim; Janssens, Julie et al

in Pauvreté en Belgique. Annuaire 2017 (in press)

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See detailL’esthétique comme composante ludo-narrative d’un jeu. L’exemple d’INSIDE
Delbouille, Julie ULg

in Art&Fact (in press)

Les champignons dans l’univers de Mario ; l’esthétique pixellisée de Minecraft ou d’Undertale ; le bleu azur dans Portal : autant de signes visuels qui, en tant que composantes d’un style ou d’une ... [more ▼]

Les champignons dans l’univers de Mario ; l’esthétique pixellisée de Minecraft ou d’Undertale ; le bleu azur dans Portal : autant de signes visuels qui, en tant que composantes d’un style ou d’une iconographie spécifique, signent l’identité esthétique d’une œuvre vidéoludique. Or, si les caractéristiques visuelles du jeu vidéo sont régulièrement évoquées, les réflexions qu’elles initient se limitent encore trop souvent à une évaluation des performances graphiques du jeu, voire à un commentaire sur l’appartenance ou non du médium au domaine artistique. Dans ce court article – qui marque une première étape, encore balbutiante, dans ce domaine de nos recherches –, nous souhaitons ouvrir un dialogue avec le lecteur sur le rôle de l’esthétique vidéoludique, à travers l’analyse d’une œuvre. Loin d’être anecdotique, la dimension esthétique d’un jeu joue un rôle essentiel dans la co- construction d’autres composantes du dispositif ludique, telles que la jouabilité ou la narration – le terme « esthétique » ne désignant donc pas ici le jugement de goût ou le beau, mais l’ensemble des caractéristiques formelles constituant l’identité visuelle du jeu. Inscrite au cœur de la structure des objets-jeux (du game), l’esthétique vidéoludique a également un impact tant sur l’expérience de jeu que sur la posture des joueurs (le play). Cet article se propose d’explorer ce rôle potentiel de l’esthétique à travers un cas d’étude : le jeu INSIDE (Playdead, 2015). Si notre analyse peut se déployer au sein de nombreuses œuvres vidéoludiques, l’exemple d’INSIDE se distingue par une particularité : son esthétique constitue un des piliers de la narration et d’une réflexivité qui marque profondément le gameplay du jeu – réflexivité qui a été étudiée dans un précédent article (Barnabé et Delbouille ; 2017). Plonger au cœur d’INSIDE permet donc non seulement d’illustrer la façon dont l’esthétique peut être mobilisée pour renforcer les autres dimensions du jeu, mais également la nécessité d’étudier l’esthétique propre au médium vidéoludique – au-delà de la simple qualité graphique ou du jugement de goût. [less ▲]

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See detailBioinspired redox-active catechol-bearing polymers as ultra-robust organic cathodes for lithium storage
Patil, Nagaraj ULg; Aqil, Abdelhafid ULg; Ouhib, Farid ULg et al

in Advanced Materials (in press)

Redox-active catechols are bioinspired precursors for ortho-quinones that are characterized by higher discharge potentials than para-quinones, the latter being extensively used as organic cathode ... [more ▼]

Redox-active catechols are bioinspired precursors for ortho-quinones that are characterized by higher discharge potentials than para-quinones, the latter being extensively used as organic cathode materials for lithium ion batteries (LIBs). Here, this study demonstrates that the rational molecular design of copolymers bearing catechol- and Li+ ion-conducting anionic pendants endow redox-active polymers (RAPs) with ultrarobust electrochemical energy storage features when combined to carbon nanotubes as a flexible, binder-, and metal current collector-free buckypaper electrode. The importance of the structure and functionality of the RAPs on the battery performances in LIBs is discussed. The structure-optimized RAPs can store high-capacities of 360 mA h g−1 at 5C and 320 mA h g−1 at 30C in LIBs. The high ion and electron mobilities within the buckypaper also enable to register 96 mA h g−1 (24% capacity retention) at an extreme C-rate of 600C (6 s for total discharge). Moreover, excellent cyclability is noted with a capacity retention of 98% over 3400 cycles at 30C. The high capacity, superior active-material utilization, ultralong cyclability, and excellent rate performances of RAPs-based electrode clearly rival most of the state-of-the-art Li+ ion organic cathodes, and opens up new horizons for large-scalable fabrication of electrode materials for ultrarobust Li storage. [less ▲]

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See detailMeasuring brain synaptic vesicle protein 2A with positron emission tomography and [18F]UCB-H.
Bahri, Mohamed Ali ULg; Plenevaux, Alain ULg; Aerts, Joël ULg et al

in Alzheimer’s & Dementia: Translational Research & Clinical Interventions (in press)

Introduction: Brain distribution of synaptic vesicle protein 2Awas measured with fluorine-18 UCBH ([18F]UCB-H) and positron emission tomography (PET). Methods: Images of synaptic density were acquired in ... [more ▼]

Introduction: Brain distribution of synaptic vesicle protein 2Awas measured with fluorine-18 UCBH ([18F]UCB-H) and positron emission tomography (PET). Methods: Images of synaptic density were acquired in healthy volunteers (two young participants and two seniors). Input function was measured by arterial blood sampling (arterial input function) and derived from PET images using carotid activity (image-derived input function). Logan graphical analysis was used to estimate regional synaptic vesicle protein 2A distribution volume. Results: [18F]UCB-H uptake was ubiquitous in cortical and subcortical gray matter. Arterial input function and image-derived input function provided regional distribution volume with a high linear relationship. Discussion: The cerebral distribution of [18F]UCB-H is similar to that recently observed with carbon-11 UCB-J ([11C]UCB-J). An accurate [18F]UCB-H quantification can be performed without invasive arterial blood sampling when no suitable reference region is available, using dynamic PET carotid activity. Brain synaptic density can be studied in vivo in normal and pathological aging. [less ▲]

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See detailSartre and Merleau-Ponty
Caeymaex, Florence ULg; Cormann, Grégory ULg

in Eshleman, Matthew; Mui, Connie; Perrin, Christophe (Eds.) Sartrean Mind (in press)

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See detailClinical classification criteria for radicular pain caused by lumbar disc herniation: the RAPIDH criteria (RAdicular PaIn caused by Disc Herniation)
Genevay, Stéphane; Courvoisier, Delphine; Konstantinou, Kika et al

in Spine Journal (in press)

BACKGROUND CONTEXT: Classification criteria are recommended for diseases that lack specific biomarkers to improve homogeneity in clinical research studies. Because imaging evidence of lumbar disc ... [more ▼]

BACKGROUND CONTEXT: Classification criteria are recommended for diseases that lack specific biomarkers to improve homogeneity in clinical research studies. Because imaging evidence of lumbar disc herniations (LDHs) may not be associated with symptoms, clinical classification criteria based on patient symptoms and physical examination findings are required. PURPOSE: This study aimed to produce clinical classification criteria to identify patients with radicular pain caused by LDH. STUDY DESIGN: The study design was a two-stage process. Phase 1 included a Delphi process and Phase 2 included a cohort study. PATIENT SAMPLE: The patient sample included outpatients recruited from spine clinics in five countries. OUTCOME MEASURES: The outcome measures were items from history and physical examination. MATERIALS AND METHODS: In Phase 1, 17 spine experts participated in a Delphi process to select symptoms and signs suggesting radicular pain caused by LDH. In Phase 2, 19 different clinical experts identified patients they confidently classified as presenting with (1) radicular pain caused by LDH, (2) neurogenic claudication (NC) caused by lumbar spinal stenosis, or (3) non-specific low back pain (NSLBP) with referred leg pain. Patients completed survey items and specialists documented examination signs. A score to predict radicular pain caused by LDH was developed based on the coefficients of the multivariate model. An unrestricted grant of less than US$15,000 was received from MSD: It was used to support the conception of the Delphi, data management, and statistical analysis. No fees were allocated to participating spine specialists. RESULTS: Phase 1 generated a final list of 74 potential symptoms and signs. In Phase 2, 209 patients with pain caused by LDH (89), NC (63), or NSLBP (57) were included. Items predicting radicular pain caused by LDH (p<.05) were monoradicular leg pain distribution, patient-reported unilateral leg pain, positive straight leg raise test <60° (or femoral stretch test), unilateral motor weakness, and asymmetric ankle reflex. The score had an AUC of 0.91. An easy-to-use weighted set of criteria with similar psychometric characteristics is proposed (specificity 90.4%, sensitivity 70.6%). CONCLUSIONS: Classification criteria for identifying patients with radicular pain caused by LDH are proposed. Their use could improve the homogeneity of patients enrolled in clinical research studies. [less ▲]

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See detailTocopherols and polyphenols in pumpkin seed oil are moderately affected by industrially relevant roasting conditions
Van Hoed; Araujo Sampaio; Felkner et al

in European Journal of Lipid Science and Technology [=EJLST] (in press)

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See detailCommunication of healthcare professionals: is there ageism?
Schroyen, Sarah ULg; Adam, Stéphane ULg; Marquet, Manon ULg et al

in European Journal of Cancer Care (in press)

Elderspeak is often used when talking to older individuals and is characterized by a slower and/or louder speech, a patronizing tone, etc. A part of the reason of such communication can be found in the ... [more ▼]

Elderspeak is often used when talking to older individuals and is characterized by a slower and/or louder speech, a patronizing tone, etc. A part of the reason of such communication can be found in the actual context of negative view of aging. However, the link between view of aging and elderspeak has never been objectively studied in oncology. Therefore, 40 healthcare professionals (physicians and medical students) record a podcast where they have to explain an endocrine therapy to two fictional patients (40 vs 70 years old). Results show that when participants explained the treatment to the older patient, they used shorter utterances and made more repetitions. They also evoked fewer side effects such as sexual issues. Moreover, reduction of length of utterances and of word-per-minute rate was observed for older patient when participants have a positive view of aging but for both patients when they have a negative view of aging. In conclusion, physicians and medical students used elderspeak when they explained a treatment to older patients. Participants with a more negative view of aging also unconsciously talked slower and made shorter utterances to a 40 year-old patient. [less ▲]

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See detailDual-Specificity Phosphatase Deletion Protects Female, but Not Male, Mice from Endotoxemia- and Polymicrobial-Induced Septic Shock
Vandereyken, Maud; Singh, Pratibha; Wathieu, Caroline ULg et al

in Journal of Immunology (in press)

Dual-specificity phosphatase 3 (DUSP3) is a small phosphatase with poorly known physiological functions and for which only a few substrates are known. Using DUSP3-deficient mice, we recently reported that ... [more ▼]

Dual-specificity phosphatase 3 (DUSP3) is a small phosphatase with poorly known physiological functions and for which only a few substrates are known. Using DUSP3-deficient mice, we recently reported that DUSP3 deficiency confers resistance to endotoxin- and polymicrobial-induced septic shock. We showed that this protection was macrophage dependent. In this study, we further investigated the role of DUSP3 in sepsis tolerance and showed that the resistance is sex dependent. Using adoptive-transfer experiments and ovariectomized mice, we highlighted the role of female sex hormones in the phenotype. Indeed, in ovariectomized female and male mice, the dominance of M2-like macrophages observed in DUSP32/2 female mice was reduced, suggesting a role for this cell subset in sepsis tolerance. At the molecular level, DUSP3 deletion was associated with estrogen dependent decreased phosphorylation of ERK1/2 and Akt in peritoneal macrophages stimulated ex vivo by LPS. Our results demonstrate that estrogens may modulate M2-like responses during endotoxemia in a DUSP3-dependent manner. [less ▲]

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See detailProtein folding at extreme temperatures: current issues
Feller, Georges ULg

in Seminars in Cell & Developmental Biology (in press)

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See detailCarte géologique de Wallonie à l'échelle 1:25 000. Notice explicative. Hamoir-Ferrières n°49/1-2
Marion, Jean-Marc ULg; Barchy, Laurent

Book published by SPW/DGARNE - Révision (in press)

New geological map of Wallonia published at the scale of 1/25 000, based on a new field work and using previous scientific data produced since the previous editions of Lohest and Fourmarier (1900)