Last 7 days
Bookmark and Share    
See detailDifferent and synergistic effect of 5-Azacytidine and Rapamycin on ex vivo expansion of natural human T Regulatory cells
Conteduca, Giuseppina ULg

Poster (2016, November 16)

Natural T regulatory cells (Treg) are challenging to expand ex vivo, and this has severely hindered in vivo evaluation of their therapeutic potential. 5-Azacytidine (5-azaC) and Rapamycin (RAPA) are ... [more ▼]

Natural T regulatory cells (Treg) are challenging to expand ex vivo, and this has severely hindered in vivo evaluation of their therapeutic potential. 5-Azacytidine (5-azaC) and Rapamycin (RAPA) are immunosuppressive drugs that promote selectively the expansion of CD4+CD25highFoxp3+ regulatory T cells. We investigated whether 5-azaC and RAPA could be used together to promote the ex vivo expansion of Tregs purified from adult human peripheral blood. : We found that 5-azaC helped maintain FOXP3 expression during the expansion process probably by promoting the conversion of T conventional (Tconv) in Treg, instead Rapa induces selectively apoptosis in Tconv cells and expansion in Treg. Addition of 5-azaC to RAPA treated cultures improved gene expression of FOXP3, CD25, STAT5 and TGF-B resulted in enhanced Treg expansion and suppressive activity. Also Rapa and 5-AzaC combination sustain Bcl-2 protein expression in Treg conferring resistance to apoptosis process. 5-azaC may have utility in ex vivo expansion of human Tregs, not as a single agent, but in combination with RAPA. These data may considerably accelerate the development of immunotherapeutic approaches for the treatment of autoimmune disease or posttransplant alloreactions by the adoptive transfer of nTreg cells. [less ▲]

Detailed reference viewed: 15 (2 ULg)
Full Text
See detailBelgian political situation
Verjans, Pierre ULg

Conference given outside the academic context (2016)

Belgian trends show that centrifugal move from the North of the country can lead to a separation or to a new form of federalism/confederalism.

Detailed reference viewed: 10 (0 ULg)
See detailLe Kimbanguisme et le prophétisme kongo : la tradition messianique dans la religion kongo / Kimbanguism and Kongo Prophetism : Messianic Tradition in Kongo Religion
Melice, Anne ULg; Sarró, Ramon

in Du Jourdain au Congo – Art et christianisme en Afrique centrale (2016)

Detailed reference viewed: 32 (2 ULg)
Full Text
Peer Reviewed
See detailIncreased Risk of Group B Streptococcus Invasive Infection in HIV-Exposed but Uninfected Infants: A Review of the Evidence and Possible Mechanisms.
DAUBY, Nicolas; CHAMEKH, Mustapha; MELIN, Pierrette ULg et al

in Frontiers in Immunology (2016), 7

Group B Streptococcus (GBS) is a major cause of neonatal sepsis and mortality worldwide. Studies from both developed and developing countries have shown that HIV-exposed but uninfected (HEU) infants are ... [more ▼]

Group B Streptococcus (GBS) is a major cause of neonatal sepsis and mortality worldwide. Studies from both developed and developing countries have shown that HIV-exposed but uninfected (HEU) infants are at increased risk of infectious morbidity, as compared to HIV-unexposed uninfected infants (HUU). A higher susceptibility to GBS infections has been reported in HEU infants, particularly late-onset diseases and more severe manifestations of GBS diseases. We review here the possible explanations for increased susceptibility to GBS infection. Maternal GBS colonization during pregnancy is a major risk factor for early-onset GBS invasive disease, but colonization rates are not higher in HIV-infected compared to HIV-uninfected pregnant women, while selective colonization with more virulent strains in HIV-infected women is suggested in some studies. Lower serotype-speci c GBS maternal antibody transfer and quantitative and qualitative defects of innate immune responses in HEU infants may play a role in the increased risk of GBS invasive disease. The impact of maternal antiretroviral treatment and its consequences on immune activation in HEU newborns are important to study. Maternal immunization presents a promising intervention to reduce GBS burden in the growing HEU population. [less ▲]

Detailed reference viewed: 18 (2 ULg)
See detailInterpellations impossibles. Question à Judith Butler
Borotto, Jessica ULg

Conference (2016, November 16)

Detailed reference viewed: 18 (1 ULg)
See detailLes débuts du Gravettien dans le Nord-Ouest de l’Europe (28.000-26.000 BP)
Touzé, Olivier ULg

Scientific conference (2016, November 16)

Detailed reference viewed: 12 (0 ULg)
Full Text
See detailSang de cordon état des lieux et perspectives
BAUDOUX, Etienne ULg

Conference (2016, November 16)

Detailed reference viewed: 19 (1 ULg)
See detailRapport sur l'Habilitation de Catherine GUYON : Par la roue de sainte Catherine. Dévots, pèlerins et pèlerinage à sainte Catherine d’Alexandrie (VIIIe- début du XVIe siècle)
George, Philippe ULg

Report (2016)

Madame Guyon a étudié le culte de sainte Catherine d'Alexandrie et son développement tous azimuts.

Detailed reference viewed: 52 (1 ULg)
Full Text
Peer Reviewed
See detailOptimizing the subwavelength grating of L-band annular groove phase masks for high coronagraphic performance
Vargas Catalán, E.; Huby, Elsa ULg; Forsberg, P. et al

in Astronomy and Astrophysics (2016), 595

Context. The annular groove phase mask (AGPM) is one possible implementation of the vector vortex coronagraph, where the helical phase ramp is produced by a concentric subwavelength grating. For several ... [more ▼]

Context. The annular groove phase mask (AGPM) is one possible implementation of the vector vortex coronagraph, where the helical phase ramp is produced by a concentric subwavelength grating. For several years, we have been manufacturing AGPMs by etching gratings into synthetic diamond substrates using inductively coupled plasma etching. <BR /> Aims: We aim to design, fabricate, optimize, and evaluate new L-band AGPMs that reach the highest possible coronagraphic performance, for applications in current and forthcoming infrared high-contrast imagers. <BR /> Methods: Rigorous coupled wave analysis (RCWA) is used for designing the subwavelength grating of the phase mask. Coronagraphic performance evaluation is performed on a dedicated optical test bench. The experimental results of the performance evaluation are then used to accurately determine the actual profile of the fabricated gratings, based on RCWA modeling. <BR /> Results: The AGPM coronagraphic performance is very sensitive to small errors in etch depth and grating profile. Most of the fabricated components therefore show moderate performance in terms of starlight rejection (a few 100:1 in the best cases). Here we present new processes for re-etching the fabricated components in order to optimize the parameters of the grating and hence significantly increase their coronagraphic performance. Starlight rejection up to 1000:1 is demonstrated in a broadband L filter on the coronagraphic test bench, which corresponds to a raw contrast of about 10[SUP]-5[/SUP] at two resolution elements from the star for a perfect input wave front on a circular, unobstructed aperture. <BR /> Conclusions: Thanks to their exquisite performance, our latest L-band AGPMs are good candidates for installation in state of the art and future high-contrast thermal infrared imagers, such as METIS for the E-ELT. [less ▲]

Detailed reference viewed: 8 (0 ULg)
Full Text
Peer Reviewed
See detailShear banding simulation in clay rock around an underground opening, and its contact mechanism with the gallery’s lining
Charlier, Robert ULg; Salehnia, Fatemeh ULg

in Proc. 5th International conference on geotechnical engineering and soil mechanics (2016, November 15)

Detailed reference viewed: 12 (2 ULg)
Full Text
Peer Reviewed
See detailSensitivity of the annual net ecosystem exchange to the cospectral model used for high frequency loss corrections at a grazed grassland site
Mamadou, Ossenatou; Gourlez de la Motte, Louis ULg; De Ligne, Anne ULg et al

in Agricultural and Forest Meteorology (2016), 228-229

Detailed reference viewed: 30 (5 ULg)
See detailLe journal des apprentissages : écrire et interagir pour mieux apprendre
Scheepers, Caroline ULg

Conference given outside the academic context (2016)

La formation est destinée aux enseignants du cycle 2 qui travaillent dans les établissements classés ZEP de Sarcelles. Elle vise à leur expliciter les fondements et modalités du journal des apprentissages ... [more ▼]

La formation est destinée aux enseignants du cycle 2 qui travaillent dans les établissements classés ZEP de Sarcelles. Elle vise à leur expliciter les fondements et modalités du journal des apprentissages que tiennent des élèves de primaire ou de secondaire. [less ▲]

Detailed reference viewed: 21 (1 ULg)
See detailFaut-il enseigner l'histoire de manière plus classique ?
Jadoulle, Jean-Louis ULg

Article for general public (2016)

Detailed reference viewed: 15 (0 ULg)
Full Text
See detailLe théorème fondamental comme pierre de touche de l'enseignement et de l'apprentissage de l'analyse au secondaire
Balhan, Kevin ULg

Doctoral thesis (2016)

Using the Anthropological Theory of Didactics and the Theory of Didactic Situations, this thesis brings an answer to several questions of learning the fundamental theorem of the analysis and shows that ... [more ▼]

Using the Anthropological Theory of Didactics and the Theory of Didactic Situations, this thesis brings an answer to several questions of learning the fundamental theorem of the analysis and shows that what prevents to understand it is significant of dysfunctions of the teaching of the analysis at the secondary level in French-speaking Belgium. [less ▲]

Detailed reference viewed: 28 (7 ULg)
See detailLe dossier patient en psychologie clinique : Aspects juridiques, éthiques et déontologiques
Blavier, Adelaïde ULg

Scientific conference (2016, November 15)

Detailed reference viewed: 20 (1 ULg)
Full Text
See detailA crucial role for cdk1 in postnatal hippocampal neurogenesis
Marlier, Quentin ULg

Poster (2016, November 15)

Cdk1 seems to be involved in the proliferation and differentiation of adult neural stem cells found in the adult dentate gyrus

Detailed reference viewed: 16 (4 ULg)
See detailActor-Network Theory’s perspectives for musicology
Levaux, Christophe ULg

Conference (2016, November 15)

Detailed reference viewed: 19 (1 ULg)
Full Text
See detailCarbon balance of an intensively grazed grassland in southern Belgium
Gourlez de la Motte, Louis ULg; Jérôme, Elisabeth; Mamadou, Ossénatou et al

in Agricultural and Forest Meteorology (2016), 228-229

Detailed reference viewed: 24 (9 ULg)