Last 7 days
Bookmark and Share    
Full Text
Peer Reviewed
See detailCO2-sourced α-alkylidene cyclic carbonates: a Step forward in the quest for functional regioregular poly(urethane)s and poly(carbonate)s
Gennen, Sandro ULg; Grignard, Bruno ULg; Tassaing, Thierry et al

in Angewandte Chemie International Edition (in press)

We describe a robust platform for the synthesis of a large diversity of novel functional CO2 -sourced polymers by exploiting the regio-controlled and site selective ring-opening of α- alkylidene ... [more ▼]

We describe a robust platform for the synthesis of a large diversity of novel functional CO2 -sourced polymers by exploiting the regio-controlled and site selective ring-opening of α- alkylidene carbonates by various nucleophiles. The remarkable reactivity of α-alkylidene carbonates is dictated by the exocyclic olefinic group that selectively orients the cyclic carbonate ring- opening with the formation of an enol species. The polyaddition of CO2 -sourced bis-α-alkylidene carbonates (bis-αCCs) with primary and secondary diamines provides novel regioregular functional poly(urethane)s. The reactivity of bis-αCCs is also exploited for producing new poly(β-oxo-carbonate)s by organocatalyzed polyaddition with a diol. All polyadditions were feasible under ambient conditions. This synthesis platform provides new functional variants of world-class leading polymers families (polyurethanes, polycarbonates) and valorises CO2 as a chemical feedstock. [less ▲]

Detailed reference viewed: 28 (8 ULg)
Full Text
Peer Reviewed
See detailA central role for Type I IFN in Th2 response induction by dendritic cells
Webb, Lauren M.; Lundie, Rachel J.; Borger, Jessica G. et al

in EMBO Journal (in press)

Detailed reference viewed: 20 (2 ULg)
Peer Reviewed
See detailMore or less integration ? Explaining Candidates’ and Citizens’ Attitudes towards European Integration in 2014 Belgium
Defacq, Samuel; Dodeigne, Jérémy ULg; Teuber, Ferdinand et al

in Vandeleene, Audrey; De Winter, Lieven; Baudewyns, Pierre (Eds.) Candidates between parties and voters in the Belgian partitocracy: a multilevel analysis (in press)

Detailed reference viewed: 5 (1 ULg)
Full Text
Peer Reviewed
See detailFocus sur les lymphocytes T dans la maladie du greffon contre l'hôte après allogreffe de cellules soucges hématopoïétiques: implications pour de nouvelles stratégies de prévention
Vrancken, L; Delens, Loïc ULg; BEGUIN, Yves ULg et al

in Oncol. Hematol. (in press)

Malgré les stratégies de prévention actuelles, la maladie du greffon contre l’hôte (greffe-versus-hôte, GVH) aiguë (GVHa) reste une complication sévère et fréquente de l’allogreffe de cellules souches ... [more ▼]

Malgré les stratégies de prévention actuelles, la maladie du greffon contre l’hôte (greffe-versus-hôte, GVH) aiguë (GVHa) reste une complication sévère et fréquente de l’allogreffe de cellules souches hématopoïétiques. Bien que la physiopathologie de celle-ci ne reste que partiellement élucidée à ce jour, il est classiquement admis que les lymphocytes T (LT) jouent un rôle important dans son processus biologique. Les progrès récents de l’immunologie des LT dans la GVHa ont permis de diversifier les pistes visant à prévenir la survenue de cette complication post-greffe. Plusieurs approches sont en cours d’exploration dans des essais cliniques avec des résultats encourageant tels que la manipulation ex vivo des LT avant leur transfert chez le patient afin de leur faire exprimer des gènes suicide, l’élimination in vivo des LT proliférant directement après la greffe, l’inhibition de l’activation des LT en interférant avec les voies de signalisation en aval du TCR ou celles induites par les cytokines, l’induction de l’anergie des LT en bloquant les signaux de costimulation, le blocage de l’adressage des LT vers les organes lymphoïdes secondaires et les tissus cibles, la promotion de l’immunotolérance par la perfusion de lymphocytes T régulateurs ou par l’utilisation d’agents favorisant leur différenciation et leurs fonctions in vivo et la modulation de l’expression génique des cellules immunitaires par des modulateurs épigénétiques. Outre la prévention de la GVHa, le défi des nouvelles stratégies consiste également à ne pas compromettre l’effet bénéfique de la greffe contre la tumeur ni la reconstitution des défenses anti-infectieuses. [less ▲]

Detailed reference viewed: 26 (10 ULg)
Full Text
Peer Reviewed
See detailSmart City concepts: from perception to acceptability
Schelings, Clémentine ULg; Elsen, Catherine ULg

in Proceedings of the 21th Conference of the Environmental and Sustainability Management Accounting Network (EMAN) (in press)

This paper studies the sustainability of the Smart City from the acceptability perspective. Assuming that there is a possibility for end-users to reject some of the Smart City principles and, consequently ... [more ▼]

This paper studies the sustainability of the Smart City from the acceptability perspective. Assuming that there is a possibility for end-users to reject some of the Smart City principles and, consequently, to jeopardize its perenniality, we argue that studying how citizens perceive some of the Smart City concepts is a prerequisite for the assessment of the Smart City sustainability scheme. In this paper, we test the acceptability of the Smart City by confronting the theoretical concepts generally mobilized in the literature with the people’s actual perceptions. To this end, a short survey was distributed on the occasion of three Smart City events. This article analyses the obtained results in regard of three demographic factors (age, gender and professional background). It thus repositions chore concepts of the Smart City in regard of acceptability, and particularly in relation to the associated risks for its sustainability. [less ▲]

Detailed reference viewed: 49 (7 ULg)
Full Text
Peer Reviewed
See detailReduced intensity and non-myeloablative allogenic stem cell transplantation from alternative HLA-mismatched donors for Hodgkin's lymphoma: a study by the French Society of Bone Marrow Transplantation and Cellular Therapy
Gauthier, J; Castagna, L; Garnier, F et al

in Bone Marrow Transplantation (in press)

Allogeneic stem cell transplantation (allo-SCT) following a non-myeloablative (NMA) or reduced-intensity conditioning (RIC) is considered a valid approach to treat patients with refractory/relapsed ... [more ▼]

Allogeneic stem cell transplantation (allo-SCT) following a non-myeloablative (NMA) or reduced-intensity conditioning (RIC) is considered a valid approach to treat patients with refractory/relapsed Hodgkin lymphoma (HL). When an HLA-matched donor is lacking a graft from a familial haploidentical (HAPLO) donor, a mismatched unrelated donor (MMUD) or cord blood (CB) might be considered. In this retrospective study, we compared the outcome of patients with HL undergoing a RIC or NMA allo-SCT from HAPLO, MMUD or CB. Ninety-eight patients were included. Median follow-up was 31 months for the whole cohort. All patients in the HAPLO group (N = 34) received a T-cell replete allo-SCT after a NMA (FLU-CY-TBI, N = 31, 91%) or a RIC (N = 3, 9%) followed by post-transplant cyclophosphamide. After adjustment for significant covariates, MMUD and CB were associated with significantly lower GvHD-free relapse-free survival (GRFS; hazard ratio (HR) = 2.02, P = 0.03 and HR = 2.43, P = 0.009, respectively) compared with HAPLO donors. In conclusion, higher GRFS was observed in Hodgkin lymphoma patients receiving a RIC or NMA allo-SCT with posttransplant cyclophosphamide from HAPLO donors. Our findings suggest they should be favoured over MMUD and CB in this setting. [less ▲]

Detailed reference viewed: 31 (5 ULg)
Full Text
Peer Reviewed
See detailObjet et pratiques sémiotiques : les enjeux médiatiques du support photographique
Honba Honba, Cédric ULg

in Signata. Annales des Sémiotiques = Annals of Semiotics (in press)

Detailed reference viewed: 20 (5 ULg)
Full Text
Peer Reviewed
See detailOutcome after failure of allogeneic hematopoietic stem cell transplantation in children with acute leukemia: a study by the Société Francophone de Greffe de Moelle et de Thérapie Cellulaire (SFGM-TC)
Rorhlich; Roux, C; Tifratene, K et al

in Bone Marrow Transplantation (in press)

Allogeneic hematopoietic stem cell transplantation (SCT) contributes to improved outcome in childhood acute leukemia (AL). However, therapeutic options are poorly defined in case of post-transplantation ... [more ▼]

Allogeneic hematopoietic stem cell transplantation (SCT) contributes to improved outcome in childhood acute leukemia (AL). However, therapeutic options are poorly defined in case of post-transplantation relapse. We aimed to compare treatment strategies in 334 consecutive children with acute leukemia relapse or progression after SCT in a recent ten-year period. Data could be analyzed in 288 patients (157 ALL, 123 AML and 8 biphenotypic AL) with a median age of 8.16 years at transplantation. The median delay from first SCT to relapse or progression was 182 days. The treatment consisted in chemotherapy alone (n=108), chemotherapy followed by second SCT (n=70), supportive/palliative care (n=67), combination of chemotherapy and DLI (n=30), or isolated reinfusion of donor lymphocytes (DLI) (n=13). The median OS duration after relapse was 164 days and differed according to therapy: DLI after chemotherapy = 385 d, second allograft = 391d, chemotherapy = 174d, DLI alone = 140d, palliative care = 43d. A second SCT or a combination of chemotherapy and donor lymphocytes infusion yielded similar outcome (HR=0.85, p=0.53) unlike chemotherapy alone (HR 1.43 p=0.04), palliative care (HR=4.24, p<0.0001) or isolated DLI (HR=1,94, p<0.04). Despite limitations in this retrospective setting, strategies including immunointervention appear superior to other approaches, mostly in AML. [less ▲]

Detailed reference viewed: 24 (2 ULg)
Full Text
Peer Reviewed
See detailThe clinical relevance of imatinib plasma trough concentrations in chronic myeloid leukemia. A Belgian study
Van Obbergh, F; Knoops, L; Devos, T et al

in Clinical Biochemistry (in press)

This retrospectivemulticenter study in patientswith chronic myeloid leukemia in chronic phasewas undertaken to confirm the clinical relevance of imatinib plasma concentrations monitoring in daily practice ... [more ▼]

This retrospectivemulticenter study in patientswith chronic myeloid leukemia in chronic phasewas undertaken to confirm the clinical relevance of imatinib plasma concentrations monitoring in daily practice. Forty-one patients, with 47 imatinib plasma measurements, were analyzed during treatment with imatinib given at a fixed 400mg daily dose. A significant inverse relationship of imatinib concentration with the patients' weight was observed (Pearson's test: p=0.02,R2=0.1). More interestingly, patientswith poor response (switched to another tyrosine kinase inhibitor because of imatinib failure, or because of disease progression after an initial response) displayed a significantly lower mean imatinib concentration as compared to patients maintained on imatinib (822 ng/mL vs 1099 ng/mL; Student's t-test, p=0.04). Failure or disease progression occurred more often in patients in the lowest quartile of imatinib concentrations compared to patients in the highest quartile (p = 0.02, logrank test). No correlation could be established with other biological or clinical parameter, including complete cytogenic response and majormolecular response. In conclusion: in patients treatedwith imatinib at a fixed daily dose of 400 mg, imatinib plasma concentrations decreased with increasing body weight and were lower in patients switched to another tyrosine kinase inhibitor due to imatinib failure. Systematic determination of imatinib plasma trough levels should be encouraged in such patients. [less ▲]

Detailed reference viewed: 25 (1 ULg)
Full Text
Peer Reviewed
See detailMorphological integration and alternative life history strategies: a case study in a facultatively paedomorphic newt
Tomašević, Natasa; Cvijanović, Milena; Denoël, Mathieu ULg et al

in Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution (in press)

Tetrapod limbs are serially homologous structures that represent a particularly interesting model for studies on morphological integration, i.e. the tendency of developmental systems to produce correlated ... [more ▼]

Tetrapod limbs are serially homologous structures that represent a particularly interesting model for studies on morphological integration, i.e. the tendency of developmental systems to produce correlated variation. In newts, limbs develop at an early larval stage and grow continuously, including after the habitat transition from water to land following metamorphosis. However, aquatic and terrestrial environments impose different constraints and locomotor modes that could affect patterns of morphological integration and evolvability. We hypothesize that this would be the case for alternative heterochronic morphs in newts, i.e. aquatic paedomorphs that keep gills at the adult stage and adult metamorphs that are able to disperse on land. To this end, we analysed patterns and strengths of correlations between homologous skeletal elements of the fore- and hindlimbs as well as among skeletal elements within limbs in both phenotypes in the alpine newt, Ichthyosaura alpestris. Our results showed that metamorphs and paedomorphs had similar, general patterns of limb integration. Partial correlations between homologous limb elements and within limb elements were higher in paedomorphs when compared to metamorphs. Decrease in partial correlation between homologous limb elements in metamorphs is accompanied with a higher evolvability of the terrestrial morph. All these results indicate that environmental demands shaped the patterns of morphological integration of alpine newt limbs and that the observed diversity in correlation structure could be related to a qualitative difference in the modes of locomotion between the morphs. [less ▲]

Detailed reference viewed: 37 (5 ULg)
Full Text
Peer Reviewed
See detailMultiple uprising invasions of Pelophylax water frogs, potentially inducing a new hybridogenetic complex
Dufresne, Christophe; Denoël, Mathieu ULg; Di Santo, Lionel et al

in Scientific Reports (in press)

Detailed reference viewed: 26 (2 ULg)
Full Text
Peer Reviewed
See detailPlaton sans métaphysique
Dewalque, Arnaud ULg

in Platon néokantien (in press)

La littérature néokantienne consacrée à la théorie platonicienne des Idées est surabondante. Elle a été alimentée par des questions profondes et a donné lieu, à son tour, à plusieurs polémiques ... [more ▼]

La littérature néokantienne consacrée à la théorie platonicienne des Idées est surabondante. Elle a été alimentée par des questions profondes et a donné lieu, à son tour, à plusieurs polémiques importantes. Compte tenu de l’ampleur du dossier et de la variété des interprétations proposées, nous devrons renoncer, dans cette introduction, à brosser un tableau général de la réception néokantienne de Platon. Nous nous bornerons à en donner un aperçu introductif en mettant en évidence un petit nombre de thèses centrales et en mentionnant quelques aspects saillants des controverses que ces thèses ont suscitées. [less ▲]

Detailed reference viewed: 19 (0 ULg)
Full Text
Peer Reviewed
See detailChondrocyte secretome: a source of novel insights and exploratory biomarkers of osteoarthritis
Sanchez, Christelle ULg; Bay-Jensen, Anne-Christine; Pap, Thomas et al

in Osteoarthritis and Cartilage (in press)

Detailed reference viewed: 40 (4 ULg)
Full Text
Peer Reviewed
See detailA method for independent component graph analysis of resting-state fMRI. Brain and Behavior 2017, in press
Ribeiro de Paula, Demetrius; Ziegler, Erik; Abeyasinghe, P et al

in Brain and Behavior (in press)

Detailed reference viewed: 68 (4 ULg)
See detailMusical practices and identity. The story of the Roman sojourn (1623-1627) of Maurice of Savoy, crown-cardinal of France
Morales, Jorge ULg

in Corswarem, Emilie; Berti, Michela (Eds.) Music and the Identity Process : the National Churches in Rome in the Early Modern Period (in press)

Les cardinaux de couronne avaient pour fonction de défendre et de représenter les intérêts d’un État étranger auprès de la Curie. Cette activité leur conférait une place centrale et particulière dans le ... [more ▼]

Les cardinaux de couronne avaient pour fonction de défendre et de représenter les intérêts d’un État étranger auprès de la Curie. Cette activité leur conférait une place centrale et particulière dans le complexe réseau diplomatique, ecclésiastique et nobiliaire romain. À travers l’étude de quelques cas, nous examinerons leur rôle culturel en tant qu’organisateurs de fêtes et de cérémonies, manifestations essentielles à leur promotion sociale, événements où s’exerçaient les pratiques musicales et lieux d’expression de l’identité nationale. L’analyse de ces marqueurs identitaires nous permettra de vérifier l’existence d’une double culture ainsi que la construction d’un modèle de cardinal protecteur national à la cour de Rome, « grand théâtre du monde ». [less ▲]

Detailed reference viewed: 12 (1 ULg)
See detailSigismondo D’India et ses mondes. Un compositeur italien d’avant-garde
Morales, Jorge ULg

Book published by Classiques Garnier (in press)

Cet ouvrage analyse le parcours artistique d’un compositeur majeur de l’époque de Monteverdi, Sigismondo D’India (c. 1582-c. 1629), depuis l’Italie méridionale de ses origines jusqu’à son séjour à Rome et ... [more ▼]

Cet ouvrage analyse le parcours artistique d’un compositeur majeur de l’époque de Monteverdi, Sigismondo D’India (c. 1582-c. 1629), depuis l’Italie méridionale de ses origines jusqu’à son séjour à Rome et à Modène, où le musicien acheva son existence. En étudiant les villes, les cours, les princes protecteurs, les dédicataires et les lieux destinés à la musique, chacune des parties suit une étape de la carrière de D’India et redonne vie aux mondes de ce compositeur italien d’avant-garde. Apparaissent alors les thématiques du voyage, de la circularité et du croisement, lesquelles permettent de penser l’histoire de la musique comme une histoire à la fois des pratiques culturelles et de l’expérience musicale. [less ▲]

Detailed reference viewed: 11 (0 ULg)