Last 7 days
Bookmark and Share    
Full Text
Peer Reviewed
See detail‘Quality by Design’ approach for the analysis of impurities in pharmaceutical drug products and drug substances
Dispas, Amandine ULiege; Avohou, Tonakpon Hermane ULiege; Lebrun, Pierre ULiege et al

in Trends in Analytical Chemistry (in press)

The pharmaceutical industry is highly regulated by quality policies. The concept of risk management is strongly integrated into the quality assurance system to ensure pharmaceuticals’ quality and ... [more ▼]

The pharmaceutical industry is highly regulated by quality policies. The concept of risk management is strongly integrated into the quality assurance system to ensure pharmaceuticals’ quality and patients’ safety. In the context of quality control, the detection of impurities in raw materials and finished products is a major concern. It can be challenging for analytical scientists to meet specificity/selectivity and sensitivity requirements. Obviously, separation techniques are widely used for the detection of impurities but the method development required to achieve Analytical Target Profile (ATP) concerns is often challenging. Therefore, to ensure pragmatic and systematic methods development and simultaneously manage the risk associated with analytical methods, the principles of Quality by Design (QbD) should be applied. This paper provides an overview of QbD principles and statistical strategies (mainly DoE-DS approach) which can be applied to impurity detection methods, as well as a review of the literature where QbD has been applied to these types of analytical methods. [less ▲]

Detailed reference viewed: 42 (14 ULiège)
Full Text
See detailMusique et culture à Rome et dans l’Italie méridionale entre Renaissance et Baroque
Morales, Jorge ULiege

in Le jardin de musique (in press), X

Alfred Einstein soulignait en 1949 qu’« à Naples comme à Palerme, le baroque le plus extravagant fleurissait à l’église, à la cour et dans la musique ». En effet, la culture de la Méditerranée – ... [more ▼]

Alfred Einstein soulignait en 1949 qu’« à Naples comme à Palerme, le baroque le plus extravagant fleurissait à l’église, à la cour et dans la musique ». En effet, la culture de la Méditerranée – immémorial carrefour de nombreuses civilisations – a donné naissance à un monde musical riche et singulier dans la période qui court de la fin de la Renaissance au début du Baroque et sur lequel il reste beaucoup à découvrir. Il en est de même pour Rome : la richesse de l’activité musicale s’y présentait sous les formes les plus éclectiques. La Ville Eternelle était alors en effet la cour la plus importante de la Péninsule, foyer culturel majeur et porte de l’Italie méridionale. Nous pouvons constater un récent regain d’intérêt pour la recherche archivistique et historique qui a permis, à travers de nombreux travaux et colloques, de jeter un regard neuf sur le milieu musical et culturel romain et méditerranéen de cette époque (musique vocale profane et sacrée, musique instrumentale, théâtre, institutions musicales, etc.). Ces travaux jettent les fondements d’une recherche qui ne demande qu’à être approfondie. [less ▲]

Detailed reference viewed: 57 (0 ULiège)
Peer Reviewed
See detailInlays
Dolce, Rita; Couturaud, Barbara ULiege

in Lebeau, Marc (Ed.) Associated Regional Chronologies for the Ancient Near East and the Eastern Mediterranean (in press)

Detailed reference viewed: 11 (1 ULiège)
Full Text
See detailA fresh look on the limit on ultralight axion-like particles from SN1987A
Payez, Alexandre ULiege

in 10th Patras Workshop on Axions, WIMPs and WISPs (in press)

We revisit the limit on very light axion-like particles (ALPs) from the absence of gamma rays coincidental with the neutrino burst from SN1987A. We use updated supernova simulations, modern models for the ... [more ▼]

We revisit the limit on very light axion-like particles (ALPs) from the absence of gamma rays coincidental with the neutrino burst from SN1987A. We use updated supernova simulations, modern models for the magnetic field inside the Galaxy, and a Primakoff cross section which takes into account proton-degeneracy and mass-reduction effects. We finally give an updated exclusion plot for the electromagnetic coupling of sub-eV ALPs, comparing our new bound with other limits as well as with future ALP searches. [less ▲]

Detailed reference viewed: 39 (6 ULiège)
See detailDisorders of consciousness: new advances in neuroimaging techniques
Soddu, Andrea ULiege; Bruno, Marie-Aurélie ULiege; VANHAUDENHUYSE, Audrey ULiege et al

in Zanotti, Bruno (Ed.) Vegetative State (in press)

Detailed reference viewed: 124 (4 ULiège)
Full Text
Peer Reviewed
See detailInsects, the next European foodie craze?
Caparros Megido, Rudy ULiege; Haubruge, Eric ULiege; Francis, Frédéric ULiege

in Edible Insects in Sustainable Food Systems (in press)

Edible insects are systematically targeted as a major future food for European consumers but success in introducing entomophagy in Western society depends on factors governing consumers’ attitudes towards ... [more ▼]

Edible insects are systematically targeted as a major future food for European consumers but success in introducing entomophagy in Western society depends on factors governing consumers’ attitudes towards insect-based products. Effectively, as for sushi in the 2000s, edible insects are considered as new food products in Europe and are deeply related to a fear or a reject feeling by consumers called “food neophobia“. Consequently, several studies have been achieved to face the actual aversion of European consumers for insects. These studies principally tried to understand the insect-related neophobia, to highlight positive arguments for entomophagy development and also to test possible ways of integration of insects as food. The purpose of this chapter is to get an overview of the actual literature on edible insect acceptability in Europe to propose conceivable solutions for product development and new approaches for further studies. [less ▲]

Detailed reference viewed: 58 (4 ULiège)
See detailAux sources des liturgies indo-iraniennes
Swennen, Philippe ULiege; Redard, Céline ULiege; Ferrer-Losilla, Joan Josep ULiege et al

Book published by Collection Religion (Presses universitaires de l’Université de Liège) (in press)

Detailed reference viewed: 21 (2 ULiège)
Full Text
See detailFin de siècle/Jahrhundertwende: Eine Tendenzgeschichte
Küpper, Achim ULiege

in Roland, Hubert (Ed.) Eine kleine deutsch-französische Literaturgeschichte vom 18. Jahrhundert bis zum Ersten Weltkrieg (in press)

Detailed reference viewed: 34 (0 ULiège)
Full Text
Peer Reviewed
See detailL'utilisation du ratio sFlt-1/PlGF dans la prééclampsie: une analyse rétrospective monocentrique
Verbeurgt, Lievine ULiege; CHANTRAINE, Frédéric ULiege; DE MARCHIN, Jérôme et al

in Revue Médicale de Liège (in press)

La fms-like tyrosine kinase 1 soluble (sFlt-1) est un facteur anti-angiogénique libéré en quantité excessive dans la prééclampsie (PE) et impliqué dans la dysfonction endothéliale. Il est comparé au ... [more ▼]

La fms-like tyrosine kinase 1 soluble (sFlt-1) est un facteur anti-angiogénique libéré en quantité excessive dans la prééclampsie (PE) et impliqué dans la dysfonction endothéliale. Il est comparé au facteur de croissance placentaire pro-angiogénique (PlGF) qui diminue dans la PE. Le ratio sFlt-1/PlGF est présenté dans la littérature comme outil dans la prédiction de la prééclampsie. Un ratio < 38 confirme l’absence de prééclampsie à court-terme. Un ratio ≥ 85 dans la PE précoce (avant 34 semaines aménorrhée (SA)) et ≥ 110 dans le «late onset» (> 34 semaines d’aménorhhée) peut poser le diagnostic de prééclampsie. Dans cette étude rétrospective monocentrique, le ratio sFlt-1/PlGF a été dosé chez 183 patientes à risque dont 67 ont présenté une prééclampsie. Le ratio sFlt-1/PlGF médian pour toutes les patientes évaluées est 100,3. Le ratio médian pour les patientes ayant déclaré une prééclampsie (N=67) est 212,7 alors que celui des femmes sans prééclampsie (N=116) est de 35,4. En accord avec ces analyses, un ratio sFlt-1/PlGF ≥ 38 possède une sensibilité égale à 95,5% et une spécificité égale à 73,3%. Les valeurs prédictives positive (VPP) et négative (VPN) sont, respectivement, 67,4% et 96,6%. Ces résultats suggèrent que le ratio sFlt-1/PlGF peut être une aide dans le diagnostic de la prééclampsie [less ▲]

Detailed reference viewed: 66 (6 ULiège)
See detailLa bataille de l'éclipse (28 mai 585 ACN)
Leloux, Kevin ULiege

in Actes du Dixième congrès de l'Association des Cercles francophones d'Histoire et d'Archéologie de Belgique (in press)

Detailed reference viewed: 20 (0 ULiège)
See detailPure and Impure Ancestors at Selinous: a note on Greek theology
Pirenne-Delforge, Vinciane ULiege

in Bielawski, Krzysztof (Ed.) Animal Sacrifice in Ancient Greece. Proceedings of the First International Workshop in Kraków (12-14.11.2015) (in press)

Detailed reference viewed: 30 (1 ULiège)
Full Text
Peer Reviewed
See detailBridging novelty and familiarity-based recognition memory: a matter of timing
Delhaye, Emma ULiege; Bastin, Christine ULiege; Moulin, Christopher et al

in Visual Cognition (in press)

Detailed reference viewed: 47 (8 ULiège)
Full Text
See detailCarte géologique de la Wallonie à l'échelle 1:25.000. Stavelot-Malmedy n°50/5-6. Notice explicative.
Lamberty, Pauline ULiege; Geukens, Fernand; Marion, Jean-Marc ULiege

Book published by SPW/ Editions, Cartes - Révision et 3ème édition (in press)

New geological map of Wallonia that will be published at the scale of 1/25.000, based on a new field work and using previous scientific data produced, since the first edition published in 1899 (Gustave ... [more ▼]

New geological map of Wallonia that will be published at the scale of 1/25.000, based on a new field work and using previous scientific data produced, since the first edition published in 1899 (Gustave Dewalque) at the scale of 1/40,000 by the "Commission Géologique de Belgique" and the second one, published in 1963 (Fernand Geukens) at the scale of 1/25,000 by the Geological Survey of Belgium. [less ▲]

Detailed reference viewed: 75 (16 ULiège)
Full Text
See detailLouveigné-Spa n°49/3-4. Carte géologique de la Wallonie à l'échelle du 1:25.000. Notice explicative
Marion, Jean-Marc ULiege; Geukens, Fernand; Lamberty, Pauline ULiege et al

Book published by SPW/Editions, Cartes - Révision et 3ème édition complète (in press)

Manuscript submitted for reviewing (2017/03); leaflet of the new geological map of Wallonia published at the scale of 1/25.000, based on a new field work and using previous scientific data produced since ... [more ▼]

Manuscript submitted for reviewing (2017/03); leaflet of the new geological map of Wallonia published at the scale of 1/25.000, based on a new field work and using previous scientific data produced since the previous editions, in 1898 (at the scale of 1/40.000, by Gustave Dewalque) and the second one, in 1958 (at the scale of 1/25.000 by Paul Fourmarier). [less ▲]

Detailed reference viewed: 41 (6 ULiège)
Full Text
See detailCurating Comics Canons: Daniel Clowes and Art Spiegelman’s Private Museums
Crucifix, Benoît ULiege

in Munson, Kim (Ed.) From Panels to Frames: Comics in Museums (in press)

This chapter tackles cartoonist-curated exhibitions of comics, in which cartoonists select examples from comics archives to frame their own histories of comics. Le Musée privée d’Art Spiegelman is a ... [more ▼]

This chapter tackles cartoonist-curated exhibitions of comics, in which cartoonists select examples from comics archives to frame their own histories of comics. Le Musée privée d’Art Spiegelman is a large, unique exhibition that was organized at the Musée de la bande dessinée in Angoulême, in which Spiegelman proposed his ‘vision’ of comics history, while Eye of the Cartoonist: Daniel Clowes’s Selections from Comics History was organized at the Wexner Center for the Arts in Columbus (Ohio), drawing on the collections from the Billy Ireland Cartoon Library & Museum. The analysis of exhibition design and paratexts shows how ‘their’ histories is remediated in the context of the museum, which helps framing a particular discourse on the past of comics relative to the institutional context of each exhibit. [less ▲]

Detailed reference viewed: 41 (11 ULiège)
Full Text
Peer Reviewed
See detailDe la cosmétique à la thérapeutique : le verbe στιμμίζειν dans les écrits médicaux grecs
Marganne, Marie-Hélène ULiege

in Boudon-Millot, Véronique; Labonnelie-Pardon, Muriel (Eds.) Le teint de Phrynè. Thérapeutique et cosmétique dans l'Antiquité. Paris, Maison de la Recherche, 14-15 janvier 2016 (in press)

When and in which context were the noun στίμμι (or στῖμι or στῖβι) — a word of Egyptian origin designating a black substance — and the verb στιμμίζειν (or στιμίζειν or στιβίζειν, as well as the compound ... [more ▼]

When and in which context were the noun στίμμι (or στῖμι or στῖβι) — a word of Egyptian origin designating a black substance — and the verb στιμμίζειν (or στιμίζειν or στιβίζειν, as well as the compound ὑποστιμμίζειν), which describes its application to the eye area, first appear in Greek medical texts? Which substance(s) do these words refer to? These are the questions that this paper tries to answer, by examining the therapeutic justifications of the use of stimmi by doctors. [less ▲]

Detailed reference viewed: 37 (7 ULiège)
See detailGellert, Schlegel und die "Lettres de Ninon de Lenclos". Eine Übersetzungsgeschichte
Viehöver, Vera ULiege

in Fink, Wolfgang (Ed.) Vernunft und Gefühl. Christian Fürchtegott Gellert und die Umbruchperiode der Aufklärung (1740-1770) (in press)

Detailed reference viewed: 34 (0 ULiège)
Full Text
Peer Reviewed
See detailThe impact of architectural representations on conveying design intent.
Cunin, Maxime; Yang, Maria C.; Elsen, Catherine ULiege

E-print/Working paper (in press)

Architects express themselves graphically in order to communicate ideas both to clients and to themselves. In practice, they rely on a variety of representations such as free-hand drawings, 3D computer ... [more ▼]

Architects express themselves graphically in order to communicate ideas both to clients and to themselves. In practice, they rely on a variety of representations such as free-hand drawings, 3D computer rendered images, and photomontages to convey their design intent. Research to date has demonstrated differences and commonalities in the ways in which expert designers and laymen perceive visual understanding. It is still unclear how architects themselves use different types of representations to express different intentions, and how accurately their expected audience perceives those intentions. The purpose of this research is to investigate how laymen interpret the initial design intent of an architect’s design, and what role different forms of representations play in this process of understanding a design. This paper describes a five-step process for developing a survey that was used to gather data from 686 laymen respondents. It was found that certain types of simpler representations presented in specific contexts are unexpectedly found to be a more efficient way to faithfully transmit an architectural intent. [less ▲]

Detailed reference viewed: 80 (1 ULiège)
Peer Reviewed
See detailTemporality
Cormann, Grégory ULiege

in Eshleman, Matthew; Mui, Connie; Perrin, Christophe (Eds.) Sartrean Mind (in press)

Detailed reference viewed: 31 (0 ULiège)