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See detailInteraction between dietary protein content and the source of carbohydrates along the gastrointestinal tract of weaned piglets.
Pieper, Robert; Boudry, Christelle ULg; Bindelle, Jérôme ULg et al

in Archives of Animal Nutrition (in press)

Although fermentable carbohydrates (CHO) can reduce metabolites derived from dietary protein fermentation in the intestine of pigs, the interaction between site of fermentation and substrate availability ... [more ▼]

Although fermentable carbohydrates (CHO) can reduce metabolites derived from dietary protein fermentation in the intestine of pigs, the interaction between site of fermentation and substrate availability along the gut is still unclear. The current study aimed at determining the impact of two different sources of carbohydrates in diets with low or very high protein content on microbial metabolite profiles along the gastrointestinal tract of piglets. Thirty-six piglets (n = 6 per group) were fed diets high (26%, HP) or low (18%, LP) in dietary protein and with or without two different sources of carbohydrates (12% sugar beet pulp, SBP, or 8% lignocellulose, LNC) in a 2 × 3 factorial design. After 3 weeks, contents from stomach, jejunum, ileum, caecum, proximal and distal colon were taken and analysed for major bacterial metabolites (D-lactate, L-lactate, short chain fatty acids, ammonia, amines, phenols and indols). Results indicate considerable fermentation of CHO and protein already in the stomach. HP diets increased the formation of ammonia, amines, phenolic and indolic compounds throughout the different parts of the intestine with most pronounced effects in the distal colon. Dietary SBP inclusion in LP diets favoured the formation of cadaverine in the proximal parts of the intestine. SBP mainly increased CHO-derived metabolites such as SCFA and lactate and decreased protein-derived metabolites in the large intestine. Based on metabolite profiles, LNC was partly fermented in the distal large intestine and reduced mainly phenols, indols and cadaverine, but not ammonia. Multivariate analysis confirmed more diet-specific metabolite patterns in the stomach, whereas the CHO addition was the main determinant in the caecum and proximal colon. The protein level mainly influenced the metabolite patterns in the distal colon. The results confirm the importance of CHO source to influence the formation of metabolites derived from protein fermentation along the intestinal tract of the pig. [less ▲]

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See detailAmulettes coptes « jumelles » de Strasbourg : P.Strasb. K 201 et K 202
de Haro Sanchez, Magali ULg

in Boud'hors; Delattre; Louis, Catherine (Eds.) et al Études coptes XII (in press)

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See detailL'idéologie de la Nieuw‐Vlaamse Alliantie
Jamin, Jérôme ULg

in Revue européenne de géopolitique Outre-Terre (in press)

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See detailMathématiques convoquées par le registre graphique au sein du cours de physique
Renkens, Céline; Henry, Valérie ULg

in Actes de la CIEAEM 66 (in press)

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See detailEfficacy and safety of currently marketed anti-osteoporosis medications
Reginster, Jean-Yves ULg; NEUPREZ, Audrey ULg; Dardenne, Nadia ULg et al

in Best Practice & Research. Clinical Endocrinology & Metabolism (in press)

During the past 2 decades, many interventions were proven effective in the management of postmenopausal osteoporosis. The objective of an anti-osteoporosis treatment is to reduce fracture rates, ideally ... [more ▼]

During the past 2 decades, many interventions were proven effective in the management of postmenopausal osteoporosis. The objective of an anti-osteoporosis treatment is to reduce fracture rates, ideally at all skeletal sites (i.e. spine, hip, and other non-spine). The armamentarium against osteoporosis includes anti-resorptive agents (i.e. bisphosphonates, selective estrogen receptor modulators and denosumab), bone-forming agents (i.e. peptides from the parathyroid hormone family) and one agent with a dual mechanism of action (i.e. strontium ranelate). All these medications combine anti-fracture efficacy with a reasonable benefit/risk profile. However, the choice of a particular chemical entity, in one individual patient is based on the knowledge and expertise of the physician. Prioritization of drugs should be based on the individual profile of the patient, the severity of osteoporosis and the specific contraindications, warnings and precautions of use of the various available medications. [less ▲]

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See detailEnvironnements Personnels d’Apprentissage : exploration des représentations et usages d’étudiants de l’enseignement supérieur
Denis, Brigitte ULg; Joris, Noémie ULg

in Sciences et technologies de l'information et de la communication pour l'éducation et la formation (in press)

Currently, it is difficult for a student to pursue higher education without using a digital environment. This leads to the emergence the concept of Personal Learning Environment (PLE). The authors define ... [more ▼]

Currently, it is difficult for a student to pursue higher education without using a digital environment. This leads to the emergence the concept of Personal Learning Environment (PLE). The authors define it and consider his competition or complementarity with the digitals institutional environments. They report exploratory study results on students’ representations about their numeric learning environments and their interests about them. Data comes from questionnaires and interviews. Their analysis shows different profiles related to the PLE. Linking the results to learning theories and aspects of technical and educational design, they propose further investigation and development related to the complementarity of PLE and institutional learning environments (ILE). [less ▲]

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See detailKnowledge Transfer in Regulatory Analytical Sciences through the Implementation of Communities of Practice
Jesionkowska, Joanna; Denis, Brigitte ULg; Taylor, Philip

in Proceedings of the conference (in press)

Promoting affiliation between scientists is relatively easy, but creating larger organisational structures is more difficult, due to traditions of scientific independance, difficulties of sharing implicit ... [more ▼]

Promoting affiliation between scientists is relatively easy, but creating larger organisational structures is more difficult, due to traditions of scientific independance, difficulties of sharing implicit knowledge, and formal organisational barrers. Hence there is a need to research possibilities given by Communities of practice. This paper presents a research projet (doctoral thesis) whose goal is to implement Communities of Practice (CoP) in order to sustain knowledge transfer in regulatory analytical sciences. [less ▲]

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See detailMurs, Frontières et Liberté(s) de Circulation
Gemenne, François ULg

Book published by Fayard (in press)

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See detailInfluence of COMT Genotype on Antero-Posterior Cortical Functional Connectivity Underlying Interference Resolution
Jaspar, Mathieu ULg; Manard, Marine ULg; DIDEBERG, Vinciane ULg et al

in Cerebral Cortex (in press)

Genetic variability related to the catechol-O-methyltransferase (COMT) gene (Val158Met) has received increasing attention as a possible modulator of executive functioning and its neural correlates ... [more ▼]

Genetic variability related to the catechol-O-methyltransferase (COMT) gene (Val158Met) has received increasing attention as a possible modulator of executive functioning and its neural correlates. However, this attention has generally centred on the prefrontal cortices because of the well-known direct impact of COMT enzyme on these cerebral regions. In this study, we were interested in the modulating effect of COMT genotype on anterior and posterior brain areas underlying interference resolution during a Stroop task. More specifically, we were interested in the functional connectivity between the right inferior frontal operculum (IFop), an area frequently associated with inhibitory efficiency, and posterior brain regions involved in reading/naming processes (the two main non-executive determinants of the Stroop effect). The Stroop task was administered during fMRI scanning to three groups of 15 young adults divided according to their COMT Val158Met genotype [Val/Val (VV), Val/Met (VM) and Met/Met (MM)]. Results indicate greater activity in the right IFop and the left middle temporal gyrus (MTG) in homozygous VV individuals than in Met allele carriers. In addition, the VV group exhibited stronger positive functional connectivity between these two brain regions and stronger negative connectivity between the right IFop and left lingual gyrus. These results confirm the impact of COMT genotype on frontal function. They also strongly suggest that differences in frontal activity influence posterior brain regions related to a non-executive component of the task. Especially, changes in functional connectivity between anterior and posterior brain areas might correspond to compensatory processes for performing the task efficiently when the available dopamine level is low. [less ▲]

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See detailOsteoporosis in patients taking selective serotonin reuptake inhibitors: a focus on fracture outcome
Bruyère, Olivier ULg; Reginster, Jean-Yves ULg

in Endocrine (in press)

Depression is one of the most important mental health problems and a leading cause of disability. Selective serotonin reuptake inhibitors (SSRIs) are considered as first-line therapy for the treatment of ... [more ▼]

Depression is one of the most important mental health problems and a leading cause of disability. Selective serotonin reuptake inhibitors (SSRIs) are considered as first-line therapy for the treatment of depressive symptoms among older adults because of their presumed favorable adverse effect profile. However, they could have deleterious effects on the bone. Evidence from longitudinal, crosssectional, and prospective cohort studies suggests that the use of antidepressants at therapeutic doses is associated with decreased bone mineral density and increased fracture risk. The association between SSRIs use and fracture risk could potentially differ depending on dose, exposure duration, time of exposure, age, or sex. However, the risk of fracture declined rapidly after discontinuation of use of SSRIs. The evidence now seems sufficient to consider adding SSRIs to the list of medications that contribute to osteoporosis. In practice, assessment of risk factor for osteoporosis or fractures could be made taking into account age, gender, duration, and severity of depression, length of SSRI treatments, and other concurrent risk factors. [less ▲]

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See detailTypus melancholicus et mélancolie : Synthèse théorique à partir d’un cas clinique
Englebert, Jérôme ULg; Stanghellini, Giovanni

in Encéphale (L') (in press)

Objective: The objective of this paper is to propose, starting from the description of a clinical emblematic case, a theoretical synthesis of the work of phenomenological psychopathology dedicated to ... [more ▼]

Objective: The objective of this paper is to propose, starting from the description of a clinical emblematic case, a theoretical synthesis of the work of phenomenological psychopathology dedicated to melancholia and typus melancholicus (TM), a clinical concept that describes the premorbid personality vulnerable to major depression (“melancholia” for the psychopathological tradition). Method: This is phenomenological analysis of a case study of melancolia, of its premorbid personality and pathogenic triggering situation. We adopt two main phenomenological keys to understanding the develpment of melancholia : role-identity theory and desynchronization theory. The former understands melancholia as a disorder of identity triggered by the loss of the social role with which one has previously over-identifed. The latter sees melancholia as the effect of the desynchronisation from the social environment that further develops into an inhibition of the conative–affective dynamics of life. We present the case of Jonas (64 years old), whose mother (94 years old) recently died. Before his mother’s death, Jonas’ life was entirely orchestrated by the caring for his mother and synchronized in time with this (e.g., he used to go to her house every 4 hours, took all his meals with her, etc.). Jonas, in addition to being hyper-synchronized and hyper-syntonic, fulfills all diagnostic criteria for TM, including “orderliness”, “conscientiousness”, “hyper/heteronomia” and “intolerance of ambiguity”. TM’s attach a disproportioned importance to their social roles (or external representations of identity) at the expense of their own ego-identity. Results: The passage from pre-morbid personality to melancholia is triggered by the death of Jonas’ mother that entails a profound depersonalization. Desynchronization and role loss cause Jonas fall into this severe depersonalization, whose core feature is the feeling of the loss of feeling. Conclusions: This original contribution demonstrates a clinical case can contribute to the construction and refinement of theoretical and conceptual frameworks (like princeps Tellenbach's studies). Over-synchronized tempo and over-identification with social role are emblematically in this case the two sides of the same coin. A parallelism can be established between synchronization (with the mother) and respect for the role at the expense of own identity. The clinical case of Jonas highlights a conceptual bridge between the model of melancholia as loss of social role and the model of melancholia as desynchronization. [less ▲]

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See detailDes représentations aux dénominations et des dénominations à l’histoire. Les enjeux de la glottonymie dans l’historiographie du français d’Acadie et de Louisiane
Urbain, Emilie ULg

in Arrighi, Laurence; LeBlanc, Matthieu (Eds.) La francophonie en Acadie : dynamiques sociales et langagières. Textes en hommage à Louise Péronnet (in press)

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See detailLangue, identité et autorité : pour une histoire des débats langagiers idéologiques en Louisiane
Urbain, Emilie ULg

in Carnets d’Ateliers de Sociolinguistique (in press)

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See detailL’ANATOMIE REVISITÉE DU PETIT BASSIN
Bonnet, Pierre ULg

in Louvain Medical (in press)

Le petit bassin est un espace cônique musculoosseux comportant la portion inférieure de la cavité péritonéale surmontant l’espace endopelvien. Les viscères pelviens reçoivent leur vascularisation des ... [more ▼]

Le petit bassin est un espace cônique musculoosseux comportant la portion inférieure de la cavité péritonéale surmontant l’espace endopelvien. Les viscères pelviens reçoivent leur vascularisation des parois latérales au sein de l’espace endopelvien, leur innervation dépend d’une double origine, abdominale et pelvienne. Les parois de cet espace abritent les nerfs somatiques et vaisseaux destinés aux parois de la partie inférieure du tronc et aux membres inférieurs. La connaissance pratique de cette anatomie peut être aidée par une approche constructive élaborant les parois et ensuite le contenu de cet espace. [less ▲]

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See detailA l'ombre de Sainte-Waudru. L'architecture religieuse dans la prévôté de Mons aux XVe et XVIe siècles
Joly, Emmanuel ULg

Article for general public (in press)

La pose de la première pierre de la nouvelle collégiale Sainte-Waudru le 9 mars 1450 marque le début d’un chantier qui s’étalera sur plus de deux siècles. Pendant ce temps, la ville de Mons ainsi que la ... [more ▼]

La pose de la première pierre de la nouvelle collégiale Sainte-Waudru le 9 mars 1450 marque le début d’un chantier qui s’étalera sur plus de deux siècles. Pendant ce temps, la ville de Mons ainsi que la circonscription administrative dont elle est le centre se dotent de nombreux autres édifices religieux. Ces modestes collégiales ou églises paroissiales (voire succursales) grandissent à l’ombre de Sainte-Waudru et présentent des partis constructifs souvent très différents de ceux mis en œuvre à la grande collégiale montoise. Pourtant, à l’inverse de la collégiale Sainte-Waudru , ces architectures ont rarement fait l’objet de publications scientifiques et restent dès lors fort méconnues. [less ▲]

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See detailL'église Saint-Julien d'Ath avant 1817 : essai de reconstitution d'un édifice disparu
Joly, Emmanuel ULg

Article for general public (in press)

L’état de l’église Saint-Julien avant l’incendie de 1817 est fort méconnu, bien que les parties gothiques de l’édifice fassent régulièrement l’objet de descriptions, de notices, de mentions voire ... [more ▼]

L’état de l’église Saint-Julien avant l’incendie de 1817 est fort méconnu, bien que les parties gothiques de l’édifice fassent régulièrement l’objet de descriptions, de notices, de mentions voire d’analyses dans les synthèses consacrées à l’architecture médiévale en Belgique ou en Hainaut. Or pour pouvoir procéder à des comparaisons et replacer l’église dans l’architecture de son époque, il est important d’en avoir une image fidèle. Il faut donc nous pencher sur les divers types de sources (iconographiques, textuelles et archéologiques) à notre disposition pour reconstituer l’église dans son aspect antérieur à 1817. [less ▲]

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See detailA mysterious giant ichthyosaur from the lowermost Jurassic of Wales
Martin, Jeremy E; Vincent, Peggy; Suan, Guillaume et al

in Acta Palaeontologica Polonica (in press)

Ichthyosaurs rapidly diversified and colonised a wide range of ecological niches during the Early and Middle Triassic period, but experienced a major decline in diversity near the end of the Triassic ... [more ▼]

Ichthyosaurs rapidly diversified and colonised a wide range of ecological niches during the Early and Middle Triassic period, but experienced a major decline in diversity near the end of the Triassic. Timing and causes of this demise and the subsequent rapid radiation of the diverse, but less disparate, parvipelvian ichthyosaurs are still unknown, notably because of inadequate sampling in strata of latest Triassic age. Here, we describe an exceptionally large radius from Lower Jurassic deposits at Penarth near Cardiff, South Wales (UK) the morphology of which places it within the giant Triassic shastasaurids. A tentative total body size estimate, based on a regression analysis of various complete ichthyosaur skeletons, yields a value of 12-15 m. The specimen is substantially younger than any previously reported last known occurrences of shastasaurids and implies a Lazarus range in the lowermost Jurassic for this ichthyosaur morphotype. [less ▲]

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