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Rates of consumption of atmospheric CO2 through the weathering of loess during the next 100 yr of climate change; ; François, Louis et alin Biogeosciences (2013), 10 Quantifying how C fluxes will change in the future is a complex task for models because of the coupling between climate, hydrology, and biogeochemical reactions. Here we investigate how pedogenesis of the ... [more ▼] Quantifying how C fluxes will change in the future is a complex task for models because of the coupling between climate, hydrology, and biogeochemical reactions. Here we investigate how pedogenesis of the Peoria loess, which has been weathering for the last 13 kyr, will respond over the next 100 yr of climate change. Using a cascade of numerical models for climate (ARPEGE), vegetation (CARAIB) and weathering (WITCH), we explore the effect of an increase in CO2 of 315 ppmv (1950) to 700 ppmv (2100 projection). The increasing CO2 results in an increase in temperature along the entire transect. In contrast, drainage increases slightly for a focus pedon in the south but decreases strongly in the north. These two variables largely determine the behavior of weathering. In addition, although CO2 production rate increases in the soils in response to global warming, the rate of diffusion back to the atmosphere also increases, maintaining a roughly constant or even decreasing CO2 concentration in the soil gas phase. Our simulations predict that temperature increasing in the next 100 yr causes the weathering rates of the silicates to increase into the future. In contrast, the weathering rate of dolomite – which consumes most of the CO2 – decreases in both end members (south and north) of the transect due to its retrograde solubility. We thus infer slower rates of advance of the dolomite reaction front into the subsurface, and faster rates of advance of the silicate reaction front. However, additional simulations for 9 pedons located along the north–south transect show that the dolomite weathering advance rate will increase in the central part of the Mississippi Valley, owing to a maximum in the response of vertical drainage to the ongoing climate change. The carbonate reaction front can be likened to a terrestrial lysocline because it represents a depth interval over which carbonate dissolution rates increase drastically. However, in contrast to the lower pH and shallower lysocline expected in the oceans with increasing atmospheric CO2, we predict a deeper lysocline in future soils. Furthermore, in the central Mississippi Valley, soil lysocline deepening accelerates but in the south and north the deepening rate slows. This result illustrates the complex behavior of carbonate weathering facing short term global climate change. Predicting the global response of terrestrial weathering to increased atmospheric CO2 and temperature in the future will mostly depend upon our ability to make precise assessments of which areas of the globe increase or decrease in precipitation and soil drainage. [less ▲] Detailed reference viewed: 3 (1 ULg) Dispositf pilote de Cellules bien-être en Fédération Wallonie Bruxelles. Rapport d'évaluation intermédiaire EvalCBE.1 : Mise en oeuvre du dispositif au niveau localVandoorne, Chantal ; Hubin, Noémie ![]() Report (2013) Detailed reference viewed: 12 (4 ULg) Morphometric analyses of the body and the branches of the normal third interosseous muscle (suspensory ligament) in StandardbredsShikh Al Sook, Mohamad Khir ; Antoine, Nadine ; Piret, Joëlle et alin Anatomia, Histologia, Embryologia (2013) The third interosseous muscle (suspensory ligament, TIOM) is composed of connective tissue (CT) with a variable proportion of muscle (MT) and adipose tissue (AT). The aim of our study is to quantify the ... [more ▼] The third interosseous muscle (suspensory ligament, TIOM) is composed of connective tissue (CT) with a variable proportion of muscle (MT) and adipose tissue (AT). The aim of our study is to quantify the CT, MT and AT within the body and the branches of right thoracic and pelvic limbs TIOM in sound horses to determine whether there are differences in CT, MT and AT between age, sex, limbs and levels. Right limbs from 11 sound horses were collected. Samples from 6 levels of the TIOM were embedded in paraffin or in Tissue-Tek®. Most of the paraffin sections were shredded. Using the cryosection, some artefacts appeared. Cryoprotection was carried out, which produced the best results. Hematoxylin–phloxine–saffron and Hematoxylin–eosin gave a good contrast of colours between the tissues observed allowing the use of an image analysis programme to calculate percentage of each tissue within the TIOM. The percentage of MT and AT decreased significantly (P < 0.0001), whereas the percentage of CT increased significantly (P < 0.0001) with age and when descending from the proximal to the distal level of the TIOM. The percentage of MT was significantly higher (P < 0.0001) in females than males, while the percentage of CT was significantly higher (P < 0.0001) in males than females. The percentage of AT was significantly higher (P = 0.0278) in pelvic limbs than in thoracic limbs. These results confirm the variation in tissue composition within the TIOM of sound horses. [less ▲] Detailed reference viewed: 28 (23 ULg) Erythropoietin therapy after allogeneic hematopoietic cell transplantation : a prospective randomised trial.JASPERS, Aurélie ; Baron, Frédéric ; WILLEMS, Evelyne et alin Belgian Journal of Hematology (2013, January) Based on the impairment of erythropoietin production after allogeneic hematopoietic cell transplantation (HCT), we previously reported in a phase-2 trial that recombinant human erythropoietin (rhEPO ... [more ▼] Based on the impairment of erythropoietin production after allogeneic hematopoietic cell transplantation (HCT), we previously reported in a phase-2 trial that recombinant human erythropoietin (rhEPO) therapy was very efficient when started one month after transplantation. We also demonstrated that anemia after nonmyeloabalative (NM) HCT was less sensitive to rhEPO therapy than after conventional allogeneic HCT. This prompted us to confirm these findings in a prospective randomised trial. One hundred and thirty-one patients were randomised (1:1) between no treatment (arm 1) or erythropoietin (Neorecormon) at the dose of 500 U/kg/week (arm 2). Once the target Hb (13g/dL) has been attained, the dose of rhEPO was reduced by half, while it was withheld when Hb was = 14g/dL. Cohort A included 42 patients on day 28 after myeloablative HCT, cohort B 39 patients on day 28 after NMHCT, and cohort C 50 patients on day 0 of NMHCT. Primary endpoints included proportion of complete correctors (i.e. patients reaching Hb = 13g/dL) and median time to achieve Hb correction in each arm. The proportion of complete correctors before day 126 posttransplant was 0% in group 1A vs 52.4% in group 2A, 0% in group 1B vs 69.5% in group 2B and 19.1% in group 1C vs 70.2% in group 2C. Median time to achieve Hb = 13g/dL was not reached in group 1B vs 49 days in group 2B; 363 and 59 days in groups 1A and 1B respectively and 363 and 87 days in groups 3A and 3B respectively (figure 1). Hb evolution in each group is shown in figure 2. Seventyone patients (47/62 in control groups and 24/57 in treated groups, p=0.0003) required red blood cell transfusions. The difference was most pronounced in cohort B. There was no difference in rates of thrombo-embolic events or other complications between the two arms. In conclusion, this is the first trial to demonstrate that EPO therapy hastens erythroid recovery and decreases transfusion requirements when started one month after allogeneic HCT. [less ▲] AKM coffee-growing cooperative and socio-economic development of Rwandan farmers, Huye DistrictGisaro Ca-Madeberi, Ya-Bititi ; Lebailly, Philippe ; Burny, Philippe et alConference (2013) Detailed reference viewed: 15 (5 ULg) Effects of surfactin on membrane models displaying lipid phase separation.Deleu, Magali ; ; Lins, Laurence et alin Biochimica et Biophysica Acta (2013), 1828(2), 801-815 Surfactin, a bacterial amphiphilic lipopeptide is attracting more and more attention in view of its bioactive properties which are in relation with its ability to interact with lipids of biological ... [more ▼] Surfactin, a bacterial amphiphilic lipopeptide is attracting more and more attention in view of its bioactive properties which are in relation with its ability to interact with lipids of biological membranes. In this work, we investigated the effect of surfactin on membrane structure using model of membranes, vesicles as well as supported bilayers, presenting coexistence of fluid-disordered (DOPC) and gel (DPPC) phases. A range of complementary methods was used including AFM, ellipsometry, dynamic light scattering, fluorescence measurements of Laurdan, DPH, calcein release, and octadecylrhodamine B dequenching. Our findings demonstrated that surfactin concentration is critical for its effect on the membrane. The results suggest that the presence of rigid domains can play an essential role in the first step of surfactin insertion and that surfactin interacts both with the membrane polar heads and the acyl chain region. A mechanism for the surfactin lipid membrane interaction, consisting of three sequential structural and morphological changes, is proposed. At concentrations below the CMC, surfactin inserted at the boundary between gel and fluid lipid domains, inhibited phase separation and stiffened the bilayer without global morphological change of liposomes. At concentrations close to CMC, surfactin solubilized the fluid phospholipid phase and increased order in the remainder of the lipid bilayer. At higher surfactin concentrations, both the fluid and the rigid bilayer structures were dissolved into mixed micelles and other structures presenting a wide size distribution. [less ▲] Detailed reference viewed: 12 (4 ULg) La mécanique du détail. Approches transversalesHagelstein, Maud ; Belloi, Livio ![]() Book published by Editions de l'Ecole Normale Supérieure de Lyon (2013) Parce qu’elle a trait aux relations nouées entre les parties et l’ensemble qui les comprend, la question du détail s’investit d’enjeux considérables pour toute tentative de réflexion interdisciplinaire ... [more ▼] Parce qu’elle a trait aux relations nouées entre les parties et l’ensemble qui les comprend, la question du détail s’investit d’enjeux considérables pour toute tentative de réflexion interdisciplinaire. En effet, dans les disciplines qui s’attachent à rendre un objet visible ou lisible, les théoriciens rencontrent à l’endroit du détail des problèmes voisins, sinon analogues, que nous voudrions ici aborder de front, dans une perspective forcément « rapprochée » et plus que jamais attentive à des objets singuliers, que ceux-ci relèvent de la littérature, du cinéma, de la photographie, de la bande dessinée, de la peinture, de la philosophie, etc. À confronter nos méthodes et les présupposés sur lesquels elles reposent, il nous a semblé possible de cerner plus finement le mode de fonctionnement propre au détail. Certes, chacun fera part ici de ses étonnements particuliers ; de même, chacun sera amené à faire rapport des découvertes enthousiasmantes ou perturbantes qui, dans son domaine spécifique, auront innervé le travail de réflexion. Pourtant, il aurait été inutile de vouloir dresser une simple liste de détails, recueillis au sein d’une compilation bariolée et forcément non exhaustive. Adoptant une perspective plus large, le présent ouvrage vise à une compréhension approfondie de la mécanique du détail (extrait de l'Avant-propos, L. Belloï & M. Hagelstein). [less ▲] Detailed reference viewed: 27 (2 ULg) Metabolic Changes in the Spinal Cord After Brachial Plexus Root Re-implantation; ; et al in Neurorehabilitation & Neural Repair (2013), 27(2), 118-124 Detailed reference viewed: 13 (0 ULg) Integrating Experimental and Computational Fluid Dynamics approaches using Proper Orthogonal Decomposition TechniquesAndrianne, Thomas ; ; Guissart, Amandine et alin Progress in Aerospace Sciences (2013) The concept of Proper Orthogonal Decomposition (POD) is used to integrate Experimental Fluid Dynamics (EFD) and Computational Fluid Dynamics (CFD) approaches. The key idea is to take advantage of the ... [more ▼] The concept of Proper Orthogonal Decomposition (POD) is used to integrate Experimental Fluid Dynamics (EFD) and Computational Fluid Dynamics (CFD) approaches. The key idea is to take advantage of the optimality of the POD technique and its capability to extract the most energetic patterns of complex aerodynamic flow fields. First, the concept of Modal Assurance Criterion (MAC) is used to obtain a simple quantitative criterion to compare EFD measurements to CFD results. The comparison is based on the POD modes, extracted from each set of data. The analysis of the energy content of the modes allows to draw important conclusions about the role of the latter. The method is applied in the study of the flow field around a rectangular cylinder, which is either static or oscillating in a low-speed flow field. The second EFD/CFD integration technique deals with the reconstruction of a flow field from measured data, making use of CFD simulation results. The POD modes are first extracted from several CFD data sets, using a snapshot POD approach. Then the entire flow field of measured data can be reconstructed using a gappy POD method. The technique is applied to the transonic flow around a civil aircraft type wind tunnel model. The EFD measurements consist in pressure coefficient data from pressure ports or pressure-sensitive paint. It is shown that the complete flow field can be reconstructed from the pressure data with satisfactory accuracy and at relatively low computational cost. The work demonstrates the potential of the POD technique to integrate EFD and CFD data, leading to a combined, validated and complete analysis of the flow under consideration. [less ▲] Detailed reference viewed: 25 (8 ULg) Comprehensive clinical and molecular analysis of 12 families with type 1 recessive cutis laxa.; ; et al in Human Mutation (2013), 34(1), 111-21 Autosomal recessive cutis laxa type I (ARCL type I) is characterized by generalized cutis laxa with pulmonary emphysema and/or vascular complications. Rarely, mutations can be identified in FBLN4 or FBLN5 ... [more ▼] Autosomal recessive cutis laxa type I (ARCL type I) is characterized by generalized cutis laxa with pulmonary emphysema and/or vascular complications. Rarely, mutations can be identified in FBLN4 or FBLN5. Recently, LTBP4 mutations have been implicated in a similar phenotype. Studying FBLN4, FBLN5, and LTBP4 in 12 families with ARCL type I, we found bi-allelic FBLN5 mutations in two probands, whereas nine probands harbored biallelic mutations in LTBP4. FBLN5 and LTBP4 mutations cause a very similar phenotype associated with severe pulmonary emphysema, in the absence of vascular tortuosity or aneurysms. Gastrointestinal and genitourinary tract involvement seems to be more severe in patients with LTBP4 mutations. Functional studies showed that most premature termination mutations in LTBP4 result in severely reduced mRNA and protein levels. This correlated with increased transforming growth factor-beta (TGFbeta) activity. However, one mutation, c.4127dupC, escaped nonsense-mediated decay. The corresponding mutant protein (p.Arg1377Alafs(*) 27) showed reduced colocalization with fibronectin, leading to an abnormal morphology of microfibrils in fibroblast cultures, while retaining normal TGFbeta activity. We conclude that LTBP4 mutations cause disease through both loss of function and gain of function mechanisms. [less ▲] Detailed reference viewed: 1 (1 ULg) Microsatellite Amplification in Plants: Optimization Procedure of Major PCR Components; Hasnaoui, Nejib ![]() in Kantartzi, Stella (Ed.) Methods in Molecular Biology™ series: Microsatllites (2013) Detailed reference viewed: 14 (2 ULg) A micro–macro approach of permeability evolution in rocks excavation damaged zonesLevasseur, Séverine ; Collin, Frédéric ; Charlier, Robert et alin Computers & Geotechnics (2013), 49 Excavation damaged zone, with significant irreversible deformations and nonnegligible changes in flow and transport properties generally occurs in indurated clay around underground structures. The stress ... [more ▼] Excavation damaged zone, with significant irreversible deformations and nonnegligible changes in flow and transport properties generally occurs in indurated clay around underground structures. The stress perturbation around the excavation could lead to a significant increase of the permeability physically due to diffuse and/or localized microcracks growth in the material. In the present study, we investigate microcracks-induced damage processes together with the subsequent modification in permeability. The proposed approach is based on a homogenization-based upper bound extended to the context of micro-cracked media in presence of initial stress. Application of this approach is done on a borehole excavation problem related to the Selfrac in situ experiments on Opalinus Clay. Although, the model fails to quan-titatively account for the in situ permeability change (which may also originated from existing macro-fractures), its prediction shows a significant evolution of the material permeability around the borehole. This is in qualitative agreement with available data. [less ▲] Detailed reference viewed: 10 (2 ULg) The country of residence and migrant transnationalism: how do opportunity structures in countries of residence affect transnational attitudes and behavior of migrant organizations from the African Great Lakes region; Perrin, Nathalie ; in Halm, Dirk; Sezgin, Zeynep (Eds.) Migration and Organized Civil Society: Rethinking national policy (2013) Detailed reference viewed: 7 (1 ULg) Mapping Magnetic Near-Field Distributions of Plasmonic Nanoantennas; ; Silhanek, Alejandro et alin ACS Nano (2013) We present direct experimental mapping of the lateral magnetic near-field distribution in plasmonic nanoantennas using aperture scanning nearfield optical microscopy (SNOM). By means of full-field ... [more ▼] We present direct experimental mapping of the lateral magnetic near-field distribution in plasmonic nanoantennas using aperture scanning nearfield optical microscopy (SNOM). By means of full-field simulations it is demonstrated how the coupling of the hollow-pyramid aperture probe to the nanoantenna induces an effective magnetic dipole which efficiently excites surface plasmon resonances only at lateral magnetic field maxima. This excitation in turn affects the detected light intensity enabling the visualization of the lateral magnetic near-field distribution of multiple odd and even order plasmon modes with subwavelength spatial resolution. [less ▲] Detailed reference viewed: 18 (2 ULg) The relevance of food composition data for nutrition surveys in rural Tibet: pilot study in the context of Kashin-Beck DiseaseDERMIENCE, Michael ; ; Barthelemy, Jean-Paul et alin Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2013), 17(1), 32-42 Kashin-Beck disease (KBD) is an endemic and chronic osteochondropathy. This disease principally occurs in the Tibet Autonomous Region and in several provinces of the People’s Republic of China. The ... [more ▼] Kashin-Beck disease (KBD) is an endemic and chronic osteochondropathy. This disease principally occurs in the Tibet Autonomous Region and in several provinces of the People’s Republic of China. The etiology of the disease remains obscure although environmental factors are assumed to be involved. Diet, in particular, differentiates the rural community, affected by KBD, from the other communities (nomads and city-dwellers), who remain unaffected. In anticipation of a nutrition survey, this study aimed to measure the mineral content (Ca, P, Mg, Fe, Zn, Mn, Cu, Ni, Se, Al, Sr, Mo, Cd, As, Pb, Hg, Cr, and Co) of eight Tibetan staple foods and to compare the results against two food composition tables (FCTs). Foods were sampled in twenty households selected from both an endemic and a non-endemic area of rural Tibet. Ten minerals involved in bone metabolism were measured using atomic and molecular spectrometric methods. Results revealed that a very limited number of food/constituent pairs showed a variation in mineral composition during a single year of testing for a given region. In addition, results showed significant differences in mineral content between the endemic and the non-endemic area, especially for wheat flour. Following our analysis of the mineral content of the Tibetan food samples, results were statistically compared with similar foods listed in two food composition tables: the USDA National Nutrient Database (USDA Food Search for Windows, Version 1.0, database version SR23), and the China Food Composition Table (book 1, 2nd edition). More than 50 to 60% of p-values < 0.05 were highlighted, suggesting the inappropriateness of using FCTs as a reference for nutrition surveys in rural Tibet, and emphasizing the need for analysis of traditional foods. Differences were found to be more or less marked depending on the element considered, and calcium content seemed to show the greatest difference. Although it is obviously too early for definite conclusions to be reached (insufficient number of samples by food and insufficient number of foods analyzed), it seems that the present pilot-study indicates significant discrepancies between measured and tabulated values of the mineral content of certain foods. A more complete survey would therefore seem mandatory. [less ▲] Detailed reference viewed: 16 (3 ULg) Identification and structure elucidation of four cannabimimetic compounds in seized productsDenooz, Raphaël ; VAN HEUGEN, Jean-Claude ; Frederich, Michel et alin Journal of Analytical Toxicology (2013) Since 2008, herbal mixtures with synthetic cannabinoid compounds have been sold as incense throughout the world. Although these new drugs are labeled as not for human consumption, these products are ... [more ▼] Since 2008, herbal mixtures with synthetic cannabinoid compounds have been sold as incense throughout the world. Although these new drugs are labeled as not for human consumption, these products are smoked for their cannabis-like effects. This study reports the structural and spectral elucidation of four cannabimimetic compounds seized in Belgium: (4-methoxyphenyl)-1-(pentyl-1H-indol-3-yl)methanone (RCS-4), 1-(5-fluoropentyl)-3-(1-naphtoyl)indole (AM-2201), 2-(2-chlorophenyl)-1-(1-pentylindol-3-yl)ethanone (JWH-203) and 4-ethylnaphthalen-1-yl-(1-pentylindol-3-yl)methanone (JWH-210). Laboratory investigations were conducted by liquid chromatography (LC)–ultraviolet spectroscopy, high-resolution accurate mass detection and nuclear magnetic resonance (NMR) analysis. This combined analytical approach allowed the detection of illicit compounds for which reference materials were not available. To facilitate identification and to complete existing databases, ultraviolet spectra and NMR data of all seized products are presented. Additionally, LC–quadrupole time-of-flight data were recorded to provide absolute identification. [less ▲] Detailed reference viewed: 32 (15 ULg) GFR Estimation Using Standardized Cystatin C in Kidney Transplant Recipients; ; et al in American Journal of Kidney Diseases (2013), 61(2), 279-284 Background: The utility of serum cystatin C (SCysC) as a filtration marker in kidney transplantation is uncertain. We took advantage of the recent validation of a reference calibrator for SCysC and of ... [more ▼] Background: The utility of serum cystatin C (SCysC) as a filtration marker in kidney transplantation is uncertain. We took advantage of the recent validation of a reference calibrator for SCysC and of newly developed CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) equations (2012) expressed for use with standardized SCysC level to reassess the performance of SCysC as a filtration marker in kidney transplant recipients. Study Design: Study of diagnostic test accuracy. Setting & Participants: 670 kidney transplant recipients from 3 centers undergoing glomerular filtration rate (GFR) measurements from December 2006 to November 2012. Index Test: Estimated GFR (eGFR) using the 2012 SCysC-based and serum creatinine (SCr)/SCysCbased CKD-EPI equations (eGFRcys and eGFRcr-cys, respectively) and the 2009 SCr-based CKD-EPI equation (eGFRcr), with SCysC and SCr measured at a single laboratory between April 2011 and June 2011. Reference Test: Measured GFR (mGFR) using urinary clearance of inulin. Results: Bias (the difference between mGFR and eGFR) was significantly smaller for eGFRcys and eGFRcr-cys versus eGFRcr ( 2.82 and 0.54 vs 4.4 mL/min/1.73 m2, respectively; P 0.001). Precision (standard deviation of the mean bias) also was better for eGFRcys and eGFRcr-cys versus eGFRcr (12 and 11 vs 13 mL/min/1.73 m2 [P 0.001 for both comparisons]). Accuracy (percentage of GFR estimates within 30% of mGFR) was greater for eGFRcys and eGFRcr-cys versus eGFRcr (81% and 86% vs 75%, respectively [P 0.004 and P 0.001]). Net reclassification index with respect to mGFR of 30 mL/min/1.73 m2 for eGFRcr-cys and eGFRcys versus eGFRcr was 18.8% [95% CI, 8.6%-28.9%] and 22.5% [95% CI, 10.2%-34.9%]. Limitations: Patients were exclusively of European descent; association with transplant outcome was not evaluated. Conclusions: Our data validate the use of both the newly developed SCysC-based and SCr/SCysC-based CKD-EPI equations (2012) in kidney transplant recipients. Both equations perform better than the SCr-based CKD-EPI equation (2009). [less ▲] Detailed reference viewed: 14 (7 ULg) Etude clinique d’une dyade, régressant en fonctionnement borderline au niveau contextuel, individuel et familial, caractérisée par un passage à l’acte abusif d’ordre sexuelAubinet, Suzanne ; D'Amore, Salvatore ; in Thérapie Familiale (2013), 2 This research is based on Luigi Cancrini’s theory of regression in borderline functioning which provides a structured and nuanced reflection on sexual abuse. It offers the possibility of establishing a ... [more ▼] This research is based on Luigi Cancrini’s theory of regression in borderline functioning which provides a structured and nuanced reflection on sexual abuse. It offers the possibility of establishing a framework for observation and analysis of both synchronic and diachronic blendings; the behavioral characteristics proposed by the victims, perpetrators and their families; and the historical sense that can give them. It leads to the identification of the central link connecting the actors and their life contexts. We analyze a clinical situation with sexual abuse. The chosen dyad, composed by a 7 year-old-girl and a 13 ½ year-old-boy, was observed in vivo during hospitalization. Relevant behavioral, relational and historical components were compiled in an analytic scale based on Cancrini (2009) and Barudy (1997) writings. Similar psychopathological functioning among perpetrators, victims and families could thus be seen within this framework. The comparison of the systems reported similar family dynamics within the different subsystems. For these children, this results in the emergence of a specific behavioral repertory, typical of a borderline functioning, characterizing both the perpetrator and the aggressed: both are embedded in rigid supporting dyadic relational patterns and intense cleaved positions, which are also found within the various systems and the individuals within them. [less ▲] Detailed reference viewed: 19 (2 ULg) Stimulation of the sphenopalatine ganglion (SPG) for cluster headache treatment. Pathway CH-1: A randomized, sham-controlled study.Schoenen, Jean ; ; et alin Cephalalgia : An International Journal of Headache (2013) BackgroundThe pain and autonomic symptoms of cluster headache (CH) result from activation of the trigeminal parasympathetic reflex, mediated through the sphenopalatine ganglion (SPG). We investigated the ... [more ▼] BackgroundThe pain and autonomic symptoms of cluster headache (CH) result from activation of the trigeminal parasympathetic reflex, mediated through the sphenopalatine ganglion (SPG). We investigated the safety and efficacy of on-demand SPG stimulation for chronic CH (CCH).MethodsA multicenter, multiple CH attack study of an implantable on-demand SPG neurostimulator was conducted in patients suffering from refractory CCH. Each CH attack was randomly treated with full, sub-perception, or sham stimulation. Pain relief at 15 minutes following SPG stimulation and device- or procedure-related serious adverse events (SAEs) were evaluated.FindingsThirty-two patients were enrolled and 28 completed the randomized experimental period. Pain relief was achieved in 67.1% of full stimulation-treated attacks compared to 7.4% of sham-treated and 7.3% of sub-perception-treated attacks (p < 0.0001). Nineteen of 28 (68%) patients experienced a clinically significant improvement: seven (25%) achieved pain relief in >/=50% of treated attacks, 10 (36%), a >/=50% reduction in attack frequency, and two (7%), both. Five SAEs occurred and most patients (81%) experienced transient, mild/moderate loss of sensation within distinct maxillary nerve regions; 65% of events resolved within three months.InterpretationOn-demand SPG stimulation using the ATI Neurostimulation System is an effective novel therapy for CCH sufferers, with dual beneficial effects, acute pain relief and observed attack prevention, and has an acceptable safety profile compared to similar surgical procedures. [less ▲] Detailed reference viewed: 10 (0 ULg) Successful Asteroseismology for a Better Characterization of the Exoplanet HAT-P-7b; ; et al in Astrophysics and Space Science Proceedings (2013), 31 It is well known that asteroseismology is the unique technique permitting the study of the internal structure of pulsating stars using their pulsational frequencies, which is per se very important. It ... [more ▼] It is well known that asteroseismology is the unique technique permitting the study of the internal structure of pulsating stars using their pulsational frequencies, which is per se very important. It acquires an additional value when the star turns out to be a planet host. In this case, the asteroseismic study output may be a very important input for the study of the planetary system. With this in mind, we use the large time-span of the Kepler public data obtained for the star system HAT-P-7, first to perform an asteroseismic study of the pulsating star using Time-Dependent-Convection (TDC) models. Secondly, we make a revision of the planet properties in the light of the asteroseismic study. [less ▲] Detailed reference viewed: 3 (1 ULg) |
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