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See detailOn the nature of cosmological time
Hauret, Clémentine ULg

Conference (2015, May 11)

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See detailLa problématique des conditionnalités dans les relations de coopération sino-congolaises et euro-congolaises
Baenda Fimbo, Zacharie ULg

Scientific conference (2015, May 11)

Les exigences politiques et économiques qui accompagnent les interventions chinoises et européennes ne cessent de faire l'objet de controverses. Cependant, les conditionnalités européennes plus politiques ... [more ▼]

Les exigences politiques et économiques qui accompagnent les interventions chinoises et européennes ne cessent de faire l'objet de controverses. Cependant, les conditionnalités européennes plus politiques visant le développement des pays partenaires à travers des reformes politiques et institutionnelles sont perçues comme une immixtion dans les affaires intérieures nationales. Alors que les préalables chinois plus économiques visent le développement des pays partenaires par le commerce et les infrastructures. Elles se trouvent aux antipodes de la politique de coopération élaborée par les bailleurs de fond européens. La Chine apparait comme un partenaire attractif et une nouvelle source de financement. Non exemptée des critiques et de zones d'ombre, la coopération chinoise s’intéresse aux infrastructures dont la RDC a besoin pour l'émergence de son économie afin de favoriser ses exportations minières dont la Chine a besoin. [less ▲]

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See detailEtude de la matière sombre par effet de mirage gravitationnel
Biernaux, Judith ULg

Scientific conference (2015, May 11)

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See detailAntimicrobial, antitumor and brine shrimp lethality assay of Ranunculus arvensis L. extracts
Muhammad Zeeshan Bhatti; Ali, Amjad ULg; Asma Saeed et al

in Pakistan Journal of Pharmaceutical Sciences (2015)

To investigate the antitumor activity, brine shrimp lethality assay, antibacterial and antifungal activity of Methanol Extract (ME), Water Extract (WE), Acetone Extract (AE), Chloroform Extract (CE ... [more ▼]

To investigate the antitumor activity, brine shrimp lethality assay, antibacterial and antifungal activity of Methanol Extract (ME), Water Extract (WE), Acetone Extract (AE), Chloroform Extract (CE), Methanol-Water Extract (MWE), Methanol-Acetone Extract (MAE), Methanol-Chloroform Extract (MCE) of Ranunculus arvensis (L.). Antitumor activity was evaluated with Agrobacterium tumefaciens (At10) induced potato disc assay. Cytotoxicity was evaluated with brine shrimp lethality assay. Antibacterial activity was evaluated with six bacterial strains including Escherichia coli, Enterobacter aerogenes, Bordetella bronchiseptica, Klebsiella pneumoniae, Micrococcus luteus and Streptococcus anginosus and antifungal screening was done against five fungal strains including Aspergillus niger, A. flavus, A. fumigates, Fusarium solani and Mucor species by using disc diffusion method. Best antitumor activity was obtained with ME and WE, having highest IC50 values 20.27±1.62 and 93.01±1.33μg/disc. Brine shrimp lethality assay showed LC50 values of AE, MAE and ME were obtained as 384.66±9.42μg/ml, 724.11±8.01μg/ml and 978.7±8.01μg/ml respectively. WE of R. arvensis revealed weak antimicrobial result against the tested microorganisms. On the other hand, the antifungal activity of the plant extracts was found to be insignificant. These findings demonstrate that extracts of R. arvensis possesses significant antitumor activity. Further extensive study is necessary to assess the therapeutic potential of the plant [less ▲]

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See detailLipin-1 regulates cancer cell phenotype and is a potential target to potentiate rapamycin treatment
Brohée, Laura ULg; Demine, Stéphane; Willems, Jérôme ULg et al

in Oncotarget (2015), 6(13), 11264-11280

Lipogenesis inhibition was reported to induce apoptosis and repress proliferation of cancer cells while barely affecting normal cells. Lipins exhibit dual function as enzymes catalyzing the ... [more ▼]

Lipogenesis inhibition was reported to induce apoptosis and repress proliferation of cancer cells while barely affecting normal cells. Lipins exhibit dual function as enzymes catalyzing the dephosphorylation of phosphatidic acid to diacylglycerol and as co-transcriptional regulators. Thus, they are able to regulate lipid homeostasis at several nodal points. Here, we show that lipin-1 is up-regulated in several cancer cell lines and overexpressed in 50 % of high grade prostate cancers. The proliferation of prostate and breast cancer cells, but not of non-tumorigenic cells, was repressed upon lipin-1 knock-down. Lipin-1 depletion also decreased cancer cell migration through RhoA activation. Lipin-1 silencing did not significantly affect global lipid synthesis but enhanced the cellular concentration of phosphatidic acid. In parallel, autophagy was induced while AKT and ribosomal protein S6 phosphorylation were repressed. We also observed a compensatory regulation between lipin-1 and lipin-2 and demonstrated that their co-silencing aggravates the phenotype induced by lipin-1 silencing alone. Most interestingly, lipin-1 depletion or lipins inhibition with propranolol sensitized cancer cells to rapamycin. These data indicate that lipin-1 controls main cellular processes involved in cancer progression and that its targeting, alone or in combination with other treatments, could open new avenues in anticancer therapy. [less ▲]

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See detailFoamability and Foam Stability of Male and Female Date Palm Sap (Phoenix dactylifera L.) During the Collection Period
Makhlouf-gafsi, Ines; Mokni-ghribi, Abir; Bchir, Brahim et al

in Food Biophysics (2015)

This work aimed to study the influence of date palm sex on the surface properties of date palm sap (DPS) (Phoenix dactylifera L.) during the collection period. The behavior at the interface and foaming ... [more ▼]

This work aimed to study the influence of date palm sex on the surface properties of date palm sap (DPS) (Phoenix dactylifera L.) during the collection period. The behavior at the interface and foaming properties were evaluated via equilibrium surface tension (drop volume) and bubbling method, respectively. Unlike male sap, the female sap was unable to produce foam due to its low rate of adsorption, low average hydrophobicity values, and low bulk viscosity values throughout the collection period. For male sap, there are significant differences (p<0.05) on foaming properties throughout the collection period. In fact, the last 3 weeks of sap collection were characterized by a decrease pace of surface tension which explains the enhancement of both foam capacity and stability. The last week of collection period present the best foam power (0.9). To explain these differences, the interactions of several factors and their affects on foaming properties were examined. Results showed a positive correlation between foam capacity and average hydrophobicity values. In the other hand, foam stability exhibits a positive correlation with the increase of protein concentration and bulk viscosity. [less ▲]

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See detailTiO2 templated films used as photoelectrode for solid-state DSSC applications: Study of the solid electrolyte infiltration by Rutherford Backscattering Spectrometry
Dewalque, Jennifer ULg; Colson, Pierre ULg; Mathis, François et al

Poster (2015, May 10)

Liquid-state dye-sensitized solar cells can suffer from electrolyte evaporation and leakage. Therefore solid-state hole transporting materials are investigated as alternative electrolyte materials ... [more ▼]

Liquid-state dye-sensitized solar cells can suffer from electrolyte evaporation and leakage. Therefore solid-state hole transporting materials are investigated as alternative electrolyte materials. However, in solid-state dye-sensitized solar cells, optimal TiO2 films thickness is limited to a few microns allowing the adsorption of only a low quantity of photoactive dye and thus leading to poor light harvesting and low conversion efficiency. In order to overcome this limitation, high surface area templated films are investigated as alternative to nanocrystalline films prepared by doctor-blade or screen-printing. Moreover, templating is expected to improve the pore accessibility what would promote the solid electrolyte penetration inside the porous network, making possible efficient charge transfers. In this study, films prepared from different structuring agents are discussed in terms of microstructural properties (porosity, crystallinity) as well as effect on the dye loading and Spiro-OMeTAD (2,2',7,7'-tetrakis-(N,N-di-p-methoxyphenylamine)9,9'-spirobifluorene) solid electrolyte filling. Different techniques such as transmission electron microscopy (TEM), atmospheric poroellipsometry (AEP) and UV-visible absorption spectroscopy (UV-vis.) have been used to describe the microstructural features of the films. Besides, we have implemented Rutherford backscattering spectrometry (RBS) as an innovative non-destructive tool to characterize the hole transporting materials infiltration. Templated films show dye loading more than two times higher than nanocrystalline films prepared by doctor-blade or screen-printing and solid electrolyte infiltration up to 88%. [less ▲]

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See detailPrevention of Synovial Membrane Inflammation & Cartilage Degradation by a Novel Chitosan
Henrotin, Yves ULg; Oprenyeszk, Frédéric ULg; Dubuc, Jean-Emile et al

Conference (2015, May 10)

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See detailMéthodes et innovations pédagogiques en enseignement supérieur
Hanzen, Christian ULg

Learning material (2015)

Cette présentation Power point a été réalisée dans le cadre d'un cycle de conférences données à la faculté de Médecine Vétérinaire de Constantine les 9 et 10 mai 2015. Elle aborde trois aspects ... [more ▼]

Cette présentation Power point a été réalisée dans le cadre d'un cycle de conférences données à la faculté de Médecine Vétérinaire de Constantine les 9 et 10 mai 2015. Elle aborde trois aspects complémentaires à savoir les étudiants, les méthodes et les évaluations. [less ▲]

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See detail"Drôleries". L'iconographie marginale des portails occidentaux et de la nef de la cathédrale de Strasbourg
Van den Bossche, Benoît ULg

Conference (2015, May 09)

Le vaste ensemble sculpté constitué par les trois portails occidentaux de la cathédrale de Strasbourg a fait l’objet, ces dernières années, de plusieurs études. Une critique d’authenticité a été menée ... [more ▼]

Le vaste ensemble sculpté constitué par les trois portails occidentaux de la cathédrale de Strasbourg a fait l’objet, ces dernières années, de plusieurs études. Une critique d’authenticité a été menée ; les choix iconographiques qui ont présidé à l’élaboration du programme ont été déterminés et justifiés. Toutes ces études ont pourtant laissé de côté une centaine de reliefs finement sculptés qui agrémentent les parties hautes du niveau des portails, à l’extérieur comme à l’intérieur de la façade. Cette iconographie, authentique pour l’essentiel, se distingue par une grande variété de « sujets ». A priori, elle rappelle celle des « drôleries » des manuscrits de la fin du XIIIe siècle et du XIVe. Mais est-ce le cas ? Et si c’est le cas, comment articuler ces sujets qui ont jusqu’à aujourd’hui été considérés comme marginaux, avec l’iconographie des ébrasements, des tympans et des voussures ? Enfin, l’ensemble de « drôleries » de la cathédrale de Strasbourg peut-il, d’un point de vue iconographique, être comparé à d’autres ensembles sculptés français et germaniques de la fin du XIIIe siècle et du XIVe ? [less ▲]

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See detailPartial volume effect impact on PET preclinical dosimetry: a simulation study
Seret, Alain ULg; Bahri, Mohamed Ali ULg; Bretin, Florian et al

Conference (2015, May 09)

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See detailRADIOPHARMACY GMP QC HPLC VALIDATION
Aerts, Joël ULg; Giacomelli, Fabrice ULg; Hubert, Philippe ULg et al

Conference (2015, May 09)

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See detailEt si nos déchets devenaient de nouveaux produits: notion d'économie circulaire
Richel, Aurore ULg

Conference given outside the academic context (2015)

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See detailAnalytical strategies for ultra-trace measurement of dioxins and related compounds in biological matrices
L'Homme, Benjamin ULg

Doctoral thesis (2015)

The human exposure to persistent organic pollutants (POPs) is a concern since these compounds are ubiquitous in the environment. This class of compounds group different families such as the ... [more ▼]

The human exposure to persistent organic pollutants (POPs) is a concern since these compounds are ubiquitous in the environment. This class of compounds group different families such as the polychlorodibenzo-p-dioxins (PCDDs), the polychlorodibenzofurans (PCDFs), the polychlorinated biphenyls (PCBs), the organochlorine pesticides (OCPs), and the halogenated flame-retardants (HFRs). Their use, their release in the environment, their presence in foodstuffs, as well as in various goods on the market are mostly regulated through international conventions, like the Stockholm convention on POPs, and at the European and national levels. Despite the proactive approach in order to reduce the overall exposure to POPs, levels of contaminants (even banned) are still found in the environment and in the human body. In this thesis, we developed several methods of analysis of POPs in different samples. The first was a confirmatory method for PCDD/Fs and PCBs analysis in food and feed following a new European Regulation No 709/2014 that recently allowed the use of gas chromatography (GC) coupled to triple quadrupole mass spectrometry (GC-QQQMS/MS) for this purpose. We fully validated the method on vegetable oil matrix around the maximum level of 1.50 ng WHO2005TEQ/kg. We showed that all analytical criteria, specific to this instrumentation, laid down by the Regulation were met, which indicates that the QQQMS/MS can successfully be used in the legal context for confirmatory purposes and could be an alternative to high-resolution sector field mass spectrometry (HRMS) in this context. The proper establishment of limits of quantitation was a key point in the discussion along with other analytical criteria proposed in the European Regulation, as new interpretations were necessary for the use of triple quadrupole mass spectrometry due to its different features from the HRMS. In addition, we developed in parallel a method for the analysis of Dechloranes in food. The measurement of ultra-trace levels of compounds from this emerging class of flame-retardants was possible after optimization of the injections parameters by means of experimental design, and of fragmentation pathways. Eventually, we reported relatively low levels in various food matrices and preliminary data about the significance of this route of exposure for humans. Besides food analysis, we developed a screening method to quickly assess levels of contaminants in human blood, involving a minimally invasive sampling technique and a couple of drops of blood. The instrumentation was first based on cryogenic zone compression (CZC) hyphenated to high-resolution time of flight mass spectrometry (HRTOFMS) applied to the analysis of two markers of exposure in regular dried-blood spots (DBS) typically used for newborn sampling. The second approach was based on GC-QQQMS/MS applied to the analysis of a broader range of OCPs and NDL-PCBs (30 analytes) in 40 µL blood. The blood was however collected using a novel Volumetric Absorptive MicroSampling (VAMS) method, directly inspired by the DBS but offering a control on the volume of blood sampled, hence opening the door to quantitation. The sample preparation of the VAMS dried sample was miniaturized and only 2 mL of solvents were necessary to prepare a sample, which makes it environmentally friendly. The focus was especially drawn to maximize the sensitivity via the optimization of the ionization energy and the electron multiplier voltage in order to reach appropriate low limits of quantitation. In this context of ultra-low volume of blood, background levels arose as the limitation of the method owing to the small signals coming from samples and closing the gap with blanks. Nevertheless, this patient-friendly approach is perfectly suitable for fast screening of population and could be useful in the context of UNEP campaigns where samples are hardly collected. [less ▲]

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See detailTraduction et représentation politique : quelques éléments pour une genèse de leur rapport et de leur pertinence comme outils d’analyse politique
Smette, Bernard ULg

Conference (2015, May 08)

J’interrogerai la problématique du rapport de la traduction à la politique à partir de la notion de représentation politique, telle que thématisée par le théoricien argentin de l’analyse de discours ... [more ▼]

J’interrogerai la problématique du rapport de la traduction à la politique à partir de la notion de représentation politique, telle que thématisée par le théoricien argentin de l’analyse de discours, Ernesto LACLAU. Je commencerai très brièvement par resituer le processus de représentation dans le champ politique actuel. Cette re-contextualisation permettra de montrer que les notions de « représentation » et de « politique » entretiennent un rapport privilégié, mais qui ne se limite pas uniquement à sa forme contemporaine la plus répandue, symbolisée par nos institutions et principes politiques, tels le régime parlementaire ou encore l’élection. Je passerai alors au cœur de ma communication en dessinant la proximité conceptuelle et fonctionnelle de la traduction et de la représentation. Je me baserai, pour ce faire, sur les développements qu’Ernsto LACLAU a proposés de cette dernière, ainsi que sur quelques développements de Jean-René LADMIRAL et Willard Van Orman QUINE au sujet de la traduction. Je montrerai notamment (1) en quoi la conception de la représentation que propose LACLAU est un outil d’analyse pertinent de la politique, mais surtout (2) en quoi cette conception de la représentation est guidée par des processus traductifs. Je tenterai enfin, en guise de conclusion, de montrer en quoi l’on peut dégager de ce qui précède une perspective d’analyse supplémentaire, voire innovante, de l’articulation entre traduction, représentation et politique. [less ▲]

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