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See detailWell-defined polyvinylamine-based copolymers: synthesis by organometallic-mediated radical polymerization and use in gene transfection
Debuigne, Antoine ULiege; Dréan, Mathilde; Detrembleur, Christophe ULiege et al

Conference (2017, August 22)

Polyvinylamine (PVAm) presents valuable properties like affinity for many supports, pH responsiveness, metal binding capacity, polyelectrolytes complexation, and is used in various applications including ... [more ▼]

Polyvinylamine (PVAm) presents valuable properties like affinity for many supports, pH responsiveness, metal binding capacity, polyelectrolytes complexation, and is used in various applications including coatings, water purification or gas membrane separation. PVAm is commonly prepared by free radical polymerization of N-vinyl monomers followed by deprotection and release of the masked amino functions. However, examples of controlled synthesis of polyvinylamine-based copolymers are scarce because of the high reactivity of the propagating radicals deriving from non-conjugated N-vinyl monomers due to the lack of resonance stabilization. The present communication aims at reporting an efficient platform for producing tailor-made PVAms via organometallic-mediated radical polymerization (OMRP) of N-vinylacetamides followed by hydrolysis of the pendent amide moieties. In this case, cobalt(II) acetylacetonate was successfully used as controlling agent. The synthesis of a series of well-defined homopolymers, statistical and block copolymers with pendent primary and/or secondary amines having low dispersities, predictable molar masses and precise compositions, will be described. Finally, we will discuss the possible use of these polyvinylamine-containing copolymers as gene transfection agents. Some of them demonstrated high DNA transfection level in combination with high cell viability. [less ▲]

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See detailGroundless altruism: Why it makes sense to risk one's life for other people's money
Dumitru, Magdalena ULiege; Joergensen, Gitte

Conference (2017, August 22)

In a study where participants were asked to make a series of assessments in distinct circumstances, we show that altruistic agents may incur disadvantages in the name of values they do not believe in (i.e ... [more ▼]

In a study where participants were asked to make a series of assessments in distinct circumstances, we show that altruistic agents may incur disadvantages in the name of values they do not believe in (i.e., saving money) as long as they believe in the overarching category (e.g., it is a ‘good deed’ to recover other people’s money). Whereas previous research mostly targeted ultimate benefits (i.e., whether or not altruistic agents incur real disadvantages), the axiological basis of altruistic acts (i.e., whether or not they have the same worth to self and to others) has remained unchallenged. Here, we explored “groundless altruism” by asking participants to rate their agreement with the statement ‘Money is worth risking my life for’ before and after presenting them with an altruistic scenario. There was a dramatic increase in the proportion of ‘yes’ responses from the first to the second rating. Moreover, as predicted by the cultural group selection theory, the status of the agent (low-rank police employee v s. secret agent) was largely irrelevant. These findings suggest that social constructs such as categorisation have the potential to significantly influence human behaviour in various domains from moral psychology to work ethics to language learning. [less ▲]

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See detailNarrative Misappropriations of Pokémon: How Fanarts and Fanfictions Playfully Feed and Reconfigure a Transmedia Universe
Barnabé, Fanny ULiege

Conference (2017, August 21)

As defined by Jenkins (2006), transmedia storytelling is intimately linked with creative practices of reception which take part in what we now call the “participatory culture” (Raessens, 2005; Jenkins ... [more ▼]

As defined by Jenkins (2006), transmedia storytelling is intimately linked with creative practices of reception which take part in what we now call the “participatory culture” (Raessens, 2005; Jenkins, 1992 and 2009). The audience plays, indeed, a key role in the construction of transmedia universes, given that “to fully experience any fictional world, consumers must assume the role of hunters and gatherers, chasing down bits of the story across media channels, comparing notes with each other via online discussion groups, and collaborating to ensure that everyone who invests time and effort will come away with a richer entertainment experience” (Jenkins, 2006: 21). Consequently, studying a media – in this case, the video game – through the lens of transmedia storytelling urges one to take into consideration how the public can participate, feed, or transform fictions by consuming them. Furthermore, in the field of game studies, it is all the more relevant to deal with the implication of players in the creative process since video games are historically and structurally related to the practice of misappropriation or detournement. As Genvo notes: “the creation of the first video game [Spacewar, 1962] already resulted from a playful act, which was expressed by the misuse of the conventional function of an MIT’s super calculator” (Genvo, 2008: 2). This original affinity now appears in a number of creative practices that prolong the game outside its primary space and enable it to seep into other medias: as fanfictions, modding or machinimas show, the video game is regularly apprehended by players not as a closed work to consume, but “more as [a] suit[e] of resources to be played with” (Newman, 2012: 123). This paper therefore seeks to study the impact of players’ misappropriations on the development of video games' fictional worlds. In this perspective, I will focus on a deeply transmedia license, the Pokémon saga, and on two creative practices that reconfigure games’ universes: fanarts and fanfictions. While amateur drawings and comics inspired by Pokémon GO have created narrative extensions from scratch about the barely characterized Team Leaders (Blanche, Candela and Spark), fan-authors have written thousands of texts that play with elements of the Pokémon universe in order to produce original stories. Yet, these textual and pictorial rewritings do not merely reuse narrative elements of Pokémon games; they also feature strictly playful components such as gameplay, glitches or actions like saving and reloading, which then become new types of narrative motifs. Fanfictions and fanarts thus construct – like the games they extend – hybrid fictions, mixing storytelling and gaming logic: in Amato’s words, “ludiegesis” (Amato, 2005 : 301). Using theoretical tools from narratology and from game studies, I will show that, by reincorporating playful aspects in their narrative structures, these derivative works hold a reflexive discourse on the original game that cannot be reduced to a binary opposition between “adhesion” and “subversion”, but which builds a whole new stratum of fiction. [less ▲]

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See detailCO2-sourced α-alkylidene cyclic carbonates: a Step forward in the quest for functional regioregular poly(urethane)s and poly(carbonate)s
Gennen, Sandro ULiege; Grignard, Bruno ULiege; Tassaing, Thierry et al

in Angewandte Chemie International Edition (2017), 56(35), 1039410398

We describe a robust platform for the synthesis of a large diversity of novel functional CO2 -sourced polymers by exploiting the regio-controlled and site selective ring-opening of α- alkylidene ... [more ▼]

We describe a robust platform for the synthesis of a large diversity of novel functional CO2 -sourced polymers by exploiting the regio-controlled and site selective ring-opening of α- alkylidene carbonates by various nucleophiles. The remarkable reactivity of α-alkylidene carbonates is dictated by the exocyclic olefinic group that selectively orients the cyclic carbonate ring- opening with the formation of an enol species. The polyaddition of CO2 -sourced bis-α-alkylidene carbonates (bis-αCCs) with primary and secondary diamines provides novel regioregular functional poly(urethane)s. The reactivity of bis-αCCs is also exploited for producing new poly(β-oxo-carbonate)s by organocatalyzed polyaddition with a diol. All polyadditions were feasible under ambient conditions. This synthesis platform provides new functional variants of world-class leading polymers families (polyurethanes, polycarbonates) and valorises CO2 as a chemical feedstock. [less ▲]

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See detailMicrobiological stability of rice tart stored at ambient temperature after baking
N'guessan, Elise; Cissé, Mohamed; Niyonzima, Eugene ULiege et al

in Journal of Food Research (2017), 6(5), 41-49

Very popular in Belgium, rice tart is a hot pastry sold in bakeries. It is then consumed at home, for dessert or snack. This study is conducted to investigate the microbiological stability of this ... [more ▼]

Very popular in Belgium, rice tart is a hot pastry sold in bakeries. It is then consumed at home, for dessert or snack. This study is conducted to investigate the microbiological stability of this foodstuff, from the end of baking to end user by consumers. In this purpose, 108 rice tart samples were collected from each of seven bakeries in five Belgium provinces. Physico-chimical analysis in addition to microbiological analysis were carried out in accordance with the European Regulation EC 2073/2005 and with references methods, to enumerate the total microorganisms count, Staphylococcus aureus, Bacillus cereus as well as Enterobacteria, susceptible likely to contaminate the tarts during the production or after baking. Even when the results meet the microbiological safety standards immediately after baking in all bakeries implicated, a significant (p <0,05) increase of mesophilic aerobic bacteria (ranging from <1 to 7 log cfu/g) and B. cereus (> 3,7 log cfu/g) was observed during the storage at non refrigerated temperature (28 to 30°C). A post-baking recontamination and other parameters like an insufficient baking time or a non uniform distribution of the oven heat could explain the observed bacteria growth. The present study shows that most rice tarts investigated are microbiologically safe. However, the possible increase of bacteria load in this foodstuff attributable to the favorable aw, pH and temperature conditions, highlight the importance of applying good hygienic practices and compliance with storage conditions after baking to ensure consumer safety. [less ▲]

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See detailGestion de la biodiversité
Monty, Arnaud ULiege

Conference (2017, August 21)

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See detailLandscape and hydrological controls on the downstream transport of dissolved organic matter in the Congo and Zambezi rivers
Lambert, T; Bouillon, S; Teodoru, CR et al

Conference (2017, August 20)

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See detailAfter and Beyond Fukushima: Probing the Role and Potential of Citizen Science in Nuclear Science and Technology Governance in Japan and Belgium
Van Oudheusden, Michiel ULiege; Yoshizawa, Go

Scientific conference (2017, August 18)

In this presentation, we discuss the role of citizen science in the governance of nuclear incidents/accidents in emergency preparedness, response and post-disaster recovery. Starting from the 2011 ... [more ▼]

In this presentation, we discuss the role of citizen science in the governance of nuclear incidents/accidents in emergency preparedness, response and post-disaster recovery. Starting from the 2011 Fukushima nuclear disaster, we (1) trace the expansion of citizen science in the nuclear field to other countries and contexts; (2) ask how citizen-science concepts, methods, and toolsets challenge institutional approaches to preparedness and response to nuclear incidents/accidents and post-disaster situations; and how nuclear safety authorities respond to such challenges; (3) probe the possibilities of incorporating citizen-science concepts and practices into Belgian and European approaches to nuclear emergency response, preparedness, and recovery. Our research draws on qualitative methods in Interpretive Policy Analysis and Science and Technology Studies to highlight the contentious politics that characterize interactions between citizen scientists and nuclear authorities in Japan and other countries. It anticipates the emergence of hybrid citizen-science forms, comprising material artifacts (e.g. new radioactivity measurement devices) and discourses (e.g. on the role of science in society), which simultaneously challenge and accommodate institutional approaches to nuclear emergency preparedness and response. By comparing citizen-science initiatives in Japan and Belgium, the project sheds light on citizen science as an emerging pattern of governance and probes its problem-solving capacities and long-term viability. [less ▲]

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See detailEffect of AP102, a subtype 2 and 5 specific somatostatin analog, on glucose metabolism in rats
Tarasco, Erika; Seebeck, Petra; Pfundstein, Svende et al

in Endocrine (2017)

Somatostatin analogs are widely used to treat conditions associated with hormonal hypersecretion such as acromegaly and metastatic neuroendocrine tumors. First generation somatostatin analogs, such as ... [more ▼]

Somatostatin analogs are widely used to treat conditions associated with hormonal hypersecretion such as acromegaly and metastatic neuroendocrine tumors. First generation somatostatin analogs, such as octreotide and lanreotide, have high affinity for somatostatin receptor subtype 2 (SSTR2), but have incomplete efficacy in many patients. Pasireotide targets multiple SSTRs, having the highest affinity for SSTR5, but causes hyperglycemia and diabetes mellitus in preclinical and clinical studies. AP102 is a new somatostatin analogs with high affinity at both SSTR2 and SSTR5. We aimed to characterize the effects of AP102 vs. pasireotide on random and dynamic glucose levels, glucoregulatory hormone concentrations and growth axis measures in healthy Sprague-Dawley rats. [less ▲]

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See detailConstruction of high-resolution trace element time-series in Belgian speleothems by LA-ICP-MS
Allan, Mohammed ULiege; verheyden, sophie; crucifix, michel et al

Conference (2017, August 17)

Speleothems, presented in Belgium, are now regarded as valuable archive of paelenvirenmental variations on the continents, offering a number of advantages relative to other continental climate proxy ... [more ▼]

Speleothems, presented in Belgium, are now regarded as valuable archive of paelenvirenmental variations on the continents, offering a number of advantages relative to other continental climate proxy recorders such as lake sediments. They are reliable continental archives of high interest due to their dating possibilities and their possibility to preserve multi-proxy records of environmental and climatic dynamics. Establishing high-resolution trace element time series in speleothems requires analytical techniques capable of representative sampling at sub-annual spatial resolution (on order of 22 µm in this study). In the Belgian Pere Noel cave (PN), high spatial resolution measurements of trace elements (e.g., Mg, Sr, Ba) were realized by using LA-ICP-MS and compared with results from lower resolution techniques (ICP-MS). The results from both techniques have been analysed in order to assess the capability of each technique to reconstruct climate changes at high resolution from PN stalagmite. Results showed that LA-ICP-MS technique allows a rapid analysis of multiple elemental concentrations, and uses minimal sample volume allowing for replicate sampling and availability of almost the entire original sample for other analyses. [less ▲]

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See detailSupercritical Fluid Chromatography in Traditional Chinese Medicine Analysis
Huang, Yang ULiege; Tang, Guangyun; Zhang, Tingting et al

in Journal of Pharmaceutical and Biomedical Analysis (2017)

Traditional Chinese medicines (TCMs) are gaining increasing popularity throughout the world due to their long historical clinical practices. Highly efficient analytical separation tools are essential for ... [more ▼]

Traditional Chinese medicines (TCMs) are gaining increasing popularity throughout the world due to their long historical clinical practices. Highly efficient analytical separation tools are essential for investigating the mysterious properties of TCMs and their quality control. Supercritical fluid chromatography (SFC) showed a great potential in TCM analysis for both nonpolar and polar components. In this paper, an overview of the experimental conditions (i.e. detection mode, stationary phase, mobile phase composition, pressure and temperature) used in SFC for achiral separations of TCM components is presented and recent applications to the analysis of different classes of compounds extracted from TCMs, such as lipids, terpene and terpenoids, phenolic compounds, flavonoids, alkaloids, saponins and carbohydrates, will be briefly described. [less ▲]

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See detailEnhancing CIDOC - CRM and compatible models with the concept of multiple interpretation
Van Ruymbeke, Muriel ULiege; Hallot, Pierre ULiege; Billen, Roland ULiege

in ISPRS Annals of the Photogrammetry, Remote Sensing and Spatial Information Sciences (2017, August 17), Volume IV-2/W2

Modelling cultural heritage and archaeological objects is used as much for management as for research purposes. To ensure the sustainable benefit of digital data, models benefit from taking the data ... [more ▼]

Modelling cultural heritage and archaeological objects is used as much for management as for research purposes. To ensure the sustainable benefit of digital data, models benefit from taking the data specificities of historical and archaeological domains into account. Starting from a conceptual model tailored to storing these specificities, we present, in this paper, an extended mapping to CIDOC-CRM and its compatible models. Offering an ideal framework to structure and highlight the best modelling practices, these ontologies are essentially dedicated to storing semantic data which provides information about cultural heritage objects. Based on this standard, our proposal focuses on multiple interpretation and sequential reality. [less ▲]

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See detailLa influencia normativa de China en América Latina y en el Caribe: ¿Un desafío estratégico para la Unión Europea?
Wintgens, Sophie ULiege

Scientific conference (2017, August 16)

El crecimiento de los intercambios económicos y comerciales entre China y el subcontinente latinoamericano va acompañado de la imposición de normas económicas y políticas, de la cual su política de ... [more ▼]

El crecimiento de los intercambios económicos y comerciales entre China y el subcontinente latinoamericano va acompañado de la imposición de normas económicas y políticas, de la cual su política de comercio internacional es portadora. Esta constatación plantea la cuestión del desafío que esta influencia normativa china representa para la estrategia desplegada por la Unión Europea en América Latina y el Caribe. A fin de responder a esta cuestión, esta presentación contiene dos objetivos relacionados entre sí: por una parte, analizar el alcance normativo de la política comercial de China en ALC, con el fin de ver si ella es portadora de un proyecto político-económica regional comparable al modelo de integración y de gobernabilidad regional desplegado por la UE en el subcontinente latinoamericano; por otra parte, medir de la influencia de la producción normativa china en ALC a través de su capacidad para competir con las normas exportadas por la UE en esta región del mundo. [less ▲]

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See detailMagma storage conditions and processes at Calbuco volcano (Central Southern Volcanic Zone, Chile)
Montalbano, Salvatrice ULiege; Namur, Olivier ULiege; Schiano, Pierre et al

Poster (2017, August 16)

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See detailCompositional gap at La Picada (CSVZ, Chile) results from critical cristallinity and compaction
Vander Auwera, Jacqueline ULiege; Namur, Olivier ULiege; Coumont, Valentin et al

Poster (2017, August 16)

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See detailComplete mitogenome sequence of Ricasolia amplissima (Lobariaceae) reveals extensive mitochondrial DNA rearrangement within the Peltigerales (lichenized ascomycetes)
Simon, Antoine ULiege; Liu, Yang; Sérusiaux, Emmanuël ULiege et al

in Bryologist (2017), 120(3), 335-339

The structure of mitochondrial genomes varies among non-lichenized fungi in terms of their genic and intronic content and genic order. Whether lichenized fungal mitogenomes are equally labile is unknown ... [more ▼]

The structure of mitochondrial genomes varies among non-lichenized fungi in terms of their genic and intronic content and genic order. Whether lichenized fungal mitogenomes are equally labile is unknown due to the paucity of available mitogenomes. We assembled the mitogenome of Ricasolia amplissima (Peltigerales, Lobariaceae), using massive parallel sequencing, and compared its structure to that of two species of Peltigera (Peltigeraceae). The mitochondrial genome of R. amplissima comprised 82,333 bp, with a 29.8% G+C content, and holds 15 unique protein-coding genes, 29 tRNA genes, two rRNA genes, and one non-coding RNA gene. Although the protein-coding gene content in the mitogenome of Peltigera and Ricasolia was identical, the relative gene order differed substantially, revealing that significant gene rearrangements also characterize the evolution of mitogenomes of lichenized ascomycetes at a relatively shallow phylogenetic depth, such as within the order Peltigerales. [less ▲]

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See detailLe cercle de lecture, un dispositif pour construire ensemble des compétences de lecteurs et d'enseignants
Scheepers, Caroline ULiege; Outers, Pierre ULiege; Werner, Anne-Catherine ULiege et al

in Didactiques en Pratique (2017)

Comment accompagner les premiers pas des stagiaires débutants ? À cette vaste et complexe question, le présent article envisage d’apporter un très modeste éclairage. Ainsi, sera décrit, conceptualisé ... [more ▼]

Comment accompagner les premiers pas des stagiaires débutants ? À cette vaste et complexe question, le présent article envisage d’apporter un très modeste éclairage. Ainsi, sera décrit, conceptualisé, analysé et discuté un projet collaboratif qui a associé étroitement théorie et pratique, université et école secondaire, expérimentation et transposition d’un dispositif, didactique disciplinaire et didactique générale. Plus concrètement, il s’est agi de faire expérimenter en tant qu’apprenants un cercle de lecture et un atelier d’écriture par les étudiants romanistes qui suivent le cours de première année de master centré sur la didactique du français langue première, avant de les inviter à transposer l’outil ainsi testé dans leur classe de stage. Seront prises en compte différentes traces : nos consignes, les journaux de stage, les portfolios, les consignes des étudiants, les traces recueillies auprès des élèves du secondaire, les rapports des maitres de stage, etc. Nous verrons in fine que le processus mis en place confirme, toutes proportions gardées, la validité et la pertinence du principe d’homologie entre les activités testées par les stagiaires lors de leur formation initiale à l’université et celles que les formateurs leur recommandent de mettre en œuvre dans leurs classes. [less ▲]

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See detailProtein–polysaccharide complexes for enhanced protein delivery in hyaluronic acid templated calcium carbonate microparticles
Ramalapa, Bathabile ULiege; Crasson, Oscar ULiege; Vandevenne, Marylène ULiege et al

in Journal of Materials Chemistry B (2017), 5

The controlled delivery of proteins within calcium carbonate (CaCO3) particles is currently widely investigated. The success of these carriers is driven by ionic interactions between the encapsulated ... [more ▼]

The controlled delivery of proteins within calcium carbonate (CaCO3) particles is currently widely investigated. The success of these carriers is driven by ionic interactions between the encapsulated proteins and the particles. This poses a great limitation on the successful loading of proteins that have no ionic affinity to CaCO3. In this study, we explored the use of polysaccharide–protein interactions to strongly enhance the encapsulation of proteins in CaCO3 microparticles. Previously, Vandevenne and colleagues inserted a human chitin binding domain (ChBD) that has intrinsic affinity for hyaluronic acid (HA) into a β-lactamase (BlaP). This generated chimeric protein, named BlaPChBD, was shown to be fully bifunctional. In this study we showed that this hybrid protein can associate with HA and be successfully loaded into vaterite CaCO3 microparticles using supercritical CO2 (ScCO2) technology aided by the templating effect of HA on CaCO3. The presence of ChBD inserted into BlaP increased the encapsulation of the protein by 6-fold when complexed with HA. Furthermore, thrombin cleavage sites were engineered on both sides of the inserted ChBD in the chimeric BlaP to achieve release of the protein from the microparticles by protease cleavage. Our results showed that thrombin cleavage increased the release of the protein from the microparticles within 36 hours from <20% to 87%. In conclusion, the presence of ChBD successfully improved the encapsulation yield of the protein while retaining up to 82% of its activity and efficient release of the protein from the microparticles was achieved by protease cleavage. [less ▲]

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