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See detailBronchial thermoplasty: a new therapeutic option for the treatment of severe, uncontrolled asthma in adults.
Dombret, Marie-Christine; Alagha, Khuder; Philippe Boulet, Louis et al

in European respiratory review : an official journal of the European Respiratory Society (2014), 23(134), 510-8

Bronchial thermoplasty is a young yet promising treatment for severe asthma whose benefit for long-term asthma control outweighs the short-term risk of deterioration and hospitalisation in the days ... [more ▼]

Bronchial thermoplasty is a young yet promising treatment for severe asthma whose benefit for long-term asthma control outweighs the short-term risk of deterioration and hospitalisation in the days following the treatment. It is an innovative treatment whose clinical efficacy and safety are beginning to be better understood. Since this is a device-based therapy, the overall evaluation of risk-benefit is unlike that of pharmaceutical products; safety aspects, regulatory requirements, study design and effect size assessment may be unfamiliar. The mechanisms of action and optimal patient selection need to be addressed in further rigorous clinical and scientific studies. Bronchial thermoplasty fits in perfectly with the movement to expand personalised medicine in the field of chronic airway disorders. This is a device-based complimentary asthma treatment that must be supported and developed in order to meet the unmet needs of modern severe asthma management. The mechanisms of action and the type of patients that benefit from bronchial thermoplasty are the most important challenges for bronchial thermoplasty in the future. [less ▲]

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See detailLe coût en droit européen de la concurrence, essai sur la réception d'une notion économique
Provost, Elise

Doctoral thesis (2014)

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See detailLes premières forêts communautaires du Gabon - Le film 1/3
Meunier, Quentin; Boldrini, Sylvie; Federspiel, Michèle et al

Diverse speeche and writing (2014)

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See detailSpeciation in Malagasy lemurs: a review of the cryptic diversity in genus Lepilemur
Wilmet, Leslie ULg; Schwitzer, Christoph; Devillers, Pierre et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2014), 18(4), 577-588

Madagascar is one of the highest biodiversity hotspots on the planet; however, it is also one of the most heavily impacted countries in the world in terms of forest degradation and general habitat ... [more ▼]

Madagascar is one of the highest biodiversity hotspots on the planet; however, it is also one of the most heavily impacted countries in the world in terms of forest degradation and general habitat destruction. Genus Lepilemur, in family Lepilemuridae, is a genus of small, nocturnal, exclusively arboreal Malagasy folivores. All species in the genus have small ranges of distribution. Fully forest-dependent, they have a high risk of extinction. Various models and theories of speciation mechanisms have been developed for the fauna and flora of Madagascar. For instance, in the northwestern part of the island, some authors used Lepilemur spp. to test two existing models of distribution: the “Martin model” and “Wilmé model”. Regarding the impact of forest destruction and habitat degradation in Madagascar, conservation strategies for Lepilemur need to be put in place. This paper gives an overview of the current knowledge of the genus Lepilemur and examines speciation for Malagasy lemurs. The understanding of species distribution within biodiversity hotspots is important to identify target for conservation. Therefore, we summarize and compare three biogeography models related to lemurs distribution in order to understand the reasons behind the high diversity (26 species in total) among the genus Lepilemur. Particular attention is also given to the concept of species regarding biodiversity issues and the taxonomic explosion in genus Lepilemur. [less ▲]

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See detailSFX Miscellaneous Free Ejournals Target: Usage Survey among the SFX Community
Renaville, François ULg; Branse, Yosef; Chen, Xiaotian et al

Report (2014)

In June 2014, the SFX® MISCELLANEOUS_FREE_EJOURNALS target contained more than 24,000 portfolios of all kinds. The SFX Knowledge Base Advisory Board (KBAB) decided to carry out an international survey to ... [more ▼]

In June 2014, the SFX® MISCELLANEOUS_FREE_EJOURNALS target contained more than 24,000 portfolios of all kinds. The SFX Knowledge Base Advisory Board (KBAB) decided to carry out an international survey to get an overview of the usage that is done of this target by the SFX community and to precisely identify what could be done to improve it. The target is widely used among the community. However, many respondents complained about these top three problems: (1) Incorrect parse params (broken links); (2) Full texts actually not free; (3) Incorrect or missing thresholds. [less ▲]

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See detailLes premières forêts communautaires du Gabon - Bonus 2
Meunier, Quentin; Boldrini, Sylvie; Federspiel, Michèle et al

Diverse speeche and writing (2014)

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See detailProjet DACEFI 2. Principes fondateurs d'une forêt communautaire au Gabon. Outils de vulgarisation et de sensibilisation.
Meunier, Quentin; Boldrini, Sylvie; Larzillière, Adélaïde et al

E-print/Working paper (2014)

Faisant suite à une première phase (2006-2008), le projet pilote Développement d’Alternatives Communautaires à l’Exploitation Forestière Illégale (DACEFI-2, de 2010 à 2014) s’emploie à tester au Gabon la ... [more ▼]

Faisant suite à une première phase (2006-2008), le projet pilote Développement d’Alternatives Communautaires à l’Exploitation Forestière Illégale (DACEFI-2, de 2010 à 2014) s’emploie à tester au Gabon la mise en oeuvre des premières forêts communautaires. Un de ses objectifs majeurs consiste à tester le concept de foresterie communautaire au sein de plusieurs sites partenaires et de témoigner de l’expérience acquise afin que le Ministère en charge des Forêts adapte le cadre réglementaire. Quatre textes majeurs régissent la foresterie communautaire au Gabon, une loi (n°16/01), un décret d’application (n°1028/PR/MEFEPEPEN) et deux arrêtés (n°018/MEF/SG/DGF/DFC et n°106/MEFEPRN). Ils encadrent le processus de création d’une forêt communautaire. Afin de les rendre accessibles à un plus grand nombre, le projet DACEFI-2 s’est proposé de développer plusieurs supports de vulgarisation à destination des agents des Eaux et Forêts et des villageois. En éditant et en diffusant une série de posters, de films ou encore de bandes dessinées, le projet a contribué à faire connaître dans les provinces de l’Ogooué-Ivindo et du Moyen-Ogooué, l’esprit de ces textes légaux qui visent à favoriser le développement des communautés locales. Ce document de capitalisation présente une compilation des outils développés par les équipes du projet pour mener à bien cette campagne de sensibilisation. Nous abordons la gestion forestière durable par le prisme de la foresterie communautaire en évoquant l’esprit de la loi et les enjeux de la foresterie sociale. Nous proposons également une série de recommandations, basées sur notre expérience au Gabon, afin d’optimiser l’efficacité des communautés engagées dans ce processus. [less ▲]

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See detailLes premières forêts communautaires du Gabon - Bonus 1
Meunier, Quentin; Boldrini, Sylvie; Federspiel, Michèle et al

Diverse speeche and writing (2014)

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See detailTheoretical power spectra of mixed modes in low-mass red giant stars
Grosjean, Mathieu ULg; Dupret, Marc-Antoine ULg; Belkacem, Kevin et al

in Astronomy and Astrophysics (2014), 572

CoRoT and Kepler observations of red giant stars revealed very rich spectra of non-radial solar-like oscillations. Of particular interest was the detection of mixed modes that exhibit significant ... [more ▼]

CoRoT and Kepler observations of red giant stars revealed very rich spectra of non-radial solar-like oscillations. Of particular interest was the detection of mixed modes that exhibit significant amplitude, both in the core and at the surface of the stars. It opens the possibility of probing the internal structure from their innermost layers up to their surface throughout their evolution on the red giant branch, as well as on the red clump. Our objective is primarily to provide physical insight into the mechanism responsible for mixed-mode amplitudes and lifetimes. Subsequently, we aim at understanding the evolution and structure of red-giant spectra along with their evolution. The study of energetic aspects of these oscillations is also important for predicting the mode parameters in the power spectrum. Non-adiabatic computations, including a time-dependent treatment of convection, are performed and provide the lifetimes of radial and non-radial mixed modes. We then combine these mode lifetimes and inertias with a stochastic excitation model that gives us their heights in the power spectra. For stars representative of CoRoT and Kepler observations, we show under which circumstances mixed modes have heights comparable to radial ones. We stress the importance of the radiative damping in determining the height of mixed modes. Finally, we derive an estimate for the height ratio between a g-type and a p-type mode. This can thus be used as a first estimate of the detectability of mixed modes. [less ▲]

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See detailWood digestion in lower termites: multidisciplinary approaches based on differential feeding
Bauwens, Julien ULg; Brasseur, Catherine ULg; Tarayre, Cédric ULg et al

Poster (2014, December)

Termites digestive tract and hindgut especially still holds many secrets despites hundreds of years of research. The complexity of the symbiotic microbial community and the contrast of physio-chemical ... [more ▼]

Termites digestive tract and hindgut especially still holds many secrets despites hundreds of years of research. The complexity of the symbiotic microbial community and the contrast of physio-chemical environments found in lower termites paunch are potentially the key point to explain the efficiency of ligno-cellulose digestion. Contribution of advancing technologies accelerates the progress of our knowledge in this field. Here, we present multiple approaches combining old and recent techniques used to highlight the effect of ligno-cellulosic compounds on termite gut and the role of populations from the symbiotic microbial community. Termites Reticulitermes flavipes (Kollar) submitted to various artificial diets showed variations in flagellates populations profile and enzymatic activities. Differential protein expression was investigated using 2D-DIGE MALDI-TOF-TOF and 2D-LC-MS/MS using high resolution orbitrap analyzer. Results from both proteomic experiments tend to support each-other and bring complementary points of view. The gel-free analysis resulted in highly contrasted identification of enzymes involved in ligno-cellulose digestion and metabolism. Finally, differential feeding experiments leaded to in vivo selection of different symbiotic communities. These communities were characterized following some metabolism assays and allowed the cultivation of diverse microbial consortia using media closely related to the respective artificial diets. This work provides relevant data on termite and associated microbial community response to alimentary diets. [less ▲]

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See detailMulti-Domain Approaches for the Solution of High-Frequency Time-Harmonic Propagation Problems
Vion, Alexandre ULg

Doctoral thesis (2014)

The numerical solution of high-frequency time-harmonic propagation problems by volumic discretization methods is a challenging task, most notably because of the very large size of the resulting linear ... [more ▼]

The numerical solution of high-frequency time-harmonic propagation problems by volumic discretization methods is a challenging task, most notably because of the very large size of the resulting linear systems. We present a framework for a class of iterative methods that distribute the work between several CPUs and exchange information between physical or artificial interfaces. The goal is to define subproblems of manageable sizes, and to exploit the power of parallel supercomputers. [less ▲]

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See detail“Negotiating the law: judges, families and court hearings in inheritance cases in Cotonou”
Andreetta, Sophie ULg

Conference (2014, December)

On 14 June 2004, Benin ratified a new Code on Persons and Family – regulating, amongst other things, inheritance matters. Over the last couple of years, the number of inheritance cases handled by state ... [more ▼]

On 14 June 2004, Benin ratified a new Code on Persons and Family – regulating, amongst other things, inheritance matters. Over the last couple of years, the number of inheritance cases handled by state courts has drastically increased in the capital city. How do people understand and use the law? While modern courts, like other public services, have been analyzed as part of everyday governance and the local state in West Africa, I on the other hand will focus on the ways in which the judiciary interprets and implements law. Within that context, hearings are a key moment of legal proceedings. How do litigants argue their cases? How do judges manage to settle inheritance quarrels? Using case studies of inheritance disputes and their litigation under the 2004 ‘Code on Persons and Family’, I try to understand how state laws are understood, utilized, and/or questioned in Cotonou. [less ▲]

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See detailNatural killer and dendritic cells collaborate in the immune response induced by the vaccine against uterine cervical cancer.
Langers, Inge ULg; Renoux, Virginie; Reschner, Anca et al

in European journal of immunology (2014), 44

Virus-like particles (VLPs) of human papillomavirus (HPV) are used as a vaccine against HPV-induced cancer, and recently we have shown that these VLPs are able to activate natural killer (NK) cells. Since ... [more ▼]

Virus-like particles (VLPs) of human papillomavirus (HPV) are used as a vaccine against HPV-induced cancer, and recently we have shown that these VLPs are able to activate natural killer (NK) cells. Since NK cells collaborate with dendritic cells (DCs) to induce an immune response against viral infections and tumors, we studied the impact of this crosstalk in the context of HPV vaccination. NK cells in the presence of HPV-VLPs enhanced DC maturation as shown by an upregulation of CD86 and HLA-DR and an increased production of IL-12p70, but not of the immunosuppressive cytokine IL-10. This activation was bi-directional. Indeed, in the presence of HPV-VLPs, DCs further activated NK cells by inducing the upregulation of cell surface activation markers (CD69 and HLA-DR). The function of NK cells was also improved as shown by an increase in IFN-gamma secretion and cytotoxic activity against an HPV+ cell line. This crosstalk between NK cells and DCs needed CD40 interaction and IL-12p70 secretion, whereas NKG2D was not implicated. Our results provide insight into how VLPs interact with innate immune cells and how NK cells and DCs play a role in the immune response induced by this vaccine agent. This article is protected by copyright. All rights reserved. [less ▲]

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See detailStigmergy as a mechanism to produce collective vortex behaviours: a study case in shoveler duck
Delcourt, Johann ULg; bode, W. Nikolaï

Poster (2014, December)

Ant mill, caterpillar circle, bat donut, bacteria vortex, duck swirl and fish torus are different names for rotating circular formations of animals, where individuals turn around a common centre. Even if ... [more ▼]

Ant mill, caterpillar circle, bat donut, bacteria vortex, duck swirl and fish torus are different names for rotating circular formations of animals, where individuals turn around a common centre. Even if the ubiquity of this behavioural phenomenon might have suggested common causes or fundamental underlying principles across contexts, a variety of proximate mechanisms can give rise to vortex behaviours. Here, we investigate if stigmergic process (mechanism of self-organisation wit hout direct communication or interaction between individuals) is able to produce different collective behaviours, notably collective vortices. We present an individual-based simulation model for the movement of populations in a resource landscape that allows us to vary the strength of the interactions mentioned above. The key assumption and novelty of our model is that individuals can cause the release of additional nutrients, as well as consuming them. Our model produces clear predictions. For example, we expect more tortuous individual movement paths and higher levels of aggregation in populations occupying homogeneous environments where individual movement makes more nutrients available. We also show how observed movement dynamics could change when local nutrient sources are depleted or when the population density increases. Our predictions are testable and qualitatively reproduce the different feeding behaviours observed in filter-feeding ducks (Anas clypeata), for example. We suggest that considering two-way interactions between feeding individuals and resource landscapes could help to explain fine-scale movement dynamics. [less ▲]

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See detailA finite-element reciprocity solution for EEG forward modeling with realistic individual head models
Ziegler, Erik ULg; Chellappa, Sarah Laxhmi ULg; Gaggioni, Giulia ULg et al

in NeuroImage (2014), 103

Highlights • Creates EEG forward models suitable for high-resolution source localization. • Automatic T1-based whole-head finite element meshing and leadfield computation. • Pipelines can incorporate ... [more ▼]

Highlights • Creates EEG forward models suitable for high-resolution source localization. • Automatic T1-based whole-head finite element meshing and leadfield computation. • Pipelines can incorporate conductivity tensors from diffusion-weighted images. • Open-source toolbox shared under a permissive software license. • Accuracy comparable to SimBio FEM and superior to OpenMEEG BEM solutions. [less ▲]

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See detailConverging to and escaping from the global equilibrium: Isostables and optimal control
Mauroy, Alexandre ULg

in Proceedings of the 53rd IEEE Conference on Decision and Control (2014, December)

This paper studies the optimal control of trajectories converging to or escaping from a stable equilibrium. The control duration is assumed to be short. When the control is turned off, the trajectories ... [more ▼]

This paper studies the optimal control of trajectories converging to or escaping from a stable equilibrium. The control duration is assumed to be short. When the control is turned off, the trajectories have not reached the target and they subsequently evolve according to the free motion dynamics. In this context, we show that the problem can be formulated as a finite-horizon optimal control problem which relies on the notion of isostables. For linear and nonlinear systems, we solve this problem using Pontryagin’s maximum principle and we study the relationship between the optimal solutions and the geometry of the isostables. Finally, optimal strategies for choosing the magnitude and duration of the control are considered. [less ▲]

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See detailIgE antibodies and FceRI are critical components of protective type 2 immunity against honeybee and russell's viper venom in mice
Starkl, Philipp; Marichal, Thomas ULg; Reber, Laurent L. et al

in Proceedings of the Type 2 Cell Symposium - Brugge (2014, December)

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See detailL'étoile de Noël
Nazé, Yaël ULg

Article for general public (2014)

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See detailGouvernementalité, subjectivité et vérité
Thirion, Nicolas ULg

in Acta Fabula : Revue des Parutions en Théorie Littéraire (2014), 15(10),

Detailed reference viewed: 13 (2 ULg)