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See detailBiopesticides: quand les biotechs se mettent au service d’une agriculture durable
Zune, Quentin ULg; Ongena, Marc ULg

Scientific conference (2014, December 10)

Présentation des différents outils de la biotechnologie (Omics et bioprocédés) pour mieux comprendre le fonctionnement des biopesticides microbiens afin d'améliorer leur efficacité lors de leurs ... [more ▼]

Présentation des différents outils de la biotechnologie (Omics et bioprocédés) pour mieux comprendre le fonctionnement des biopesticides microbiens afin d'améliorer leur efficacité lors de leurs applications sur les cultures. [less ▲]

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See detailPlaidoyer pour une recherche-compagne
Havelange, Carl ULg

Conference (2014, December 10)

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See detailLa puissance divine en images. Les figures « panthées »
Veymiers, Richard ULg

Scientific conference (2014, December 10)

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See detailDevelopment and validation of a 3D kinematic-based method for determining gait events during overground walking
Boutaayamou, Mohamed ULg; Schwartz, Cédric ULg; Denoël, Vincent ULg et al

in IEEE International Conference on 3D Imaging (IC3D) (2014, December 09)

A new signal processing algorithm is developed for quantifying heel strike (HS) and toe-off (TO) event times solely from measured heel and toe coordinates during overground walking. It is based on a rough ... [more ▼]

A new signal processing algorithm is developed for quantifying heel strike (HS) and toe-off (TO) event times solely from measured heel and toe coordinates during overground walking. It is based on a rough estimation of relevant local 3D position signals. An original piecewise linear fitting method is applied to these local signals to accurately identify HS and TO times without the need of using arbitrary experimental coefficients. We validated the proposed method with nine healthy subjects and a total of 322 trials. The extracted temporal gait events were compared to reference data obtained from a force plate. HS and TO times were identified with a temporal accuracy ± precision of 0.3 ms ± 7.1 ms, and –2.8 ms ± 7.2 ms in comparison with reference data defined with a force threshold of 10 N. This algorithm improves the accuracy of the HS and TO detection. Furthermore, it can be used to perform stride-by-stride analysis during overground walking with only recorded heel and toe coordinates. [less ▲]

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See detailAn Introduction to the Additive Manufacturing of Metallic Materials - Two Case Studies on the Processing of Stainless Steel 316L and of Ti Alloy Ti-6Al-4V
Mertens, Anne ULg

Learning material (2014)

This powerpoint presentation was used as teaching material in a seminar given as part of the course “Ingénierie des matériaux métalliques” at Université de Liège. It outlines important current issues in ... [more ▼]

This powerpoint presentation was used as teaching material in a seminar given as part of the course “Ingénierie des matériaux métalliques” at Université de Liège. It outlines important current issues in the developments of additive technologies for the processing of metallic materials by discussing two case studies from researches carried out by the Metallic Materials Science Unit (ULg). In particular, two different metallic alloys, i.e. stainless steel 316L and Ti-6Al-4V, have been processed by laser beam melting under similar conditions, and their microstructures and mechanical behaviours have been compared in details. Under the investigated conditions, Ti-6Al-4V exhibits a more complex behaviour than stainless steel 316L with respect to the occurrence of microstructural and mechanical anisotropy. Moreover, Ti-6Al-4V appears more sensitive to the build-up of internal stresses when compared with stainless steel 316L, whereas stainless steel 316L appears more prone to the formation of “lack of melting” defects. This correlates nicely with the difference in thermal conductivity between the two materials. Thermal conductivity was also shown to increase strongly with increasing temperature. [less ▲]

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See detailModification de la microstructure des métaux après déformation plastique : Restauration et recristallisation
Mertens, Anne ULg

Learning material (2014)

Cette présentation powerpoint vient compléter et illustrer les notes du cours MECA0473-1 "Ingénierie des matériaux métalliques" traitant de l'évolution de la microstructure des métaux suite à une ... [more ▼]

Cette présentation powerpoint vient compléter et illustrer les notes du cours MECA0473-1 "Ingénierie des matériaux métalliques" traitant de l'évolution de la microstructure des métaux suite à une déformation plastique telle que celle imposée typiquement par un procédé de mise en forme comme le laminage. Les phénomènes de restauration et de recristallisation sont discutés en détails du point de vue tant de leurs mécanismes que de leurs cinétiques. Le vieillissement des aciers après déformation est également abordé. [less ▲]

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See detailEglise, libéralisme et franc-maçonnerie en Belgique sous le régime hollandais (1815-1830)
Genin, Vincent ULg

Conference given outside the academic context (2014)

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See detailEco-quartiers : avec la ville ou contre la ville ?
Ruelle, Christine ULg; Marique, Anne-Françoise ULg

Conference given outside the academic context (2014)

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See detailHigh plasma concentrations of sclerostin, an inhibitor of the Wnt signaling pathway in young horses affected by osteochondrosis
Serteyn, Didier ULg; Mendoza García, Luis ULg; Sandersen, Charlotte ULg et al

in Open journal of orthepedics (2014)

Osteochondrosis (OC) is a developmental disease in horses with a significant impact on the horse’s welfare and performance. The early disturbance of enchondral ossification progresses to inflammatory and ... [more ▼]

Osteochondrosis (OC) is a developmental disease in horses with a significant impact on the horse’s welfare and performance. The early disturbance of enchondral ossification progresses to inflammatory and healing process in older horses. Metabolic pathway analysis showed an obvious dysregulation of several signaling pathways related to cartilage formation and cartilage repair such as Wnt/β-catenin, Indian hedgehog and TGF-β signaling pathways. Other regulated genes appeared to be involved in high carbohydrate diet, abnormal insulin metabolism or inflammation. Sclerostin is an osteocyte-secreted soluble antagonist of the Wnt/β-catenin signaling pathway. It is crucial for osteoblast development and activity and is increased in naturally occurring lesions of equine osteochondrosis. The aim of this study is to compare the circulating sclerostin levels between OC-affected (n = 20) and healthy horses (n = 19). A significant linear regression between plasma sclerostin and age is observed especially in the healthy young horses. The mean plasma sclerostin concentration is significantly higher in young horses suffering from osteochondrosis compared to the control horses. These results reinforce the possible role of the Wnt/β-catenin signaling pathway in the OC pathogeny. The inhibition of this essential pathway could disturb the osteo-chondral differentiation. More studies are currently needed to define the eventual clinic interest of plasma sclerostin as future biomarker in bone and cartilage diseases. [less ▲]

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See detailBias-variance decomposition in Random Forests
Louppe, Gilles ULg

Conference (2014, December 09)

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See detailReversible cross-linking of aliphatic polyamides bearing thermo- and photoresponsive cinnamoyl moieties
Tunc, Deniz ULg; Le Coz, Cédric; Alexandre, Michaël et al

in Macromolecules (2014), 47(23), 8247-8254

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See detailRisk of emergence of a hyperpathogenic bovine leukemia virus by mutation of a single envelope N-linked glycosylation site
De Brogniez, Alix ULg; Bouzar, Amel-Baya; Jacques, Jean-Rock ULg et al

Scientific conference (2014, December 08)

Pathogens have co-evolved with their host to allow efficient replication and transmission without inducing excessive pathogenicity that would indirectly impair their persistence. This is exemplified by ... [more ▼]

Pathogens have co-evolved with their host to allow efficient replication and transmission without inducing excessive pathogenicity that would indirectly impair their persistence. This is exemplified by the bovine leukemia virus (BLV) model that induces lymphoproliferative disorders in ruminants only after extended latency periods of several years. In principle, the equilibrium reached between the virus and its host could be disrupted by emergence of more pathogenic strains. Intriguingly, this type of hyperpathogenic BLV strain could never been isolated in vivo nor designed in vitro. Using reverse genetics of an infectious molecular provirus, we have now identified a N-linked envelope glycosylation site that limits viral replication and pathogenicity. Onset of this particular mutation may thus represent a potential threat associated with emergence of hyperpathogenic BLV strains and possibly of new variants of the related primate T-lymphotropic viruses. [less ▲]

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See detailLa promotion de l’activité physique chez les seniors : approche au sein d’une communauté locale
Mouton, Alexandre ULg

Doctoral thesis (2014)

In our contemporary society, get moving is rarely necessary to perform our daily routine. Consequently, physical inactivity is currently considered as the fourth cause of premature death worldwide. Faced ... [more ▼]

In our contemporary society, get moving is rarely necessary to perform our daily routine. Consequently, physical inactivity is currently considered as the fourth cause of premature death worldwide. Faced with an aging population, involving a doubling of the people aged 60 years and over in 2050, physical activity promotion could contribute to preserve individual health in supporting people to adopt an active lifestyle. Our personal contribution aimed at developing an appropriate physical activity promotion intervention at a local level. The Introduction chapter theoretically legitimate the need to implement new interventions, especially at a local level. In this thesis, we focused our attention on a particular Belgian French-speaking municipality, Esneux, in order to develop a structured and evidence-based physical activity promotion process. The Planned Health Promotion model guided this local approach. The Chapter 1 of our contribution aimed at analysing the local context in terms of physical activity behaviours in the population and opportunities to be physically active in the municipality environment. As observed on a larger scale, the results of this survey exposed that the majority of the participants did not respect the official recommendations for physical activity. Because participants aged 50 years and over were on average less active than younger participants, we developed a local intervention dedicated to seniors in Chapter 2. The purpose of this chapter was to assess the relevance of an original web-based physical activity promotion intervention addressed to older adults. The presented literature review and pilot study highlighted the suitability of such an approach for seniors, on condition that it includes a local perspective and a sufficient social support. The aim of the study presented in Chapter 3 was to compare the long-term effects of three different physical activity promotion interventions’ conditions implemented at the municipality level on physical activity behaviour and knowledge of older adults. Participants took part in a web-based intervention, a group-based intervention or a combined intervention during three months. Leading to significant improvements of the physical activity behaviour, but also of the knowledge about physical activity in general and regarding to the local opportunities, the combined approach could be considered as the most appropriate for a local level dissemination. The study presented in Chapter 4 specified the interest of a local environment-centered approach for physical activity promotion among older adults. This study underlined the mediating role of the perception of the local opportunities to be physically active and of the perception about the quality of the environment for physical activity on the intention-behaviour relationship. In the General discussion, we provide a critical look to each step of our local physical activity promotion approach and suggest potential avenues for future research in the field. [less ▲]

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See detailÉtudes littéraires et jeu vidéo
Barnabé, Fanny ULg; Dozo, Björn-Olav ULg

Scientific conference (2014, December 08)

Quels regards les études littéraires (en tant que "sciences du document") portent-elles sur le jeu vidéo ? Quelles perspectives peuvent-elles apporter aux game studies ? Cette intervention visait à ... [more ▼]

Quels regards les études littéraires (en tant que "sciences du document") portent-elles sur le jeu vidéo ? Quelles perspectives peuvent-elles apporter aux game studies ? Cette intervention visait à décrire ce croisement de disciplines en parcourant trois chantiers de recherche. [less ▲]

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See detailKracauer : Peinture et Wirklichkeit
Barbion, Sébastien ULg

Scientific conference (2014, December 08)

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See detailIntraocular lenses with functionalized surfaces by biomolecules in relation with lens epithelial cell adhesion
Huang, Yi-Shiang ULg

Doctoral thesis (2014)

Posterior Capsular Opacification (PCO) is the capsule fibrosis developed onto the implanted IntraOcular Lens (IOL) by the de-differentiation of Lens Epithelial Cells (LEC) undergoing Epithelial ... [more ▼]

Posterior Capsular Opacification (PCO) is the capsule fibrosis developed onto the implanted IntraOcular Lens (IOL) by the de-differentiation of Lens Epithelial Cells (LEC) undergoing Epithelial-Mesenchymal Transition (EMT). Literature has shown that the incidence of PCO is multifactorial including patient’s age or disease, surgical technique, and IOL design and material. Reports comparing hydrophilic and hydrophobic acrylic IOLs show the former has more severe PCO after EMT transition. Additionally, the LEC adhesion is favored onto the hydrophobic materials compared to the hydrophilic ones. A biomimetic strategy to promote LEC adhesion without de-differentiation to reduce PCO development risk is proposed. RGD peptides, as well as their grafting and quantification methods on a hydrophilic acrylic polymer were investigated. The surface functionalized IOL promoting LEC adhesion via integrin receptors can be used to reconstitute the capsule-LEC-IOL sandwich structure, which is considered to prevent PCO formation in literature. The results show the innovative biomaterial improves LEC adhesion, and also exhibits similar optical (light transmittance, optical bench) and mechanical (haptic compression force, IOL injection force) properties comparing to the starting material. In addition, comparing to the hydrophobic IOL material, this bioactive biomaterial exhibits similar abilities in LEC adhesion, morphology maintenance, and EMT biomarker expression. The in vitro assays suggest this biomaterial has the potential to reduce some risk factors of PCO development. [less ▲]

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See detailOrigines développementales des anomalies de l'homéostasie glucidique, de la croissance osseuse et prédisposition à l'ostéochondrose chez le poulain
Peugnet, Pauline ULg

Doctoral thesis (2014)

Fetal adaptations to intra-uterine stimuli have immediate and long term effects on the offspring’s health after birth. In equids, this concept known as the DOHaD (Developmental Origins of Health and ... [more ▼]

Fetal adaptations to intra-uterine stimuli have immediate and long term effects on the offspring’s health after birth. In equids, this concept known as the DOHaD (Developmental Origins of Health and Disease) was validated using crossbreeding: the mare’s size which affects the fetal environment throughout gestation and then lactation, has a critical impact on the foal’s post-natal growth, as well as on the neonate’s sensitivity to insulin. Osteochondrosis, a pathology of the growing horse, induces heavy financial losses in the equine industry. It has been associated to abnormalities in glucose homeostasis and its antenatal origin is highly suspected. The present research aimed to evaluate the impact of experimental disturbances during fetal development on growth, glucose homeostasis and predisposition to osteochondrosis in the foal until age 1½ year. Increased versus restricted fetal growth was obtained using between-breed embryo transfers (“ponies in draft horses” versus “saddlebreds in ponies”, respectively). The lush environment of the draft mare versus the restricted environment of the pony mare turned out to be critical in the regulation of bone growth, thyroid hormones secretion, β-cells function, insulin sensitivity and the osteoarticular status of the foal from birth to 1½ year of age. This validates the concept of the DOHaD in equids and shows that recipient mares should be carefully selected in embryo transfer practice. By demonstrating the scope of post-natal effects which were programmed in utero and throughout the lactating period, it also alerts the breeder about the importance of broodmare management and its long term impacts. Thus, the second model was developed to address breeders' practices. A disturbance of the nutritional environment of the fetus was induced by supplementing mares in late pregnancy with concentrated feed (barley). So far, only the neonatal foal's glucose homeostasis was affected, whereas all other studied parameters, including growth, were not affected. The foal’s predisposition to osteochondrosis, however, was increased at 6 months of age, which does not preclude that it will affect the animals afterwards since the osteoarticular status of the 6-month-old foal will evolve beyond weaning time. This research could help adjust nutritional recommendations to broodmares. [less ▲]

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