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See detailQuaternary prevention, the art of “primum non nocere”
Jamoulle, Marc ULg

Conference (2017, April 03)

State of the art of the concept of Quaternary prevention

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See detailLe patriotisme économique : nationalisme banal et communauté imaginée
Claisse, Frédéric ULg

Conference (2017, April 03)

Revenant sur les appels à la « fierté collective », au « patriotisme économique » et au « nationalisme d’ouverture » réitérés par les derniers Ministres-Présidents à la tête de la Wallonie, la ... [more ▼]

Revenant sur les appels à la « fierté collective », au « patriotisme économique » et au « nationalisme d’ouverture » réitérés par les derniers Ministres-Présidents à la tête de la Wallonie, la communication s’attache à montrer comment ces tentatives de revitalisation d’un sentiment d’attachement identitaire, tout en relevant des manifestations du « nationalisme banal » (M. Billig), entretiennent le déficit d’imaginaire régional, réduit au développement de la « marque Wallonie » et de sa promotion auprès de ses habitants et des investisseurs. L’insistance sur la seule valeur économique et instrumentale de la communauté, visant à améliorer la compétitivité de la région sur son marché global et intérieur, fait d’autant mieux ressortir, par contraste, la dimension narrative sous-jacente à l’imagination nationaliste, particulièrement mise en évidence dans la nouvelle économie de l’enrichissement (L. Boltanski et A. Esquerre), fondée sur la patrimonialisation et l’exploitation du passé comme gisement de valeur. Du croisement des deux axes ainsi dégagés (nationalisme de faible ou forte intensité ; recours plus ou moins appuyé au storytelling), émerge une conception élargie du nationalisme, qui en fait apparaître de nouvelles modalités et permet d’ouvrir à une autre compréhension de doctrines comme le national-libéralisme ou le projet post-national. Dans la continuité des observations de M. Billig, notre cadre d'analyse structurale tend à faire des mouvements nationalistes (au sens le plus courant du terme dans l’analyse politique) un simple cas particulier parmi d’autres modes de participation plus ordinaires, infra-conscientes et naturalisées, à la communauté nationale. [less ▲]

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See detailThemes related to prevention in the Q-Codes taxonomy. Call to a collaborative exploration into the abstracts of Europrev meetings
Jamoulle, Marc ULg

Conference (2017, April 03)

Background For the documentation of the clinical data, the International Classification of Primary Care (ICPC-2) is used, often in conjunction with the more granular International Classification of ... [more ▼]

Background For the documentation of the clinical data, the International Classification of Primary Care (ICPC-2) is used, often in conjunction with the more granular International Classification of Diseases (ICD). For retrieval of scientific bibliographic information in GP/FM, Medical Subject Headings (MeSH) are used. With over 25,000 available MeSH descriptors, indexing is not easy, and yet not all aspects of the broad field of GM/FM are covered . ICPC-2 has been developed to identify reasons for encounter, symptoms, acts performed or requested and diagnosis in daily practice: It captures clinical encounters for epidemiological research. But, it was not constructed to reflect the non-clinical aspects of the profession, such as organizational, managerial, educational, and investigational aspects. Recently, a new taxonomy of organizational aspect of GM/FM has been developed to ameliorate this situation. The purpose of this development was to provide tools to exploit modern technology in terminology for information storage and retrieval systems , such as machine learning, semantic web techniques and natural language processing (NLP). The 182 concepts identified were thoroughly described in terminology records, which are freely accessible on the web (www.hetop.eu/Q). All concept and definitions were translated into 8 languages and are available online. (http://3cgp.woncaeurope.org). A book is available in 6 languages To develop the Q-codes 1700 abstracts of GP/FM congresses have been carefully analyzed. This has been the basis of the work. As a team of the EGRPN has also analyzed 600 EGPRN abstracts and developed a taxonomy of research, I have this work has been incorporated to update the QR domain. Thus ongoing Q-Codes are based on the analysis of 2300 abstracts The most important fact is that there is a Q-Codes only if the theme has been discussed by physicians during congresses. This is a bottom-up approach which contrast with the expert approach of the authors of textbook The Q-Codes have been integrated with the clinical classification ICPC-2 into a coherent whole, under the name Core Content of General Practice and Family Medicine (3CGP), for further enhancement of medical documentation and indexing of GP/FM master thesis and congress abstracts The value of a taxonomy is determined by the quality and speed of the maintenance and updating process. This will be handled by a working group of the Wonca International Classification Committee (WICC) (www.ph3c.org/Q) already authors of ICPC-2. Aim to present the preventive aspects of the Q-codes, a taxonomy specifically directed to describe the managerial aspects of GP/FM. To make a call to Europrev members to come an board of the Q-codes working group and to help to make more accurate the preventive fields in the Q-Codes taxonomy download abstract below [less ▲]

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See detailStable GPR101 over-Expressing Cell Lines As an Invaluable Tool for Functional Studies, Ligand Screening, and the Identification of Deregulated Genes/Pathways in Patients with X-Linked Acrogigantism
Trivellin, Giampaolo; Janjic, Maria; Larco, Darwin et al

Poster (2017, April 02)

Background: GPR101 is an orphan G protein-coupled receptor (GPCR) that is duplicated in patients with X-linked acrogigantism (X-LAG) and over-expressed in their GH- and PRL-secreting tumors. GPR101 is a ... [more ▼]

Background: GPR101 is an orphan G protein-coupled receptor (GPCR) that is duplicated in patients with X-linked acrogigantism (X-LAG) and over-expressed in their GH- and PRL-secreting tumors. GPR101 is a constitutively active GPCR that strongly activates the cAMP pathway. To elucidate the mechanisms through which GPR101 causes GH over-secretion we generated HEK293 and GH/PRL-secreting (GH3) cells with stable GPR101 expression. Methods: Both cell lines were created via direct integration of a human GPR101-coding sequence into their genome. In HEK293 cells this was achieved by transient transfection of a GPR101-expressing plasmid, while GH3 were transduced with GPR101 lentiviral particles. Cells were selected with appropriate antibiotics and the surviving clones expanded. GPR101 expression was quantified by RT-qPCR and immunofluorescence/western blotting. Cell proliferation (MTT assay), cAMP levels (125I-labeled cAMP tracer), and calcium signaling (FURA 2 AM) were determined. RNA was extracted from both cell lines and subjected to RNA-seq. Differential gene expression between control and GPR101-expressing cells and pathway analysis was carried out with the Stirplate and MetaCore softwares, respectively. De-regulated genes were validated by RT-qPCR. Results: High GPR101 expression was achieved in both cell lines and confirmed at the mRNA and protein level. GPR101-expressing cells proliferated at different rates from the respective controls: GPR101-HEK293 cells were slow-dividing, while GPR101-GH3 divided faster. cAMP production was enhanced in GPR101-GH3 and accompained by increased excitability of cells. Differential expression analysis in HEK293 cells revealed several up-regulated and few down-regulated genes. Among the genes with high expression, several were linked to the cAMP pathway: CGA, PCK1, LINC00473 and PDE3A. Enrichment analysis ranked cytoskeleton remodeling and cell cycle regulation (inhibition of G1/S transition) as the most relevant pathways. In GH3 cells most of the genes with a significantly different expression encoded for membrane-localized proteins, among which were ion channels (Trpm8, Kcnj1), GPCRs (Trhr), and calcium sensors (Syt4, Anxa1). Biological processes associated with these genes are: vesicle transport and fusion, cytoskeleton organization, and energy homeostasis. Conclusions: These results show that the intrinsic activity of GPR101 strongly stimulates cAMP production and this in turn facilitates voltage-gated calcium influx. Changes in cAMP/calcium signaling are accompanied with faster/slower cell division depending on the cell type. Accordingly, several genes associated with these and related pathways are differentially expressed. The establishment of these cell lines will be of paramount importance to validate putative GPR101 ligands and to conduct functional studies. [less ▲]

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See detailFrom parts to whole and back again. The emblem system in the French Jesuit Festivals
De Marco, Rosa ULg

in Höpel, Ingrid; McKeown, Simon (Eds.) Emblems and Impact Volume II Von Zentrum und Peripherie der Emblematik. Selected Proceedings of the 10th International Conference of the Society for Emblem Studies (2017, April 01)

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See detailI viaggi di studio: una risorsa per accompagnare il lavoro educativo
Pirard, Florence ULg

Conference (2017, April 01)

Quand ils sont inscrits dans des dispositifs d’accompagnement organisés en réseau et ancrés dans les pratiques professionnelles, on peut faire l’hypothèse que les voyages d’étude contribuent à une ... [more ▼]

Quand ils sont inscrits dans des dispositifs d’accompagnement organisés en réseau et ancrés dans les pratiques professionnelles, on peut faire l’hypothèse que les voyages d’étude contribuent à une transformation à la fois des acteurs qui découvrent d’autres manières de penser et d’agir et des actions qu’ils sont susceptibles d’améliorer. Ils s’inscrivent dans des dispositifs qui relèvent d’une culture de la professionnalisation et se démarquent d'autres types d'actions formatives inscrites dans les cultures de l'enseignement et de la formation. Ils constituent des opportunités d'apprentissage professionnels en situation informelles. La conférence questionne la place du voyage d’étude dans la formation des professionnel-le-s de l'enfance, les conditions de sa mise en œuvre et les effets observés sur les pratiques professionnelles. [less ▲]

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See detailLa poésie à Liège : d'Izoard et Jacqmin à nos jours
Purnelle, Gérald ULg

Article for general public (2017)

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See detailAsymptotic behavior of regular sequences
Leroy, Julien ULg

Scientific conference (2017, April)

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See detailOut of the ground: two coexisting fossorial toad species differ in their emergence and movement patterns
Székely, Diana ULg; Cogalniceanu, Dan; Székely, Paul et al

in Zoology (2017), 121

Understanding the way species with similar niches can coexist is a challenge in ecology.The niche partitioning hypothesis has received much support, positing that species can exploit available resources ... [more ▼]

Understanding the way species with similar niches can coexist is a challenge in ecology.The niche partitioning hypothesis has received much support, positing that species can exploit available resources in different ways. In the case of secretive species, behavioural mechanisms of partitioning are still poorly understood. This is especially true for fossorial frogs because individuals hide underground by day and are active only during the night. We investigated the nocturnal activity and tested the niche partitioning hypothesis in two syntopic fossorial spadefoot toads (Pelobates fuscus and P. syriacus) by examining interspecific variation in emergence from the soil. We employed a night vision recording system combined with video-tracking analyses in a replicated laboratory setting to quantify individual movement patterns, a procedure that has not been used until now to observe terrestrial amphibians. Most individuals appeared on the surface every night and returned to their original burrow (about 60% of the times), or dug a new one around morning. There was a large temporal overlap between the two species. However, P. syriacus was significantly more active than P. fuscus in terms of total distance covered and time spent moving, while P. fuscus individuals left their underground burrow more frequently than P. syriacus. Consequently, P. fuscus adopted more of a sit-and-wait behaviour compared to P. syriacus, and this could facilitate their coexistence. The use of night video-tracking technologies offered the advantage of individually tracking these secretive organisms during their nocturnal activity period and getting fine-grain data to understand their movement patterns. [less ▲]

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See detailSignification et notification en Europe Entre efficacité et droits de la défense
Wautelet, Patrick ULg

Conference (2017, April)

Cette présentation a comme objectif d'offrir un aperçu de la jurisprudence de la Cour de justice relative au Règlement 1393/2007

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See detailInterest of creatine supplementation insoccer
Miny, Kevin ULg; Burrowes, J; Jidovtseff, Boris ULg

in Science & Sports (2017), 32(2), 61-72

Objectives This review article aimed to summarize the current state of understanding on creatine supplementation for soccer players. In other words, it investigated the beneficial (and potentially ... [more ▼]

Objectives This review article aimed to summarize the current state of understanding on creatine supplementation for soccer players. In other words, it investigated the beneficial (and potentially negative) effects of this supplementation on sport-specific skills and performance in soccer players. Furthermore, this article accordingly discussed the safest and most recommended protocols for the consumption of creatine by these athletes. News Studies have shown that creatine supplementation can have positive effects on sprint and vertical jump performances in soccer players. This supplementation may also enhance soccer players’ muscle strength and adaptation to a high-intensity training regimen. Besides, creatine may be able to enhance muscle glycogen (as well as phosphocreatine) storage, reduce oxidative stress, and improve muscular repair and hypertrophy. Interestingly, creatine supplementation does not seem to affect aerobic performance. Prospects and projects Soccer players could take creatine during pre-season training (3 to 5g/day) in order to help them endure a high-intensity training regimen and enhance their muscular strength and adaptation resulting from strength and/or resistance training. A lower dosage (less than 3g/day) might also be sufficient and beneficial during the season in case of fatigue, in order to sustain adequate levels of phosphocreatine and glycogen in the muscles. Occasional intakes (about 3g) before games and/or extenuating practices could also give a physical and mental boost to the players. Conclusion Most of the studies measured the effects of creatine on skills or physical performances in isolation from the true athletic demands of soccer match play. In conclusion, there is still a need for more research in order to determine whether creatine supplementation is ergogenic regarding the (aerobic) capacity to repeat (very) high-intensity actions, more particularly during competitive soccer. [less ▲]

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See detailImpact of tillage on greenhouse gas emissions by an agricultural crop and dynamics of N2O fluxes: Insights from automated closed chamber measurements
Lognoul, Margaux ULg; Theodorakopoulos, Nicolas ULg; Hiel, Marie-Pierre ULg et al

in Soil & Tillage Research (2017), 167

Our experiment aimed at studying the impact of long term tillage treatments – reduced tillage (RT) and conventional tillage (CT), on CO2 and N2O emissions by soil and at describing the dynamics of N2O ... [more ▼]

Our experiment aimed at studying the impact of long term tillage treatments – reduced tillage (RT) and conventional tillage (CT), on CO2 and N2O emissions by soil and at describing the dynamics of N2O fluxes. Gas measurements were performed from June to October 2015 in a Belgian maize crop, with homemade automated closed chambers, allowing continuous measurement at a high temporal resolution. After 7 years of treatment, CO2 and N2O average emissions were significantly larger in the RT parcel than in the CT parcel. This observation was attributed to the effect of tillage on the distribution of crop residues within the soil profile, leading to higher soil organic C and total N contents and a greater microbial biomass in the upper layer in RT. A single N2O emission peak triggered by a sudden increase of water- filled pore space (WFPS) was observed in the beginning of the measuring campaign. The absence of large emission afterwards was most likely due to a decreasing availability of N as crop grew. N2O background fluxes showed to be significantly correlated to CO2 fluxes but not to WFPS, while the influence of soil temperature remained unclear. Our results question the suitability of reduced tillage as a “climate-smart” practice and suggest that more experiments be conducted on conservation practices and their potent negative effect on environment. [less ▲]

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See detailAn investigation into the fraction of particle accelerators among colliding-wind binaries. Towards an extension of the catalogue
De Becker, Michaël ULg; Benaglia, Paula; Romero, Gustavo E. et al

in Astronomy and Astrophysics (2017), 600

Particle-accelerating colliding-wind binaries (PACWBs) are multiple systems made of early-type stars able to accelerate particles up to relativistic velocities. The relativistic particles can interact ... [more ▼]

Particle-accelerating colliding-wind binaries (PACWBs) are multiple systems made of early-type stars able to accelerate particles up to relativistic velocities. The relativistic particles can interact with different fields (magnetic or radiation) in the colliding-wind region and produce non-thermal emission. In many cases, non-thermal synchrotron radiation might be observable and thus constitute an indicator of the existence of a relativistic particle population in these multiple systems. To date, the catalogue of PACWBs includes about 40 objects spread over many stellar types and evolutionary stages, with no clear trend pointing to privileged subclasses of objects likely to accelerate particles. This paper aims at discussing critically some criteria for selecting new candidates among massive binaries. The subsequent search for non-thermal radiation in these objects is expected to lead to new detections of particle accelerators. On the basis of this discussion, some broad ideas for observation strategies are formulated. At this stage of the investigation of PACWBs, there is no clear reason to consider particle acceleration in massive binaries as an anomaly or even as a rare phenomenon. We therefore consider that several PACWBs will be detected in the forthcoming years, essentially using sensitive radio interferometers which are capable of measuring synchrotron emission from colliding-wind binaries. Prospects for high-energy detections are also briefly addressed. [less ▲]

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See detailLes retardateurs de flamme bromés : impact sur l'environnement et la santé des individus exposés
Dufour, Patrice ULg; Charlier, Corinne ULg

in Annales de Biologie Clinique (2017), 75(2), 146-157

Depuis l’antiquité, l’homme utilise des moyens chimiques pour protéger ses biens des incendies. Efficaces et faciles d’emploi, les retardateurs de flamme bromés sont utilisés depuis plusieurs décennies de ... [more ▼]

Depuis l’antiquité, l’homme utilise des moyens chimiques pour protéger ses biens des incendies. Efficaces et faciles d’emploi, les retardateurs de flamme bromés sont utilisés depuis plusieurs décennies de façon massive dans l’industrie du plastique. À l’instar d’autres composés organohalogénés, les retardateurs de flamme bromés sont très persistants dans l’environnement et capables de s’accumuler le long de la chaîne alimentaire. De nombreux auteurs ont mis en évidence leur présence dans notre environnement, chez différentes espèces animales mais également dans le sérum humain. Plus inquiétant encore, l’homme est exposé à ces polluants dès la grossesse et par la suite via le lait maternel. Cette exposition pourrait avoir des conséquences sur notre santé. De nombreuses études in vitro, in vivo ou épidémiologiques ont mis en lumière une influence néfaste des retardateurs de flamme bromés sur notre système endocrinien, principalement au niveau de la fonction thyroïdienne mais également de la reproduction, du neurodéveloppement chez l’enfant et du métabolisme avec un risque accru de développer un diabète. Si une certaine prise de conscience a déjà eu lieu au niveau des autorités et de certaines grandes entreprises, de nouvelles études sont nécessaires pour confirmer les tendances déjà dégagées, élucider les mécanismes sous-jacents et déterminer s’il existe des synergies avec d’autres polluants tels que par exemple les PCB. [less ▲]

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See detailBien raisonner en TSUM (Transition Secondaire-Université en Mathématiques)
Bair, Jacques ULg

E-print/Working paper (2017)

Bien raisonner est assurément une des compétences clés que doivent acquérir et développer les étudiants entrant à l’Université. Nous y consacrons entièrement ce travail illustré par de nombreux exemples ... [more ▼]

Bien raisonner est assurément une des compétences clés que doivent acquérir et développer les étudiants entrant à l’Université. Nous y consacrons entièrement ce travail illustré par de nombreux exemples construits à partir de notre expérience professionnelle. En premier lieu, nous distinguons, à la suite de G. Polya, les raisonnements plausibles des raisonnements démonstratifs. Ensuite, nous nous intéressons à certains éléments de logique qui nous paraissent importants au niveau d’une TSUM. Puis, nous analysons la nature de preuves mathématiques à ce stade de l’apprentissage. Enfin, nous dissertons quelque peu sur l’usage des démonstrations dans l’enseignement. Ce travail se termine par deux annexes techniques, relatives respectivement à différents types de syllogismes et à quelques éléments plus formels de logique mathématique. [less ▲]

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See detailétude sur l'intolérance à l'incertitude et ses biais cognitifs chez les parents d'un enfant en rémission d'un cancer
Vander Haegen, Marie ULg; Etienne, Anne-Marie ULg; Piette, Caroline

in Revue Médicale de Liège (2017), 72

Résumé : Les études en oncologie pédiatrique décrivent une relativement bonne qualité de vie chez les enfants survivants de cancer. À ce jour, peu d’études se sont intéressées aux parents d’un enfant ... [more ▼]

Résumé : Les études en oncologie pédiatrique décrivent une relativement bonne qualité de vie chez les enfants survivants de cancer. À ce jour, peu d’études se sont intéressées aux parents d’un enfant survivant de cancer. Soixante-et-un parents sont recrutés dans les hôpitaux belges. Trois groupes de parents sont constitués : les parents dont l’enfant est à 4 ans de rémission (groupe 1), à 5 ans de rémission (groupe 2) et à 6 ans de rémission (groupe 3). Des échelles cliniques et une tâche de Stroop émotion sont administrées. Les parents (des 3 groupes) présentent une faible tolérance à l’incertitude, ont des inquiétudes excessives quant à l’évolution de la santé de leur enfant et souffrent de symptômes anxieux. Le Stroop émotion révèle un biais cognitif de l’attention en faveur des stimuli de nature menaçante. L’étude met en exergue l’importance de détecter les parents intolérants à l’incertitude lors du diagnostic d’annonce du cancer et leur suivi psychologique continu une fois les traitements terminés. [less ▲]

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