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See detailEnergy assessment of suburban neighborhoods : insights from Wallonia and perspectives for a suburban renewal
Marique, Anne-Françoise ULg

Conference (2017, April 12)

The aim of the paper is to present a method to assess the energy efficiency of suburban areas, taking into account both energy efficiency of buildings and the impacts of location and urban form on the ... [more ▼]

The aim of the paper is to present a method to assess the energy efficiency of suburban areas, taking into account both energy efficiency of buildings and the impacts of location and urban form on the energy balance of suburban areas. The method is applied to the Walloon region of Belgium and perspectives for a sustainable suburban renewal are proposed. [less ▲]

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See detailAzacytidine prevents experimental xenogeneic graft-versus-host disease without abrogating graft-versus-leukemia effects
Ehx, Grégory ULg; Fransolet, Gilles ULg; De Leval, Laurence et al

in Oncoimmunology (2017)

The demethylating agent 5-azacytidine (AZA) has proven its efficacy as treatment for myelodysplastic syndrome and acute myeloid leukemia. In addition, AZA can demethylate FOXP3 intron 1 (FOXP3i1) leading ... [more ▼]

The demethylating agent 5-azacytidine (AZA) has proven its efficacy as treatment for myelodysplastic syndrome and acute myeloid leukemia. In addition, AZA can demethylate FOXP3 intron 1 (FOXP3i1) leading to the generation of regulatory T cells (Treg). Here, we investigated the impact of AZA on xenogeneic graft-versus-host disease (xGVHD) and graft-versus-leukemia effects in a humanized murine model of transplantation (human PBMCs-infused NSG mice), and described the impact of the drug on human T cells in vivo. We observed that AZA improved both survival and xGVHD scores. Further, AZA significantly decreased human T-cell proliferation as well as IFN-γ and TNF-α serum levels, and reduced the expression of GRANZYME B and PERFORIN 1 by cytotoxic T cells. In addition, AZA significantly increased Treg frequency through hypomethylation of FOXP3i1 as well as increased Treg proliferation. The later was subsequent to higher STAT5 signaling in Treg from AZA-treated mice, which resulted from higher IL-2 secretion by conventional T cells from AZA-treated mice itself secondary to demethylation of the IL-2 gene promoter by AZA. Importantly, Tregs harvested from AZA-treated mice were suppressive and stable over time since they persisted at high frequency in secondary transplant experiments. Finally, graft-versus-leukemia effects (assessed by growth inhibition of THP-1 cells, transfected to express the luciferase gene) were not abrogated by AZA. In summary, our data demonstrate that AZA prevents xGVHD without abrogating graft-versus-leukemia effects. These findings could serve of basis for further studies of GVHD prevention by AZA in acute myeloid leukemia patients offered an allogeneic transplantation. [less ▲]

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See detailDocking and molecular dynamics simulations of the Fyn-SH3 domain with free and phospholipid bilayer-associated 18.5-kDa myelin basic protein (MBP) – Insights into a non-canonical and fuzzy interaction
Bessonov, Kyrylo ULg; Harauz, George; Vassall, Kenrick

in Proteins (2017)

The molecular details of the association between the human Fyn-SH3 domain, and the fragment of 18.5-kDa myelin basic protein (MBP) spanning residues S38–S107 (denoted as xα2-peptide, murine sequence ... [more ▼]

The molecular details of the association between the human Fyn-SH3 domain, and the fragment of 18.5-kDa myelin basic protein (MBP) spanning residues S38–S107 (denoted as xα2-peptide, murine sequence numbering), were studied in silico via docking and molecular dynamics over 50-ns trajectories. The results show that interaction between the two proteins is energetically favorable and heavily-dependent on the MBP proline-rich region (P93-P98) in both aqueous and membrane environments. In aqueous conditions, the xα2-peptide/Fyn-SH3 complex adopts a “sandwich”-like structure. In the membrane context, the xα2-peptide interacts with the Fyn-SH3 domain via the proline-rich region and the β-sheets of Fyn-SH3, with the latter wrapping around the proline-rich region in a form of a clip. Moreover, the simulations corroborate prior experimental evidence of the importance of upstream segments beyond the canonical SH3-ligand. This study thus provides a more-detailed glimpse into the context-dependent interaction dynamics and importance of the β-sheets in Fyn-SH3 and proline-rich region of MBP. [less ▲]

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See detailParacervix Parametrium
Bonnet, Pierre ULg

Scientific conference (2017, April 11)

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See detailQuaternary prevention library and resources (QP library)
Pizzanelli, Miguel; Lavalle, Ricardo; Jamoulle, Marc ULg

Learning material (2017)

Collaborative Database on Quaternary Prevention Resources and References. Base de datos colaborativa de recursos y referencias bibliográficas sobre Prevención Cuaternaria. Base de Dados Colaborativa de ... [more ▼]

Collaborative Database on Quaternary Prevention Resources and References. Base de datos colaborativa de recursos y referencias bibliográficas sobre Prevención Cuaternaria. Base de Dados Colaborativa de Recursos e Referências sobre Prevenção Quaternária. Réseau collaboratif de ressources et de références en matière de Prévention du Quaternaire [less ▲]

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See detailThe role of natural hazards and human activities on change of sedimentation patterns: The case of Lake Yamanaka (Fuji Five Lakes, Japan)
Lamair, Laura ULg; Hubert, Aurelia ULg; El Ouahabi, Meriam ULg et al

Conference (2017, April 10)

The last eruption of Mt Fuji (Japan) occurred in A.D. 1707. The eruption lasted 16 days from 16 December 1707 to 1 January 1708 (Tsuya, 1955) and 1.8 km3 of volcanic materials were ejected in total ... [more ▼]

The last eruption of Mt Fuji (Japan) occurred in A.D. 1707. The eruption lasted 16 days from 16 December 1707 to 1 January 1708 (Tsuya, 1955) and 1.8 km3 of volcanic materials were ejected in total (Miyaji et al., 2011). Lake Yamanaka, a very shallow lake (max. 14. 3 m depth) located at the foot of the east-north-eastern flank of Mt Fuji, was heavily impacted by the eruption. A thick scoria layer entirely covered the catchment of Lake Yamanaka. The thickness of the deposit varies from 5 to 37 cm around Lake Yamanaka and reaches up to 149 cm at the south-west extremity of the catchment (Miyaji et al., 2011). In order to study the influence of Hoei eruption on Lake Yamanaka, 5 gravity cores were taken during the 2014 QuakeRecNankai campaign. The Hoei scoria was present at the bottom of the one core and in the core catcher of the four other cores. High resolution magnetic susceptibility, XRD, XRF, LOI, C/N and 210Pb/137Cs analyses were performed on the gravity cores. The results shows three distinct periods of sedimentation: (1) From Hoei eruption to A.D. 1900; (2) From A.D. 1900 to A.D. 1990; (3) From A.D. 1990 to A.D. 2014. The first period is characterized by a very low sedimentation rate (~0.07 cm/yr). During this period, the sediments of the catchment were trapped below the thick Hoei scoria layer. However, peaks of terrigenous input are recorded. We link such detrical signals with violent typhoons that hit the Fuji Five Lakes region. The water from the heavy rains percolated through the porous thick scoria layer and saturated it. As a result, surface runoffs carried the sediments from the catchment into Lake Yamanaka. The second period (from A.D. 1900 to A.D. 1990) is defined by an increase of the sedimentation rate (~0.16 cm/yr). The development of soil and the agriculture (e.g. pastureland, rice field, mulberry plantations) reduced the impact of Hoei scoria. The terrigenous inputs are higher than previously but remained more or less constant during this period of time. As the thickness of the scoria layer is partially reduced or covered by new soil, rains triggered by smaller typhoons could drain the sediments from watershed and transport them into the lake. The most recent period representing the last 27 years is characterized by a very high sedimentation rate (~1.036 cm/yr). The transition between period 2 and period 3 corresponds to the development of mass tourism and the urbanization around Lake Yamanaka. It is marked by an increasing of atmospheric pollution (Pb, Zn). In the upper part of the cores, a peak of 137Cs is observed. Such peak is related to cesium fall-out after Fukushima incident in 2011. In addition to the fingerprint of human impact, the lake also record a terrigenous signal related to the 2007 Fitow typhoon which provoked damage in the area. This study highlights the influence of eruptions and typhoons on the sedimentation of Lake Yamanaka. In the present day, the sedimentation recovery after a major eruption is accelerated by human activity. References: Miyaji N., Kan'no A., Kanamaru T., Mannen K. 2011. High-resolution reconstruction of the Hoei eruption (AD 1707) of Fuji volcano, Japan. Journal of Volcanology and Geothermal Research 207, 113–129. Tsuya, H. 1955. Geological and petrological studies of volcano, Fuji, V.: 5. on the 1707 eruption of Volcano Fuji. Bulletin of the Earthquake Research Institute 33, 341–383. [less ▲]

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See detailPelvic anatomy, a constructive approach
Bonnet, Pierre ULg

Scientific conference (2017, April 10)

Detailed reference viewed: 12 (1 ULg)
See detailPelvic ureter
Bonnet, Pierre ULg

Scientific conference (2017, April 10)

Detailed reference viewed: 8 (1 ULg)
See detailTopographic anatomy of the pelvic vessels
Bonnet, Pierre ULg

Scientific conference (2017, April 10)

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See detailTowards Knowledge management in General Practice & Family Medicine; Guide to the indexing of master thesis.
Jamoulle, Marc ULg

Learning material (2017)

The Francophone Coordination Center for Training in General Practice (CCFFMG) (www.ccffmg.be)(French) is in charge of organizing the public release of the End-of-Study works (Master thesis) in General ... [more ▼]

The Francophone Coordination Center for Training in General Practice (CCFFMG) (www.ccffmg.be)(French) is in charge of organizing the public release of the End-of-Study works (Master thesis) in General Practice/Family Medicine (GP/FM) . This work is carried out at the end of the Master of Specialty of the Departments of General Practice of the Free University of Brussels (ULB), the Catholic University of Louvain (UCL) and the University of Liège (ULg). A dedicated website (www.mgtfe.be) offers an online copywriting guide. This site provides also a description and instruction manual for a GP/FM indexing system discussed in this document. This experimental system, based on the assembly of the International Classification of Primary Care, second version (ICPC-2), and a new contextual classification called Q-Codes version 2.5 is intended to help the manual indexation of the Master Thesis. The package, called Core Content Classification in GP/FM (3CGP), is now available in 8 languages (en-fr-nl-es-pt-vi-ko-tr) on the multilingual web site of Department of Medical Information and Medical Informatics (B2IM) of the University of Rouen (www.hetop.eu/q) together with a companion site (http://3cgp.woncaeurope.org) (in English). Family physician will be asked to choose a number of proposed codes to index their jobs at the time of online filing. The publishing site will be equipped with a search module based on the 3CGP indexing system. An evaluation of the system of indexing by the users is organized. [less ▲]

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See detailRevista "Esfera pública discursiva"
Becerra Mayor, David ULg

in Esfera pública discursiva (2017), 1

Número 1 de la revista de crítica e información literaria realizada por las y los estudiantes de "Stylistique et critique de l’espagnol moderne" del curso 2016-2017, de la Université de Liège.

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See detailLe sens de la vue et le sens de la marche. Déambulation et signification dans l'œuvre de Marc-Antoine Mathieu
Belloi, Livio ULg

Conference (2017, April 08)

Dans la foulée de l'ouvrage publié par Ian Hague ("Comics and the Senses", Routledge, 2014), cette conférence aborde la double question du sens et des sens dans le domaine de la bande dessinée ... [more ▼]

Dans la foulée de l'ouvrage publié par Ian Hague ("Comics and the Senses", Routledge, 2014), cette conférence aborde la double question du sens et des sens dans le domaine de la bande dessinée contemporaine, en se concentrant d'abord sur l'œuvre de Marc-Antoine Mathieu. Chemin faisant, l'œuvre de Mathieu se voit mise en regard avec "La Différence invisible" (2016) de Julie Dachez et Mademoiselle Caroline. [less ▲]

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See detailModellierung der chemischen Kinetik. Entwicklung eines Verständnisses auf molekularer Ebene anhand gezielter Versuche
Nihant, Brigitte ULg; Karous, Hamad ULg; Leyh, Bernard ULg

Conference (2017, April 08)

Damit die Lernenden als zukünftige verantwortliche Bürger eine authentische Vision der Wissenschaft und ihrer Grenzen gewinnen, heben die Rahmen- und Lehrpläne immer mehr die Notwendigkeit hervor, sie mit ... [more ▼]

Damit die Lernenden als zukünftige verantwortliche Bürger eine authentische Vision der Wissenschaft und ihrer Grenzen gewinnen, heben die Rahmen- und Lehrpläne immer mehr die Notwendigkeit hervor, sie mit wissenschaftlichen Modellen und derer Erarbeitung vertraulich zu machen. Die chemische Kinetik bietet einen günstigen Rahmen, solche Modellierungskompetenzen zu fördern. Das didaktische Ziel kann wie folgt zusammengefasst werden: Eine chemische Reaktion als das Resultat wirksamer Stöße zwischen Molekülen beschreiben, um den Einfluss verschiedener experimenteller Faktoren auf die Reaktionsgeschwindigkeit zu erklären. Dies verlangt eine Modellierung, bei der die vier Ebenen (empirisch, makroskopisch, symbolisch, mikroskopisch) des didaktischen Tetraeders von Kermen und Méheut (2009) (Chemistry Education Research and Practice, 10, 24-34) erörtert werden. In diesem Vortrag werden verschiedene Aktivitäten (z.B. Versuche über molekulare Diffusion, Einführung des Begriffes des Übergangszustandes anhand angepasster, selbstgebauter Molekülmodelle) präsentiert und didaktisch ausgewertet. Großes Gewicht wird darauf gelegt, dass die Lernenden sich der erklärenden Rolle der Modelle bewusst werden, dass ihre Autonomie gefördert wird, indem der Schwierigkeitsgrad der sogenannten Zone der nächsten Entwicklung (Wygotski) entspricht, und dass das vorgestellte didaktische Modellierungsverfahren die Denkweise der Wissenschaftler reflektiert. [less ▲]

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See detailL'excuse est devenue une arme en politique
Grandjean, Geoffrey ULg

Article for general public (2017)

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See detailOptimization of houseflies’ larvae production on pig wastes and brewers’ grains for integrated fish and pig farms in the tropics
Mafwila Kinkela, Patrick ULg; BWABWA, Denis; Kambashi Mutiaka, Bienvenu ULg et al

Conference (2017, April 07)

Improved maggot production of flies in integrated farm by farmers , using available by-product, on-farm wastes and agricultural stored wet can be an opportunity to provide an important additional source ... [more ▼]

Improved maggot production of flies in integrated farm by farmers , using available by-product, on-farm wastes and agricultural stored wet can be an opportunity to provide an important additional source of high quality protein and can intensify fish production. [less ▲]

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See detailEffects of various design parameters on system-level fire fragility functions for steel buildings
Elhami Khorasani, Negar; Gernay, Thomas ULg; Garlock, Maria

Conference (2017, April 07)

The existing literature in fire engineering is mostly based on single component study of structures, as opposed to system level building performance. In current practice, fire does not need to be ... [more ▼]

The existing literature in fire engineering is mostly based on single component study of structures, as opposed to system level building performance. In current practice, fire does not need to be considered as part of the structural design of the building. The required fire protection for steel components in a building is based on prescriptive design guidelines, which are based on standard fire tests on individual structural members. In addition, the fire-structure engineering has primary focused on deterministic analysis, while the field is moving towards performance-based design in recent years. Meanwhile, the scenarios leading to a fire event and the performance of the structure at elevated temperatures involve a great level of uncertainty. This work focuses on fire-structure interaction with the objective of developing fire fragility functions that capture fire damage uncertainty for the entire building (i.e., at the system-level). A fragility function provides the probability of exceeding a damage state for a given intensity measure of a given hazard. Fire fragility functions can be developed to measure the expected losses based on performance of a building structural system, rather than a single component. Different functions can be developed for buildings with different typologies (e.g. high-rise steel building with moment resisting frame, low rise steel building with bracing). This presentation derives fragility functions based on stochastic analyses of prototype buildings. In developing the fragility functions, uncertainties in the fire model, the heat transfer model and the thermo-mechanical response should be considered; but such a large number of random variables adds to the complexity of analysis and the computational time. Based on a sensitivity analysis for steel gravity frames, this work identifies the most important input parameters to be considered as random variables when developing fire fragility functions for an entire building. The sensitivity analysis for a multi-story steel building prototype is completed considering uncertainties at the compartment and building levels. At the compartment level, uncertainty in the fire scenario, compartment geometry, applied load, thermal and mechanical properties of steel and insulating materials are considered. At the building level, the influence of fire-resistance rating, building height, and occupancy type are studied. The results of this study identify the local and global parameters needed as part of deriving system-level fire fragility functions for a steel building. [less ▲]

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See detailMapping the impact of research-by-design : paths cleared by architectural experimentation
Joachim, Guillaume ULg

Conference (2017, April 07)

This paper aims at building a critical reflection on the valuation of design experimentation in architectural research and its impact on knowledge production. These considerations are rooted in the ... [more ▼]

This paper aims at building a critical reflection on the valuation of design experimentation in architectural research and its impact on knowledge production. These considerations are rooted in the observation of a hybrid and prospective research experience led at the University of Liège (Revisiting the apartment building 2015-2016), combining documentary research, field investigation, and a research-by-design international design studio gathering 40 architects and students in architecture. We first position the essay on the issue of harnessing design activity for the benefit of architectural research. Secondly we report on the investigation observed and the distinct knowledge production modalities involved in the project. The particular implication of the act of designing is highlighted, among other steps of the investigation, and we put forward some characteristic features of the research process. We particularly consider the different design techniques, tools and representational processes involved in four distinct architectural experimentations and their impact in the emergence of design strategies or spatial interventions. We finally open a discussion on the questions raised by the valuation of these proposals in the research, and stress the inherent tension between opening new perspectives and redefining the scope of inquiry. [less ▲]

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See detailComputerized adaptive testing: Principles, issues and implementation
Magis, David ULg

Scientific conference (2017, April 07)

Computerized adaptive testing (CAT) has become an important field of research for educational and psychological measurement. It provides tailored testing at the test taker level, focusing on the optimal ... [more ▼]

Computerized adaptive testing (CAT) has become an important field of research for educational and psychological measurement. It provides tailored testing at the test taker level, focusing on the optimal administration of the items to improve accuracy and precision in individual ability estimation. Yet, practical implementation of CAT programs are still demanding both in terms of item bank creation and calibration, and require appropriate online platforms and suitable algorithms for underlying psychometric computations. The purpose of this workshop is twofold: (a) to briefly introduce the concepts of item response theory (IRT) and CAT in a practical, end-user approach; (b) to present a package of the R software, called catR, that performs all underlying IRT- and CAT-related calculations. This package is also adequate to perform simulation studies, which are most useful to assess the quality of an item and help in designing efficient CATs. Some live demonstrations of catR will be proposed to conclude the workshop. participants are invited to bring their laptops with R and RStudio software pre-installed. Electronic copies of the presentation and an R script with the code for illustrative examples will be provided. [less ▲]

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See detailPhenomenological Analysis of Existentialist Novels: Body, Emotion, Perception
Franck, Thomas ULg

Conference (2017, April 07)

Detailed reference viewed: 40 (2 ULg)