Last 7 days
Bookmark and Share    
Full Text
Peer Reviewed
See detailPaleomagnetic and geochemical record from cores from the Sea of Marmara, Turkey: Age constraints and implications of sapropelic deposition on early diagenesis
Drab, Laureen; Carlut, Julie; Hubert, Aurelia ULg et al

in Marine Geology (2015), 360

We present results of a multi-proxy analysis of two sediment cores from the Marmara Sea. The cores were ana- lyzed using paleomagnetic and geochemical measurements. Two sapropels are documented in the ... [more ▼]

We present results of a multi-proxy analysis of two sediment cores from the Marmara Sea. The cores were ana- lyzed using paleomagnetic and geochemical measurements. Two sapropels are documented in the last 11 kyr and are recorded in several locations across the Marmara Sea. These two sapropels have contrasting magnetic prop- erties. The magnetic record is affected by intense early diagenesis; the most recent upper sapropelic layer has low remanence and susceptibility values. A record of paleomagnetic inclinations could still be isolated above the dia- genesis front and is compared with secular variation models. The lower sapropel is identified in the deep part of the oldest studied core (Klg07) and has distinct magnetic properties characterized by high remanence and sus- ceptibility values. Using the magnetic properties it is possible to constrain bottom water ventilation and recon- nection episodes between the Marmara Sea and the Black Sea following the sea level rise during the last glacial to inter-glacial transition. [less ▲]

Detailed reference viewed: 3 (2 ULg)
Full Text
Peer Reviewed
See detailCost-effectiveness of vitamin D and calcium supplementation in the treatment of elderly women and men with osteoporosis.
Hiligsmann, Mickaël ULg; Ben Sedrine, Wafa; Bruyère, Olivier ULg et al

in European journal of public health (2015), 25(1), 20-25

BACKGROUND: The supplementation with vitamin D and calcium has been recommended for elderly, specifically those with increased risk of fractures older than 65 years. This study aims to assess the cost ... [more ▼]

BACKGROUND: The supplementation with vitamin D and calcium has been recommended for elderly, specifically those with increased risk of fractures older than 65 years. This study aims to assess the cost-effectiveness of vitamin D and calcium supplementation in elderly women and men with osteoporosis and therefore to assess if this recommendation is justified in terms of cost-effectiveness. METHODS: A validated model for economic evaluations in osteoporosis was used to estimate the cost per quality-adjusted life-year (QALY) gained of vitamin D/calcium supplementation compared with no treatment. The model was populated with cost and epidemiological data from a Belgian health-care perspective. Analyses were conducted in women and men with a diagnosis of osteoporosis (i.e. bone mineral density T-score </=-2.5). A literature search was conducted to describe the efficacy of vitamin D and calcium in terms of fracture risk reduction. RESULTS: The cost per QALY gained of vitamin D/calcium supplementation was estimated at euro40 578 and euro23 477 in women and men aged 60 years, respectively. These values decreased to euro7912 and euro10 250 at the age of 70 years and vitamin D and calcium supplementation was cost-saving at the age of 80 years, meaning that treatment cost was less than the costs of treating osteoporotic fractures of the no-treatment group. CONCLUSION: This study suggests that vitamin D and calcium supplementation is cost-effective for women and men with osteoporosis aged over 60 years. From an economic perspective, vitamin D and calcium should therefore be administrated in these populations including those also taking other osteoporotic treatments. [less ▲]

Detailed reference viewed: 26 (11 ULg)
Full Text
Peer Reviewed
See detailLes difficultés d'apprentissage procédural chez les enfants dysphasiques
Desmottes, Lise ULg; Meulemans, Thierry ULg; Maillart, Christelle ULg

in ANAE : Approche Neuropsychologique des Apprentissages chez l'Enfant (2015)

Through a review of the literature, this paper shows that linguistic and non-linguistic disorders in children with specific language impairment might be linked to difficulties in procedural learning ... [more ▼]

Through a review of the literature, this paper shows that linguistic and non-linguistic disorders in children with specific language impairment might be linked to difficulties in procedural learning, especially regarding sequential abilities. Indeed, children with specific language impairment encounter difficulties to learn visuo-motor and linguistic sequences. These difficulties are not limited to initial learning but extend to the consolidation stage in long-term memory. Finally, recent studies show that it is possible to improve procedural learning abilities, suggesting new avenues for rehabilitation. [less ▲]

Detailed reference viewed: 6 (0 ULg)
Full Text
Peer Reviewed
See detailEstetrol is a weak estrogen antagonizing estradiol-dependent mammary gland proliferation.
Gérard, Céline ULg; Blacher, Silvia ULg; Communal, Laudine et al

in Journal of Endocrinology (2015), 224(1), 86-95

Estetrol (E4) is a natural estrogen produced exclusively by the human fetal liver during pregnancy. Its physiological activity remains unknown. In contrast to ethinyl estradiol (EE) and estradiol (E2), E4 ... [more ▼]

Estetrol (E4) is a natural estrogen produced exclusively by the human fetal liver during pregnancy. Its physiological activity remains unknown. In contrast to ethinyl estradiol (EE) and estradiol (E2), E4 has a minimal impact on liver cells activity and could provide a better safety profile in contraception or hormone therapy. The aim of this study was to delineate if E4 exhibits an activity profile distinct from that of E2 on mammary gland. Compared to E2, E4 acted as a low affinity estrogen in both, human in vitro and murine in vivo, models. E4 was 100 times less potent than E2 to stimulate the proliferation of human breast epithelial (HBE) cells and murine mammary gland in vitro and in vivo, respectively. This effect was prevented by fulvestrant and by tamoxifen supporting the notion that ERalpha is the main mediator of the estrogenic effect of E4 on the breast. Interestingly, when E4 was administered along with E2, it significantly antagonized the strong stimulatory effect of E2 on HBE cells proliferation and on the growth of mammary ducts. This study characterizes for the first time the impact of E4 on mammary gland. Our results highlight that E4 is less potent than E2 and exhibits antagonistic properties towards the proliferative effect of E2 on breast epithelial cells. These data support E4 as a potential new estrogen for clinical use with a reduced impact on breast proliferation. [less ▲]

Detailed reference viewed: 14 (7 ULg)
Full Text
Peer Reviewed
See detailRestoring testosterone levels by adding dehydroepiandrosterone to a drospirenone containing combined oral contraceptive: I. Endocrine effects.
Zimmerman, Y.; Foidart, Jean-Michel ULg; Pintiaux, Axelle ULg et al

in Contraception (2015), 91(2), 127-33

OBJECTIVES: Combined oral contraceptives (COCs) decrease testosterone (T) levels. This study investigated restoration of T and other androgen concentrations during COC use by 'co-administration' of ... [more ▼]

OBJECTIVES: Combined oral contraceptives (COCs) decrease testosterone (T) levels. This study investigated restoration of T and other androgen concentrations during COC use by 'co-administration' of dehydroepiandrosterone (DHEA). STUDY DESIGN: In this randomized, double-blind, placebo-controlled study in 99 new COC starters (18-35 years old with body mass index range 18-34kg/m(2)), a COC containing 30mcg ethinylestradiol (EE) and 3mg drospirenone (DRSP) was used for 3cycles, followed by 6cycles of the same COC combined with either 50mg/day DHEA or placebo. Total T, albumin, sex hormone-binding globulin (SHBG), DHEA-sulfate (DHEA-S), Delta4-androstenedione (AD), 3alpha-androstanediol glucuronide (ADG) and estradiol (E2) were measured, whereas free T and the free T index (FTI) were calculated. Assessments took place at baseline (no COC use), after the run-in period (COC use alone) and during the treatment period (DHEA or placebo). RESULTS: During COC use alone, androgen levels decreased, especially total T by 62% and free T by 86%, and SHBG increased by 243%. Total T increased with DHEA compared to placebo (change from end of run-in period to end of treatment period - 1.3+/-1.2nmol/L vs. 0.0+/-0.4nmol/L; p<.0001) - and was restored to baseline levels. Free T and the FTI increased significantly (p<.0001), but the free T level was still 53% below baseline levels. DHEA-S, AD and ADG increased significantly to levels above baseline (p<.0001 for each). DHEA had no effect on SHBG, albumin and E2. CONCLUSIONS: An EE/DRSP containing COC strongly suppressed endogenous androgen concentrations in all users. The addition of 50mg DHEA to a COC regimen containing EE/DRSP restored total T to baseline levels, but free T levels were restored by only 47% as most of the T remains bound to SHBG. IMPLICATIONS: When using a COC that increases SHBG considerably, a daily dose of 50mg DHEA is insufficient to normalize free T levels completely. [less ▲]

Detailed reference viewed: 4 (0 ULg)
Full Text
Peer Reviewed
See detailRestoring testosterone levels by adding dehydroepiandrosterone to a drospirenone containing combined oral contraceptive: II. Clinical effects.
Zimmerman, Y.; Foidart, Jean-Michel ULg; Pintiaux, Axelle ULg et al

in Contraception (2015), 91(2), 134-42

OBJECTIVES: Combined oral contraceptives (COCs) decrease androgen levels, including testosterone (T), which may be associated with sexual dysfunction and mood complaints in some women. We have shown that ... [more ▼]

OBJECTIVES: Combined oral contraceptives (COCs) decrease androgen levels, including testosterone (T), which may be associated with sexual dysfunction and mood complaints in some women. We have shown that 'co-administration' of dehydroepiandrosterone (DHEA) to a drospirenone (DRSP)-containing COC restored total T levels to baseline and free T levels by 47%. Here we describe the effects on sexual function, mood and quality of life of such an intervention. STUDY DESIGN: This was a randomized, double-blind, placebo-controlled study in 99 healthy COC starters. A COC containing 30mcg ethinylestradiol (EE) and 3mg DRSP was used for three cycles, followed by six cycles of the same COC combined with 50mg/day DHEA or placebo. Subjects completed the Moos Menstrual Distress Questionnaire (MDQ), the McCoy Female Sexuality Questionnaire and the short form of the Quality of Life Enjoyment and Satisfaction Questionnaire (Q-LES-Q). Safety and tolerability, including effects on skin, were evaluated. RESULTS: The addition of DHEA induced small but significant improvements compared to placebo in the MDQ score for autonomic reactions during the menstrual (-2.0 vs. 0.71; p=0.05) and the premenstrual phase (-3.1 vs. 2.9; p=0.01) and for behavior during the intermenstrual phase (-1.4 vs. 3.6; p=0.02). A significant difference was found in the MDQ score for arousal during the premenstrual phase in favor of placebo (-5.0 vs. 1.0; p=0.01). There were no statistically significant differences between groups for the MSFQ and Q-LES-Q scores. DHEA 'co-administration' resulted in an acceptable safety profile. DHEA negated the beneficial effect of the COC on acne according to the subjects' self-assessment. CONCLUSIONS: 'Co-administration' with DHEA did not result in consistent improvements in sexual function, mood and quality of life indicators in women taking EE/DRSP. Retrospectively, the 50 mg dose of DHEA may be too low for this COC. IMPLICATIONS: A well-balanced judgment of the clinical consequences of normalizing androgens during COC use may require complete normalization of free T. [less ▲]

Detailed reference viewed: 4 (0 ULg)
Full Text
Peer Reviewed
See detailBilberry extract (Antho 50) selectively induces redox-sensitive caspase 3-related apoptosis in chronic lymphocytic leukemia cells by targeting the Bcl-2/Bad pathway
Alhosin, Mahmoud; León-González1, Antonio J.; Dandache et al

in Scientific Reports (2015)

Defect in apoptosis has been implicated as a major cause of resistance to chemotherapy observed in B cell chronic lymphocytic leukaemia (B CLL). This study evaluated the pro-apoptotic effect of an ... [more ▼]

Defect in apoptosis has been implicated as a major cause of resistance to chemotherapy observed in B cell chronic lymphocytic leukaemia (B CLL). This study evaluated the pro-apoptotic effect of an anthocyanin-rich dietary bilberry extract (Antho 50) on B CLL cells from 30 patients and on peripheral blood mononuclear cells (PBMCs) from healthy subjects, and determined the underlying mechanism. Antho 50 induced concentration- and time-dependent pro-apoptotic effects in B CLL cells isolated from patients but little or no effect in PBMCs. Among the main phenolic compounds present in this bilberry extract, delphinidin-3-O-glucoside and delphinidin-3-O-rutinoside showed the highest apoptotic effect on B CLL cells, suggesting that anthocyanins play a main role in the cytotoxic activity. Antho 50-induced apoptosis is associated with activation of caspase 3 and down-regulation of the anti-apoptotic protein UHRF1. Antho 50 induced also rapid dephosphorylation of Akt and Bad, and down-regulation of Bcl-2 resulting in reduced cell viability. Antho 50 significantly induced PEG-catalase-sensitive formation of reactive oxygen species in B CLL cells. PEG-catalase prevented the Antho 50-induced reduced cell viability, induction of apoptosis, up-regulation of caspase 3, down-regulation of UHRF1 and Bcl-2, and dephosphorylation of Bad. The present findings indicate that Antho 50 exhibits strong pro-apoptotic activity through redox-sensitive caspase 3 activation-related mechanism in B CLL cells involving dysregulation of Bad/Bcl-2 pathway. This activity is due, at least in part, to a composition rich on glucoside and rutinoside derivatives of delphinidin. They further suggest that Antho 50 has chemotherapeutic potential by targeting selectively B CLL cells. [less ▲]

Detailed reference viewed: 2 (0 ULg)
Full Text
Peer Reviewed
See detailA generic anisotropic continuum damage model integration scheme adaptable to both ductile damage and biological damage-like situations
Mengoni, Marlène ULg; Ponthot, Jean-Philippe ULg

in International Journal of Plasticity (2015), 66

This paper aims at presenting a general versatile time integration scheme applicable to anisotropic damage coupled to elastoplasticity, considering any damage rate and isotropic hardening formulations ... [more ▼]

This paper aims at presenting a general versatile time integration scheme applicable to anisotropic damage coupled to elastoplasticity, considering any damage rate and isotropic hardening formulations. For this purpose a staggered time integration scheme in a finite strain framework is presented, together with an analytical consistent tangent operator. The only restrictive hypothesis is to work with an undamaged isotropic material, assumed here to follow a J2 plasticity model. The only anisotropy considered is thus a damage-induced anisotropy. The possibility to couple any damage rate law with the present algorithm is illustrated with a classical ductile damage model for aluminium, and a biological damage-like application. The later proposes an original bone remodelling law coupled to trabecular bone plasticity for the simulation of orthodontic tooth movements. All the developments have been considered in the framework of the implicit non-linear finite element code Metafor (developed at the LTAS/MN2L, University of Liège, Belgium - www.metafor.ltas.ulg.ac.be). [less ▲]

Detailed reference viewed: 53 (8 ULg)
Full Text
Peer Reviewed
See detailAphid species and associated natural enemies in field crops: what about the invasive ladybird Harmonia axyridis (Coleoptera: Coccinellidae)?
Vandereycken, Axel ULg; Durieux, Delphine ULg; Joie, Emilie ULg et al

in Entomologie Faunistique = Faunistic Entomology (2015), 68

Following the introduction in the 80's of the invasive coccinellid species Harmonia axyridis (Pallas) in Europe, several studies have begun to focus on the interactions with other aphid predator species ... [more ▼]

Following the introduction in the 80's of the invasive coccinellid species Harmonia axyridis (Pallas) in Europe, several studies have begun to focus on the interactions with other aphid predator species. In this study, aphids and associated predators were sampled to determine their relative abundance in four agricultural crops (broad bean, corn, potato, and wheat) in Belgium during 2010 and 2011. The Moericke trap was used to quantify the mean number of aphids and aphid predators from May to September in both years. A total of 28 aphid species and 21 aphidophagous species were observed. In both years, H. axyridis was among the most abundant aphidophagous predators in all four crops, and was the second most abundant coccinellid species after Coccinella septempunctata L. The community of aphidophagous species was similar across all four inventoried crops. However, the highest population densities of this alien species were recorded in broad bean and potato crops, which also hosted the highest aphid population densities. In conclusion, this study demonstrates that the communities of aphid predators are highly diversified in the agroecosystems, despite the high occurrence of H. axyridis, an introduced predator that has become well established in this environment. [less ▲]

Detailed reference viewed: 6 (1 ULg)
Full Text
See detailChemical abundances of fast-rotating OB stars
Cazorla, Constantin ULg; Morel, Thierry ULg; Nazé, Yaël ULg et al

in Proceedings of the International Astronomical Union - New windows on massive stars: asteroseismology, interferometry, and spectropolarimetry (2015)

Fast rotation in massive stars is predicted to induce mixing in their interior, but a population of fast-rotating stars with normal nitrogen abundances at their surface has recently been revealed (Hunter ... [more ▼]

Fast rotation in massive stars is predicted to induce mixing in their interior, but a population of fast-rotating stars with normal nitrogen abundances at their surface has recently been revealed (Hunter et al. 2009; Brott et al. 2011, but see Maeder et al. 2014). However, as the binary fraction of these stars is unknown, no definitive statements about the ability of single-star evolutionary models including rotation to reproduce these observations can be made. Our work combines for the first time a detailed surface abundance analysis with a radial-velocity monitoring for a sample of bright, fast-rotating Galactic OB stars to put strong constraints on stellar evolutionary and interior models. [less ▲]

Detailed reference viewed: 25 (18 ULg)
Full Text
Peer Reviewed
See detailMinimal anomaly-free chiral fermion sets and gauge coupling unification
Ceboa, Luis; Emmanuel-Costa, David; González Felipe, Ricardo et al

in Physical Review. D, Particles, Fields, Gravitation, and Cosmology (2014)

We look for minimal chiral sets of fermions beyond the standard model that are anomaly free and, simultaneously, vectorlike particles with respect to color SU(3) and electromagnetic U(1). We then study ... [more ▼]

We look for minimal chiral sets of fermions beyond the standard model that are anomaly free and, simultaneously, vectorlike particles with respect to color SU(3) and electromagnetic U(1). We then study whether the addition of such particles to the standard model particle content allows for the unification of gauge couplings at a high energy scale, above 5.0 × 1015 GeV so as to be safely consistent with proton decay bounds. The possibility to have unification at the string scale is also considered. Inspired in grand unified theories, we also search for minimal chiral fermion sets that belong to SU(5) multiplets, restricted to representations up to imension 50. It is shown that, in various cases, it is possible to achieve gauge unification provided that some of the extra fermions decouple at relatively high intermediate scales. [less ▲]

Detailed reference viewed: 19 (0 ULg)
Full Text
See detailThe seed dispersal of the afro- tropical tree species Staudtia kamerunensis (Myristicaceae)
Hambuckers, Alain ULg

Scientific conference (2014, December 27)

Detailed reference viewed: 17 (1 ULg)
Full Text
Peer Reviewed
See detailBacterial Community Composition in Three Freshwater Reservoirs of Different Alkalinity and Trophic Status
Llirós, Marc; Inceoğlu, Özgul; García-Armisen, Tamara et al

in PLoS ONE (2014)

Detailed reference viewed: 27 (0 ULg)
Full Text
See detailETAT DE LIEU DE LA FILIERE APICOLE EN REPUBLIQUE DEMOCRATIQUE DU CONGO ET EVALUATION DES CAPACITES POLLINISATRICES DES ABEILLES DOMESTIQUES (Apis mellifera adansonii, L.) SUR LA CULTURE DE MELON AFRICAIN (Cucumeropsis mannii Naudin) A KISANGANI.
Posho Ndola, Boniface ULg

Doctoral thesis (2014)

La présente étude s’inscrit dans le cadre de la recherche d’une meilleure compréhension de la filière apicole en RDC, de l’influence de l’environnement sur la qualité de pains d'abeille et de miel pour la ... [more ▼]

La présente étude s’inscrit dans le cadre de la recherche d’une meilleure compréhension de la filière apicole en RDC, de l’influence de l’environnement sur la qualité de pains d'abeille et de miel pour la survie d’Apis mellifera adansonii, L. 1758 en RDC et de l’impact de la pollinisation des abeilles introduites (A. mellifera adansonii, L. 1758) sur la production de Cucumeropsis mannii (Naudin) à Kisangani. Trois approches ont été adoptées pour faire l’état de lieu de la filière apicole en RDC, dont (1) la distribution des questionnaires structurés aux apiculteurs, (2) des visites de ruchers et (3) des recherches documentaires. Dans le cadre de l’évaluation de la qualité de miels et pains d’abeilles, les échantillons de miels et de pollens ont été collectés dans trois sites écologiquement différents de la RDC. Les échantillons de miels ont été évalués suivant les critères et les protocoles établis par Codex Alimentarius; tandis que les pollens ont été évalués suivant les critères de teneur en protéines et en acides aminés essentiels. Les teneurs en protéines et en acides aminés essentiels de pains d’abeilles collectés ont été déterminées respectivement par la méthode Kjeldahl et par les hydrolyses acides et basiques. Les essais comparatifs de la pollinisation des abeilles domestiques ont été également conduits dans deux sites expérimentaux à Kisangani. Sur chaque site, deux champs d'un hectare séparés de 3 kilomètres ont été installés. Deux colonies d'abeilles ont été installées au milieu du champ expérimental de chaque site pendant la floraison (quand 10 % des plantes ont fleuri). Le second champ expérimental, sans colonies d’abeilles, a été considéré comme témoin. Les résultats obtenus après l’étude exploratoire sur l’apiculture en RDC montrent que l’apiculture congolaise reste encore semi traditionnelle; 54 % des apiculteurs congolais travaillent en coopérative; 100 % du cheptel apicole congolais est constitué d’A. mellifera adansonii, L. ; 96 % des apiculteurs utilisent les ruches Kenyanes; le nombre de ruches utilisé par un apiculteur congolais varie entre 2 et 120; la production d’une colonie par récolte oscille entre 1 et 25 litres de miel; la production annuelle par apiculteur est évaluée entre 10 et 900 litres de miel, le nombre de récoltes de miel effectué par an varie de 1 à 2. Cette étude a révélé que la teneur moyenne en protéines de pollens recueillies en RDC était 14,11 ± 5,27 %. Cette teneur en protéines était faible comparativement aux besoins alimentaires des abeilles en Europe. Tous les échantillons de pollen étaient constitués de dix acides aminés essentiels et leurs concentrations étaient dans la fourchette optimale des exigences alimentaires des abeilles en Europe. Les analyses des échantillons de miels ont révélé que la teneur en sucres réducteurs des échantillons de miel recueillies variait de 63,40 à 73,80 %, la teneur en saccharose était comprise entre 0,30 et 1,90 %, la teneur en eau oscillait entre 16,80 et 22,00 %, le pH des échantillons de miel analysés variait de 4,22 à 4,53, la moyenne de la conductivité électrique de miels récoltés a été ( 47,74 ± 13,93 ) S/cm et la concentration de HMF varié de 1,75 à 31,38 mg / kg de HMF miel. Les miels et les pollens collectés dans la forêt tropicale de Kisangani étaient moyennement plus nutritifs pour les abeilles que ceux de la savane de Kavwaya. Après les observations des essais comparatifs de pollinisation, il a révélé que la pollinisation des abeilles introduites a amélioré significativement le nombre de graines par fruit de 83,78 %, tandis que le nombre de fruits par plante et le poids de graines par fruit ont été améliorés respectivement de 422,89 % et 185,61 % par rapport au témoin. La taille de graine a été positivement influencée par la présence de colonie d’abeille dans le champ de C. mannii (Naudin). Dans cette étude, la distance par rapport aux ruches et l’orientation de vol des ouvrières n'ont pas influencé significativement le rendement et la taille des graines de C. mannii (Naudin) [less ▲]

Detailed reference viewed: 79 (8 ULg)
Full Text
See detailTowards generic image classification: an extensive empirical study
Marée, Raphaël ULg; Geurts, Pierre ULg; Wehenkel, Louis ULg

E-print/Working paper (2014)

This paper considers the general problem of image classification without using any prior knowledge about image classes. We study variants of a method based on supervised learning whose common steps are ... [more ▼]

This paper considers the general problem of image classification without using any prior knowledge about image classes. We study variants of a method based on supervised learning whose common steps are the extraction of random subwindows described by raw pixel intensity values and the use of ensemble of extremely randomized trees to directly classify images or to learn image features. The influence of method parameters and variants is thoroughly evaluated so as to provide baselines and guidelines for future studies. Detailed results are provided on 80 publicly available datasets that depict very diverse types of images (more than 3800 image classes and over 1.5 million images). [less ▲]

Detailed reference viewed: 64 (1 ULg)
Full Text
See detailNavigating the uncertain seas of controversies – A pedagogical wind rose
Verpoorten, Dominique ULg

in Melard, François; Stassart, Pierre M (Eds.) Proceedings of the International Interdisciplinary Working Conference "Teaching complexity and uncertainty on Environmental Issues - Practices, Theories and Products" (2014, December 23)

The Arlon conference brought together lecturers willing to share and discuss aspects of their practice of “controversies”, seen as a teaching/learning method suited to the contextual needs and demands of ... [more ▼]

The Arlon conference brought together lecturers willing to share and discuss aspects of their practice of “controversies”, seen as a teaching/learning method suited to the contextual needs and demands of higher education environmental studies. The paper contributes to this joint reflective effort by providing conceptual tools helping to interpret the practice, to question what it puts at stake and to detect, from a pedagogical viewpoint, key issues and upcoming questions. The contribution falls within the Conference's aim n°2: “share theories or conceptual propositions that make it possible to equip the teaching approaches and to give them theoretical and methodological foundations” (Program Arlon Conference 2014, p. 2). The article takes a traditional stance, looking at the contributions to the conference through “constructive alignment”(Biggs, 1996), a basic principle meant to secure the pedagogical validity of any given learning situation by establishing a triple consistency (Kovertaite & Leclercq, 2006; Leclercq, 1995; Petit, Castaigne, & Verpoorten, 2007; Tyler, 1949) between objectives, methods and assessment. [less ▲]

Detailed reference viewed: 90 (4 ULg)
Full Text
See detailToward a Consistent Application of International Financial Reporting Standards (IFRSs) across Companies and Countries
Yammine, Mira ULg

Doctoral thesis (2014)

International Financial Reporting Standards (IFRSs) were developed to be a single set of high-quality globally accepted accounting standards. They are meant to allow uniformity in financial reporting ... [more ▼]

International Financial Reporting Standards (IFRSs) were developed to be a single set of high-quality globally accepted accounting standards. They are meant to allow uniformity in financial reporting, enhance comparability of financial statements in the midst of economical globalization, and allow companies with international subsidiaries to prepare their financial statements using similar global standards. The objective of the dissertation is to study whether the application of IFRSs is consistent across companies and countries; in particular we tackle the following two questions: -Does the application of IFRSs in the preparation of financial statements lead to consistency? -Does the public enforcement of accounting standards impact the consistent application of IFRSs? To answer the first question we have addressed standard IAS 36 that was developed by the International Accounting Standards Board (IASB) and covering impairment of assets. We found that managers’ opportunism still has an impact on the impairment of assets recognition and magnitude when taking impairment decisions. To address the second question, a survey covering enforcement of accounting standards activities was prepared and sent to public enforcement bodies in a number of countries mandating the adoption of IFRSs. The survey allowed us to construct an index that represents the activities of the public enforcement bodies. We studied the impact of public enforcement on specific applications of the standards, the results show a decrease in earnings management in countries with effective public enforcement. [less ▲]

Detailed reference viewed: 73 (10 ULg)
Full Text
See detailUn guide de la rédaction du mémoire : pourquoi et comment ?
Grandjean, Geoffrey ULg

Scientific conference (2014, December 19)

Detailed reference viewed: 32 (0 ULg)
Peer Reviewed
See detailLa thermoplastie bronchique dans le traitement de l'asthme sévère de l'adulte.
Chanez, P.; Boulet, L.-P.; Brillet, P.-Y. et al

in Revue des maladies respiratoires (2014)

Bronchial thermoplasty is a recent endoscopic technique for the treatment of severe asthma. It is an innovative treatment whose clinical efficacy and safety are beginning to be better understood. Since ... [more ▼]

Bronchial thermoplasty is a recent endoscopic technique for the treatment of severe asthma. It is an innovative treatment whose clinical efficacy and safety are beginning to be better understood. Since this is a device-based treatment, the evaluation procedure of risks and benefits is different that for pharmaceutical products; safety aspects, regulatory requirements, study design and the assessment of the magnitude of effects may all be different. The mechanism of action and optimal patient selection need to be assessed further in rigorous clinical and scientific studies. This technique is in harmony with the development of personalised medicine in the 21st century. It should be developed further in response to the numerous challenges and needs not yet met in the management of severe asthma. [less ▲]

Detailed reference viewed: 4 (0 ULg)