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See detailCan meandering flows in shallow rectangular reservoir be modelled with the 2D shallow water equations?
Peltier, Yann ULg; Erpicum, Sébastien ULg; Archambeau, Pierre ULg et al

in Journal of Hydraulic Engineering (2015)

In this article, the ability of the 2D shallow water equations to model meandering flows in shallow rectangular reservoirs is discussed. Four meandering flows, of various shallowness, were modelled using ... [more ▼]

In this article, the ability of the 2D shallow water equations to model meandering flows in shallow rectangular reservoirs is discussed. Four meandering flows, of various shallowness, were modelled using the academic flow model WOLF 2D, which includes a depth-averaged k- model accounting for the horizontal and vertical turbulent length-scales. The bottom friction was modelled with the Colebrook-White formula and different roughness heights were considered. A Proper Orthogonal Decomposition (POD) was applied to the simulation results to extract the behaviour of the main structures responsible for the meandering flow. The same POD analysis was also performed for the reference experimental flow fields, obtained by Large-Scale Particle Image Velocimetry. The first two POD modes obtained from the numerical simulations assuming a smooth bottom are in good agreement with the experimental modes in terms of energy, as well as temporal and spatial variations, whatever the shallowness. In contrast, the remaining simulated modes are not well rendered. The effect of an increased roughness height in the simulations is finally discussed. It leads to an improved reproduction of the first two modes and of the following modes, except when significant viscous effects govern in the flow. [less ▲]

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See detailPharmacodynamics, Efficacy and Safety of Sodium-Glucose Co-Transporter Type 2 (SGLT2) Inhibitors for the Treatment of Type 2 Diabetes Mellitus.
Scheen, André ULg

in Drugs (2015), 75(1), 33-59

Inhibitors of sodium-glucose co-transporter type 2 (SGLT2) are proposed as a novel approach for the management of type 2 diabetes mellitus (T2DM). Several compounds are already available in many countries ... [more ▼]

Inhibitors of sodium-glucose co-transporter type 2 (SGLT2) are proposed as a novel approach for the management of type 2 diabetes mellitus (T2DM). Several compounds are already available in many countries (dapagliflozin, canagliflozin, empagliflozin and ipragliflozin) and some others are in a late phase of development. The available SGLT2 inhibitors share similar pharmacokinetic characteristics, with a rapid oral absorption, a long elimination half-life allowing once-daily administration, an extensive hepatic metabolism mainly via glucuronidation to inactive metabolites, the absence of clinically relevant drug-drug interactions and a low renal elimination as parent drug. SGLT2 co-transporters are responsible for reabsorption of most (90 %) of the glucose filtered by the kidneys. The pharmacological inhibition of SGLT2 co-transporters reduces hyperglycaemia by decreasing renal glucose threshold and thereby increasing urinary glucose excretion. The amount of glucose excreted in the urine depends on both the level of hyperglycaemia and the glomerular filtration rate. Results of numerous placebo-controlled randomised clinical trials of 12-104 weeks duration have shown significant reductions in glycated haemoglobin (HbA1c), resulting in a significant increase in the proportion of patients reaching HbA1c targets, and a significant lowering of fasting plasma glucose when SGLT2 inhibitors were administered as monotherapy or in addition to other glucose-lowering therapies including insulin in patients with T2DM. In head-to-head trials of up to 2 years, SGLT2 inhibitors exerted similar glucose-lowering activity to metformin, sulphonylureas or sitagliptin. The durability of the glucose-lowering effect of SGLT2 inhibitors appears to be better; however, this remains to be more extensively investigated. The risk of hypoglycaemia was much lower with SGLT2 inhibitors than with sulphonylureas and was similarly low as that reported with metformin, pioglitazone or sitagliptin. Increased renal glucose elimination also assists weight loss and could help to reduce blood pressure. Both effects were very consistent across the trials and they represent some advantages for SGLT2 inhibitors when compared with other oral glucose-lowering agents. The pharmacodynamic response to SGLT2 inhibitors declines with increasing severity of renal impairment, and prescribing information for each SGLT2 inhibitor should be consulted regarding dosage adjustments or restrictions in moderate to severe renal dysfunction. Caution is also recommended in the elderly population because of a higher risk of renal impairment, orthostatic hypotension and dehydration, even if the absence of hypoglycaemia represents an obvious advantage in this population. The overall effect of SGLT2 inhibitors on the risk of cardiovascular disease is unknown and will be evaluated in several ongoing prospective placebo-controlled trials with cardiovascular outcomes. The impact of SGLT2 inhibitors on renal function and their potential to influence the course of diabetic nephropathy also deserve more attention. SGLT2 inhibitors are generally well-tolerated. The most frequently reported adverse events are female genital mycotic infections, while urinary tract infections are less commonly observed and generally benign. In conclusion, with their unique mechanism of action that is independent of insulin secretion and action, SGLT2 inhibitors are a useful addition to the therapeutic options available for the management of T2DM at any stage in the natural history of the disease. Although SGLT2 inhibitors have already been extensively investigated, further studies should even better delineate the best place of these new glucose-lowering agents in the already rich armamentarium for the management of T2DM. [less ▲]

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See detailL’agentivité engagée chez Charles Taylor. De l’interprétation à l’évaluation de soi
Gauvry, Charlotte ULg

in Boccaccini, Federico; Cormann, Grégory (Eds.) Le soi agent (2015)

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See detailComplex dynamics of a nonlinear aerospace structure: numerical continuation and normal modes
Renson, Ludovic ULg; Noël, Jean-Philippe ULg; Kerschen, Gaëtan ULg

in Nonlinear Dynamics (2015), 79(2), 1293-1309

This paper investigates the dynamics of a real-life aerospace structure possessing a strongly nonlinear component with multiple mechanical stops. A full-scale finite element model is built for gaining ... [more ▼]

This paper investigates the dynamics of a real-life aerospace structure possessing a strongly nonlinear component with multiple mechanical stops. A full-scale finite element model is built for gaining additional insight into the nonlinear dynamics that was observed experimentally, but also for uncovering additional nonlinear phenomena, such as quasiperiodic regimes of motion. Forced/unforced, damped/undamped numerical simulations are carried out using advanced techniques and theoretical concepts such as numerical continuation and nonlinear normal modes. [less ▲]

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See detailEarly seed plants from Western Gondwana: Paleobiogeographical and ecological implications based on Tournaisian (Lower Carboniferous) records from Argentina
Prestianni, C.; Rustan, J.J.; Balseiro, D. et al

in Palaeogeography, Palaeoclimatology, Palaeoecology (2015), 417

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See detailCalcium-dependent potassium channels.
Drion, Guillaume ULg; Philippart, Fabian ULg; Sepulchre, Rodolphe ULg et al

in Jaeger, Dieter; Jung, Ranu (Eds.) Encyclopedia of Computational Neuroscience (2015)

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See detailGiven to a Deity? Religious and Social Reappraisal of Human Consecrations in the Hellenistic and Roman East
Caneva, Stefano ULg; Delli Pizzi, Aurian ULg

in Classical Quarterly (2015), 65(1), 167-191

Various cases of human beings ‘dedicated’ to deities are attested in Greek epigraphic evidence. Are these kinds of offerings comparable to the dedication of inanimate objects? Besides, does the fact that ... [more ▼]

Various cases of human beings ‘dedicated’ to deities are attested in Greek epigraphic evidence. Are these kinds of offerings comparable to the dedication of inanimate objects? Besides, does the fact that someone is said to be ‘sacred’ to a specific deity necessarily involve that he went through a process of dedication? This article aims at providing a global picture of different situations in which processes of dedications took place. Among the several issues that are tackled, the cornerstone of this article consists of two questions: for what purposes did some people decide to consecrate a human being to a deity and what were the consequences for the consecrated individuals on religious and social levels? Different categories of persons will be contrasted, in terms of processes through which they acquire their new status but also in terms of the freedom/lack of freedom which is conveyed by this new status. It will also be shown that, as far as method is concerned, it is necessary to complete a lexical analysis with a contextual perspective for a deeper understanding of the problem. [less ▲]

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See detailExtracellular peptidase hunting for improvement of protein production in plant cells and roots
Lallemand, Jérôme ULg; Bouché, Frédéric ULg; Desiron, Carole et al

in Frontiers in Plant Science (2015), 6(37),

Plant-based recombinant protein production systems have gained an extensive interest over the past few years, because of their reduced cost and relative safety. Although the first products are now ... [more ▼]

Plant-based recombinant protein production systems have gained an extensive interest over the past few years, because of their reduced cost and relative safety. Although the first products are now reaching the market, progress are still needed to improve plant hosts and strategies for biopharming. Targeting recombinant proteins toward the extracellular space offers several advantages in terms of protein folding and purification, but degradation events are observed, due to endogenous peptidases. This paper focuses on the analysis of extracellular proteolytic activities in two production systems: cell cultures and root-secretion (rhizosecretion), in Arabidopsis thaliana and Nicotiana tabacum. Proteolytic activities of extracellular proteomes (secretomes) were evaluated in vitro against two substrate proteins: bovine serum albumin (BSA) and human serum immunoglobulins G (hIgGs). Both targets were found to be degraded by the secretomes, BSA being more prone to proteolysis than hIgGs. The analysis of the proteolysis pH-dependence showed that target degradation was mainly dependent upon the production system: rhizosecretomes contained more peptidase activity than extracellular medium of cell suspensions, whereas variations due to plant species were smaller. Using class-specific peptidase inhibitors, serine and metallopeptidases were found to be responsible for degradation of both substrates. An in-depth in silico analysis of genomic and transcriptomic data from Arabidopsis was then performed and led to the identification of a limited number of serine and metallo-peptidases that are consistently expressed in both production systems. These peptidases should be prime candidates for further improvement of plant hosts by targeted silencing. [less ▲]

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See detailQuantitative temperature monitoring of a heat tracing experiment using cross-borehole ERT
Hermans, Thomas ULg; Wildemeersch, Samuel ULg; Jamin, Pierre ULg et al

in Geothermics (2015), 53

The growing demand for renewable energy leads to an increase in the development of geothermal energy projects and heat has become a common tracer in hydrology and hydrogeology. Designing geothermal ... [more ▼]

The growing demand for renewable energy leads to an increase in the development of geothermal energy projects and heat has become a common tracer in hydrology and hydrogeology. Designing geothermal systems requires a multidisciplinary approach including geological and hydrogeological aspects. In this context, electrical resistivity tomography (ERT) can bring relevant, qualitative and quantitative information on the temperature distribution in operating shallow geothermal systems or during heat tracing experiments. We followed a heat tracing experiment in an alluvial aquifer using cross-borehole time-lapse ERT. Heated water was injected in a well while water of the aquifer was extracted at another well. An ERT section was set up across the main flow direction. The results of ERT were transformed into temperature using calibrated petrophysical relationships. These ERT-derived temperatures were then compared to direct temperature measurements in control piezometers collected with distributed temperature sensing (DTS) and groundwater temperature loggers. Spatially, it enabled to map the horizontal and vertical extent of the heated water plume, as well as the zones where maximum temperatures occurred. Quantitatively, the temperatures and breakthrough curves estimated from ERT were in good agreement with the ones observed directly during the rise and maximum of the curve. An overestimation, likely related to 3D effects, was observed for the tail of the heat breakthrough curve. The error made on temperature can be estimated to be between 10 to 20 %, which is a fair value for indirect measurements. From our data, we estimated a quantification threshold for temperature variation of 1.2°C. These results suggest that ERT should be considered when designing heat tracing experiments or geothermal systems. It could help also to assess the geometrical complexity of the concerned reservoirs. It also appears that ERT could be a useful tool to monitor and control geothermal systems once they are in operation. [less ▲]

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See detailUsing zero-inlated models to predict the relative distribution and abundance of roe deer over very large spatial scales
Bouyer, Yaëlle ULg; Rigot, Thibaud; Panzacchi, Manuela et al

in Annales Zoologici Fennici (2015), 52

In Norway, recovering populations of large carnivores commonly prey on roe deer (Capreolus capreolus). Understanding predator habitat use and ecology requires fine-scaled information on prey distribution ... [more ▼]

In Norway, recovering populations of large carnivores commonly prey on roe deer (Capreolus capreolus). Understanding predator habitat use and ecology requires fine-scaled information on prey distribution and abundance. However, the massive spatial scales at which large carnivores use the landscape presents many practical and statistical challenges for developing functional prey distribution models. Pellet-count data from >1000 km of transects gathered across southeastern Norway from 2005 to 2011 were used to derive a map of relative prey abundance for roe deer. These data were modeled using zero-inflated hurdle models using both environmental and anthropogenic variables. Snow depth and agricultural fields were the most significant variables in explaining both presence and abundance. Internal k-cross validation of the model showed medium accuracy (Spearman r = 0.35), whereas external evaluation carried out on the basis of independently collected snow-tracking data (Spearman r = 0.37) and hunting statistics (Spearman r = 0.88) showed high accuracy. The map generated can facilitate both the study of broad scale processes linking predators and prey as well as roe deer management in southeastern Norway. [less ▲]

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See detailDevelopment of the lemann index to assess digestive tract damage in patients with Crohn's disease.
Pariente, Benjamin; Mary, Jean-Yves; Danese, Silvio et al

in Gastroenterology (2015), 148(1), 52-633

BACKGROUND & AIMS: There is a need for a scoring system that provides a comprehensive assessment of structural bowel damage, including stricturing lesions, penetrating lesions, and surgical resection, for ... [more ▼]

BACKGROUND & AIMS: There is a need for a scoring system that provides a comprehensive assessment of structural bowel damage, including stricturing lesions, penetrating lesions, and surgical resection, for measuring disease progression. We developed the Lemann Index and assessed its ability to measure cumulative structural bowel damage in patients with Crohn's disease (CD). METHODS: We performed a prospective, multicenter, international, cross-sectional study of patients with CD evaluated at 24 centers in 15 countries. Inclusions were stratified based on CD location and duration. All patients underwent clinical examination and abdominal magnetic resonance imaging analyses. Upper endoscopy, colonoscopy, and pelvic magnetic resonance imaging analyses were performed according to suspected disease locations. The digestive tract was divided into 4 organs and subsequently into segments. For each segment, investigators collected information on previous operations, predefined strictures, and/or penetrating lesions of maximal severity (grades 1-3), and then provided damage evaluations ranging from 0.0 (no lesion) to 10.0 (complete resection). Overall level of organ damage was calculated from the average of segmental damage. Investigators provided a global damage evaluation (from 0.0 to 10.0) using calculated organ damage evaluations. Predicted organ indexes and Lemann Index were constructed using a multiple linear mixed model, showing the best fit with investigator organ and global damage evaluations, respectively. An internal cross-validation was performed using bootstrap methods. RESULTS: Data from 138 patients (24, 115, 92, and 59 with upper tract, small bowel, colon/rectum, and anus CD location, respectively) were analyzed. According to validation, the unbiased correlation coefficients between predicted indexes and investigator damage evaluations were 0.85, 0.98, 0.90, 0.82 for upper tract, small bowel, colon/rectum, anus, respectively, and 0.84 overall. CONCLUSIONS: In a cross-sectional study, we assessed the ability of the Lemann Index to measure cumulative structural bowel damage in patients with CD. Provided further successful validation and good sensitivity to change, the index should be used to evaluate progression of CD and efficacy of treatment. [less ▲]

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See detailMaternal transfer of organohalogenated compounds in sharks and stingrays
Weijs, Liesbeth; Briels, Nathalie; Adams, Douglas et al

in Marine Pollution Bulletin (2015)

Elasmobranchs can bioaccumulate considerable amounts of persistent organic pollutants (POPs) and utilize several reproductive strategies thereby influencing maternal transfer of contaminants. This study ... [more ▼]

Elasmobranchs can bioaccumulate considerable amounts of persistent organic pollutants (POPs) and utilize several reproductive strategies thereby influencing maternal transfer of contaminants. This study provides preliminary data on the POP transfer from pregnant females to offspring of three species (Atlantic stingrays, bonnethead, blacktip sharks) with different reproduction modes (aplacental, placental viviparity). Polychlorinated biphenyl (PCB) levels were generally higher than any other POPs. Stingrays and blacktip shark embryos contained the lowest POP concentrations while bonnetheads and the blacktip adult female had the highest concentrations. Results suggest that are more readily transferred from the mother to the embryo compared to what is transferred to ova in stingrays. Statistically significant differences in levels of selected POPs were found between embryos from the left and right uterus within the same litter as well as between female and male embryos within the same litter for bonnetheads, but not for the blacktip sharks. [less ▲]

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See detailHypothalamic Expression Of Oestrogen Receptor Alpha And Androgen Receptor Is Sex, Age And Region Dependent In Mice.
Brock, Olivier; Mees, Christelle De; Bakker, Julie ULg

in Journal of neuroendocrinology (2015)

Sex steroid hormones act on developing neural circuits regulating the hypothalamic-pituitary-gonadal axis and are involved in hormone-sensitive behaviours. These hormones act mainly via nuclear receptors ... [more ▼]

Sex steroid hormones act on developing neural circuits regulating the hypothalamic-pituitary-gonadal axis and are involved in hormone-sensitive behaviours. These hormones act mainly via nuclear receptors, i.e. oestrogen receptor-alpha (ERalpha) and androgen receptor (AR). By using immunohistochemistry, we analysed the expression level of ERalpha and AR throughout perinatal life [at embryonic (E) day 19 and postnatal (P) days 5-15-25] and in adulthood in several hypothalamic nuclei controlling reproduction in both wild-type (WT) and aromatase knockout (ArKO) (which cannot convert testosterone into oestradiol) mice to determine whether there are sex differences in hypothalamic ERalpha and AR expression and if so, whether these are established by oestradiol action. As early as E19, ERalpha immunoreactivity (-ir) was observed at same expression levels in both sexes in the anteroventral periventricular nucleus (AVPv), the medial preoptic area (MPOA), the bed nucleus of the stria terminalis (BnST), the ventrolateral part of the ventromedial hypothalamic nucleus (VMHvl) and the arcuate nucleus (ARC). Sex differences (female > male) in ERalpha-ir were only observed during the prepubertal period in the BnST (P5 to P25) and the MPOA (P15), but also in adulthood in these two brain regions. Sex differences in AR-ir (male > female) were observed at P5 in the AVPv and ARC, and at P25 in the MPOA and ARC as well as in adulthood in all hypothalamic regions analysed. In adulthood, gonadectomy and hormonal treatment (oestradiol or dihydrotestosterone) also strongly modulated ERalpha-ir and AR, respectively. Taken together, sex differences in ERalpha-ir and AR-ir were observed in all hypothalamic regions analysed, but most likely do not reflect oestradiol actions since ArKO mice of both sexes showed very similar expression levels as WT mice throughout perinatal development. This article is protected by copyright. All rights reserved. [less ▲]

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See detailCombining satellite, aerial and ground measurements to assess forest carbon stocks in Democratic Republic of Congo
Beaumont, Benoît; Bouvy, Alban; Stephenne, Nathalie et al

in Geophysical Research Abstracts, Vol. 17, EGU2015-4765-2, 2015 (2015)

Monitoring tropical forest carbon stocks changes has been a rising topic in the recent years as a result of REDD+ mechanisms negotiations. Such monitoring will be mandatory for each country willing to ... [more ▼]

Monitoring tropical forest carbon stocks changes has been a rising topic in the recent years as a result of REDD+ mechanisms negotiations. Such monitoring will be mandatory for each country willing to benefit from these financial incentives in the future. Aerial and satellite remote sensing technologies offer cost advantages in implementing large scale forest inventories. Despite the recent progress made in the use of airborne LiDAR for C stocks estimation, no widely operational and cost effective method has yet been delivered for central Africa forest monitoring. Within the Maï Ndombe region of DRC, the EO4REDD project develops a method combining satellite, aerial and ground measurements. This combination is done in three steps: [1] mapping and quantifying forest cover changes using an object-based semi-automatic change detection (deforestation and forest degradation) methodology based on very high resolution satellite imagery (RapidEye), [2] developing an allometric linear model for above ground biomass measurements based on dendrometric parameters (tree crown areas and heights) extracted from airborne stereoscopic image pairs and calibrated using ground measurements of individual trees on a data set of 18 one hectare plots and [3] relating these two products to assess carbon stocks changes at a regional scale. Given the high accuracies obtained in [1] (> 80% for deforestation and 77% for forest degradation) and the suitable, but still to be improved with a larger calibrating sample, model (R2 of 0.7) obtained in [2], EO4REDD products can be seen as a valid and replicable option for carbon stocks monitoring in tropical forests. Further improvements are planned to strengthen the cost effectiveness value/REDD+ suitability in the 2nd phase of EO4REDD. This 2nd phase will include [A] specific model developments per forest type; [B] measurements of afforestation, reforestation and natural regeneration processes and [C] study of Sentinel data series potential use. [less ▲]

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See detailTopology on new sequence spaces defined with wavelet leaders
Bastin, Françoise ULg; Esser, Céline ULg; Simons, Laurent ULg

E-print/Working paper (2015)

Using wavelet leaders instead of wavelet coefficients, new sequence spaces of type Sν are defined and endowed with a natural topology. Some classical topological properties are then studied; in particular ... [more ▼]

Using wavelet leaders instead of wavelet coefficients, new sequence spaces of type Sν are defined and endowed with a natural topology. Some classical topological properties are then studied; in particular, a generic result about the asymptotic repartition of the wavelet leaders of a sequence in Lν is obtained. Eventually, comparisons and links with Oscillation spaces are also presented as well as with Sν spaces. [less ▲]

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See detailLacunary wavelet series on Cantor sets
Esser, Céline ULg

E-print/Working paper (2015)

We construct functions with prescribed multifractal spectra which satisfy the leaders profile method.

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See detailConcept et perception. Le conceptualisme en question
Gauvry, Charlotte ULg; Brisart, Robert

Book published by Olms (2015)

Introduction et traductions de textes de Bill Brewer, Tim Crane, Fred Dretske, Gareth Evans, John McDowell, Christopher Peacocke, Charles Travis et Michael Tye. Par une introduction détaillée et une ... [more ▼]

Introduction et traductions de textes de Bill Brewer, Tim Crane, Fred Dretske, Gareth Evans, John McDowell, Christopher Peacocke, Charles Travis et Michael Tye. Par une introduction détaillée et une sélection de neuf textes emblématiques traduits en français, l’enjeu de ce volume est d’introduire le lecteur francophone à l’histoire de la controverse sur le contenu conceptuel de la perception et de lui en proposer une fine compréhension par l’analyse des différents arguments mobilisés dans les deux camps. Simultanément, le volume a pour ambition de tester la longévité de ces arguments et d’interroger la place qui est dévolue à la controverse sur la scène philosophique la plus contemporaine. [less ▲]

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See detailCompte rendu de 'Mutations et déterminisme chez Bourdieu'
Saint-Amand, Denis ULg

in Lectures (2015)

En définitive, il aurait sans doute mieux valu resserrer le propos sous la forme d’un article critique qui aurait pu trouver place dans une revue spécialisée : ne se donnant par les moyens de ses trop ... [more ▼]

En définitive, il aurait sans doute mieux valu resserrer le propos sous la forme d’un article critique qui aurait pu trouver place dans une revue spécialisée : ne se donnant par les moyens de ses trop hautes ambitions, l’ouvrage se révèle trop léger en plus de se distinguer par le manque de soin apporté à sa réalisation [less ▲]

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