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See detailRelevance of vitamin D in the pathogenesis and therapy of frailty.
Bruyère, Olivier ULg; Cavalier, Etienne ULg; Buckinx, Fanny ULg et al

in Current Opinion in Clinical Nutrition & Metabolic Care (2017), 20(1), 26-29

PURPOSE OF REVIEW: This article reviews recently published evidence regarding the role of vitamin D in the physiopathology of physical frailty in elderly populations and its role in the management of this ... [more ▼]

PURPOSE OF REVIEW: This article reviews recently published evidence regarding the role of vitamin D in the physiopathology of physical frailty in elderly populations and its role in the management of this geriatric condition. RECENT FINDINGS: Some recent studies have found a low level of 25-hydroxyvitamin D, considered the best marker of vitamin D status, in frail individuals. All prospective studies consistently report that low vitamin D status is associated with an increased risk of becoming frail. Recent studies also suggest that the relationship between vitamin D status and frailty is largely mediated by the development of sarcopenia. Very few well designed randomized controlled trials are available that assess the effectiveness of vitamin D supplementation in the prevention or management of frailty. In the absence of specific guidelines, a minimal serum 25-hydroxyvitamin D level of 75 nmol/l is proposed for frail elderly patients by some scientific societies. The doses necessary to reach this target are between 800 and 2000 IU/day. SUMMARY: Several studies suggest a potential effect of vitamin D on physical frailty but large clinical trials are lacking at this time to provide solid evidence of clinical benefit. [less ▲]

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See detailUn « Laboratoire belge » du droit international (1869-1940) ? Réseaux internationaux, expériences et mémoires de guerre des juristes belges
Genin, Vincent ULg

Doctoral thesis (2017)

Circonscrire une problématique implique de dégager plusieurs hypothèses de travail. La Première Guerre mondiale représente le pivot autour duquel ces hypothèses s’articuleront et seront mises à l’épreuve ... [more ▼]

Circonscrire une problématique implique de dégager plusieurs hypothèses de travail. La Première Guerre mondiale représente le pivot autour duquel ces hypothèses s’articuleront et seront mises à l’épreuve. Celle-ci étant destinée à les « mettre à l’épreuve ». À l’issue de ce travail, nous espérons que la confrontation de ces hypothèses à l’analyse historique permettra la décantation de conclusions générales dont émanera une thèse définie. La Guerre de 1914-1918, par son caractère global, ses « innovations » technologiques, son degré de violence, marque une étape significative de l’histoire contemporaine. La Belgique, premier pays du front Ouest à être envahi, se situe aux premières loges de cette nouvelle phase historique. Territoire dont la neutralité « perpétuelle, permanente et garantie » est violée, en transgression du droit international public, ce point d’ancrage semble propice à l’étude d’un milieu ayant peu attiré l’attention des historiens : les juristes belges de droit international. Nous estimons que cette étude est à même de mieux nous informer sur les caractéristiques de ce milieu professionnel en soi, concerné au premier chef par l’acte inaugural de la guerre, sur ses pratiques, ses codes, ses réseaux internationaux, la positionnalité des juristes, mais aussi, en négatif, de nous renseigner sur un aspect méconnu de l’image de la Belgique et de sa position dans la hiérarchie internationale, à savoir sa contribution au droit international. L’évolution de ce milieu et de ce qu’il représente, à l’aune de la Guerre de 1914-1918, reconnue pour avoir acceléré la juridicisation des relations internationales, constitue l’essentiel de l’angle d’approche adopté par notre recherche. Toutefois, il est permis de dégager plusieurs hypothèses, dont chacune recouvre un critère de cette approche plus générale : En effet, le conflit modifie-t-il le degré de légitimité de cette catégorie de juristes dans le champ scientifique belge et exerce-t-il une influence similaire dans le champ académique ? Dans quelle mesure les internationalistes belges jouent-ils un nouveau rôle, après 1918, dans le cadre de la politique étrangère officielle du pays ? Par extension, nous nous intéresserons à leur rapport au milieu des diplomates. Nous tenterons également d’évaluer dans quelle mesure ces juristes sont les acteurs d’un phénomène transnational ou, au contraire, s’ils poursuivent des objectifs dont les intérêts sont « nationaux ». Par ailleurs, ces juristes peuvent-ils être considérés comme des indicateurs, des pierres de touche, de l’évolution de la position de la Belgique dans le « Concert des nations » ? Le cas échéant, nous tenterons de comprendre dans quelle mesure cette « condition » d’indicateur évolue entre l’avant-1914 et l’après-1918. Ces juristes contribuent-ils à la défense d’enjeux idéologiques et/ou politiques et comment se positionnent-ils par rapport aux conceptions jusnaturalistes et juspositivistes ? À l’aune des réflexions précédentes, il est possible d’envisager une problématique générale, que l’on peut énoncer comme suit : Dans quelle mesure les juristes belges de droit international public, de la fin du XIXème siècle au milieu du XXème siècle, ont tissé des réseaux internationaux, été des indicateurs de l’évolution de la Belgique dans la hiérarchie internationale et, surtout, ont été influencés par l’expérience de la Guerre de 1914-1918, en tant que génératrice d’une mémoire influant sur les modes d’expressions et de représentations de ce groupe social, jusqu’en 1940. [less ▲]

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See detailCharacteristics of EoL Printed Wiring Boards processed by ElectroDynamic Fragmentation
Martino, Rémi ULg; Iseli, Cedric; Gaydardzhiev, Stoyan ULg et al

in Chemie Ingenieur Technik (2017), 89(1-2), 1-10

The ElectroDynamic Fragmentation (EDF) is an innovative technique which enables selective fragmentation of material. Its inherent selective breakage principles enable liberation while avoiding fine ... [more ▼]

The ElectroDynamic Fragmentation (EDF) is an innovative technique which enables selective fragmentation of material. Its inherent selective breakage principles enable liberation while avoiding fine grinding. In this study, the specific effects of the EDF on End-of-Life Printed Wiring Boards have been assessed. A novel methodology for their EDF processing has been developed and compared with hammer mill shredding. Various energy inputs and treatment stages have resulted in fragmentation degrees ranging from removal of components to structure delamination and subsequent size reduction. [less ▲]

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See detailAttention et simultanéité intellectuelle chez Descartes, Clauberg et Spinoza
Dubouclez, Olivier ULg

in Les études philosophiques (2017), 1

Abstract. – is paper deals with a classical problem, can we think or apprehend many things at once ? as it was understood and solved by Descartes and its followers. e idea that we can apprehend di erent ... [more ▼]

Abstract. – is paper deals with a classical problem, can we think or apprehend many things at once ? as it was understood and solved by Descartes and its followers. e idea that we can apprehend di erent ideas at once is central in Descartes’ theory of knowledge, especially in the Rules, and it relies on the claim that attention can be divided between two objects or ideas. Clauberg considers on the contrary that the imagination alone can graps things simultaneously and holds the living body as the true paradigm of simultaneous activity. Spinoza has a synthetic point of view : simultaneity within the body and the mind are expressions of the power of the individ- ual and of his develoment. Attention is no more a condition of intellectual simultaneity, as in Descartes, but is rather an obstacle which needs to be overcome to reach a richer and better understanding of reality. [less ▲]

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See detailLinking pollutant exposure of humpback whales breeding in the Indian Ocean to their feeding habits and feeding areas off Antarctica
Das, Krishna ULg; Malarvannan, Govindan; Dirtu, Alin et al

in Environmental Pollution (2017), 220

Humpback whales, Megaptera novaeangliae, breeding off la Reunion Island (Indian Ocean) undergo large-scale seasonal migrations between summer feeding grounds near Antarctica and their reproductive winter ... [more ▼]

Humpback whales, Megaptera novaeangliae, breeding off la Reunion Island (Indian Ocean) undergo large-scale seasonal migrations between summer feeding grounds near Antarctica and their reproductive winter grounds in the Indian Ocean. The main scope of the current study was to investigate chemical exposure of humpback whales breeding in the Indian Ocean by providing the first published data on this breeding stock concerning persistent organic pollutants (POPs), namely polychlorinated biphenyls (PCBs), hexachlorobenzene (HCB), hexachlorocyclohexanes (HCHs), DDT and its metabolites (DDTs), chlordane compounds (CHLs), polybrominated diphenyl ethers (PBDEs), and methoxylated PBDEs (MeO-PBDEs). Analyses of stable isotopes δ13C and δ15N in skin resulted in further insight in their feeding ecology, which was in agreement with a diet focused mainly on low trophic level prey species, such as krill from Antarctica. POPs were measured in all humpback whales in the order of HCB > DDTs > CHLs > HCHs > PCBs > PBDEs > MeO-BDEs. HCB (median: 24 ng.g-1 lw) and DDTs (median: 7.7 ng.g-1 lw) were the predominant compounds in all whale biopsies. Among DDT compounds, p,p’-DDE was the major organohalogenated pollutant, reflecting its long-term accumulation in humpback whales. Significantly lower concentrations of HCB and DDTs were found in females than in males (p<0.001). Other compounds were similar between the two genders (p>0.05). Differences in the HCB and DDTs suggested gender-specific transfer of some compounds to the offspring. POP concentrations were lower than previously reported results for humpback whales sampled near the Antarctic Peninsula, suggesting potential influence of their nutritional status and may indicate different exposures of the whales according to their feeding zones. Further investigations are required to assess exposure of southern humpback whales throughout their feeding zones. [less ▲]

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See detailSpatial variation in the accumulation of POPs and mercury in bottlenose dolphins of the Lower Florida Keys and the coastal Everglades (South Florida)
Damseaux, France ULg; Kiszka, J.; Heithaus, M.R. et al

in Environmental Pollution (2017), 220

The bottlenose dolphin (Tursiops truncatus) is an upper trophic level predator and the most common cetacean species found in nearshore waters of southern Florida, including the Lower Florida Keys (LFK ... [more ▼]

The bottlenose dolphin (Tursiops truncatus) is an upper trophic level predator and the most common cetacean species found in nearshore waters of southern Florida, including the Lower Florida Keys (LFK) and the Florida Coastal Everglades (FCE). The objective of this study was to assess contamination levels of total mercury (T-Hg) in skin and persistent organic pollutants (PCBs, PBDEs, DDXs, HCHs, HCB, Σ PCDD/Fs and Σ DL-PCBs) in blubber samples of bottlenose dolphins from LFK (n = 27) and FCE (n = 24). PCBs were the major class of compounds found in bottlenose dolphin blubber and were higher in individuals from LFK (Σ 6 PCBs LFK males: 13421 ± 7730 ng.g-1 lipids, Σ 6 PCBs LFK females: 9683 ± 19007 ng.g-1 lipids) than from FCE (Σ 6 PCBs FCE males: 5638 ng.g-1 ± 3627 lipids, Σ 6 PCBs FCE females: 1427 ± 908 ng.g-1 lipids). These levels were lower than previously published data from the southeastern USA. The Σ DL-PCBs were the most prevalent pollutants of dioxin and dioxin like compounds (Σ DL-PCBs LFK: 739 ng.g-1 lipids, Σ DL-PCBs FCE: 183 ng.g-1 lipids) since PCDD/F concentrations were low for both locations (mean 0.1 ng.g-1 lipids for LFK and FCE dolphins). The toxicity equivalences of PCDD/Fs and DL-PCBs expressed as TEQ in LFK and FCE dolphins is mainly expressed by DL-PCBs (81% LFK - 65% FCE). T-Hg concentrations in skin were significantly higher in FCE (FCE median 9314 ng.g-1 dw) compared to LFK dolphins (LFK median 2941 ng.g-1 dw). These bottlenose dolphins concentrations are the highest recorded in the southeastern USA, and may be explained, at least partially, by the biogeochemistry of the Everglades and mangrove sedimentary habitats that create favourable conditions for the retention of mercury and make it available at high concentrations for aquatic predators. [less ▲]

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See detailTracing Migrant-Mothers’ ‘Return’ Narratives in the Mexico-U.S and Peru-Belgium Migratory Circuits.
Vivas Romero, Maria ULg; Sanchez-Martinez, Anabela

in Travaux et recherches dans les amériques du centre (2017)

How do contemporary migrant mothers strategize return to their home countries? And how does the social protections available for their bi-national children in sending and destination countries factor in ... [more ▼]

How do contemporary migrant mothers strategize return to their home countries? And how does the social protections available for their bi-national children in sending and destination countries factor in the decision to return? Through this contribution, we aimed to tackle these questions. We draw from the analysis of two longitudinal migratory careers and argue that our participant’s return decisions were influenced both by their children’s effective access to social protection and their subjective perceptions of ‘good-motherhood’. This Trans-Atlantic comparison shows how different situated-institutional-contexts, cultures of care and motherhood resulted into different patterns of mobility for these women and their families. [less ▲]

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See detailMorphology of the filtration apparatus of three planktivorous fishes and relation with ingested anthropogenic particles
Collard, France ULg; Gilbert, Bernard ULg; Eppe, Gauthier ULg et al

in Marine Pollution Bulletin (2017)

Anthropogenic particles (APs), including microplastics, are ingested by a wide variety of marine organisms. Exposure of Clupeiformes (e.g. herrings, anchovies, sardines) is poorly studied despite their ... [more ▼]

Anthropogenic particles (APs), including microplastics, are ingested by a wide variety of marine organisms. Exposure of Clupeiformes (e.g. herrings, anchovies, sardines) is poorly studied despite their economic and ecological importance. This study aims to describe the morphology of the filtration apparatus of three wild-caught Clupeiformes (Sardina pilchardus, Clupea harengus and Engraulis encrasicolus) and to relate the results to ingested APs. Consequently, the species with the more efficient filtration apparatus will be more likely to ingest APs. We hypothesized that sardines were the most exposed species. The filtration area and particle retention threshold were determined in the three species, with sardines displaying the highest filtration area and the closest gill rakers. Sardines ingested more fibers and smaller fragments, confirming that it is the most efficient filtering species. These two results lead to the conclusion that, among the three studied, the sardine is the species most exposed to APs. [less ▲]

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See detailGREDOR. Outcomes and recommendations
Cornélusse, Bertrand ULg; Ernst, Damien ULg

Report (2017)

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See detailAssessment of vitamin D status - a changing landscape.
Herrmann, Markus; Farrell, Christopher-John L.; Pusceddu, Irene et al

in Clinical Chemistry & Laboratory Medicine (2017)

In recent years it has been shown that vitamin D deficiency is associated with an increased incidence as well as the progression of a broad range of diseases including osteoporosis, rickets ... [more ▼]

In recent years it has been shown that vitamin D deficiency is associated with an increased incidence as well as the progression of a broad range of diseases including osteoporosis, rickets, cardiovascular disease, autoimmune disease, multiple sclerosis and cancer. Consequently, requests for the assessment of vitamin D status have increased dramatically. Despite significant progress in the analysis of vitamin D metabolites and an expansion of our pathophysiological knowledge of vitamin D, the assessment of vitamin D status remains a challenging and partially unresolved issue. Current guidelines from scientific bodies recommend the measurement of 25-hydroxy vitamin D (25-OHD) in blood as the preferred test. However, growing evidence indicates significant limitations of this test, including analytical aspects and interpretation of results. In addition, the relationships between 25-OHD and various clinical indices, such as bone mineral density and fracture risk, are rather weak and not consistent across races. Recent studies have systematically investigated new markers of vitamin D status including the vitamin D metabolite ratio (VMR) (ratio between 25-OHD and 24,25-dihydroxy vitamin D), bioavailable 25-OHD [25-OHD not bound to vitamin D binding protein (DBP)], and free 25-OHD [circulating 25-OHD bound to neither DBP nor albumin (ALB)]. These parameters may potentially change how we will assess vitamin D status in the future. Although these new biomarkers have expanded our knowledge about vitamin D metabolism, a range of unresolved issues regarding their measurement and the interpretation of results prevent their use in daily practice. It can be expected that some of these issues will be overcome in the near future so that they may be considered for routine use (at least in specialized centers). In addition, genetic studies have revealed several polymorphisms in key proteins of vitamin D metabolism that affect the circulating concentrations of vitamin D metabolites. The affected proteins include DBP, 7-dehydrocholesterol synthase and the vitamin D receptor (VDR). Here we aim to review existing knowledge regarding the biochemistry, physiology and measurement of vitamin D. We will also provide an overview of current and emerging biomarkers for the assessment of vitamin D status, with particular attention methodological aspects and their usefulness in clinical practice. [less ▲]

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See detailSilicate mineralogy at the surface of Mercury
Namur, Olivier ULg; Charlier, Bernard ULg

in Nature Geoscience (2017)

NASA’s MESSENGER spacecraft has revealed geochemical diversity across Mercury’s volcanic crust. Near-infrared to ultraviolet spectra and images have provided evidence for the Fe2+-poor nature of silicate ... [more ▼]

NASA’s MESSENGER spacecraft has revealed geochemical diversity across Mercury’s volcanic crust. Near-infrared to ultraviolet spectra and images have provided evidence for the Fe2+-poor nature of silicate minerals, magnesium sulfide minerals in hollows and a darkening component attributed to graphite, but existing spectral data is insufficient to build a mineralogical map for the planet. Here we investigate the mineralogical variability of silicates in Mercury’s crust using crystallization experiments on magmas with compositions and under reducing conditions expected for Mercury. We find a common crystallization sequence consisting of olivine, plagioclase, pyroxenes and tridymite for all magmas tested. Depending on the cooling rate, we suggest that lavas on Mercury are either fully crystallized or made of a glassy matrix with phenocrysts. Combining the experimental results with geochemical mapping, we can identify several mineralogical provinces: the Northern Volcanic Plains and Smooth Plains, dominated by plagioclase, the High-Mg province, strongly dominated by forsterite, and the Intermediate Plains, comprised of forsterite, plagioclase and enstatite. This implies a temporal evolution of the mineralogy from the oldest lavas, dominated by mafic minerals, to the youngest lavas, dominated by plagioclase, consistent with progressive shallowing and decreasing degree of mantle melting over time. [less ▲]

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See detailUne anomalie du Congrès de Vienne : le Territoire neutre de Moresnet : Repenser la frontière politique et linguistiqueomalie du Congrès de Vienne : le Territoire neutre de Moresnet : Repenser la frontière politique et linguistique
Robelin, Cyril ULg

in Austriaca (2017, January)

An anomaly in the Congress of Vienna: Neutral Moresnet or how to rethink the political and linguistic boundaries. Neutral-Moresnet was a 3.4 km² neutral territory near Aachen. Its history is the result of ... [more ▼]

An anomaly in the Congress of Vienna: Neutral Moresnet or how to rethink the political and linguistic boundaries. Neutral-Moresnet was a 3.4 km² neutral territory near Aachen. Its history is the result of a misunderstanding. In Article 25 of the Vienna Final Act, Moresnet is annexed to Prussia, but in Article 66 this province is placed under Dutch sovereignty. In the site of "Vieille-Montagne” an important zinc mine is discovered. They decided to establish co-sovereignty. From then on, two commissioners oversee the area. Over time, Moresnet developed a national folklore, especially with the process of Nation-State at the end of the 19th century. This triangle is seen by foreign observers as the smallest country in the world and even as an "imaginary country" (vampires, new Eldorado). Some Esperantists hoped to make Moresnet the country of international languages ​​because in this tiny territory German, French and dialects are spoken. Moresnet rethinks the concept of border. After the Treaty of Versailles in 1919, this small state belongs to Belgium. [less ▲]

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See detailUsutu virus, Belgium, 2016
Garigliany, Mutien-Marie ULg; Linden, Annick ULg; Gilliaux, Gautier ULg et al

in Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics of Infectious Diseases (2017), 48(1), 116-119

During late summer 2016, in a northwest European region extending over Belgium, the Netherlands and the eastern border of the German state of North Rhine Westphalia, an outbreak of wild bird deaths ... [more ▼]

During late summer 2016, in a northwest European region extending over Belgium, the Netherlands and the eastern border of the German state of North Rhine Westphalia, an outbreak of wild bird deaths occurred similar to those reported on the continent since 1996. Dead birds were necropsied and examined by complementary methods. Pathologic and immunohistological investigations strongly suggested an infection by Usutu virus. Subsequently, genomic segments of the said virus were detected, the virus was isolated and its complete genome was sequenced. The strain, designated Usutu-LIEGE, is a close phylogenetic relative of those isolated in Germany which form a distinct group within the USUV phylogeny, the so-called Europe_3 lineage. Should this outbreak recapitulate the characteristics of those in southwest Germany in 2011 and in/around Vienna (Austria) in 2001, it is expected that specific avian populations in the affected area will face a significant reduction in size for a few years. [less ▲]

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See detailAs teorias semióticas diante da fotografia
Dondero, Maria Giulia ULg

in Rodrigues, Angelica; Rocha, Nildicéia (Eds.) Proceedings VI SELIN – The Unesp Linguistics Studies Seminar (2017, January)

Dans ce texte, je me propose de revenir sur les travaux en sémiotique qui ont marqué les études du champ interdisciplinaire de la photographie et de les poursuivre; l’objectif principal est de fournir ... [more ▼]

Dans ce texte, je me propose de revenir sur les travaux en sémiotique qui ont marqué les études du champ interdisciplinaire de la photographie et de les poursuivre; l’objectif principal est de fournir quelques pistes pour étudier, d’un point de vue sémiotique, l’image photographique en tant qu’objet pris dans des pratiques d’usage et d’interprétation diversifiées au sein des statuts sociaux de l’art, de la science, de la religion. [less ▲]

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See detailPost-embryonic development of sheepshead minnow Cyprinodon variegatus: a staging tool based on externally visible anatomical traits
Schnitzler, Joseph ULg; Dussenne, Mélanie ULg; Frederich, Bruno ULg et al

in Ichthyological Research (2017), 64

The sheepshead minnow Cyprinodon variegatus has become a favoured model for laboratory studies because of their small size, rapid development, and tolerance of laboratory conditions. Here, we analyse ... [more ▼]

The sheepshead minnow Cyprinodon variegatus has become a favoured model for laboratory studies because of their small size, rapid development, and tolerance of laboratory conditions. Here, we analyse sheepshead minnow post-embryonic development with the goal of providing a generally useful method for staging fish after embryogenesis. Groups of three females and two males were placed in breeding chambers designed for this experiment. More than 100 eggs were collected and maintained in seawater. Embryos were selected under a dissection microscope and placed in incubation dishes (50 per dish) at 26 °C. On day six, embryos hatched and larvae were transferred to 1 L beakers. To define a simplified normalization table for sheepshead minnow development, we measured each fish for its standard length and examined the fish for four externally evident traits: pigmentation pattern, caudal fin morphology, anal fin morphology, and dorsal fin morphology. The four traits were chosen, because they are easily visualized with standard laboratory equipment such as the stereomicroscope and camera. We have provided criteria for staging sheepshead minnows in studies of post-embryonic development. Our data suggest that dorsal and anal fin morphology may serve as a useful phenotype for defining metamorphic climax stages throughout post-embryonic development in C. variegatus. The staging systems we propose should facilitate detailed anatomical and developmental analyses in relation to ecotoxicological studies on potential disruption of the thyroid axis by xenobiotics and endocrine-disrupting compounds. [less ▲]

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