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See detailTraining alters the innate immune response in the lower airway of horses
Frellstedt, Linda ULg

Doctoral thesis (2014)

Many human and animal studies have examined various markers of the innate and/or adaptive immunity in association with exercise and have come to the general conclusion that exercise, either acute or ... [more ▼]

Many human and animal studies have examined various markers of the innate and/or adaptive immunity in association with exercise and have come to the general conclusion that exercise, either acute or chronic, modifies the immune response. Regular moderate exercise has beneficial and protective effects on immunity because it results in a balance of pro- and anti-inflammatory effects. This balance may be disturbed during exhaustive exercise, such as that experienced during competition and overtraining, resulting in immunosuppression. Humans frequently suffer from upper respiratory tract infections after prolonged intense exercise, whereas horses suffer primarily from lower airway inflammation and/or infection. The underlying mechanism for this difference remains unknown at this time. The sampling of different cell types is limited in humans and therefore, these studies focus on the evaluation of cells in peripheral blood or markers in saliva. Two groups of researchers in human sports medicine have compared populations of sedentary and regularly exercising people. The expression of Toll-like receptors (TLRs) 1, 2, 3 and 4 was decreased in peripheral blood monocytes in exercising subjects. This altered expression of TLRs was also associated with a lower production of pro-inflammatory cytokines (IL-6, IL-1α, TNF-α). Regular exercise induced circulating anti-inflammatory cytokines (IL-10, IL-6) and, therefore, limited the effects of pro-inflammatory cytokines. The first line of defense in the airways is provided by pulmonary alveolar macrophages and bronchial epithelial cells. Strenuous exercise impairs the viability of bronchial epithelial cells, reduces the viral defense mechanisms, and decreases oxidative burst activity of pulmonary alveolar macrophages. The altered immune response in association with exercise/training does not only lead to an increased risk for infection but may also cause the development of allergies and chronic inflammation in the lower airway. This may explain why young equine athletes frequently suffer from Inflammatory Airway Disease (IAD). The etiology of IAD remains unknown but an association with subclinical viral infections as well as inflammatory stimuli from the environment has been suspected. The objective of this work was to increase our knowledge of immune mechanisms in young equine athletes by evaluating the effect of acute exercise and training on the innate immune responses of pulmonary alveolar macrophages (PAM), bronchial epithelial cells (BEC) and monocytes. The hypothesis was that exercise and training modify the TLR mRNA expression as well as the production of pro-inflammatory cytokines and interferons in these three cell types. Eight Standardbred horses were studied over a period of 9 months during which they were acclimatized, trained and deconditioned. Standardized exercise tests were performed regularly and biological samples (blood, bronchoalveolar lavages, and biopsies of the bronchial epithelium) were taken at defined intervals in order to allow a longitudinal evaluation of the different parameters. Monocytes, PAM and BEC were harvested and analyzed. The expression of TLR3 was decreased in equine PAM and monocytes after a period of training, but not after a single strenuous exercise session. In addition, the expression of TLR4 was increased in equine monocytes after training. The production of TNF-α and IFN-β was also examined in PAM and monocytes ex vivo after the stimulation with different TLR ligands. The production of these cytokines was reduced in PAM after a defined period of training and remained decreased for three months thereafter. In contrast, the synthesis of TNF-α was increased after a period of training in equine monocytes and remained increased thereafter. In a second study, a model for the culture of equine bronchial epithelial cells (EBEC) was developed which allowed us to evaluate the effect of exercise and training on the innate immune response of these cells. Acute exercise or training did not alter the TLR mRNA expression in EBEC. The production of IFN-β was increased in EBEC from trained horses after stimulation with a TLR3 ligand. Concurrently, the secretion of TNF-α and IL-6 was impaired in EBEC from trained horses after the stimulation with TLR2 and TLR3 ligands. This study focused on a single aspect of the innate immunity in horses, gaining knowledge of the TLR expression in three cell types and their response to specific TLR agonists. These results have to be considered in the global context of the innate immunity remembering that they represent only a small part of the complex immune system. Only one type of training (Standardbred race training) and one model of acute exercise (standardized exercise test on a treadmill) were evaluated in this study. This should be considered when drawing conclusions, because it is currently understood that the effects on immune responses vary with different types, intensity and duration of exercise and/or training. Nonetheless, this work has established that a local immunosuppression develops within the lungs in trained horses, and may explain the increased susceptibility of exercising horses to pulmonary viral infections. This local immunosuppression is associated with an increased potential of monocytes to produce pro-inflammatory cytokines when challenged with pathogens. The effects of exercise on innate immunity are complex and further studies are needed to continue the work in this field. In addition to the response to training in young sport horses, a number of environmental factors associated with their nutrition and housing may play important roles in the development of pulmonary infections and inflammation (e.g. IAD). To confirm the significance of the presented results, it would be interesting to investigate the innate immune response in trained horses when challenged with equine pathogens, such as equine influenza and equine herpesviruses. The ultimate goal of this work and other studies in the future is to develop immuno-modulating molecules that could be used for the prevention and treatment of equine respiratory diseases. [less ▲]

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Peer Reviewed
See detailThe Initial Upper Paleolithic in Northeast Asia: toward the definition of a techno-complex
Zwyns, N.; Teyssandier, N.; Izuho, M. et al

Conference (2014, October 23)

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See detailUniversité : Les interactions possibles avec l’enseignement non-universitaire
Winand, Jean ULg

Conference (2014, October 23)

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See detailProblèmes du plurilinguisme dans l'antiquité gréco-romaine
Rochette, Bruno ULg

Scientific conference (2014, October 23)

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See detailManaging understory light to maintain the coexistence of forest tree species with different shade tolerances
Ligot, Gauthier ULg

Doctoral thesis (2014)

Similar to the management of the other environmental resources, forest management has been questioned and more sustainable practices of forest management are being sought. New close-to-nature practices ... [more ▼]

Similar to the management of the other environmental resources, forest management has been questioned and more sustainable practices of forest management are being sought. New close-to-nature practices aim to favor natural processes over human interventions. Particularly, continuous-cover forestry has the goal of relying on natural regeneration, and maintaining irregular stand structure and tree species mixture. However, maintaining mixture of species with different shade tolerances appears arduous with such a silvicultural system. Successfully managing irregular and mixed forests, relying on natural processes, requires a strong knowledge of the ecology of natural regeneration. In particular, strong knowledge is required to predict the result of the interspecific competition in the understory depending upon light availability. The amount of radiation transmitted to the understory is indeed a critical factor determining regeneration dynamics. It determines, at least in part, regeneration composition because of interspecific differences of growth and survival under shade. Moreover, our quantitative understanding of understory light in uneven-aged and mixed stands remains incomplete. A better quantitative understanding of understory light is needed to provide quantitative guidelines for the management of understory light in uneven-aged and mixed stands and, hence, for the management of natural regeneration. The purpose of this thesis is to determine how close-to-nature forest management can maintain mixtures of species with contrasting shade tolerances. I consider ecological conditions with good water and nutrient supplies. In these conditions, partially closed canopy limits the amount of light that reaches the understory, and light is the major factor driving regeneration composition. Consequently, I study the dynamics of natural regeneration with regards to light availability as well as the interception of light by the canopy of heterogeneous stands. Studying the regeneration ecology of two species with contrasting shade tolerances (Fagus sylvatica L. and Quercus petraea (Matt.) Liebl.), I find that the shade-tolerant species outgrow the less shade-tolerant species in all light conditions. Even though the control of understory light with continuous-cover silviculture is required to sustain the growth of less shade-tolerant regenerations, it might not be sufficient to maintain the coexistence of species with contrasting shade tolerances. In order to examine the effects of canopy structure and composition on understory light availability, I use a model of light interception by heterogeneous canopies after synthesizing and discussing the approaches reported in the literature. The model predicts satisfactorily measures of transmitted light even though it is a relatively simple radiative transfer model. I next explore how various silvicultural treatments can be manipulated to provide favorable understory light conditions for natural regeneration. These silvicultural strategies correspond to selective thinnings of five different types, e.g., harvesting preferentially small trees, large trees, or trees of shade-tolerant species or creating circular gaps. The results underline that creating favorable understory light conditions for natural regeneration can be achieved with various regeneration treatments. However, the adequate reduction of stand density depends upon the chosen silvicultural strategies. In particular, creating gaps of about 500 m2 provides adequate light for small regeneration clumps. Harvesting preferentially small and trees of shade-tolerant species are also appropriate but required higher harvest intensity. Harvesting preferentially large trees slightly increases understory light and promotes more shade-tolerant species than less shade-tolerant species. In order to maintain the coexistence of species with contrasting shade tolerances, forest manager must control understory light and manually suppress the regeneration of the shade-tolerant species. The outcome of this study provides foresters with the necessary tools to evaluate how silvicultural treatments can be manipulated to create or maintain favorable light conditions for the regeneration of species of different shade tolerances. Guidelines are additionally proposed for forest managers wanting to maintain the coexistence of species with contrasting shade tolerances. [less ▲]

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Peer Reviewed
See detailCombined holography and thermography in a single sensor through image-plane holography at thermal infrared wavelengths
Georges, Marc ULg; Vandenrijt, Jean-François ULg; Thizy, Cédric ULg et al

in Optics Express (2014), 22(21), 25517-25529

Holographic interferometry in the thermal wavelengths range, combining a CO2 laser and digital hologram recording with a microbolometer array based camera, allows simultaneously capturing temperature and ... [more ▼]

Holographic interferometry in the thermal wavelengths range, combining a CO2 laser and digital hologram recording with a microbolometer array based camera, allows simultaneously capturing temperature and surface shape information about objects. This is due to the fact that the holograms are affected by the thermal background emitted by objects at room temperature. We explain the setup and the processing of data which allows decoupling the two types of information. This natural data fusion can be advantageously used in a variety of nondestructive testing applications. [less ▲]

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See detailLa famille isiaque en bords de Vesdre
Winand, Jean ULg

Scientific conference (2014, October 20)

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See detailQuelles aides proposer aux victimes d’infractions ?
Garcet, Serge ULg

Article for general public (2014)

L'article propose un panorama de l'offre en matière d'aide aux victimes.

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Peer Reviewed
See detailSensitivity of Greenland Ice Sheet surface mass balance to perturbations in sea surface temperature and sea ice cover: a study with the regional climate model MAR
Noel, Brice; Fettweis, Xavier ULg; van de Berg, W.J. et al

in Cryosphere (The) (2014), 8

During recent summers (2007–2012), several surface melt records were broken over the Greenland Ice Sheet (GrIS). The extreme summer melt resulted in part from a persistent negative phase of the North ... [more ▼]

During recent summers (2007–2012), several surface melt records were broken over the Greenland Ice Sheet (GrIS). The extreme summer melt resulted in part from a persistent negative phase of the North Atlantic Oscillation (NAO), favoring warmer atmospheric conditions than normal over the GrIS. Simultaneously, large anomalies in sea ice cover (SIC) and sea surface temperature (SST) were observed in the North Atlantic, suggesting a possible connection. To assess the direct impact of 2007–2012 SIC and SST anomalies on GrIS surface mass balance (SMB), a set of sensitivity experiments was carried out with the regional climate model MAR forced by ERA-Interim. These simulations suggest that perturbations in SST and SIC in the seas surrounding Greenland do not considerably impact GrIS SMB, as a result of the katabatic wind blocking effect. These offshore-directed winds prevent oceanic near-surface air, influenced by SIC and SST anomalies, from penetrating far inland. Therefore, the ice sheet SMB response is restricted to coastal regions, where katabatic winds cease. A topic for further investigation is how anomalies in SIC and SST might have indirectly affected the surface melt by changing the general circulation in the North Atlantic region, hence favoring more frequent warm air advection towards the GrIS. [less ▲]

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See detailThe Airline Container Loading Problem with Pickup and Delivery
Lurkin, Virginie ULg; Schyns, Michael ULg

Conference (2014, October 19)

The present paper looks into the problem of optimizing the loading of a set of containers and pallets into cargo aircraft serving multiple airports. Due to the pickup and delivery operations occurring at ... [more ▼]

The present paper looks into the problem of optimizing the loading of a set of containers and pallets into cargo aircraft serving multiple airports. Due to the pickup and delivery operations occurring at intermediate airports, this problem is simultaneously a weight and balance problem and a sequencing problem. Our objective is to minimize fuel and handling operations costs. This problem is shown to be NP-hard. We resort to a mixed integer linear program. On the basis of a professional partner's real-world data, TNT Airways, we perform numerical experiments using a standard B&C library. This approach yields better solutions than traditional manual planning, which results in substantial cost savings. [less ▲]

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See detailDe l’homme de laboratoire à l’homme en situation : La rigueur d’une phénoménologie clinique
Englebert, Jérôme ULg

Scientific conference (2014, October 17)

Nous voudrions d’abord revenir sur de fausses évidences attachées aux différences entre pratique clinique et recherche. Nous sommes convaincu que la complexité, la rigueur, l’efficacité, voire une ... [more ▼]

Nous voudrions d’abord revenir sur de fausses évidences attachées aux différences entre pratique clinique et recherche. Nous sommes convaincu que la complexité, la rigueur, l’efficacité, voire une hypothétique véracité ne se situent pas, par nature et par principe, uniquement du côté de la recherche fondamentale au détriment d’une pratique clinique qui serait plus intuitive et moins rigoureuse. Nous proposerons ensuite un modèle de recherche directement inscrit dans le paradigme clinique. La psychopathologie phénoménologique, courant émergeant dans la littérature internationale, se caractérise par deux influences majeures : d’une part l’héritage de la réflexion de la philosophie et, d’autre part, elle trouve ses fondements – ses données pourrions-nous dire – dans l’observation de l’homme en situation, c’est-à-dire dans cette pratique clinique. Nous prendrons pour exemples différentes psychopathologies (schizophrénie, anorexie, psychopathie) qui nous permettront de suggérer que la compréhension du patient, et la rencontre de sa subjectivité et de sa sensation, ne peut se limiter à la recherche fondamentale et faire l’économie d’une phénoménologie clinique. Enfin, nous conclurons sur la nécessité d’un regard réciproque à poser entre les connaissances issues des protocoles de recherche en laboratoire et le savoir émergeant de la pratique clinique et de la rencontre de l’homme en situation. [less ▲]

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See detailThe Effect of Urtica dioica Supplements on Egg Quality
Touazi, Leghel; Moula, Nassim ULg

Poster (2014, October 17)

Eggs are a rich source of lipids and proteins. Because of their low production cost, they represent a cheap source of animal proteins and lipids. recently, in Algeria, consumers’ interest are oriented of ... [more ▼]

Eggs are a rich source of lipids and proteins. Because of their low production cost, they represent a cheap source of animal proteins and lipids. recently, in Algeria, consumers’ interest are oriented of healthiness and dietetic values food. The purpose of this study was to investigate the effects a dietary supplement of Urtica dioica on laying hen's performance and egg quality. The study was conducted from may to june 2014 in the area of Chemini (Algeria). Sixty, 25-wk-old Lohmann Brown layers were randomly divided into 3 groups with 20 hens in each group. Group 1 was the control group fed a standard commercial diet based on corn and soybean, whereas the groups 2 and 3 were fed the control diet supplemented with 1% and 1.5% of nettle respectively. The hens were housed in cages in the same local and fed ad libitum. Fifty five eggs were sampled 4 times in each group from 25 to 27 weeks. A total of 220 eggs were examined. A series of measurements were carried out on each egg, namely egg weight, form index (egg shape), yolk to albumen ratio (Y:A), Yolk color, egg shell thickness, Haugh’s units. Egg weight, yolk color and Haugh Units (HU) were affected by age. Significant differences (P<0.05) were recorded between feeding type in total egg weight, yolk color and Haugh Units. The egg from group 2 proved to have a higher egg weight (57.67g; group 1: 55.41g; group 3: 56.70g; P<0.05), (33.4%), intermediate Yolk color (8.53; group 1: 9.03 ; group 3: 9.38; P<0.05) and HU (79.81; group 1: 80.85; group 3: 76.92). The results showed that the use of 1% and 1.5% of Urtica dioica, had positive effects on the color of yolk of laying hens. Using different levels of Urtica dioica could change the characteristics of egg and could meet the preferences of consumers for the intense color of the yolk. [less ▲]

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See detailMélancolie et dépression : étude phénoménologique
Ramackers, Amélia; Englebert, Jérôme ULg

Poster (2014, October 17)

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See detailL'evidence-based practice en psychologie et en logopédie
Durieux, Nancy ULg

Conference (2014, October 17)

L’evidence-based practice (EBP) est une approche qui recommande d’optimiser les soins de santé en intégrant les meilleures données actuelles issues de la recherche scientifique, l’expertise des cliniciens ... [more ▼]

L’evidence-based practice (EBP) est une approche qui recommande d’optimiser les soins de santé en intégrant les meilleures données actuelles issues de la recherche scientifique, l’expertise des cliniciens ainsi que la situation et les préférences de chaque patient (Sackett et al., 1996). L’EBP fait couler beaucoup d’encre en médecine, où elle prend sa source, mais également dans d’autres disciplines. Certains praticiens ne jurent que par elle, d’autres la décrient… Quoiqu’il en soit, le recours à l’EBP est de plus en plus encouragé en logopédie et en psychologie. Les principaux objectifs de cette conférence seront de définir l’EBP, d’en décrire les étapes et d’exposer les bénéfices et les obstacles à son application. Des perspectives d’avenir seront également discutées afin que l’EBP puisse intégrer le quotidien des logopèdes et des psychologues en Belgique. [less ▲]

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See detailDépression, niveau d'engagement dans des activités et processus psychologiques : Nouvel axe de lecture et nouveaux outils d'évaluation
Wagener, Aurélie ULg

Conference (2014, October 17)

Cet atelier aura pour objectif de présenter un modèle théorique, testé auprès de 500 personnes, des liens entre la dépression, le niveau d’engagement dans des activités et différentes familles de ... [more ▼]

Cet atelier aura pour objectif de présenter un modèle théorique, testé auprès de 500 personnes, des liens entre la dépression, le niveau d’engagement dans des activités et différentes familles de processus psychologiques (image de soi, pensées négatives répétitives, évitement expérientiel, satisfaction environnementale, régulation émotionnelle et tendance à l’approche). Plus précisément, nous menons actuellement une étude dont les résultats nous permettront d’identifier les processus psychologiques médiateurs de la relation entre la dépression et le niveau d’engagement dans des activités. Ces processus psychologiques médiateurs pourront donc devenir des cibles précises et identifiées du traitement psychothérapeutique. Pour mener à bien cette étude, nous avons réalisé une revue de la littérature des outils évaluant spécifiquement ces processus psychologiques. Certains questionnaires ont été traduits de l’Anglais au Français et sont en cours de validation. L’ensemble des échelles utilisées, leur utilité et leur cotation, seront présentées lors de l’atelier. Elles seront également mises à disposition des cliniciens intéressés. Une discussion concernant les patients avec lesquels les utiliser sera également proposée. [less ▲]

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See detailCroire ou douter : comment en sortir ? Regards et pratiques croisés pour penser la maltraitance
Glowacz, Fabienne ULg

Conference given outside the academic context (2014)

Detailed reference viewed: 7 (0 ULg)