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See detailA review of gliptins for 2014.
Scheen, André ULg

in Expert opinion on pharmacotherapy (2015), 16(1), 43-62

Introduction: Dipeptidyl peptidase-4 (DPP-4) inhibitors (gliptins) occupy an increasing place in the armamentarium of drugs used for the management of hyperglycaemia and offer new opportunities for a ... [more ▼]

Introduction: Dipeptidyl peptidase-4 (DPP-4) inhibitors (gliptins) occupy an increasing place in the armamentarium of drugs used for the management of hyperglycaemia and offer new opportunities for a personalized medicine in patients with Type 2 diabetes. Areas covered: An updated review providing an analysis of available recent data with commercialized DPP-4 inhibitors, with a special focus on: differences between the various molecules, novelties regarding their mechanism of action, clinical efficacy in mono- and various combined therapies, comparison with other new therapies, efficacy-safety profile in at risk patients, concern about pancreatic safety, perspectives in cardiovascular prevention and, finally, a selection of remaining unanswered important questions for the clinician. Expert opinion: DPP-4 inhibitors offer various advantages when compared to other glucose-lowering agents. Despite they have been commercialized since a few years only, available data obtained in randomised controlled trials are of better quality compared to those available with ancient classical glucose-lowering agents, especially in more fragile populations such as elderly people, individuals with renal impairment or at high cardiovascular risk and patients at higher risk of hypoglycaemia. However, there remain uncertainties and controversies that should be resolved by further ongoing large prospective controlled trials and increasing clinical experience combined with a careful post-marketing surveillance. [less ▲]

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See detailOn the necessity and biological significance of threshold-free regulon prediction outputs
Rigali, Sébastien ULg; Nivelle, Renaud; Tocquin, Pierre ULg

in Molecular Biosystems (2015)

The in silico prediction of cis-acting elements in a genome is an efficient way to quickly obtain an overview of the biological processes controlled by a trans-acting factor, and connections between ... [more ▼]

The in silico prediction of cis-acting elements in a genome is an efficient way to quickly obtain an overview of the biological processes controlled by a trans-acting factor, and connections between regulatory networks. Several regulon prediction web tools are available, designed to identify DNA motifs predicted to be bound by transcription factors using position weight matrix-based algorithms. In this paper we expose and discuss the conflicting objectives of software creators (bioinformaticians) and software users (biologists), who aim for reliable and exhaustive prediction outputs, respectively. Software makers, concerned with providing tools that minimise the number of false positive hits, often impose a stringent threshold score for a sequence to be included in the list of the putative cis-acting sites. This rigidity eventually results in the identification of strongly reliable but largely straightforward sites, i.e. those associated with genes already anticipated to be targeted by the studied transcription factor. Importantly, this biased identification of strongly bound sequences contrasts with the biological reality where, in many circumstances, a weak DNA-protein interaction is required for the appropriate gene's expression. We show here a series of transcriptionally controlled systems involving weakly bound cis-acting elements that could never have been discovered because of the policy of preventing software users from modifying the screening parameters. Proposing only trustworthy prediction outputs thus prevents biologists from fully utilising their knowledge background and deciding to analyse statistically irrelevant hits that could nonetheless be potentially involved in subtle, unexpected, though essential cis-trans relationships. [less ▲]

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See detailA new species of Groenlandaspis Heintz, 1932 (Placodermi, Arthrodira) from the Famennian (Late Devonian) of Belgium
Olive, Sébastien ULg; Prestianni, Cyrille; Dupret, Vincent

in Journal of Vertebrate Paleontology (2015), 35(5),

A new species of the phlyctaeniid arthrodire genus Groenlandaspis from the upper Famennian of Belgium is described. The remains of Groenlandaspis potyi sp. nov. consist of dissociated thoracic armor ... [more ▼]

A new species of the phlyctaeniid arthrodire genus Groenlandaspis from the upper Famennian of Belgium is described. The remains of Groenlandaspis potyi sp. nov. consist of dissociated thoracic armor elements, but the specimen designed to be the holotype displays the median dorsal, anterior and posterior dorsolateral plates in connection. Though incomplete, the new species is characterized by an equilateral triangle-shaped median dorsal plate, a protruding posterodorsal apron of the posterior dorsolateral plate behind the overlap area for the median dorsal plate, and an overall lack of ornamentation. Groenlandaspis potyi sp. nov. constitutes the second occurrence of a Groenlandaspis species in continental Europe after the description of Groenlandaspis thorezi from upper Famennian quarries of Belgium. Another probable new species of Groenlandaspis is also described, though of unknown locality and horizon; it can however be deduced from the upper Famennian of Belgium without more precision. Together with some unpublished material of groenlandaspidids from the Famennian tetrapod-bearing locality of Strud, this material highlights the richness of the Groenlandaspididae diversity in Belgium. The discovery of Groenlandaspis potyi sp. nov. in Belgium reinforces the Famennian global distribution of this widespread genus during this period. Also, since those organisms have possibly been considered as non-marine indicators, this material is another argument pleading for close relationships between Euramerica and Gondwana around the Frasnian-Famennian boundary. [less ▲]

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See detailElsvier, Computers in Industry, Special Issue on Natural Language Processing and Text Analytics in Industry
Ittoo, Ashwin ULg; Bosh, v.d., Antal; Nguyen, Le Minh

Book published by Elsevier (2015)

Detailed reference viewed: 29 (6 ULg)
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See detail"Des muets qui veulent parler". Lectures politiques, des Temps Modernes à L'Idiot de la famille
Cormann, Grégory ULg

in Bolmain, Thomas; Cormann, Grégory (Eds.) Politiques de la littérature. Bourdieu, Sartre, Foucault (2015)

Detailed reference viewed: 26 (2 ULg)
See detailAlbum zutique - Dixains réalistes
Saint-Amand, Denis ULg; Grojnowski, Daniel

Book published by Garnier Flammarion (2015)

Édition de deux recueils collectifs emblématiques de la poésie française du XIXe siècle, comprenant une introduction, des notes explicatives pour chaque texte, un dossier et un dictionnaire des auteurs.

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See detailManuel. Les contrats spéciaux
Kohl, Benoît ULg; Burette, Caroline ULg; Daenen, Thomas et al

Book published by Larcier (2015)

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See detailLeibniz
Bouquiaux, Laurence ULg

in Bouaniche, Arnaud; Leclercq, Jean (Eds.) Une histoire de la philosophie (2015)

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See detailA mortar method combined with an augmented Lagrangian approach for treatment of mechanical contact problems
Cavalieri, Federico J.; Bruls, Olivier ULg; Cardona, Alberto

in Terze, Zdravko (Ed.) Multibody Dynamics: Computational Methods and Applications (2015)

This work presents a mixed penalty-duality formulation from an augmented Lagrangian approach for treating the contact inequality constraints. The augmented Lagrangian approach allows to regularize the non ... [more ▼]

This work presents a mixed penalty-duality formulation from an augmented Lagrangian approach for treating the contact inequality constraints. The augmented Lagrangian approach allows to regularize the non differentiable contact terms and gives a C1 differentiable saddle-point functional. The relative displacement of two contacting bodies is described in the framework of the Finite Element Method (FEM) using the mortar method, which gives a smooth representation of the contact forces across the bodies interface. To study the robustness and performance of the proposed algorithm, validation numerical examples with finite deformations and large slip motion are presented. [less ▲]

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See detailImpact of light and melanopsin on human cognitive brain function
Vandewalle, Gilles ULg

Conference (2015)

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See detailEnchanting gods and dolphins. A cross cultural analysis of uncanny encounters
Halloy, Arnaud; Servais, Véronique ULg

in Ethos (Berkeley, Calif.) (2015), 43(1),

Drawing on first–hand accounts of possession experiences in an Afro–Brazilian cult and Dolphin encounters at sea, we compare the two settings in order to identify the common features in people’s ... [more ▼]

Drawing on first–hand accounts of possession experiences in an Afro–Brazilian cult and Dolphin encounters at sea, we compare the two settings in order to identify the common features in people’s experiences, but also in the technologies of enchantment that make them possible. By “technology of enchantment”, we mean a space of practice, neither totally material, nor totally subjective, that supports “revelation”–like encounters with real or imagined intentional entities. Our analysis suggests that both types of experiences share at least five common traits: the presence of a prolific imagination marked by ontological and epistemological uncertainty; uncanny feelings; attentional focus on inner bodily and mental states; trance–like states; and an intentional shift from active to passive. The immersion of the individual in a sensorily organized environment (sensescape), made of distributed perceptual saliences, is found to play a central role in the merging of unusual body states with the imagination, which in turn enables the production of “new” embodied meanings belonging to enchantment. [less ▲]

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See detailLe chien des sciences de l'homme
Servais, Véronique ULg

Book published by Le bord de l'eau (2015)

L'ouvrage est divisé en deux parties. La première confronte différentes perspectives théoriques permettant de faire entrer le chien en sciences sociales. La seconde partie présente des études empiriques ... [more ▼]

L'ouvrage est divisé en deux parties. La première confronte différentes perspectives théoriques permettant de faire entrer le chien en sciences sociales. La seconde partie présente des études empiriques documentant la présence des chiens auprès des humains. [less ▲]

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See detailVers une généralisation des quartiers durables ? Présentation du référentiel d’aide à la conception et à l’évaluation développé en Wallonie et analyse prospective de douze quartiers.
Marique, Anne-Françoise ULg; Delbar, Caroline; Loiseau, Véronique ULg et al

in Urbia (2015)

Un référentiel a été développé en Wallonie, à la demande du Ministre de l’Environnement, de l’Aménagement du Territoire et de la Mobilité, pour opérationnaliser le concept de « quartier durable » en ... [more ▼]

Un référentiel a été développé en Wallonie, à la demande du Ministre de l’Environnement, de l’Aménagement du Territoire et de la Mobilité, pour opérationnaliser le concept de « quartier durable » en objectivant les critères minimum à respecter pour inscrire un quartier dans une vision transversale de développement durable. Ce référentiel constitue un cadre général qui régira les projets de quartiers durables menés en Wallonie (Belgique). Les 5 thématiques et les 25 critères qui constituent ce référentiel sont présentés. La grille de critères est ensuite appliquée à douze quartiers de façon à identifier les invariants communs aux processus de conception de ces quartiers et les freins à l’intégration des principes transversaux du développement durable dans les opérations de ce type. Si les critères relatifs aux performances énergétiques des bâtiments ont percolé dans un grand nombre de cas, la mixité des logements et leur accessibilité, la mixité sociale et la participation restent peu abordés. Le référentiel est disponible depuis début 2014 pour tous les acteurs de l’architecture et de l’urbanisme. [less ▲]

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See detailLa correction de l’expression écrite en langue étrangère en Fédération Wallonie-Bruxelles : expliciter l’implicite
Noiroux, Kevin ULg; Simons, Germain ULg

in Les cahiers de l’Association des chercheurs et enseignants didacticiens des langues étrangères (acedle) (2015)

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See detailFair Trade and Social Enterprise
Huybrechts, Benjamin ULg

in Raynolds, Laura; Bennett, Elizabeth (Eds.) The Handbook of Research on Fair Trade (2015)

This chapter suggests that the notion of ‘social enterprise’ is useful to capture the DNA of organizations focused on fair trade and to locate them within a broader organizational taxonomy. Without ... [more ▼]

This chapter suggests that the notion of ‘social enterprise’ is useful to capture the DNA of organizations focused on fair trade and to locate them within a broader organizational taxonomy. Without seeking to impose a new term that may not resonate for certain actors or regions, this chapter aims to bring two contributions to fair trade research and practice. First, it is suggested that the social enterprise approach is particularly useful as an analytical tool enabling researchers and other stakeholders to capture the evolution and diversification of organizational models in fair trade. Second, the use of a broader organizational approach that is not specific to the sole fair trade sector allows for connections with similar organizations in other sectors and brings a shift from considering mainly what the organizations do (fair trade in this case) towards also addressing what they are (innovative social enterprise models combining market dynamics with social purpose). This chapter is structured as follows. First, the concept of social enterprise is introduced and discussed. Then, the evolution of the organizational landscape of fair trade (in the North) is summarized. Finally, fair trade organizations are examined in the light of the social enterprise concept, with illustrations from a study in four European countries (Huybrechts 2010a; 2012). [less ▲]

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See detailSartre, les passions de la liberté. Phénoménologie, politique, savoirs critiques
Cormann, Grégory ULg

Book published by Peter Lang (2015)

Detailed reference viewed: 57 (8 ULg)
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See detailIbn ʿAbd al-Ẓāhir, Muḥyī l-Dīn
Bauden, Frédéric ULg

in Encyclopaedia of Islam Three (2015)

Detailed reference viewed: 12 (1 ULg)