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See detailRationale for the potential use of mesenchymal stromal cells in liver transplantation
VANDERMEULEN, Morgan ULg; DE ROOVER, Arnaud ULg; BRIQUET, Alexandra ULg et al

in World Journal of Gastroenterology (in press), 20(44), 16418-16432

Mesenchymal stromal cells (MSCs) are multipotent and self-renewing cells that reside essentially in the bone marrow as a non-hematopoietic cell population, but may also be isolated from the connective ... [more ▼]

Mesenchymal stromal cells (MSCs) are multipotent and self-renewing cells that reside essentially in the bone marrow as a non-hematopoietic cell population, but may also be isolated from the connective tissues of most organs. MSCs represent a heterogeneous population of adult, fibroblast-like cells characterized by their ability to differentiate into tissues of mesodermal lineages including adipocytes, chondrocytes and osteocytes. For several years now, MSCs have been evaluated for their in vivo and in vitro immunomodulatory and 'tissue reconstruction' properties, which could make them interesting in various clinical settings, and particularly in organ transplantation. This paper aims to review current knowledge on the properties of MSCs and their use in pre-clinical and clinical studies in solid organ transplantation, and particularly in the field of liver transplantation. The first available clinical data seem to show that MSCs are safe to use, at least in the medium-term, but more time is needed to evaluate the potential adverse effects of long-term use. Many issues must be resolved on the correct use of MSCs. Intensive in vitro and pre-clinical research are the keys to a better understanding of the way that MSCs act, and to eventually lead to clinical success. [less ▲]

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See detailDe l’intérêt de Lambert Lombard pour les aegyptiaca
Laboury, Dimitri ULg

in Allart, Dominique; Bert, Mathilde; Gilles, Isabelle (Eds.) Liège au XVIe siècle. Art et culture autour de L.Lombard (in press)

Envisagée sous l’angle de l’égyptologie, et, plus précisément, sous celui de ce qu’il est aujourd’hui convenu d’appeler l’Ägyptenrezeption, l’œuvre attribuée à Lambert Lombard étonne tant elle apparaît ... [more ▼]

Envisagée sous l’angle de l’égyptologie, et, plus précisément, sous celui de ce qu’il est aujourd’hui convenu d’appeler l’Ägyptenrezeption, l’œuvre attribuée à Lambert Lombard étonne tant elle apparaît véritablement constellée de références à l’Égypte antique, ou plus exactement à l’image que l’on se faisait au XVIe siècle de la civilisation des lointains pharaons. Dans l’état actuel de notre connaissance, cette présence de « la matière égyptienne » (suivant l’expression de l’égyptologue français Serge Sauneron) dans les productions de l’artiste liégeois semble pouvoir se décliner sous quatre formes, qui nous renseignent, à divers titres, sur la représentation que Lambert Lombard pouvait avoir de l’Égypte antique et, surtout, sur la perspective dans laquelle il a développé ces références et cet intérêt manifeste pour la culture pharaonique. [less ▲]

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See detailRéflexions sur la datation du cycle des « Femmes vertueuses ». De l’utilisation des sources antiques par les peintres antiquisants des Temps Modernes
Laboury, Dimitri ULg; Huby, Caroline

in Allart, Dominique; Bert, Mathilde; Gilles, Isabelle (Eds.) Liège au XVIe siècle. Art et culture autour de L.Lombard (in press)

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See detailLe scribe et le peintre. À propos d’un scribe qui ne voulait pas être pris pour un peintre
Laboury, Dimitri ULg

in Collombert, Philippe; Lefèvre, Dominique; Polis, Stéphane (Eds.) et al Volume d'hommage dédiée à un distingué collègue (in press)

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See detailOn the master painter of the tomb of Amenhotep Sise, second High Priest of Amun Under the reign of Thutmose IV (TT 75)
Laboury, Dimitri ULg

in Cooney, Kathlyn; Jasnow, Richard (Eds.) Volume dedicated to a distinguished colleague (in press)

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See detailIn search of the painters of the Theban necropolis in the 18th dynasty. Prolegomena to an analysis of painterly practices in the tomb of Amenemope (TT29)
Laboury, Dimitri ULg; Tavier, Hugues

in Angenot, Valérie; Tiradritti, Francesco (Eds.) Artists and Painting in Ancient Egypt (in press)

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See detailRevisiting the origin and diversification of vascular plants through a comprehensive Bayesian analysis of the fossil record
Silvestro, Daniel; Cascales - Miñana, Borja ULg; Bacon, Christine D. et al

in New Phytologist (in press)

Plants have a long evolutionary history, during which mass extinction events dramatically affected Earth’s ecosystems and its biodiversity. The fossil record can shed light on the diversi- fication ... [more ▼]

Plants have a long evolutionary history, during which mass extinction events dramatically affected Earth’s ecosystems and its biodiversity. The fossil record can shed light on the diversi- fication dynamics of plant life and reveal how changes in the origination–extinction balance have contributed to shaping the current flora. We use a novel Bayesian approach to estimate origination and extinction rates in plants throughout their history. We focus on the effect of the ‘Big Five’ mass extinctions and on estimating the timing of origin of vascular plants, seed plants and angiosperms. Our analyses show that plant diversification is characterized by several shifts in origination and extinction rates, often matching the most important geological boundaries. The estimated origin of major plant clades predates the oldest macrofossils when considering the uncertainties associated with the fossil record and the preservation process. Our findings show that the commonly recognized mass extinctions have affected each plant group differently and that phases of high extinction often coincided with major floral turnovers. For instance, after the Cretaceous–Paleogene boundary we infer negligible shifts in diversification of non-flowering seed plants, but find significantly decreased extinction in spore-bearing plants and increased origination rates in angiosperms, contributing to their current ecological and evolutionary dominance. [less ▲]

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See detailRelire Durkheim à partir de Zola : Ce que le roman naturaliste fait à la sociologie du suicide de Durkheim
Ledent, David ULg

in Le suicide : question individuelle ou question sociétale ? (in press)

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See detailLe partage du sensible
Havelange, Carl ULg

in Fritz, Jean-Marie; Duhl, Olga (Eds.) Les cinq sens entre Moyen Age et Renaissance (in press)

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See detailLiège de 1914 à 1927 : mort et résurrection d’un bassin industriel
Pirot, Pascal ULg; Peters, Arnaud ULg; Destatte, Julien ULg

in Actes du colloque: Guerres mondiales et bassins industriels en territoire occupé (1900-1950), Maubeuge, 20-21 novembre 2014 (titre provisoire) (in press)

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See detailDiversity patterns of the vascular plant group Zosterophyllopsida in relation to Devonian palaeogeography
Cascales - Miñana, Borja ULg; Meyer-Berthaud, Brigitte

in Palaeogeography, Palaeoclimatology, Palaeoecology (in press)

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See detailConclusion. De nouvelles approches pour repenser l’(in)sécurité
Wintgens, Sophie ULg; Grandjean, Geoffrey ULg; Vanhaeren, Stéphanie ULg

in Wintgens, Sophie; Grandjean, Geoffrey; Vanhaeren, Stéphanie (Eds.) L’insécurité en question. Définition, enjeux et perspectives (in press)

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See detailIntroduction. L’(in)sécurité : entre représentations et perceptions des concepts
Grandjean, Geoffrey ULg; Wintgens, Sophie ULg; Vanhaeren, Stéphanie ULg

in Wintgens, Sophie; Grandjean, Geoffrey; Vanhaeren, Stéphanie (Eds.) L’insécurité en question. Définition, enjeux et perspectives (in press)

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See detailL'insécurité en question. Définition, enjeux et perspectives
Wintgens, Sophie ULg; Grandjean, Geoffrey ULg; Vanhaeren, Stéphanie ULg

Book published by Presses Universitaires de Liège (in press)

Ces dernières années, l’analyse et les pratiques de la sécurité et de l’insécurité ont fortement évolué sous l’influence de plusieurs facteurs fortement imbriqués, tels que le déclin de la souveraineté ... [more ▼]

Ces dernières années, l’analyse et les pratiques de la sécurité et de l’insécurité ont fortement évolué sous l’influence de plusieurs facteurs fortement imbriqués, tels que le déclin de la souveraineté nationale, l’accroissement de l’intensité des interactions transnationales ou encore l’éclatement conflictuel sous-tendu par des dynamiques identitaires. Ces constats et les représentations qui leur sont associées ont enjoint un réexamen de la manière dont la sécurité et l’insécurité se pensent et se pratiquent. Inscrit au cœur de ce double questionnement contemporain, cet ouvrage met en question la définition et les enjeux liés aux dynamiques actuelles d’(in)sécurité tout en proposant de nouvelles perspectives. Privilégiant les études empiriques et les approches originales en termes de politique interne et/ou externe, il repose sur trois axes de recherche transversaux : la (re)définition des concepts de sécurité et d’insécurité à l’heure de la globalisation ; les enjeux inhérents aux pratiques (in)sécuritaires et aux sentiments d’(in)sécurité qui les fondent ; les réponses à apporter aux questions de sécurité et d’insécurité. Complémentaire aux analyses disciplinaires classiques de ces objets de recherche en Science politique, cet ouvrage livre un regard neuf sur des thématiques plus que jamais d’actualité. [less ▲]

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See detailLe faussaire
Havelange, Carl ULg

in Durante, Erica (Ed.) De l'humain au post-humain: le double et ses récits (in press)

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See detailProgress on research on rodents and rodent-borne zoonoses in Southeast Asia
Blasdell, Kim; Bordes, Frédéric; Chaisiri, Kittipong et al

in Wildlife Research (in press)

This review aims to synthesize the knowledge on the taxonomy of Southeast Asian murine rodents and the challenges associated with the identification of habitat preferences and associated rodent-borne ... [more ▼]

This review aims to synthesize the knowledge on the taxonomy of Southeast Asian murine rodents and the challenges associated with the identification of habitat preferences and associated rodent-borne diseases. Recent studies concerning the Rattini tribe have identified unclear species boundaries that would benefit from further investigation. The development of barcoding may allow more accurate identification of rodents, specifically for complex species. However, knowledge on the distribution and habitat specializations of many common murine rodents is still scarce, particularly regarding the specific habitat preferences of most synanthropic rodent species (Rattus tanezumi or Rattus exulans). Several studies have analyzed the prevalence of major rodent-borne diseases in Southeast Asia and it appears that the greatest risk of rodent zoonoses are in the lowland rainfed and irrigated landscapes, generally in and around rice fields. [less ▲]

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See detailAnalytical Procedure Validation and the Quality by Design Paradigm
Rozet, Eric ULg; Rozet, Eric

in Journal of Biopharmaceutical Statistics (in press)

Since the adoption of the ICH Q8 document concerning the development of pharmaceutical processes following a Quality by Design (QbD) approach, there have been many discussions on the opportunity for ... [more ▼]

Since the adoption of the ICH Q8 document concerning the development of pharmaceutical processes following a Quality by Design (QbD) approach, there have been many discussions on the opportunity for analytical procedure developments to follow a similar approach. While development and optimization of analytical procedure following QbD principles have been largely discussed and described, the place of analytical procedure validation in this framework has not been clarified. This article aims at showing that analytical procedure validation is fully integrated into the QbD paradigm and is an essential step in developing analytical procedure that are effectively fit for purpose. Adequate statistical methodologies have also their role to play: such as design of experiments, statistical modelling and probabilistic statements. The outcome of analytical procedure validation is also an analytical procedure Design Space and from it, control strategy can be set. [less ▲]

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See detailImaging myeloma and related monoclonal plasma cell disorders: Still room for standard radiography?
WITHOFS, Nadia ULg; Nanni, Cristina; Fanti, Stefano et al

in Clin.Translat.Imaging (in press)

A majority of multiple myeloma patients present with osteolytic bone lesions that can cause bone pain, fractures or hypercalcaemia. Correct identification of these lesions is important in the initial ... [more ▼]

A majority of multiple myeloma patients present with osteolytic bone lesions that can cause bone pain, fractures or hypercalcaemia. Correct identification of these lesions is important in the initial assessment of the disease. Although the radiological skeletal survey is the gold standard to detect bone osteolytic lesions, it may miss small bone lesions or lesions located in the spine or pelvis due to the superimposed images of soft tissues. These limitations propelled newer imaging techniques such as positron emission tomography combined with computed tomography (PET/CT) and magnetic resonance imaging (MRI) in the diagnosis of multiple myeloma. In addition, 18F-fluorodeoxyglucose PET/CT and MRI have prognostic value and can be used to monitor disease. This review discusses the additional value of PET/CT and MRI in the management of MM. [less ▲]

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