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See detailPolitique, Profil et Parcours linguistiques face à la mondialisation universitaire
Defays, Jean-Marc ULg

in Dezutter, Olivier; Borge, Serge (Eds.) Actes du IIIe Forum mondial des centres de langues de l’enseignement supérieur HÉRACLES, "Les Centres de langues et la mise en œuvre des politiques linguistiques" (in press)

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See detailPractical management of Chronic Myeloid Leukemia in Belgium
Benghiat, FS.; Beguin, Yves ULg; Dessars, B. et al

in Belgian Journal of Hematology (in press)

Imatinib has drastically changed the outcome of patients with chronic myeloid leukemia (CML), with the majority of them showing a normal life span. Recently, the development of second and third generation ... [more ▼]

Imatinib has drastically changed the outcome of patients with chronic myeloid leukemia (CML), with the majority of them showing a normal life span. Recently, the development of second and third generation tyrosine kinase inhibitors (TKIs) and the possibility of treatment discontinuation made the management of these patients more challenging. In this review, practical management guidelines of CML are presented, adapted to the Belgian situation in 2014. In first line chronic phase patients, imatinib, nilotinib and dasatinib can be prescribed. While second generation TKIs give faster and deeper responses, their impact on long-term survival remain to be determined. The choice of the TKI depends on CML risk score, priority for a deep response to allow a treatment-free remission protocol, age, presence of comorbid conditions, side effect profile, drug interactions, compliance concerns and price. Monitoring the response has to be made according the 2013 ELN criteria, and is based on the bone-marrow cytogenetic response during the first months and on the blood molecular response. Molecular follow-up is sufficient in patients with a complete cytogenetic response. For patients who fail frontline therapy, nilotinib, dasatinib, bosutinib and ponatinib are an option depending of the type of intolerance or resistance. T315I patients are only sensitive to ponatinib, which has to be carefully handled due to cardiovascular toxicity. Advanced phase diseases are more difficult to handle, with treatments including allogeneic stem cell transplantation, which is also an option for patients failing at least two TKIs. The possibility of treatment-free remission and pregnancy are also discussed. [less ▲]

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See detailCircadian and circannual variations in cord blood hematopoietic cell composition
Servais, Sophie ULg; BAUDOUX, Etienne ULg; Brichard, B. et al

in Haematologica (in press)

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See detailOrigin and immunoescape of uterine cervical cancer
Van hede, Dorien ULg; Langers, Inge ULg; DELVENNE, Philippe ULg et al

in Presse Médicale (in press)

Human papillomavirus associated uterine cervical cancer is an important public health problem since it is classified as the fourth most common cancer in women worldwide with more than 500 000 recorded ... [more ▼]

Human papillomavirus associated uterine cervical cancer is an important public health problem since it is classified as the fourth most common cancer in women worldwide with more than 500 000 recorded cases. This review is focused on where and why HPV infection induces cervical cancers and how this virus avoids the host immune response. Immunological therapeutic approaches are also addressed. [less ▲]

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See detailCalibration and precision of serum creatinine and plasma cystatin C measurement: impact on the estimation of glomerular filtration rate
DELANAYE, Pierre ULg; CAVALIER, Etienne ULg; Cristol, Jean-Paul et al

in Journal of Nephrology (in press)

Serum creatinine (SCr) is the main variable for estimating glomerular filtration rate (GFR). Due to interassay differences, the prevalence of chronic kidney disease (CKD) varies according to the assay ... [more ▼]

Serum creatinine (SCr) is the main variable for estimating glomerular filtration rate (GFR). Due to interassay differences, the prevalence of chronic kidney disease (CKD) varies according to the assay used, and calibration standardization is necessary. For SCr, isotope dilution mass spectrometry (IDMS) is the gold standard. Systematic differences are observed between Jaffe and enzymatic methods. Manufacturers subtract 0.30 mg/dl from Jaffe results to match enzymatic results (‘compensated Jaffe method’). The analytical performance of enzymatic methods is superior to that of Jaffe methods. In the original Modification of Diet in Renal Disease (MDRD) equation, SCr was measured by a Jaffe Beckman assay, which was later recalibrated. A limitation of this equation was an underestimation of GFR in the high range. The Chronic Kidney Disease Epidemiology (CKD-EPI) consortium proposed an equation using calibrated and IDMS traceable SCr. The gain in performance was due to improving the bias whereas the precision was comparable. The CKD-EPI equation performs better at high GFR levels (GFR[60 ml/ min/1.73 m2). Analytical limitations have led to the recommendation to give a grade ([60 ml/min/1.73 m2) rather than an absolute value with the MDRD equation. By using both enzymatic and calibrated methods, this cutoff-grade could be increased to 90 ml/min/1.73 m2 (with MDRD) and 120 ml/min/1.73 m2 (with CKD-EPI). The superiority of the CKD-EPI equation over MDRD is analytical, but the precision gain is limited. IDMS traceable enzymatic methods have been used in the development of the Lund– Malmo¨ (in CKD populations) and Berlin Initiative Study equations (in the elderly). The analytical errors for cystatin C are grossly comparable to issues found with SCr. Standardization is available since 2011. A reference method for cystatin C is still lacking. Equations based on standardized cystatin C or cystatin C and creatinine have been proposed. The better performance of these equations (especially the combined CKD-EPI equation) has been demonstrated. [less ▲]

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See detail27 entrées du dictionnaire (Adorno, Bataille, Benjamin, Brecht, Burckhardt, etc.)
Hagelstein, Maud ULg

in Talon-Hugon, Carole (Ed.) Dictionnaire des théoriciens de l'art (in press)

Les notices du dictionnaire que je prends en charge : Adorno, Bataille, Benjamin, Burckhardt, Cassirer, Chastel, Deleuze, Dilthey, Faure, Focillon, Foucault, Francastel, Freud, Kracauer, Luckacs, Malraux ... [more ▼]

Les notices du dictionnaire que je prends en charge : Adorno, Bataille, Benjamin, Burckhardt, Cassirer, Chastel, Deleuze, Dilthey, Faure, Focillon, Foucault, Francastel, Freud, Kracauer, Luckacs, Malraux, Nietzsche, Panofsky, Riegl, Rousseau, Simmel, Valery, Vasari, Winkelman, Wölfflin, Worringer, Warburg. [less ▲]

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See detailThe Childhood Executive Function Inventory (CHEXI): Confirmatory Factor Analyses and Cross-Cultural Clinical Validity in a Sample of 8- to 11-Year-Old Children
Catale, Corinne ULg; Meulemans, Thierry ULg; Thorell, Lisa B.

in Journal of Attention Disorders (in press)

The Childhood Executive Functioning Inventory (CHEXI) is a new rating instrument for executive functioning developed by Thorell and Nyberg (2008). Through exploratory factor analyses, this inventory has ... [more ▼]

The Childhood Executive Functioning Inventory (CHEXI) is a new rating instrument for executive functioning developed by Thorell and Nyberg (2008). Through exploratory factor analyses, this inventory has been shown to tap into working memory and inhibition-related behaviors in young children. In this study, we present the psychometric characteristics of the French adaptation of the CHEXI in 8- to 11-year-old children. In addition, we explore the cross-cultural validity of the CHEXI in discriminating between children with ADHD and normally developing children in two culturally different samples (Belgian and Swedish). Confirmatory factor analyses replicated the two-factor solution, referred to as inhibition and working memory, that was identified in the original study with Swedish children. Supplementary analyses indicated that both subscales have good psychometric properties. From a clinical point of view, the CHEXI was found to discriminate, with high sensitivity and specificity, between children with ADHD and normally developing controls in both cultural samples. Cross-cultural clinical implications are discussed. [less ▲]

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See detailChemical composition of colostrum from Azawak cow in Niger compared with meta-analytical data
Abdou, Harouna; Marichatou, Hamani; Beckers, Jean-François ULg et al

in Animal Genetic Resources Information = Bulletin d'Information sur les Ressources Génétiques Animales = Boletin de Informacion sobre Recursos Geneticos Animales (in press)

This study aimed at comparing data obtained from Azawak zebu colostrum with literature data. The comparison was performed by a meta-analytical approach. Colostrum samples were hand-collected after 5 h ... [more ▼]

This study aimed at comparing data obtained from Azawak zebu colostrum with literature data. The comparison was performed by a meta-analytical approach. Colostrum samples were hand-collected after 5 h from 7 Azawak cows at calving between August 27, to September 10, 2009 in the Sahel. For data from literature, twenty one (21) references were identified in the following analytical databases: PubMed, Science Direct, Google scholar, Collection from University of Liege. The references were selected according to the following two criteria: i) only studies reported on bovine colostrum were used irrespective of breeds, and ii) among the selected studies, those not providing complete information to allow meta-analytical calculation were excluded. Samples were analyzed for immunoglobulins (IgG, IgM, IgA), lactoferrin, and chemical composition (dry mater, protein, fat, lactose, ash, Ca, P, NA, K, Mg). The mean levels of IgG, IgM, dry matter, protein and fat for Azawak cows were lower (P ˂ 0.001) than those obtained in other breeds; however colostrum from the Azawak was higher in IgA but the difference was not significant. For lactose and ash, mean values for Azawak cows were higher (P ˂ 0.001) than those from the literature. Contents of Ca, P, Na and Mg in Azawak bovine colostrum were significantly higher (P ˂ 0.001) than the mean levels in form the literature data. In conclusion, the colostrum from Azawak cows appears to be lower in most immunoglobulins, in fat and in protein than the values reported in the literature, but higher in lactose and minerals. This could be an adaptation to sahelian contraints. [less ▲]

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See detailEstablishment of a murine graft-versus-myeloma model using allogeneic stem cell transplantation
Binsfeld, Marilène ULg; Beguin, Yves ULg; Belle, Ludovic et al

in PLoS ONE (in press)

Background: Multiple myeloma (MM) is a malignant plasma cell disorder with poor long-term survival and high recurrence rates. Despite evidence of graft-versus-myeloma (GvM) effects, the use of allogeneic ... [more ▼]

Background: Multiple myeloma (MM) is a malignant plasma cell disorder with poor long-term survival and high recurrence rates. Despite evidence of graft-versus-myeloma (GvM) effects, the use of allogeneic hematopoietic stem cell transplantation (allo-SCT) has remained controversial in MM. In the current study, we investigated the anti-myeloma effects of allo-SCT from B10.D2 mice into MHC-matched myeloma-bearing Balb/cJ mice (previously injected with the MOPC315.BM myeloma cell line), based on a chronic graft-versus-host disease (GvHD) murine model. Methods and results: Balb/cJ mice were injected intravenously with luciferase-transfected MOPC315.BM cells, and received 30 days later an allogeneic (B10.D2 donor) or autologous (Balb/cJ donor) transplantation by intravenous administration of bone marrow cells and splenocytes. We observed a graft-versus-myeloma effect in 94% of the allogeneic transplanted mice, as luciferase signal completely disappeared after transplantation, whereas all the autologous transplanted mice showed myeloma evolution. Lower serum paraprotein levels and myeloma infiltration in bone marrow and spleen in the allogeneic setting confirmed the observed GvM effect, while allogeneic mice also displayed chronic GvHD symptoms. In vivo and in vitro data suggest the involvement of effector memory CD4 and CD8 T cells in the GvM effect. The essential role of CD8 T cells was demonstrated in vivo where CD8 T-cell depletion of the graft resulted in reduced GvM effects. Finally, TCR V spectratyping analysis identified V families within CD4 and CD8 T cells which were associated with both GvM effects and GVHD, whereas other V families within CD4 T cells were associated exclusively with either GvM or GvHD responses. Conclusions: We successfully established an immunocompetent murine model of graft-versus-myeloma. This is the first immunocompetent murine model which is based on a MM model closely resembling human MM disease (bone marrow tropism, ...) and using allo-SCT after the disease establishment, as a curative treatment [less ▲]

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See detailCircadian and homeostatic regulation of sleepiness and cognition and its neuronal underpinnings
Schmidt, Christina; Chellappa, Sarah Laxhmi ULg; Cajochen, Christian

in Garbarino, Sergio (Ed.) Sleepiness and Human Impact Assessment (in press)

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See detailCompte rendu de l'ouvrage de C. E. Barrett, "Egyptianizing Figurines from Delos. A Study in Hellenistic Religion"
Veymiers, Richard ULg

in Kernos : Revue Internationale et Pluridisciplinaire de Religion Grecque (in press), 27

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See detailCircadian Rhythm Sleep Disorder: Genetic and Environmental Factors
Chellappa, Sarah Laxhmi ULg; Viola, Antoine; Mongrain, Valerie

in Kushida, Clete (Ed.) Encyclopaedia of Sleep (in press)

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See detailThe extension of Early Upper Palaeolithic with blade leaf-points (Lincombian-Ranisian-Jerzmanowician): the issue of Kostenki 8 level I
Flas, Damien ULg

in Ashton, Nick (Ed.) No Stone Unturned: Papers in Honour of Roger Jacobi (in press)

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See detailL’impact du règlement Bruxelles 1bis sur les règlements TEE, IPE et RPL
Berthe, Aude ULg

in Guinchard, Emmanuel (Ed.) Le nouveau règlement Bruxelles I bis - Règlement n° 1215/2012 du 12 décembre 2012 concernant la compétence judiciaire, la reconnaissance et l'exécution des décisions en matière civile et commerciale (in press)

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See detailNeurophysiological basis of sleep and wakefulness
Chellappa, Sarah Laxhmi ULg; Schmidt, Christina; Cajochen, Christian

in Garbarino, Sergio (Ed.) Sleepiness and Human Impact Assessment (in press)

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See detailTwo time pieces for sleep regulation: the circadian clock and the homeostatic hourglass
Cajochen, Christian; Schmidt, Christina; Chellappa, Sarah Laxhmi ULg

in Garbarino, Sergio (Ed.) Sleepiness and Human Impact Assessment (in press)

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See detailThe mata'a and the "collapse hypothesis"
Flas, Damien ULg

in De Dapper, Morgan; Cauwe, Nicolas; Huyghe, Dirk (Eds.) Easter Island. Collapse or Transformation ? A State of the Art. Proceedings of the International Conference of Bruxelles (November 9th-10th 2012) (in press)

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See detailEvolution of Treatment and Investigative Approaches in Sleep Medicine
Ly, Julien; Chellappa, Sarah Laxhmi ULg; MAQUET, Pierre ULg

in Billiard, Michael (Ed.) Sleep Medicine: a comprehensive guide (in press)

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See detailThe Sceptical President: Václav Klaus' Influence on Czech Public Opinion on Climate Change
De Pryck, Kari; Gemenne, François ULg

in Climatic Change (in press)

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See detailnotices et contribution
Allart, Dominique ULg

in Van Grieken, Joris; Van der Stock, Jan; Luyten, Ger (Eds.) Hieronymus Cock. The Renaissance in Print (in press)

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