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See detailThe RIAD peptidomimetic inhibits HIV-1 replication in humanized NSG mice
Singh, Maneesh; Singh, Pratibha; Vaira, Dolores et al

in European Journal of Clinical Investigation (in press)

Background Increased intracellular concentration of cyclic AMP (cAMP) in T cells is associated with various immunodeficiency conditions including human immunodeficiency virus (HIV) infection. Several ... [more ▼]

Background Increased intracellular concentration of cyclic AMP (cAMP) in T cells is associated with various immunodeficiency conditions including human immunodeficiency virus (HIV) infection. Several reports indicate a critical role of activated protein kinase A (PKA) in the susceptibility of cells to HIV infection. We have used a cell permeable, stable peptidomimetic version (P3) of the RI-anchoring disruptor (RIAD), which prevents PKA interaction with A-kinase-anchoring proteins (AKAPs). It is known that RIAD peptide abrogates effects of localized cAMP signalling through anchored type I PKA in lymphocytes and prevents murine AIDS (MAIDS) infection when expressed as a transgene in mice. Methods and Results In vitro HIV-infected human peripheral blood mononuclear cells (PBMCs) show reduced levels of p24 and intracellular cAMP in T cells when treated with RIAD peptidomimetic (RIAD-P3). Humanized NOD/SCID/IL2cnull (NSG) mice infected with HIV-1 JRCSF and treated with RIAD-P3 (3􏰀5 mg) once every 2 weeks showed significantly reduced levels of viral load at +28, +42 and +56 days and increased CD4 numbers at +56 days after the start of treatment. RIAD-P3-treated humanized mice had lower levels of intracellular cAMP in T cells sorted from splenocytes. Conclusions Treatment with RIAD-P3 limits HIV-1 viral replication and stabilizes CD4 levels by mechanisms involving cAMP/PKA-I pathway in human PBMCs and humanized NSG mice. [less ▲]

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See detailThe BNP and the FN. Between Islamophobia and the “defence” of democratic values
Jamin, Jérôme ULg

in Jackson, Paul (Ed.) The British Far Right in Transition: 1945 to Today (in press)

In this article Jérôme Jamin examines the ideological development of the British National Party (BNP) and the Front National (FN) since 9/11. He argues that if both parties have evolved towards discourses ... [more ▼]

In this article Jérôme Jamin examines the ideological development of the British National Party (BNP) and the Front National (FN) since 9/11. He argues that if both parties have evolved towards discourses more in line with democracy and liberal values, it can be explained by the opportunity the “threat” of Islam offered. After a reminder of the birth and the electoral evolution of the two parties, Jamin focuses on the perception and the definition of democracy as depicted in their manifestos and main public speeches. The study reveals an ethnic-styled perception of democracy at the BNP in opposition with a more civic perception at the FN, even if the analysis shows an ambiguity behind the use of the concept of “people” in the FN rhetoric mixing frequently “demos” and “ethnos”. The author confronts the combination of this new democratic rhetoric with the birth of Islam as a threat incompatible with “British democracy” in the United Kingdom and “Republican secularism” in France. In both parties, stereotypes of Islam are used to portray the BNP and the FN as defenders of a true and legitimate democracy and to a great extent, Jamin argues, “Islam” provided an unexpected opportunity to replace migrants, foreigners and Arabs with a new stereotype: the Muslim who threatens the separation between state and religion, equality between men and women, freedom of speech, and so on. Jamin concludes by emphasising that both parties required time to identify this new scapegoat. [less ▲]

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See detailArrêt(s) sur image(s) : usages et pratiques du photogramme
Thonon, Jonathan ULg

in MethIS : Méthodes et Interdisciplinarité en Sciences Humaines (in press)

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See detailComparative biogeochemistry-ecosystem-human interactions on dynamic continental margins
Levin, Lisa A.; Liu, Kon-Kee; Kay-Christian, Emeis et al

in Journal of Marine Systems (in press)

The ocean’s continental margins face strong and rapid change, forced by a combination of direct human activity, anthropogenic CO2-induced climate change, and natural variability. Stimulated by discussions ... [more ▼]

The ocean’s continental margins face strong and rapid change, forced by a combination of direct human activity, anthropogenic CO2-induced climate change, and natural variability. Stimulated by discussions in Goa, India at the IMBER IMBIZO III, we (1) provide an overview of the drivers of biogeochemical variation and change on margins, (2) compare temporal trends in hydrographic and biogeochemical data across different margins (3) review ecosystem responses to these changes, (4) highlight the importance of margin time series for detecting and attributing change and (5) examine societal responses to changing margin biogeochemistry and ecosystems. We synthesize information over a wide range of margin settings in order to identify the commonalities and distinctions among continental margin ecosystems. Key drivers of biogeochemical variation include long-term climate cycles, CO2-induced warming, acidification, and deoxygenation, as well as sea level rise, eutrophication, hydrologic and water cycle alteration, changing land use, fishing, and species invasion. Ecosystem responses are complex and impact major margin services including primary production, fisheries production, nutrient cycling, shoreline protection, chemical buffering, and biodiversity. Despite regional differences, the societal consequences of these changes are unarguably large and mandate coherent actions to reduce, mitigate and adapt to multiple stressors on continental margins. [less ▲]

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See detailProcédés et enjeux de l'écriture polémique dans le dossier épistolaire anti-adoptianiste du concile de Francfort (794)
Close, Florence ULg; Veyrard-Cosme, Christiane

in Actes du colloque international ""Écriture et genre épistolaires, IVe-XIe s". 5-8 juin 2013 (in press)

Relecture à deux voix – historico-littéraire – des pièces du dossier épistolaire de Francfort attribué à Alcuin visant à dégager les stratégies littéraires et oratoires mises en œuvres par Alcuin au nom ... [more ▼]

Relecture à deux voix – historico-littéraire – des pièces du dossier épistolaire de Francfort attribué à Alcuin visant à dégager les stratégies littéraires et oratoires mises en œuvres par Alcuin au nom des évêques francs, d’une part, et de Charlemagne, de l’autre, pour tenter de ramener l’épiscopat espagnol dans le giron romain. Réflexion sur le rôle, l’importance et la puissance stylistique du genre épistolaire, hérité de l’Antiquité, dans deux foyers importants de haute culture de l’époque – la péninsule ibérique et le monde insulaire. [less ▲]

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See detailOccurrence of bottlenose dolphins (Tursiops truncatus) in the Río Negro Estuary, Argentina, and their mid-distance movements along the Northeast Patagonian coast
Failla, Mauricio; Seijas, Veronica; Vermeulen, Els ULg

in Latin American Journal of Aquatic Mammals (in press)

A systematic study on the presence of bottlenose dolphins (Tursiops truncatus) in the Río Negro Estuary (RNE), Patagonia Argentina, was carried out between the months March – July from 2008 to 2011. Data ... [more ▼]

A systematic study on the presence of bottlenose dolphins (Tursiops truncatus) in the Río Negro Estuary (RNE), Patagonia Argentina, was carried out between the months March – July from 2008 to 2011. Data on the dolphin’s activity patterns were gathered via an Ad Libitum focal group sampling mode accompanying dorsal fin images taken for identification and re-identification of individuals. A total effort of 188 h resulted in 58 h of positive observation of 124 dolphin groups (sightings per unit effort (SPUE) = 0.66 groups/h). Data analysis showed two main activity states for the observed groups, travelling (65%) and foraging (26%). The remaining 9% of the groups were involved in other activity states. The photo-identification effort, which started opportunistically in 2006, resulted in a catalogue of 21 individual dolphins, with a total mean re-identification rate of 9 days (max = 24 days). When comparing these pictures to the existing catalogue of Bahía San Antonio (approximately 200 km west from the study area) dorsal fins of 20 individuals could be positively matched and most (n = 17) could be subsequently re-identified in both areas, indicating their long distance movements along the North Patagonian coast during the austral autumn months. This season coincides with the lowest amount of feeding activity observed in Bahía San Antonio. This study suggests that bottlenose dolphins enter RNE, mainly during autumn, to forage. It appears that the search for food resources may be the trigger for their movement patterns along the North Patagonian coast during this season, at least for certain individuals. More research is needed to accurately confirm this hypothesis. [less ▲]

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See detailPre-war Planning in Belgium
Bechet, Christophe ULg

in Janz, Oliver; Apostolopoulos, Nicolas (Eds.) 1914-1918-online. International Encyclopedia of the First World War (in press)

Abstract: Since the Treaty of London in 1839, pre-war planning theories in Belgium oscillated between two positions: on one hand secure and defend which border would be endangered, on the other hand ... [more ▼]

Abstract: Since the Treaty of London in 1839, pre-war planning theories in Belgium oscillated between two positions: on one hand secure and defend which border would be endangered, on the other hand constitute in Antwerp a powerful national sanctuary. This concentration of most of the available military means in Antwerp was far more appropriate in the event of a French invasion. But this perspective decreased after the Franco-Prussian war in 1870, while the possibility of a trespassing by the two belligerents became greater and greater. The fortifications of Namur and Liège were voted by the Chambers in 1887 as a deterrent to both France and Germany. Nevertheless, without totally putting aside the defence of the Belgian southwestern border, high-ranking officers seemed to fear more and more a violation of the eastern border. Due to the completion of fortifications on the Meuse in 1892, German columns were supposed to move forward south of the river, through the Belgian Ardennes. On the eve of the Great War, King Albert I would have preferred to concentrate the army on the Meuse but his Chief of Staff selected a central position in order to maintain and secure his line of communication with Antwerp. The lack of a determined and “standardized” doctrine at the highest level of the army led to a “mixed” or compromise plan adopted in a hurry during the first days of mobilization in August 1914. [less ▲]

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See detailNon-isothermal moisture balance equation in porous media: a review of mathematical formulations in Building Physics
Dubois, Samuel ULg; Lebeau, Frédéric ULg; Evrard, Arnaud ULg

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (in press)

Understanding heat and mass transfers in porous materials is crucial in many areas of scientific research. Mathematical models have constantly evolved, their differences lying mainly in the choice of the ... [more ▼]

Understanding heat and mass transfers in porous materials is crucial in many areas of scientific research. Mathematical models have constantly evolved, their differences lying mainly in the choice of the driving potentials used to describe moisture flows, as well as in the complexity of characterizing the physical phenomena involved. Models developed in the field of Building Physics (HAM models) are used to describe the behavior of envelope parts and assess their impact on user comfort and energy performance. The water balance equation can be described in many ways; it is a function of the boundary conditions considered and the fact they induce high or low water content in the porous materials used. This paper gives an overview of various formulations for this equation that are found in the Building Physics literature. It focuses first on the physically based formulation of moisture balance, drawing on the Representative Elementary Volume (REV) concept, coupled with thermodynamic flow rates description. This is then reformulated in line with various main moisture state variables offering a wide variety of expressions that are compared with available models. This approach provides access to all secondary transport coefficients associated with the process of mathematical transformation. Particular emphasis is placed on the moisture storage function choice and its impact on the final mathematical formulations. [less ▲]

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See detailWorking memory deficits in developmental dyscalculia: the importance of serial order.
Attout, Lucie ULg; Majerus, Steve ULg

in Child Neuropsychology : A Journal on Normal & Abnormal Development in Childhood & Adolescence (in press)

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See detailLa fin du Paléolithique moyen dans le Nord de l’Europe : la question des origines du Lincombien-Ranisien-Jerzmanowicien
Flas, Damien ULg

in Depaepe, Pascal (Ed.) Les plaines du Nord-Ouest : carrefour de l’Europe au Paléolithique moyen ? (in press)

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See detailSens et signification dans l'esthétique de Mallarmé
Durand, Pascal ULg

in Signata. Annales des Sémiotiques = Annals of Semiotics (in press), 5

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See detailProteins in the gas phase
Meyer, Tim; Gabelica, Valérie ULg; Grubmüller, Helmut et al

in Wiley Interdisciplinary Reviews: Computational Molecular Science (in press)

Proteins are complex macromolecules that evolved over billions of years to be active in aqueous solution. Water is a key element that stabilizes their structure, and most structural studies on proteins ... [more ▼]

Proteins are complex macromolecules that evolved over billions of years to be active in aqueous solution. Water is a key element that stabilizes their structure, and most structural studies on proteins have thus been carried out in aqueous environment. However, recent experimental approaches have opened the possibility to gain structural information on proteins from gas-phase measurements. The obtained results revealed significant structural memory in proteins when transferred from water to the gas phase. However, after several years of experimental and theoretical research, the nature of the structural changes induced by vaporization, the exact characteristics of proteins in the gas phase, and the physicochemical forces stabilizing dehydrated proteins are still unclear. We will review here these issues using both experimental and theoretical sources of information. [less ▲]

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See detailÉclairer les enjeux de la reconstruction industrielle du bassin liégeois : l'apport des archives des Etablissements insalubres et dangereux (1919-1925)
Peters, Arnaud ULg; Defechereux, Olivier ULg; Destatte, Julien ULg

in Parmentier, Isabelle (Ed.) Actes des Deuxièmes Rencontres d'Histoire de l'Environnement en Belgique (Belgique, Luxembourg, Congo, Rwanda, Burundi) (in press)

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See detailMoyens et enjeux d’une approche didactique des Illuminations
Saint-Amand, Denis ULg

in Parade Sauvage (in press), 25

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See detailEntre répit et déréliction : Berlin clubbing
Saint-Amand, Denis ULg

in Zimmermann, Margarete (Ed.) Ville des émotions : Berlin dans la littérature francophone contemporaine (in press)

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See detailLe Mur et le masque. À propos de Banksy.
Saint-Amand, Denis ULg

in MethIS : Méthodes et Interdisciplinarité en Sciences Humaines (in press)

Detailed reference viewed: 30 (4 ULg)
See detailInventer. Le jeune Descartes et les voies de l’inventio en 1619-1620
Dubouclez, Olivier ULg

in Savini, Massimiliano (Ed.) Les écrits de jeunesse de Descartes (in press)

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See detailDialectique de l’inattendu. Voies et impasses de la philosophie dans l’œuvre de Valère Novarina
Dubouclez, Olivier ULg

in Née, Laure (Ed.) Valère Novarina (in press)

Novarina entretient avec la philosophie une relation faite d’attraction et de défiance. Le primat accordé à la parole et le refus de toute ontologie le conduisent à définir un nouveau modèle théorique ... [more ▼]

Novarina entretient avec la philosophie une relation faite d’attraction et de défiance. Le primat accordé à la parole et le refus de toute ontologie le conduisent à définir un nouveau modèle théorique, celui de la « fugue » et, tout en poursuivant le dialogue avec les philosophes, à construire ce que nous appellerons une dialectique de l’inattendu, mouvement par lequel le vide actif qui habite la personne humaine nourrit le renouvellement de la pensée et de l’action. [less ▲]

Detailed reference viewed: 8 (0 ULg)