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See detailCorticatus
Pfister, Max; Valenti, Gianluca ULg

in Lessico Etimologico Italiano (in press)

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See detailComparative assessment of 6-[18F]fluoro-L-m-tyrosine and 6-[18F]fluoro-L-dopa to evaluate dopaminergic presynaptic integrity in a Parkinson’s disease rat model.
Becker, Guillaume ULg; Bahri, Mohamed Ali ULg; Michel, Anne et al

in Journal of Neurochemistry (in press)

Because of the progressive loss of nigro-striatal dopaminergic terminals in Parkinson’s disease (PD), in vivo quantitative imaging of dopamine (DA) containing neurons in animal models of PD is of critical ... [more ▼]

Because of the progressive loss of nigro-striatal dopaminergic terminals in Parkinson’s disease (PD), in vivo quantitative imaging of dopamine (DA) containing neurons in animal models of PD is of critical importance in the pre-clinical evaluation of highly awaited disease-modifying therapies. Among existing methods, the high sensitivity of positron emission tomography (PET) is attractive to achieve that goal. The aim of this study was to perform a quantitative comparison of brain images obtained in 6-hydroxydopamine (6-OHDA) lesioned rats using two dopaminergic PET radiotracers, namely [18F]fluoro-3,4-dihydroxyphenyl-L-alanine ([18F]FDOPA) and 6-[18F]fluoro-L-m-tyrosine ([18F]FMT). Because the imaging signal is theoretically less contaminated by metabolites, we hypothesized that the latter would show stronger relationship with behavioural and post-mortem measures of striatal dopaminergic deficiency. We used a within-subject design to measure striatal [18F]FMT and [18F]FDOPA uptake in eight partially lesioned, eight fully lesioned and ten sham-treated rats. Animals were pretreated with an L-aromatic amino acid decarboxylase (AADC) inhibitor. A catechol-O-methyl transferase inhibitor was also given before [18F]FDOPA PET. Quantitative estimates of striatal uptake were computed using conventional graphical Patlak method. Striatal dopaminergic deficiencies were measured with apomorphine-induced rotations and post-mortem striatal DA content. We observed a strong relationship between [18F]FMT and [18F]FDOPA estimates of decreased uptake in the denervated striatum using the tissue-derived uptake rate constant Kc. However, only [18F]FMT Kc succeeded to discriminate between the partial and the full 6-OHDA lesion and correlated well with the post-mortem striatal DA content. This study indicates that the [18F]FMT could be more sensitive, with respect of [18F]FDOPA, to investigate DA terminals loss in 6-OHDA rats, and open the way to in vivo AADC activity targeting in future investigations on progressive PD models. [less ▲]

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See detailCarte géologique de Wallonie. Louveigné-Spa n°49/3-4
Marion, Jean-Marc ULg; Geukens, Fernand; Lamberty, Pauline ULg et al

Cartographic material (in press)

New geological map of Wallonia published at the scale of 1/25.000, based on a new field work and using previous scientific data produced since the previous editions, in 1898 (at the scale of 1/40.000, by ... [more ▼]

New geological map of Wallonia published at the scale of 1/25.000, based on a new field work and using previous scientific data produced since the previous editions, in 1898 (at the scale of 1/40.000, by Gustave Dewalque) and the second one, in 1958 (at the scale of 1/25.000 by Paul Fourmarier). [less ▲]

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See detailOrganometallic-mediated radical polymerization of 'less activated monomers': fundamentals, challenges and opportunities
Debuigne, Antoine ULg; Jérôme, Christine ULg; Detrembleur, Christophe ULg

in Polymer (in press)

Access to well-defined polymers made of the so-called ‘Less Activated Monomers’ (LAMs) via controlled radical polymerization has long been a challenge due to the lack of radical stabilizing group on the ... [more ▼]

Access to well-defined polymers made of the so-called ‘Less Activated Monomers’ (LAMs) via controlled radical polymerization has long been a challenge due to the lack of radical stabilizing group on the double bond of these monomers. This Feature Article summarizes substantial progress in the organometallic-mediated radical polymerization (OMRP) of this important class of monomers including vinyl esters, olefins, vinyl chloride, vinyl amides, or ionic-liquid vinyl monomers. It aims to provide a clear and comprehensive account of the fundamentals and challenges in the OMRP of LAMs as well as an overview of the resulting macromolecular engineering opportunities. The input of photochemistry, environmentally friendly solvents or flow reactors in OMRP is also presented. Finally, it emphasizes how some well-defined LAMs-based materials contributed to the development of specific applications notably in the fields of biomedicine or energy. [less ▲]

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See detailOvertopping induced failure of non-cohesive, homogenous fluvial dikes
Rifai, Ismail ULg; Erpicum, Sébastien ULg; Archambeau, Pierre ULg et al

in Water Resources Research (in press)

Accurate predictions of breach characteristics are necessary to reliably estimate the outflow hydrograph and the resulting inundation close to fluvial dikes. Laboratory experiments on the breaching of ... [more ▼]

Accurate predictions of breach characteristics are necessary to reliably estimate the outflow hydrograph and the resulting inundation close to fluvial dikes. Laboratory experiments on the breaching of sand-filled fluvial dikes were performed, considering a flow parallel to the dike axis. The breach was triggered by overtopping of the dike crest. A detailed monitoring of the transient evolution of the breach geometry was conducted, providing key insights into the gradual and complex processes involved in fluvial dike failure. The breach develops in two phases: (1) the breach becomes gradually wider and deeper eroding on the downstream side along the main channel, and (2) breach widening controlled by side slope failures, continuing in the downstream direction only. Increasing the inflow discharge in the main channel, the breach formation time decreases significantly and the erosion occurs preferentially on the downstream side. The downstream boundary condition has a strong influence on the breach geometry and the resulting outflow hydrograph. [less ▲]

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See detailDe culpable a perseguido: Baudelaire y el proceso de Las Flores del mal
Mogollon Zapata, Juan Manuel ULg

in Revista Historia, Teoría, Crítica (in press)

¿Cómo el poeta de Las Flores del Mal paso de ser un autor proscrito, y en consecuencia sospechoso, al autor perseguido e incomprendido que ha inmortalizado la historia literaria? ¿Cómo Baudelaire pudo ... [more ▼]

¿Cómo el poeta de Las Flores del Mal paso de ser un autor proscrito, y en consecuencia sospechoso, al autor perseguido e incomprendido que ha inmortalizado la historia literaria? ¿Cómo Baudelaire pudo desviar a su favor una circunstancia que, a primera vista, era desafortunada? Baudelaire supo utilizar el escándalo que provocó la publicación de Las Flores del Mal para promover su figura pública. Un análisis de las posturas discursivas desplegadas por Baudelaire y por sus pares durante y después del proceso nos permitirá comprender mejor la inversión que el poeta hace de su condenación al transformar la sanción penal y moral, y la exclusión a la que ésta conduce, en un signo de su grandeza y de su gloria póstuma. [less ▲]

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See detailPlace des Guillemins, le public domestiqué
Bianchi, Michaël ULg

Article for general public (in press)

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See detailCharleroi, the 'placerelle'
Bianchi, Michaël ULg

in Masterclass Bridges (in press)

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See detailConditor
Pfister, Max; Valenti, Gianluca ULg

in Lessico Etimologico Italiano (in press)

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See detailLa Vita Benedicti de Grégoire le Grand confrontée aux œuvres narratives de l’Antiquité classique : une étude quantitative de la distribution des parties du discours
Longrée, Dominique ULg; Philippart de Foy, Caroline ULg

in Carlier, Anne; Guillot, Céline (Eds.) Du latin tardif au français ancien : continuités et rupture (in press)

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See detail*Corticea
Pfister, Max; Valenti, Gianluca ULg

in Lessico Etimologico Italiano (in press)

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See detailLiving and Printing in Antwerp in the Late Fifteenth and Early Sixteenth Centuries: a Social Enquiry
Adam, Renaud ULg

in Van Bruaene, Anne-Laure; Kavaler, Ethan Matt (Eds.) Urban Perspectives on Sixteenth-Century Netherlandish Art & Culture (in press)

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See detailFair Trade and Co-operatives
Nicholls, Alex; Huybrechts, Benjamin ULg

in Michie, Jonathan; Blassi, J.; Borzaga, Carlo (Eds.) The Handbook of Co-operative and Mutual Businesses (in press)

The Fair Trade and co-operative movements have much in common. This chapter aims to examine the convergences and divergences between the two fields, highlighting what they can learn from each other and ... [more ▼]

The Fair Trade and co-operative movements have much in common. This chapter aims to examine the convergences and divergences between the two fields, highlighting what they can learn from each other and how practitioners and researchers in the two areas can better collaborate. Fair trade is an innovative approach to economic development that uses a market-driven approach to exploit the growing trend in ethical, or caused-based, consumption (Nicholls & Opal 2005). Fair Trade organizations aim to re-engineer the value chains between poor producers and artisans - typically in developing countries - and their wholesale buyers such that a greater proportion of the overall rents accrue to those who provide the inputs. Put simply, Fair Trade aims to ensure that the poorest actors in a supply chain benefit from more of the overall financial value creation as a development tool. Moreover, Fair Trade reconnects producers and consumers at the point of purchase such that consumption becomes a political – or, at least, life style – choice. This chapter is structured as follows. After this introduction, the second section describes the development of Fair Trade from its historical roots to the current organizational landscape and market organization. Next there is a discussion of several key issues and challenges that have emerged as Fair Trade has become increasingly institutionalized. Then, the fourth section explores the relationship between Fair Trade and the co-operative and mutual movements. Finally, conclusions serve to sum up the chapter. [less ▲]

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See detailLes symboles chrétiens dans les papyrus littéraires et documentaires grecs : forme, disposition et fonction (IIIe – VIIe/VIIIe siècles)
Carlig, Nathan ULg

in Signes dans les textes. Continuités et les ruptures des pratiques scribales en Égypte pharaonique, gréco-romaine et byzantine (in press)

In this paper we study the Christian symbols, as the cross (), the staurogramm (⳨, and its variant with an appendage ), the chi-rho sign (⳩), and the crux ansata (☥) in Greek literary and documentary ... [more ▼]

In this paper we study the Christian symbols, as the cross (), the staurogramm (⳨, and its variant with an appendage ), the chi-rho sign (⳩), and the crux ansata (☥) in Greek literary and documentary papyri. The first part is dedicated to the study of the form and the origin of the Christian symbols, on the ground of both the oldest papyri which bear them and the literary sources about them. In the second part we analyze their disposition in the papyri and in relation to the texts they bear. Finally, in the third part, the data studied before lead to identifying the functions of the Christian symbols in the papyri. [less ▲]

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See detailDFT investigation of the reaction mechanism for the guanidine catalyzed ring-opening of cyclic carbonates by aromatic and alkyl-amines
Alves, Margot ULg; Méreau, Raphaël; Grignard, Bruno ULg et al

in RSC Advances (in press)

The guanidine catalysed aminolysis of propylene carbonate has been investigated using the density functional theory (DFT) and highlights that different reaction pathways are involved depending on the ... [more ▼]

The guanidine catalysed aminolysis of propylene carbonate has been investigated using the density functional theory (DFT) and highlights that different reaction pathways are involved depending on the aromatic or aliphatic nature of the amine. The structural ability of 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) to simultaneously give and receive protons was demonstrated by a detailed mechanistic investigation. The bifunctional activity (base/H-bond donor) of TBD significantly reduces the Gibbs energy of the reaction and allows understanding its higher efficiency compared to its methyl counterpart (MTBD). [less ▲]

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See detailHistoire du thymus : d'un organe vestigial à la programmation de la tolérance immunitaire
Geenen, Vincent ULg

in Medecine Sciences : M/S (in press)

This synthesis presents the most important disruptions of conceptions about the thymus since its discovery in Antique Greece. For centuries, the thymus has been considered as a vestigial organ, and its ... [more ▼]

This synthesis presents the most important disruptions of conceptions about the thymus since its discovery in Antique Greece. For centuries, the thymus has been considered as a vestigial organ, and its role in T-lymphocyte differentiation has been proposed only in the 1960’s. Most recent studies attribute to the thymus an essential and unique role in the programming of central immunological self-tolerance. The basal mechanism implicated in this function is the transcription in thymic epithelium of genes encoding precursors of self-antigens. Processing of these latters leads to presentation of self-antigens by the major histocompatibility complex (MHC) machinery expressed by thymic epithelial and dendritic cells. During fetal life, this presentation drives negative selection of T-cell clones harboring receptors with high affinity for these complexes MHC/self-antigen. After birth, this presentation promotes the generation of regulatory T cells specific for these complexes. A number of studies, as well as the identification of Aire and Fezf2 genes, have shown that a thymus dysfunction plays a crucial role in the development of organ-specific autoimmunity. [less ▲]

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See detailLes jugements de Dominique Lampson sur Jan Gossart et Lambert Lombard
Allart, Dominique ULg

in Delfosse, Annick; Glesener, Thomas (Eds.) Ecrire, lire et éduquer à la Renaissance, Hommage en l’honneur de Franz Bierlaire (in press)

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