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See detailA classification of barycentrically associative polynomial functions
Marichal, Jean-Luc; Mathonet, Pierre ULg; Tomaschek, Jörg

in Aequationes Mathematicae (in press)

We describe the class of polynomial functions which are barycentrically associative over an infinite commutative integral domain.

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See detailBiodistribution and radiation dosimetry for the novel SV2A radiotracer [18F]UCB-H: Firstin- human study.
Bretin, Florian ULg; Bahri, Mohamed Ali ULg; BERNARD, Claire ULg et al

in Molecular Imaging & Biology (in press)

Abstract- [18F]UCB-H is a novel radiotracer with a high affinity for SV2A, a protein expressed in synaptic vesicles. SV2A is the binding site of levetiracetam, a “first in class” antiepileptic drug with a ... [more ▼]

Abstract- [18F]UCB-H is a novel radiotracer with a high affinity for SV2A, a protein expressed in synaptic vesicles. SV2A is the binding site of levetiracetam, a “first in class” antiepileptic drug with a distinct but still poorly understood mechanism of action. The objective of this study was to determine the biodistribution and radiation dosimetry of [18F]UCB-H in a human clinical trial and to establish injection limits according to biomedical research guidelines. Additionally, the clinical radiation dosimetry results were compared to estimations in previously published preclinical data. Dynamic whole body PET/CT imaging was performed over approximately 110 minutes on five healthy male volunteers after injection of 144.5 ± 7.1 MBq (range, 139.1 – 156.5 MBq) of [18F]UCB-H. Major organs were delineated on CT images and time-activity curves were obtained from co-registered dynamic PET emission scans. Time-integrated activity coefficients were calculated as area under the curve using trapezoidal numerical integration. Urinary excretion data based on PET-activities including voiding was simulated using the dynamic bladder module of OLINDA/EXM. The radiation dosimetry was calculated using OLINDA/EXM. The effective dose to the OLINDA/EXM 70 kg standard male was 1.54E-02 ± 6.84E-04 mSv/MBq, with urinary bladder wall, gallbladder wall and the liver receiving the highest absorbed dose. The brain, the tracer’s main organ of interest, received an absorbed dose of 1.89E-02 ± 2.32E-03 mGy/MBq. This first human dosimetry study of [18F]UCB-H indicated that the tracer shows similar radiation burdens to widely used common clinical tracers. Single injections of at maximum 672 MBq for USA practice and 649 MBq for European practice keep radiation exposure below recommended limits. Recently published preclinical dosimetry data extrapolated from mice provided satisfactory prediction of total body and effective dose, but showed significant differences in organ absorbed doses compared to human data. [less ▲]

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See detailClinical pharmacology of antifungal agents to overcome drug resistance in pediatric patients
STERGIOPOULOU, Theodouli ULg; Walsh, Thomas J.

in Expert opinion on pharmacotherapy (in press), 16(2), 213-26

INTRODUCTION: Antifungal resistance is an emerging problem that increases morbidity and mortality in immunosuppressed pediatric patients, who suffer from invasive fungal diseases. Optimal pharmacological ... [more ▼]

INTRODUCTION: Antifungal resistance is an emerging problem that increases morbidity and mortality in immunosuppressed pediatric patients, who suffer from invasive fungal diseases. Optimal pharmacological management is critical for the successful treatment of invasive fungal infections by resistant strains. AREAS COVERED: This paper reviews the mechanisms of resistance of different classes of antifungal agents and the current understanding of pediatric antifungal pharmacology for overcoming antifungal resistance in children based on laboratory and clinical studies in the English literature. The therapeutic choices against fungal pathogens with intrinsic or acquired resistance are further reviewed. EXPERT OPINION: There is a paucity of data in the pediatric population regarding the epidemiology of the resistant organisms to different antifungal agents. It is also unknown if there are more prevalent molecular mechanisms that promote antifungal resistance. Selection and dosages of the most effective antifungal agent for overcoming the antifungal resistance is crucial. However, there are limited studies guiding the optimal dosage and duration of treatment for management of emergent antifungal resistance. Further studies are warranted to elucidate the optimal pharmacology of the current antifungal agents against resistant organisms and to advance the development of new antifungal agents. [less ▲]

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See detailEnzymatic hydrolysis of softwood and hardwood regenerated celluloses
Jacquet, Nicolas ULg; Maniet, Guillaume ULg; Richel, Aurore ULg et al

in Current Chemical Biology (in press)

Regenerated celluloses from Kraft wood pulps (from hardwoods and softwoods) were hydrolysed by mean of cellulase of Trichoderma reesei. Our results highlighted that a 75% hydrolysis yield was reached for ... [more ▼]

Regenerated celluloses from Kraft wood pulps (from hardwoods and softwoods) were hydrolysed by mean of cellulase of Trichoderma reesei. Our results highlighted that a 75% hydrolysis yield was reached for hardwood regenerated cellulose (HRC) and 90% for softwood regenerated cellulose (SRC). Crystallinity indices from X-Ray diffraction patterns were used to measure hydrolysis rate of crystalline and amorphous regions. Addition of β-glucosidase to the enzymatic complex of Trichoderma reesei was confirmed to enhance yields of hydrolysis. [less ▲]

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See detail« À table ! ». Indexation et organisation des livres de cuisine aux 17e et 18e siècles
Colson, Maryse ULg

in Mathieu, Georges (Ed.) Les Tables des matières (in press)

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See detailL’Union européenne et l’interrégionalisme : trajectoire, situation actuelle et perspective
Santander, Sébastian ULg

in Chabal, Pierre (Ed.) Concurrences Interrégionales Europe-Asie au 21ème siècle (in press)

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See detailÉtude anatomoradiologique d’un crâne déformé d’Ancón (Pérou)
Ricciardetto, Antonio ULg; Boman, Françoise; Duchat, Florent et al

in Charlier, Philippe (Ed.) Actes du Ve Colloque international de Pathographie (in press)

Matériels et méthodes : l’étude porte sur un crâne déformé provenant d’Ancón au Pérou, inventorié au Muséum National d’Histoire Naturelle (MNHN) de Paris en 1889. L’étude est géographique, historique ... [more ▼]

Matériels et méthodes : l’étude porte sur un crâne déformé provenant d’Ancón au Pérou, inventorié au Muséum National d’Histoire Naturelle (MNHN) de Paris en 1889. L’étude est géographique, historique, macroscopique et tomodensitométrique. Résultats : situé sur la côte à 40 km au nord de Lima, la capitale du Pérou, le site d’Ancón est un site archéologique de la période lithique, et un lieu de sépulture depuis l’époque Chavín (1250 à 250 av. J.-Chr.). Dès l’époque Chavín, les peuples du Pérou ancien construisaient des centres cérémoniels dirigés par une élite théocratique, et déformaient le crâne des enfants dès les premiers jours de la vie, à l’aide de moyens de pression variés. La déformation du crâne d’Ancón est une déformation antéro-postérieure oblique, brachycéphale, bilobée et asymétrique, sans trépanation ni déformation dentaire associée. C’est une variante bilobée du type Huaura de déformation crânienne, qui est associé aux régions de Chancay-Ancón et Lima. L’étude tomodensitométrique des variations d’épaisseur de la voûte, avec amincissement en regard des zones de pression, a montré que la déformation était intentionnelle, et caractérisée par une pression fronto-pariéto-temporale bilatérale surtout antérieure et dégressive d’avant en arrière, associée à une pression frontale, occipitale, et sagittale médiane. En l’absence de contexte et de datation, l’ancienneté du crâne étudié ne peut pas être précisée au long d’une période de presque trois millénaires, jusqu’à la domination Inca et l’arrivée des Espagnols (1532). Le crâne pourrait appartenir à l’une ou l’autre des cultures successives du site d’Ancón : Chavín, Baňos de Boza o Miramar, Lima, Wari, et Chancay (1200 à 1470), dont les céramiques représentent la déformation bilobée. Le crâne est probablement celui d’une femme âgée de plus de 45 ans à son décès, de statut social élevé, faisant partie de l’élite magico-religieuse, politique et économique dirigeante. L’étude de l’endocrâne a permis d’observer la déformation des veines superficielles et des lobes du cerveau. Il existe des signes de parodonpathie chronique à un stade avancé. Un abcès d’origine dentaire pourrait avoir été la cause du décès. Conclusions et perspectives : en ce qui concerne la pratique des déformations crâniennes, la région d’Ancón-Chancay et de Lima paraît être remarquable à trois égards : par le grand nombre de crânes déformés, par le grand nombre de crânes bilobés, et par la proportion importante de femmes, dont on peut supposer qu’elles étaient nées de familles nobles, et destinées dès l’enfance à faire partie de l’élite théocratique. La reconstitution 3D de l’épaisseur de la voûte crânienne a permis pour la première fois à notre connaissance de caractériser ce type de déformation, et pourrait permettre de reconstituer l’appareil déformateur. Seule la reprise des exhumations programmées sur le site d’Ancón, dans le cadre d’un projet prospectif pluridisciplinaire, pourrait permettre de mieux préciser la proportion d’individus à crâne déformé, la proportion des crânes bilobés, et le sex ratio, dans chaque contexte historique et socio-culturel de ce type de déformation crânienne intentionnelle ; et, peut-être, de retrouver in situ l’appareil déformateur correspondant. [less ▲]

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See detailÉVOLUTION DE LA TENEUR EN EAU LE LONG D’UNE TOPOSEQUENCE FORESTIERE ARGILO-LIMONEUSE
Deraedt, Deborah ULg; Colinet, Gilles ULg; Degré, Aurore ULg

in Milieux Poreux et Transferts Hydriques (in press)

For the hydrological modeling of forested watersheds, the understanding of the forest hydrodynamic is essential. This study focusses on the hydrology of a Belgian forested plot with high stoniness and ... [more ▼]

For the hydrological modeling of forested watersheds, the understanding of the forest hydrodynamic is essential. This study focusses on the hydrology of a Belgian forested plot with high stoniness and steep slope. The soil water content is monitored at several positions on the toposequence and at different depth. During rain events, peak in soil water content are observed in different depth depending on the position along the toposequence. [less ▲]

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See detailPETRA: Multivariate analyses for neuroimaging data
Segovia-Román, Fermín ULg; Álvarez Illán, Ignacio; Salas-Gonzalez, Diego et al

in Proceeding of 2nd International Work-Conference on Bioinformatics and Biomedical Engineering (in press)

In last years, many research efforts in neurosciences have focused in multivariate approaches based on machine learning as an al- ternative to the use of Statistical Parametric Mapping and the univariate ... [more ▼]

In last years, many research efforts in neurosciences have focused in multivariate approaches based on machine learning as an al- ternative to the use of Statistical Parametric Mapping and the univariate analyses that it provides. However, this relatively new field still lacks of a software framework that completely meets the needs of the scientific community. In this work we present a toolbox designed to facilitate the access to the recent advances in neuroimaging data analysis based on multivariate approaches. The toolbox, written on Matlab, is freely avail- able and implements a Graphical User Interface that allows managing neuroimaging data in an easy way. [less ▲]

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See detailDer "vernünftige Genuß des Lebens" − Annotations to the travel journal of Sophie Becker
Viehöver, Vera ULg; Leyh, Valérie ULg

in Renker, Cindy (Ed.) Women from the Parsonage. Pastors’ Daughters as Writers, Translators, Salonnières, and Educators (in press)

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See detailA serious LAT relationship or a crazy machine? Metaphors in citizens’ perception of Belgian federalism
Perrez, Julien ULg; Reuchamps, Min

in Mots. Les Langages du Politique (in press)

This paper proposes a quantitative and qualitative corpus-based analysis of the use of metaphors in political discourse from the original perspective of citizen discourse. Our data were collected from ... [more ▼]

This paper proposes a quantitative and qualitative corpus-based analysis of the use of metaphors in political discourse from the original perspective of citizen discourse. Our data were collected from focus group discussions respectively held in the French-speaking and Dutch-speaking parts of Belgium, which tackled the citizens’ perceptions of Belgian federalism. Our findings suggest that citizens do produce metaphors when talking about complex political processes and that these metaphors reveal different political visions. This research also suggests differences in saliency of the source domains in terms of which citizens make sense of Belgian federalism. In this regard, the family domain, and more especially the metaphor BELGIAN FEDERALISM IS A LOVE RELATIONSHIP appears to function as an important conceptual reference point for the citizens’ understanding of the political relations in the Belgian context. [less ▲]

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See detailIntroduction
Canettieri, Paolo; Proto, Teresa; Valenti, Gianluca ULg

in Canettieri, Paolo; Proto, Teresa; Valenti, Gianluca (Eds.) Text and Tune. On the Association of Music and Lyrics in Sung Verse. Proceedings of the International Conference hosted in Rome the 23th-25th of February 2012 (in press)

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See detailIntroduction
Levaux, Christophe ULg

in Belloi, Livio; Delville, Michel; Levaux, Christophe (Eds.) et al Boucle et répétition : musique, littérature, arts visuels (in press)

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See detailFaire de la musique : rythmes et rapports chez Mallarmé
Durand, Pascal ULg

in Bazantay, Pierre; Bonnet, Antoine; Frangne, Pierre-Henry (Eds.) Mallarmé et la Musique, la Musique et Mallarmé (in press)

Inséparable du processus d'autonomisation du discours poétique et de la radicalisation que ce processus connaît chez lui, sur fond de propagande wagnérienne et de propagation du vers libre, le modèle ... [more ▼]

Inséparable du processus d'autonomisation du discours poétique et de la radicalisation que ce processus connaît chez lui, sur fond de propagande wagnérienne et de propagation du vers libre, le modèle musical prend, dans l'esthétique de Mallarmé, l'aspect d'un système de rapports généralisés à tous les paramètres de l'écrit. L'inhérence réciproque que le poète établit entre la "Musique" et les "Lettres", représentation imaginaire dont Un Coup de dés constitue la contrepartie réalisée, répond d'un côté à un matérialisme de la forme et de l'autre à un idéalisme fictif, voulant que les structures verbales et prosodiques s'offrent en miroir du système de rapports avec quoi se confond, en sa finitude sans extériorité, l’univers même. [less ▲]

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See detailExploring the Interest in and the Usage of the Internet Among Patients Eligible for Osteoporosis Screening.
Slomian, Justine ULg; Reginster, Jean-Yves ULg; Gaspard, Ulysse ULg et al

in Calcified tissue international (in press)

The aim of this study was to evaluate the interest in the Internet and its usage for health-related issues among people eligible for osteoporosis screening. Self-administered questionnaires have been ... [more ▼]

The aim of this study was to evaluate the interest in the Internet and its usage for health-related issues among people eligible for osteoporosis screening. Self-administered questionnaires have been distributed to subjects who were screened for osteoporosis and to menopausal women. 177 patients have responded to the survey (64.5 +/- 10.1 years, 88.1 % of women). There are 78.5 % of Internet users. Among them, 67.2 % said searching information about their health and 74.5 % said using the Internet for this purpose. All respondents attributed an average score, out of 10, of 5.7 +/- 2.3 regarding the reliability of information that they could find on the Internet. The use of the Internet differs significantly depending on age: those who use the Internet are younger (62.1 +/- 8.91 years) than those who do not use it (73.3 +/- 9.42 years). The socioeconomic status also has an impact on the Internet use: Internet users have a higher education, are more professionally active and have a higher net monthly household income compared to the group of non-users. Even if age and socioeconomic status appear to be determining factors in the use of the Internet for the search of health information in patients eligible for osteoporosis screening, almost 75 % of the study population use the Internet for this purpose. Action to promote health through an Internet platform must therefore take these parameters into account. [less ▲]

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