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See detailDevelopment of functionalized nanoparticles for vaccine delivery to dendritic cells: a mechanistic approach
Silva, Joana M.; Vandermeulen, Gaëlle; Oliveira, Vanessa G. et al

in Nanomedicine (in press)

Aim: Produce biodegradable nanoparticles to target antigen-presenting cells and evaluate their potential to be used as a vaccine delivery system. Materials & methods: Untargeted PEGylated PLGA-based ... [more ▼]

Aim: Produce biodegradable nanoparticles to target antigen-presenting cells and evaluate their potential to be used as a vaccine delivery system. Materials & methods: Untargeted PEGylated PLGA-based nanoparticles and mannose-grafted nanoparticles were formulated and physicochemically characterized. Immortalized and primary antigen-presenting cells were used to study nanoparticle internalization patterns. The endocytic pathways and intracellular trafficking followed by nanoparticles were also investigated. Results & discussion: Nanoparticles displayed mannose residues available for binding at the nanoparticle surface. Different nanoparticle internalization patterns by immortalized and primary antigen presenting cells were verified. Macropinocytosis, clathrin-mediated endocytosis, caveolin- and lipid raft-dependent endocytosis are involved in nanoparticles internalization. Nanoparticles demonstrate both endo-lysosomal and cytosolic localizations and a tendency to accumulate nearby the endoplasmic reticulum. Conclusion & future perspective: The developed nanoparticles might drive antigens to be presented through MHC class I and II molecules to both CD8+ and CD4+ T cells, favoring a complete and coordinated immune response. [less ▲]

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See detailRethinking Vulnerability Analysis and Governance with Emphasis on a Participatory Approach
Rossignol, Nicolas ULg; Delvenne, Pierre ULg; Turcanu, Catrinel

in Risk Analysis : An Official Publication of the Society for Risk Analysis (in press)

This paper draws on vulnerability analysis as it emerged as a complement to classical risk analysis, and it aims at exploring its ability of nurturing risk and vulnerability governance actions. An ... [more ▼]

This paper draws on vulnerability analysis as it emerged as a complement to classical risk analysis, and it aims at exploring its ability of nurturing risk and vulnerability governance actions. An analysis of the literature on vulnerability analysis allows us to formulate a threefold critique: first, vulnerability analysis has been treated separately in the natural and the technological hazards fields. This separation prevents vulnerability to unleash the full range of its potential, as it constraints appraisals into artificial categories and thus already closes down the outcomes of the analysis. Second, vulnerability analysis focused on assessment tools that are mainly quantitative, whereas qualitative appraisal is a key to assessing vulnerability in a comprehensive way and to informing policy-making. Third, a systematic literature review of case studies reporting on participatory approaches to vulnerability analysis allows us to argue that participation has been important to address the above, but it remains too closed down in its approach and would benefit from embracing a more open, encompassing perspective. Therefore, we suggest rethinking vulnerability analysis as one part of a dynamic process between opening-up and closing-down strategies, in order to support a vulnerability governance framework. [less ▲]

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See detailBeyond corruption. The everyday life of a justice of the peace court in the Democratic Republic of Congo
Rubbers, Benjamin ULg; Gallez, Emilie

in Olivier de Sardan, Jean-Pierre; De Herdt, Tom (Eds.) The games of the rule. The practical norms of real governance in Sub-Saharan Africa (in press)

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See detailBreed-specific hematologic reference intervals in healthy adult Dogue de Bordeaux dogs
Lavoué, Rachel; Geffré, A; Braun, JP et al

in Veterinary Clinical Pathology (in press)

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See detailLes Grecs ont-ils étudié le latin ? Quelques témoignages datant du Haut-Empire
Rochette, Bruno ULg

in Sans, Benoît; Foubert, Frédéric; Vanhalme, Charlotte (Eds.) Hommages à Ghislaine Viré (in press)

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See detailLa contribution du CHST à l'inventaire wallon des terrains potentiellement pollués
Defechereux, Olivier ULg; Peters, Arnaud ULg

in Actes du IXème Congrès de l’Association des Cercles francophones d’Histoire et d’Archéologie de Belgique (in press)

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See detailLa carte de Vandermaelen et le paysage industriel wallon à la fin de la première industrialisation
Peters, Arnaud ULg; Defechereux, Olivier ULg

in Actes du IXème Congrès de l’Association des Cercles francophones d’Histoire et d’Archéologie de Belgique (in press)

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See detailQuantification des politiques versus démocratisation de l’évaluation : Etude des plans de cohésion sociale en Wallonie
Fallon, Catherine ULg; Feron, Pauline

in Mespoulet, Martine (Ed.) Usages des chiffres dans l’action publique territoriale (in press)

L’usage des chiffres dans l’action publique (ou la « quantification du politique ») mobilise deux registres en tension : premièrement celui de la performance, où « le chiffre est conçu comme un acteur ... [more ▼]

L’usage des chiffres dans l’action publique (ou la « quantification du politique ») mobilise deux registres en tension : premièrement celui de la performance, où « le chiffre est conçu comme un acteur contribuant à encadrer l’action en restreignant les options soumises à délibération et les choix ouverts à la décision collective », et deuxièmement la démocratie, perçue comme « un facteur d’extension du débat public et d’accroissement des sphères d’exercice de la responsabilité politique des citoyens ». Ogien relève le renforcement de cette tension, tout en soulignant l’absence de démocratisation de la mesure elle-même. Afin de remédier à cet écueil, l’auteur propose que les citoyens, rarement pris en considération dans l’élaboration et la définition des termes de la mesure, soient parties prenantes « du système du chiffre qui sert à rendre compte de leur existence et de leur destinée ». Cette contribution analyse les modalités concrètes de cette tension dans le cadre de l’évaluation d’une politique régionale mise en place au niveau local, les plans de cohésion sociale (PCS) en Région wallonne (Belgique), en mobilisant les données recueillies lors de l’évaluation des PCS terminée en mars 2013 . En effet, un enjeu important des PCS était la mise en place d’un processus d’évaluation qui se voulait « participatif» . La participation citoyenne étant une notion centrale de la philosophie PCS, un des objectifs de la Direction interdépartementale de la cohésion sociale (DiCS – administration régionale en charge du programme) était de la promouvoir à travers toutes les étapes de mise en œuvre de cette politique, y compris pour l’évaluation d’impact, inspirée en cela par les propositions méthodologiques du Conseil de l’Europe. Dans un premier temps, le bureau régional de statistique avait développé un indicateur composite « d’accès aux droits sociaux fondamentaux » afin d’objectiver la clé de répartition des ressources entre les territoires locaux. Ce n’est que dans un second temps, en fin de programme, que la DiCS était sommée de produire une « évaluation participative » mesurant l’impact des actions réalisées à travers les PCS sur la cohésion sociale et le bien-être. L’article propose de confronter ces deux démarches d’évaluation : celle qui aboutit à un indicateur quantitatif fondé sur une logique statistique et l’approche participative favorisant l’expression des parties prenantes. [less ▲]

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See detailLe speedrun : pratique compétitive, ludique ou créative ? Trajectoire d’un détournement de jeu vidéo institué en nouveau game
Barnabé, Fanny ULg

in Culture Numérique (in press)

Ce travail vise à interroger la manière dont les jeux vidéo et les dynamiques de détournement qu’ils suscitent chez les joueurs redéfinissent la traditionnelle opposition entre consommation et création ... [more ▼]

Ce travail vise à interroger la manière dont les jeux vidéo et les dynamiques de détournement qu’ils suscitent chez les joueurs redéfinissent la traditionnelle opposition entre consommation et création. Dans ce but, nous étudierons un usage spécifique du médium vidéoludique qui s’est institué en véritable pratique créative sur internet : le speedrun (et son dérivé, le tool-assisted speedrun). L’analyse se déroulera en deux temps : une première partie envisagera les déplacements concrets qu’opère le speedrun dans les notions liées au pôle de la réception (qu’est-ce qu’être un joueur ou un spectateur au sein de ce domaine ?) ; la seconde étudiera la façon dont cette pratique participe à redéfinir le pôle de la production (que deviennent les notions d’auteur, d’œuvre et de création dans le cadre de cette activité ?). [less ▲]

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See detailDevelopment of novel SOlid Materials for high power Li polymer BATteries (SOMABAT). Recyclability of components.
Zubizarreta, Leire; Gil-Agusti, Mayte; Garcia. et al

in Lecture notes on Mobility (in press)

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See detailSur Capitalisme, désir et servitude. Lettre à Frédéric Lordon
Pieron, Julien ULg

in Dissensus (in press), 6(printemps 2014),

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See detailDevelopment and validation of the French version of a tool assessing patient's expectations in lower limb osteoarthritis
NEUPREZ, Audrey ULg; Delcour, JP; Fatemi, F et al

in Journal of Orthopaedics (in press)

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See detailConstructing Quebec and Wallonia: How Political Parties Speak about their Region
Mercenier, Heidi; Perrez, Julien ULg; Reuchamps, Min

in Reuchamps, Min (Ed.) Minority Nations in Multinational Federations. A comparative study of Quebec and Wallonia (in press)

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See detailEnjeux politiques et critiques d'une philosophie des normes
Caeymaex, Florence ULg; Pieron, Julien ULg

in Dissensus (in press), 6(printemps 2014),

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See detailSens et signification dans l'esthétique de Mallarmé
Durand, Pascal ULg

in Signata. Annales des Sémiotiques = Annals of Semiotics (in press), 5

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See detailCost-effectiveness of vitamin D and calcium supplementation in the treatment of elderly women and men with osteoporosis.
Hiligsmann, Mickaël ULg; Ben Sedrine, Wafa; Bruyère, Olivier ULg et al

in European journal of public health (in press)

BACKGROUND: The supplementation with vitamin D and calcium has been recommended for elderly, specifically those with increased risk of fractures older than 65 years. This study aims to assess the cost ... [more ▼]

BACKGROUND: The supplementation with vitamin D and calcium has been recommended for elderly, specifically those with increased risk of fractures older than 65 years. This study aims to assess the cost-effectiveness of vitamin D and calcium supplementation in elderly women and men with osteoporosis and therefore to assess if this recommendation is justified in terms of cost-effectiveness. METHODS: A validated model for economic evaluations in osteoporosis was used to estimate the cost per quality-adjusted life-year (QALY) gained of vitamin D/calcium supplementation compared with no treatment. The model was populated with cost and epidemiological data from a Belgian health-care perspective. Analyses were conducted in women and men with a diagnosis of osteoporosis (i.e. bone mineral density T-score </=-2.5). A literature search was conducted to describe the efficacy of vitamin D and calcium in terms of fracture risk reduction. RESULTS: The cost per QALY gained of vitamin D/calcium supplementation was estimated at euro40 578 and euro23 477 in women and men aged 60 years, respectively. These values decreased to euro7912 and euro10 250 at the age of 70 years and vitamin D and calcium supplementation was cost-saving at the age of 80 years, meaning that treatment cost was less than the costs of treating osteoporotic fractures of the no-treatment group. CONCLUSION: This study suggests that vitamin D and calcium supplementation is cost-effective for women and men with osteoporosis aged over 60 years. From an economic perspective, vitamin D and calcium should therefore be administrated in these populations including those also taking other osteoporotic treatments. [less ▲]

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See detailCT SCAN FEATURES OF PRESUMPTIVE HAEMORRHAGIC STROKE IN A DOG WITH CUSHING’S DISEASE
Liotta, Annalisa Pia ULg; Cavrenne, Romain; Peeters, Dominique ULg et al

in Case reports in Veterinary Medicine (in press)

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See detailTasting the World. A Cultural History of Taste in the Early Modern Era
Von Hoffmann, Viktoria ULg

Book published by University of Illinois Press (in press)

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See detailEstimated daily intake and cumulative risk assessment of phthalate diesters in a Belgian general population
Dewalque, Lucas ULg; Charlier, Corinne ULg; PIRARD, Catherine ULg

in Toxicology Letters (in press)

The daily intakes (DI) were estimated in a Belgian general population for 5 phthalates, namely diethyl phthalate (DEP), di-n-butyl phthalate (DnBP), di-iso-butyl phthalate (DiBP), butylbenzyl phthalate ... [more ▼]

The daily intakes (DI) were estimated in a Belgian general population for 5 phthalates, namely diethyl phthalate (DEP), di-n-butyl phthalate (DnBP), di-iso-butyl phthalate (DiBP), butylbenzyl phthalate (BBzP) and di-2-ethylhexyl phthalate (DEHP), based on the urinary measurements of their corresponding metabolites. DI values ranged between <LOD and 59.65 μg/kg bw/day depending on the congener, and were globally higher for children than adults. They were compared to acceptable levels of exposure (tolerable daily intakes) to evaluate the hazard quotients (HQ), which highlight an intake above the dose considered as safe for values greater than 1. If very few of our Belgian participants exceeded this threshold for phthalates considered individually, 6.2% of the adults and 25% of the children showed an excessive hazard index (HI) which took into account the cumulative risk of adverse anti-androgenic effects. These results are of concern since these HI were based on only 3 phthalates (DEHP, DiBP and DnBP), and showed a median of 0.55 and 0.29 for children and adults respectively. The comparison with previously determined dietary intakes demonstrated that for DEHP, food intake was nearly the only route of exposure while other pathways occurred mainly for the other studied phthalates. [less ▲]

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