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See detailin and out-of sequence event stratigraphy across the Devonian-Carboniferous Boundary - a view from the shelf in S Belgium
Denayer, Julien ULiege; Mottequin, Bernard; Prestianni, Cyrille et al

in 33rd International Meeting of Sedimentology - 16ème Congrès français de sédimentologie : Abstract book (2017, October)

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See detailDevelopment and decease of the so-called Frasnian reefs in the Frasnian of Belgium
Poty, Edouard; Denayer, Julien ULiege; Mottequin, Bernard

in 33rd International Meeting of Sedimentology - 16ème Congrès français de sédimentologie : Abstrcat Book (2017, October)

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See detailLifetime of 5 non-commercial boluses evaluated in dairy cows by X Rays and plasmatic trace elements concentrations
Guyot, Hugues ULiege; Cheleux, Gaël ULiege; Wajda-Dubos, Jean-Pierre et al

Poster (2017, October)

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See detailA 5-year survey of dermatophytes strains circulating in Belgium
SACHELI, Rosalie ULiege; DARFOUF, Rajae ULiege; ADJETEY BAHUN, Akolé ULiege et al

Poster (2017, October)

Objectives Dermatophytosis refers to superficial fungal infections of keratinized tissues caused by keratinophilic dermatophytes. They are the most common cause of superficial fungal infections worldwide ... [more ▼]

Objectives Dermatophytosis refers to superficial fungal infections of keratinized tissues caused by keratinophilic dermatophytes. They are the most common cause of superficial fungal infections worldwide. Epidemiological studies regarding dermatophytes infections have been conducted in several countries and differences in the incidence and in etiological agents have been reported. That is why national surveillance of circulating strains causing dermatophytosis is critical. The National Reference Center (NRC) for mycoses conducted a survey on dermatophytes strains circulating in Belgium from 2012 to 2016. The present study was performed to assess the profile of dermatophytosis and to identify the species involved. Methods The Belgian NRC for mycoses (Leuven and Liège) collected 14227 strains between January 2012 and December 2016. The strains were obtained from clinically suspected fungal infections of skin, hair and nails. Strains were collected from Belgian laboratories in order to confirm the fungal identification which was performed by microscopy and in case of doubt by ITS sequencing. Results Among the 14227 samples collected, 6248 were identified as dermatophytes (44%). Trichophyton rubrum was the most prevalent species accounting for 61,3% (n=3820) of the strains collected from all sources, followed by T. mentagrophytes complex (19,2%, n=1199) according to the ancient classification (including T. interdigitale, T. benhamiae and T. mentagrophytes). Other less prevalent species were also recorded: M. audouinii (n=507, 8,1%), M. canis (n=210, 3,3%), T. tonsurans (n= 140, 2,2%), T. violaceum (n=133, 2,1%), T. soudanense (n=125, 2%), M. praecox (n=60, 0,96%) and E. floccosum (n=19, 0,3%) for the main ones. Our data show the predominance of anthropophilic species causing tinea capitis especially M. audouinii responsible for 43,4% (n=303/716) of hair/scalp infection with an increasing number from 2014 to 2016. Trichophyton soudanense, rarely observed in Belgium in the past, is an emerging agent of tinea capitis particularly since 2013, accounting for 11,3% (n=81) of the cases during the 5-year study period. Zoophilic strains such as M. canis which were well represented in the past epidemiology of tinea capitis are decreasing accounting for only 8,8% (n=63) of hair/scalp infection. Finally, our data confirm the high prevalence of T. rubrum as the main etiologic agent of onychomycosis (78,1%, n=3094/3968) followed by T. mentagrophytes complex (18,8%, n=743/3968). Both latter strains were also responsible for the majority of skin infections as they were isolated respectively in 46,2% (n=693/1612) and 21,7% (n=348/1612) of skin samples. Conclusions The present epidemiological survey provides recent data on the prevalence of all dermatophytes circulating in Belgium. Analyzing such data is critical for the establishment of measures for prevention and control of dermatophytes infections. Our study confirms the predominance of T. rubrum followed by species from the ancient T. mentagrophytes complex (T. interdigitale + T. benhamiae) in the Belgian population. This survey highlights also the persistent predominance of M. audouinii and the emergence of T. soudanense as causative agents of tinea capitis. [less ▲]

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See detailMerging supercritical carbon dioxide and organocatalysis for the precision and green synthesis of poly(lactide)-based (co)polymers
Grignard, Bruno ULiege; De Winter, Julien; Gerbaux, Pascal et al

in European Polymer Journal (2017), 95

Well-defined poly(lactide)-based block copolymers were synthesized by a heterogeneous solvent and metal-free green approach by using organocatalysts in supercritical carbon dioxide (scCO2). We first ... [more ▼]

Well-defined poly(lactide)-based block copolymers were synthesized by a heterogeneous solvent and metal-free green approach by using organocatalysts in supercritical carbon dioxide (scCO2). We first report on the homopolymerization of both L- and D,L- lactide by organocatalyzed Ring-Opening Polymerization (o-ROP) by using a bicomponent organocatalyst composed of a thiourea derivative and various tertiary amines as cocatalysts. Control over the molar mass and dispersity is achieved until high monomer conversion although the polylactides are insoluble in the polymerization medium. The precision synthesis of PLA-based block copolymers from various CO2-phobic hydroxyl end-capped macroinitiators such as polyethylene glycol, polycaprolactone, polybutylene succinate and polyphosphoester was then reported. Merging scCO2 with this organocatalytic system provides therefore a unique tool for the design under solvent-free conditions of poly(lactide)-based block copolymers that are insoluble in scCO2. [less ▲]

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See detailComparison of four methods for the identification of Trichophyton benhamiae strains: Maldi-Tof MS, ITS sequencing, Diversilab® system and DermaGenius® Multiplex Real-Time PCR kit.
SACHELI, Rosalie ULiege; Ferrer Clusella, Aida ULiege; ADJETEY BAHUN, Akolé ULiege et al

Poster (2017, October)

Background: Infections due to the zoophilic dermatophyte Trichophyton benhamiae are being more frequently diagnosed in Belgium since a few years. This species has been recently included in the T ... [more ▼]

Background: Infections due to the zoophilic dermatophyte Trichophyton benhamiae are being more frequently diagnosed in Belgium since a few years. This species has been recently included in the T. benhamiae series together with T. concentricum, T. verrucosum and T. erinacei (De Hoog et al 2016). The strains appear in culture with a bright yellow thallus and do not easily sporulate making them difficult to identify by microscopy. Maldi-Tof MS may present an alternative to microscopic or molecular identification of this species. Molecular methods as ITS sequencing, Rep-PCR by Diversilab® system and realtime PCR by DermaGenius® kit, have been evaluated as identification methods. Methods: A total of 37 strains have been analyzed, all collected by the National Reference Center for mycosis between 2012 and 2016. Strains appearing with a yellow pigment in culture were compared to strains appearing white in culture and presenting characteristics of Trichophyton interdigitale by microscopy. All strains were characterized by Maldi-Tof MS (Bruker), ITS sequencing, rep-PCR (Diversilab® system, bioMérieux) and real-time PCR (DermaGenius® Nail multiplex kit, Pathonostics). Results: Among the 37 strains, ITS sequencing identified 10 T. benhamiae and 27 T. interdigitale. Most of the time, white strains gave rise to T. interdigitale identification while strains with yellow pigmentation were identified as T. benhamiae. However, two strains were identified as T. benhamiae but did not produce clear yellow pigmentation. DermaGenius®kit was able to detect the same 27 white strains previously identified by ITS sequencing as T. interdigitale but nor the 8 strains with yellow pigmentation nor the two white strains identified as T. benhamiae by ITS sequencing could be recognized. This is explained by the lack of specific designed primers and probes included in the kit. The Diversilab® system classified 19 white strains in a unique cluster belonging to T. interdigitale. Six strains producing yellow pigment as well as the two white strains identified as T. benhamiae by ITS sequencing belonged to a single cluster sharing only 75% of similarity with the cluster of T. interdigitale strains. Finally Maldi-Tof MS could identified14 white strains as T. interdigitale, one white strain was identified as T. benhamiae and 4 analyzed strains producing a yellow pigment were identified as T. benhamiae (51,5% of correct identification). T. interdigitale strains and T. benhamiae strains formed two different clusters easily visualized on the dendrogram. Conclusion: ITS sequencing is the method of choice to identify T. benhamiae strains. The DermaGenius® kit is not yet able to detect this emerging species. Improvement of this method is necessary as the number of T. benhamiae isolated in Europe is increasing. Rep-PCR by Diversilab® is a typing method able to classify the strains into two different clusters of strains belonging to T. interdigitale and T. benhamiae, sharing few similarities and justifying the change of classification of T. benhamiae outside the ancient T. mentagrophytes complex. Finally, Maldi-Tof MS in our settings could identify only 50% of T. benhamiae strains and improvement of the extraction method is necessary to increase the method efficiency. [less ▲]

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See detailPriorities for health economic methodological research: results of an expert consultation.
Tordrup, D.; Chouaid, C.; Cuijpers, P. et al

in International Journal of Technology Assessment in Health Care (2017)

Background: The importance of economic evaluation in decision making is growing with increasing budgetary pressures on health systems. Diverse economic evidence is available for a range of interventions ... [more ▼]

Background: The importance of economic evaluation in decision making is growing with increasing budgetary pressures on health systems. Diverse economic evidence is available for a range of interventions across national contexts within Europe, but little attention has been given to identifying evidence gaps that, if filled, could contribute to more efficient allocation of resources. One objective of the Research Agenda for Health Economic Evaluation project is to determine the most important methodological evidence gaps for the ten highest burden conditions in the European Union (EU), and to suggest ways of filling these gaps. Methods: The highest burden conditions in the EU by Disability Adjusted Life Years were determined using the Global Burden of Disease study. Clinical interventions were identified for each condition based on published guidelines, and economic evaluations indexed in MEDLINE were mapped to each intervention. A panel of public health and health economics experts discussed the evidence during a workshop and identified evidence gaps. Results: The literature analysis contributed to identifying cross-cutting methodological and technical issues, which were considered by the expert panel to derive methodological research priorities. Conclusions: The panel suggests a research agenda for health economics which incorporates the use of real-world evidence in the assessment of new and existing interventions; increased understanding of cost-effectiveness according to patient characteristics beyond the “-omics” approach to inform both investment and disinvestment decisions; methods for assessment of complex interventions; improved cross-talk between economic evaluations from health and other sectors; early health technology assessment; and standardized, transferable approaches to economic modeling. [less ▲]

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See detailVers une masterisation de la logopédie ! Partie 1- Situation internationale
Maillart, Christelle ULiege

Article for general public (2017)

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See detailStratospheric circulation in the WACCM chemistry-climate model: mean age of air against observations and CTM
Minganti, Daniele ULiege

Poster (2017, October)

The mean age of air is a classical diagnostic of the transit time from the troposphere to the various regions of the stratosphere, providing insights on the strength and structure of the Brewer-Dobson ... [more ▼]

The mean age of air is a classical diagnostic of the transit time from the troposphere to the various regions of the stratosphere, providing insights on the strength and structure of the Brewer-Dobson Circulation (BDC), the polar vortex and the irreversible mixing in the mid-latitudes. We apply this diagnostic to the WACCM chemistry-climate model for the 1985-2014 period. A comparison is presented between unconstrained simulations (FR-WACCM) with and without the representation of the QBO, simulations nudged to the MERRA-2 reanalysis (SD-WACCM), in-situ measurements and a chemistry-transport model (CTM). The results are different depending on the simulation, with SD-WACCM resulting closer to the observations w.r.t. FR-WACCM. In the FR-WACCM the QBO plays a role leading to older age of air. The time evolution over the considered period is slightly decreasing, while observations show a positive (not significant) trend. Given those results, further studies have to be carried out investigating the multi-decadal trends of mean age of air and involving actual tracers. [less ▲]

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See detailLe droit du recouvrement en ses aspects notariaux
Georges, Frédéric ULiege

in Leleu, Yves-Henri (Ed.) Chroniques notariales (2017)

Cette contribution analyse d'une part les récentes réformes législatives touchant à la matière abordée et d'autre part la jurisprudence pertinente

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See detailEléments relatifs à la saisie-exécution immobilière
Georges, Frédéric ULiege

Scientific conference (2017, October)

Ce document constitue une étude synthétique de la procédure de saisie-exécution immobilière, régie par les articles 1560 à 1626 du Code judiciaire

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See detailAdorno in France. The first critical Reception of the Critical Theory in the 50's
Franck, Thomas ULiege

Scientific conference (2017, October)

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See detailD'hier à aujourd'hui, le rôle de la fratrie
Haxhe, Stéphanie ULiege

Conference given outside the academic context (2017)

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See detailIntramolecular Continuous-Flow Strategy Towards Methylphenidate (Ritalin) Hydrochloride
Gerardy, Romaric ULiege; Winter, Marc; Vizza, Alessandra et al

Poster (2017, October)

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See detailPour une « didactique de l’enquête » : quels fondements, quels outils ?
Jadoulle, Jean-Louis ULiege

Scientific conference (2017, October)

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See detailMultidisciplinary rehabilitation program after breast cancer: benefits on physical function, anthropometry and quality of life.
Leclerc, Anne-France ULiege; Foidart-Dessalle, Marguerite ULiege; Tomasella, Marco ULiege et al

in European Journal of Physical and Rehabilitation Medicine (2017), 53(5), 633-642

BACKGROUND: Different clinical trials show beneficial effects of physical training offered during and / or after breast cancer treatment. However, given the variety of side effects that may be encountered ... [more ▼]

BACKGROUND: Different clinical trials show beneficial effects of physical training offered during and / or after breast cancer treatment. However, given the variety of side effects that may be encountered, physical training could be combined with psychological, relational and social guidance. This kind of multidisciplinary program has been little studied so far. AIM: To determine the benefits of a three-month multidisciplinary rehabilitation program among women after breast cancer treatment. DESIGN: Controlled no-randomized trial. SETTING: University for outcomes, University Hospital Center for interventions. POPULATION: Two hundred and nine outpatients who have been treated for a primary breast carcinoma. METHODS: Patients were divided into a control group (n=106) and an experimental group (n=103) which has benefited from a rehabilitation program of three months including physical training and psycho-educational sessions. The assessments, performed before and after the program, included functional assessments ("Sit and Reach Test", maximal incremental exercise test and "Six-Minute Walk Test"), body composition measurements (body mass index (BMI) and body fat percentage) and a questionnaire (European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30). RESULTS: After three months, flexibility, walking distance and all parameters measured during the maximal incremental exercise, except maximal heart rate, were significantly improved in the experimental group. The body fat percentage was significantly decreased and a significant improvement was observed for perceived health status (quality of life), functional role, emotional state, physical, cognitive and social functions and for most symptoms. In the control group, most of these improvements didn't appear and a significant increase in BMI and body fat percentage was observed. CONCLUSIONS: This trial identifies the benefits of a well detailed multidisciplinary rehabilitation program, including physical re-conditioning and psycho-educational sessions, with important improvements in functional capacity, body composition and the majority of functions and symptoms among women after breast cancer treatment. CLINICAL REHABILITATION IMPACT: Through its results, this study could contribute to the development of hospital quality standards for oncologic rehabilitation. Physiotherapists can efficiently propose this kind of multidisciplinary rehabilitation program. [less ▲]

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See detailPond drying cues and their effects on growth and metamorphosis in a fast developing amphibian
Székely, Diana ULiege; Denoël, Mathieu ULiege; Székely, Paul et al

in Journal of Zoology (2017), 303(2), 129-135

The hydroperiod of breeding habitats imposes a strong selection on amphibians and pond-breeding species usually exhibit a high degree of plasticity in the duration of larval period. However, the potential ... [more ▼]

The hydroperiod of breeding habitats imposes a strong selection on amphibians and pond-breeding species usually exhibit a high degree of plasticity in the duration of larval period. However, the potential for phenotypic plasticity in fast developing species was investigated only in a small number of anurans, and the specific response to environmental cues such as low water versus decreasing water level, as well as the effects of such cues on particular developmental stages, are even less understood. In this context, we investigated the plastic response to pond desiccation in a neotropical species (Ceratophrys stolzmanni) by raising tadpoles in three water level treatments: constant high, constant low and decreasing. The growth rates were the highest reported for amphibian tadpoles (up to 0.3g/day) and the time to metamorphosis was short in all treatments, with the fastest developing tadpole metamorphosing in only 16 days after egg deposition. Individuals from the constant high water level treatment had a higher growth rate than those in the other two treatments, whereas decreasing and constant low water levels had similar effects on development, speeding up metamorphosis. In turn, this involved a cost as these tadpoles had a lower body size and mass at metamorphosis than the ones raised in constant high water levels. The final stages of metamorphosis, when tadpoles are the most vulnerable, were shorter in tadpoles exposed to a decreasing water level, allowing them to leave water quickly. Our experiment demonstrates that phenotypic plasticity is maintained even in environments devoid of permanent aquatic habitats. Ceratophryd tadpoles are able to shorten their developmental time when they perceive a risk of desiccation and react similarly to cues coming from the two unfavorable water conditions showing their adaptation to ephemeral and unpredictable breeding habitats. [less ▲]

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