Last 7 days
Bookmark and Share    
Full Text
Peer Reviewed
See detailImpact of the cumulated proteins and energy deficits on ICU patient’s outcome
PAGE, Isaline ULg; Warnier, Stéphanie; NYS, Monique ULg et al

in Annals of Intensive Care (2017, January), 7(Suppl1), 200

Detailed reference viewed: 21 (2 ULg)
Full Text
Peer Reviewed
See detailNo copper required for germination of an endangered endemic species from the Katangan Copperbelt (Katanga, DR Congo): Diplolophium marthozianum
Boisson, Sylvain ULg; Ortmans, William ULg; Maréchal, Justine et al

in Tropical Ecology (2017), 58(1), 193-198

Two hypotheses were tested with respect to the germination of Diplolophium marthozianum, an endemic plant species of the copper-cobalt outcrops in Katanga, Democratic Republic of Congo: (1) germination of ... [more ▼]

Two hypotheses were tested with respect to the germination of Diplolophium marthozianum, an endemic plant species of the copper-cobalt outcrops in Katanga, Democratic Republic of Congo: (1) germination of copper-endemics is limited by fungal infection in the absence of pathogen control and (2) the germination success of this copper-endemic species is copper-dependent. Seed lots of twenty seeds were weighed, soaked in different disinfection treatments and then placed in a germination medium containing four distinct copper concentrations for 30 days. Seed viability was measured at the beginning and at the end of the experiment by a cut test. Final germination percentage (15.2 ± 8.2 %) and seed viability (24.2 ± 10.3 %) were not affected by copper concentration or disinfection treatments. D. marthozianum is able to germinate in a substrate without added copper, despite pervasive fungal infection. However, seed mass had a significant positive effect on seed germination suggesting that selecting the largest seeds may ensure the highest germination success in ex situ conservation programs. [less ▲]

Full Text
Peer Reviewed
See detailMolecular-Based Recursive Partitioning Analysis Model for Glioblastoma in the Temozolomide Era: A Correlative Analysis Based on NRG Oncology RTOG 0525.
Bell, Erica Hlavin; Pugh, Stephanie L.; McElroy, Joseph P. et al

in JAMA Oncology (2017)

Importance: There is a need for a more refined, molecularly based classification model for glioblastoma (GBM) in the temozolomide era. Objective: To refine the existing clinically based recursive ... [more ▼]

Importance: There is a need for a more refined, molecularly based classification model for glioblastoma (GBM) in the temozolomide era. Objective: To refine the existing clinically based recursive partitioning analysis (RPA) model by incorporating molecular variables. Design, Setting, and Participants: NRG Oncology RTOG 0525 specimens (n = 452) were analyzed for protein biomarkers representing key pathways in GBM by a quantitative molecular microscopy-based approach with semiquantitative immunohistochemical validation. Prognostic significance of each protein was examined by single-marker and multimarker Cox regression analyses. To reclassify the prognostic risk groups, significant protein biomarkers on single-marker analysis were incorporated into an RPA model consisting of the same clinical variables (age, Karnofsky Performance Status, extent of resection, and neurologic function) as the existing RTOG RPA. The new RPA model (NRG-GBM-RPA) was confirmed using traditional immunohistochemistry in an independent data set (n = 176). Main Outcomes and Measures: Overall survival (OS). Results: In 452 specimens, MGMT (hazard ratio [HR], 1.81; 95% CI, 1.37-2.39; P < .001), survivin (HR, 1.36; 95% CI, 1.04-1.76; P = .02), c-Met (HR, 1.53; 95% CI, 1.06-2.23; P = .02), pmTOR (HR, 0.76; 95% CI, 0.60-0.97; P = .03), and Ki-67 (HR, 1.40; 95% CI, 1.10-1.78; P = .007) protein levels were found to be significant on single-marker multivariate analysis of OS. To refine the existing RPA, significant protein biomarkers together with clinical variables (age, Karnofsky Performance Status, extent of resection, and neurological function) were incorporated into a new model. Of 166 patients used for the new NRG-GBM-RPA model, 97 (58.4%) were male (mean [SD] age, 55.7 [12.0] years). Higher MGMT protein level was significantly associated with decreased MGMT promoter methylation and vice versa (1425.1 for methylated vs 1828.0 for unmethylated; P < .001). Furthermore, MGMT protein expression (HR, 1.84; 95% CI, 1.38-2.43; P < .001) had greater prognostic value for OS compared with MGMT promoter methylation (HR, 1.77; 95% CI, 1.28-2.44; P < .001). The refined NRG-GBM-RPA consisting of MGMT protein, c-Met protein, and age revealed greater separation of OS prognostic classes compared with the existing clinically based RPA model and MGMT promoter methylation in NRG Oncology RTOG 0525. The prognostic significance of the NRG-GBM-RPA was subsequently confirmed in an independent data set (n = 176). Conclusions and Relevance: This new NRG-GBM-RPA model improves outcome stratification over both the current RTOG RPA model and MGMT promoter methylation, respectively, for patients with GBM treated with radiation and temozolomide and was biologically validated in an independent data set. The revised RPA has the potential to contribute to improving the accurate assessment of prognostic groups in patients with GBM treated with radiation and temozolomide and to influence clinical decision making. Trial Registration: clinicaltrials.gov Identifier: NCT00304031. [less ▲]

Detailed reference viewed: 25 (0 ULg)
Full Text
Peer Reviewed
See detailConcise Reviews: Regeneration in Mammalian Cochlea Hair Cells: Help from Supporting Cells Transdifferentiation.
Franco, Benedicte; Malgrange, Brigitte ULg

in Stem cells (Dayton, Ohio) (2017)

It is commonly assumed that mammalian cochlear cells do not regenerate. Therefore, if hair cells are lost following an injury, no recovery could occur. However, during the first postnatal week, mice ... [more ▼]

It is commonly assumed that mammalian cochlear cells do not regenerate. Therefore, if hair cells are lost following an injury, no recovery could occur. However, during the first postnatal week, mice harbor some progenitor cells that retain the ability to give rise to new hair cells. These progenitor cells are in fact supporting cells. Upon hair cells loss, those cells are able to generate new hair cells both by direct transdifferentiation or following cell cycle re-entry and differentiation. However, this property of supporting cells is progressively lost after birth. Here, we review the molecular mechanisms that are involved in mammalian hair cell development and regeneration. Manipulating pathways used during development constitute good candidates for inducing hair cell regeneration after injury. Despite these promising studies, there is still no evidence for a recovery following hair cells loss in adult mammals. Stem Cells 2017. [less ▲]

Detailed reference viewed: 16 (1 ULg)
Full Text
Peer Reviewed
See detailInfluence of the crustal magnetic field on the Mars aurora electron flux and UV brightness
Bisikalo, D. V.; Shematovich, V. I.; Gérard, Jean-Claude ULg et al

in Icarus (2017), 282

Observations with the SPICAM instrument on board Mars Express have shown the occasional presence of localized ultraviolet nightside emissions associated with enhanced energetic electron fluxes. These ... [more ▼]

Observations with the SPICAM instrument on board Mars Express have shown the occasional presence of localized ultraviolet nightside emissions associated with enhanced energetic electron fluxes. These features generally occur in regions with significant radial crustal magnetic field. We use a Monte-Carlo electron transport model to investigate the role of the magnetic field on the downward and upward electron fluxes, the brightness and the emitted power of auroral emissions. Simulations based on an ASPERA-3 measured auroral electron precipitation indicate that magnetic mirroring leads to an intensification of the energy flux carried by upward moving electrons- from about 20% in the absence of crustal magnetic field up to 33-78% when magnetic field is included depending on magnetic field topology. Conservation of the particle flux in a flux tube implies that the presence of the B-field does not appreciably modify the emission rate profiles for an initially isotropic pitch angle distribution. However, we find that crustal magnetic field results in increase of the upward electron flux, and, consequently, in reduction of the total auroral brightness for given energy flux of precipitating electrons. [less ▲]

Detailed reference viewed: 23 (3 ULg)
Full Text
Peer Reviewed
See detailMars Topography Investigated Through the Wavelet Leaders Method: a Multidimensional Study of its Fractal Structure
Deliège, Adrien ULg; Kleyntssens, Thomas ULg; Nicolay, Samuel ULg

in Planetary and Space Science (2017), 136C

This work examines the scaling properties of Mars topography through a wavelet-based formalism. We conduct exhaustive one-dimensional (both longitudinal and latitudinal) and two-dimensional studies based ... [more ▼]

This work examines the scaling properties of Mars topography through a wavelet-based formalism. We conduct exhaustive one-dimensional (both longitudinal and latitudinal) and two-dimensional studies based on Mars Orbiter Laser Altimeter (MOLA) data using the multifractal formalism called Wavelet Leaders Method (WLM). This approach shows that a scale break occurs at approximately 15 km, giving two scaling regimes in both 1D and 2D cases. At small scales, these topographic profiles mostly display a monofractal behavior while a switch to multifractality is observed in several areas at larger scales. The scaling exponents extracted from this framework tend to be greater at small scales. In the 1D context, these observations are in agreement with previous works and thus suggest that the WLM is well-suited for examining scaling properties of topographic fields. Moreover, the 2D analysis is the first such complete study to our knowledge. It gives both a local and global insight on the scaling regimes of the surface of Mars and allows to exhibit the link between the scaling exponents and several famous features of the Martian topography. These results may be used as a solid basis for further investigations of the scaling laws of the Red planet and show that the WLM could be used to perform systematic analyses of the surface roughness of other celestial bodies. [less ▲]

Detailed reference viewed: 42 (23 ULg)
See detailMamlūk Cairo: A Crossroad for Embassies
Bauden, Frédéric ULg; Dekkiche, Malika

Book published by Brill Academic Publishers (2017)

Detailed reference viewed: 162 (12 ULg)
Peer Reviewed
See detailA Reconstructed Qarā Qoyūnlū Letter
Bauden, Frédéric ULg

in Bauden, Frédéric; Dekkiche, Malika (Eds.) Mamlūk Cairo: A Crossroad for Embassies (2017)

Detailed reference viewed: 55 (9 ULg)
Peer Reviewed
See detailLa bibliothèque d'Antoine Galland
Bauden, Frédéric ULg

in Bauden, Frédéric; Waller, Richard (Eds.) Antoine Galland (1646-1715) et son Journal. Actes du colloque international organisé à l’Université de Liège (16-18 janvier 2015) à l’occasion du tricentenaire de sa mort (2017)

Detailed reference viewed: 14 (0 ULg)
Peer Reviewed
See detailMamluk Diplomatics: The Present State of Research
Bauden, Frédéric ULg

in Bauden, Frédéric; Dekkiche, Malika (Eds.) Mamlūk Cairo: A Crossroad for Embassies (2017)

Detailed reference viewed: 20 (0 ULg)
Peer Reviewed
See detailLists of Gifts in the Mamluk Diplomatic Tradition
Bauden, Frédéric ULg

in Bauden, Frédéric (Ed.) Culture matérielle et contacts diplomatiques entre l’Occident latin, Byzance et l’Orient islamique (XIe-XVIe siècle) (2017)

Detailed reference viewed: 34 (4 ULg)
See detailThe Mamlūk Sultanate and Its Periphery
Bauden, Frédéric ULg

Book published by Brill Academic Publishers (2017)

Detailed reference viewed: 30 (0 ULg)
Peer Reviewed
See detailMaqriziana XIII: An Exchange of Correspondence Between al-Maqrīzī (d. 845/1442) and al-Qalqašandī (d. 821/1418)
Bauden, Frédéric ULg

in Ben Bassat, Yuval (Ed.) Developing Perspectives in Mamluk History: Festschrift in Honor of Prof. Amalia Levanoni (2017)

Detailed reference viewed: 80 (7 ULg)
Full Text
Peer Reviewed
See detailThe Tourist on the farm: a 'muddled' image
Dubois, Charline ULg; Cawley, Mary; Schmitz, Serge ULg

in Tourism Management (2017), 59

Agritourism is promoted as a method of offsetting decline in farm incomes, and is defined in different ways which creates difficulties in attracting tourists. The present research contributes to a better ... [more ▼]

Agritourism is promoted as a method of offsetting decline in farm incomes, and is defined in different ways which creates difficulties in attracting tourists. The present research contributes to a better understanding of agritourism, based on evidence in Wallonia (Belgium) and Luxembourg. It does so by studying the image held by four groups of actors: (i) farmers who provide ‘agritourist’ experiences; (ii) promotional organisations; and tourists who both (iii) have and (iv) have not engaged in agritourism. Agritourism is a muddled concept between realities and stakeholder expectations but opportunities exist for targeting particular niche interests. [less ▲]

Detailed reference viewed: 66 (15 ULg)
See detailLa diffusion des Blattmasken dans le bassin Méditerranéen. Entre tradition et innovation
Derwael, Stéphanie ULg

in Actes du colloque "Colloque La diffusion des répertoires décoratifs en Méditerranée antique et médiévale" (2017)

Detailed reference viewed: 16 (0 ULg)
Full Text
Peer Reviewed
See detailAdaptation of targeted nanocarriers to changing requirements in antimalarial drug delivery
Marques, J.; Valle-Delgado, J.; Urbán, P. et al

in Nanomedicine : Nanotechnology, Biology, and Medicine (2017)

Detailed reference viewed: 21 (3 ULg)