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See detailSerum calcitriol concentrations measured with a new direct automated assay in a large population of adult healthy subjects and in various clinical situations
Souberbielle, JC; CAVALIER, Etienne ULg; DELANAYE, Pierre ULg et al

in Clinica Chimica Acta (2015), 451 (Pt B)

The measurement of calcitriol [1,25(OH2)D], is important for the differential diagnosis of several disorders of calcium/phosphorus metabolism but is time-consuming and tricky. We measured serum calcitriol ... [more ▼]

The measurement of calcitriol [1,25(OH2)D], is important for the differential diagnosis of several disorders of calcium/phosphorus metabolism but is time-consuming and tricky. We measured serum calcitriol with a new automated direct assay on the Liaison XL platform in 888 healthy French Caucasian subjects aged 18–89 years, 32 patients with a surgically-proven PHPT, 32 pregnant women at the end of the first and at the end of the third trimester, and 24 dialysis patients before and after one year of supplementationwith vitamin D3 or placebo. The mean calcitriol concentration (±SD) in the healthy population was 52.9 ± 14.5 ng/L with a 95% CI interval of 29–83.6 ng/L. In PHPT patients, calcitriol concentration was 81.6±29.0 ng/L, 15 of them (46.9%) having a concentration N83.6 ng/L. In pregnant women, calcitriol was 80.4 ± 26.4 ng/L at the end of the first trimester, and 113.1±33.0 ng/L at the end of the third trimester, 12 (37.5%) and 26 (81.3%) of them having a calcitriol concentration N83.6 ng/L at the first and third trimesters respectively. In 14 dialysis patients, calcitriol was 9.5±7.7 ng/L and rose to 19.3 ng/L after one year of supplementation with 50,000 IU vitamin D3/month. In 10 other dialysis patients, calcitriol was 9.9±2.9 ng/L and remained stable (12.4±3.7 ng/L) after one year of placebo. In conclusion, this new automated calcitriol assay, in addition to presenting excellent analytical performances, gives the expected variations in patients compared to “normal” values obtained in an extensive reference population [less ▲]

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See detailHeavy-chain antibody fragments as model proteins to investigate the molecular mechanism of formation of amyloid fibrils
Chavignon, Chloé ULg

Doctoral thesis (2015)

Amyloidoses are rather common and widespread debilitating and/or life-threatening diseases. They display structurally identical amyloid fibrils, and consequently appears to share a common, but still ... [more ▼]

Amyloidoses are rather common and widespread debilitating and/or life-threatening diseases. They display structurally identical amyloid fibrils, and consequently appears to share a common, but still poorly understood, mechanism of fibrillogenesis. Variable domains of camelid heavy-chain antibodies, referred to as VHHs or nanobodies, were chosen to investigate the factors that favour amyloid fibrillogenesis and to get a better understanding of the mechanism of Ig fibrillogenesis. Our study focused on the contribution of protein regions, i.e. the framework (FR) and the complementary determining regions (CDRs) of VHHs, to the formation of amyloid fibrils. Three VHHs were selected: cAb HuL6, cAb BcII10 and cAb BcII10 H H H, a chimera bearing the FR of cAb BcII10 and the CDRs of cAb HuL6. We first established experimental conditions suitable for fibrillogenesis: even the especially stable and soluble VHHs can form amyloid fibrils in denaturing conditions. This comforts the proposal that amyloid conformation is a generic structural form that all proteins can adopt in the appropriate conditions. Amyloid fibrils were characterised by transmission electron microscopy (TEM), circular dichroism (CD), thioflavin T (ThT) fluorescence and X-ray fibre diffraction. The kinetics of fibril formation were monitored by turbidity measurements. We then determined conditions suitable for characterising self-seeding and cross-seeding kinetics, and ascertained that the three VHHs convert into amyloid fibrils according to a nucleation-dependent process. Fibril elongation rates in self-seeding and cross-seeding experiments suggest that amyloid fibril elongation occurs through sequential addition of protein monomers to preformed fibrils. The kinetics of aggregation and self-seeding of cAb-HuL6 and cAb-BcII10 differ significantly, and a remarkable specificity for cross-seeding was observed, with cAb-BcII10 being unable to cross-seed the formation of fibrils by the two other VHHs, while cAb-HuL6 and cAb BcII10 H-H-H mutually cross-seed each other’s fibril formation. With the help of three prediction algorithms (AGGRESCAN, Zyggregator and 3D-profile), we showed that various peptides of the VHHs had the ability to form fibrils by themselves. Our results strongly suggest that the sequences of the regions forming the core of the fibrils essentially correspond to the CDRs. Concurrently, we set up experimental conditions for interrupting the fibril formation process and we characterised the multimer and fibril species formed in the early stages of fibrillogenesis by analytical ultracentrifugation (AUC) and small angle neutron scattering (SANS) ex situ. [less ▲]

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See detailCombining tree-based and dynamical systems for the inference of gene regulatory networks
Huynh-Thu, Vân Anh ULg; Sanguinetti, Guido

Conference (2015, December 07)

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See detailG-CSF as a non-invasive predictive marker for embryo implantation
Munaut, Carine ULg; NOEL, Laure ULg; Lédée, N et al

Scientific conference (2015, December 07)

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See detailRecent technical developments of non-invasive cultural heritage analysis at the University of Liège
Strivay, David ULg; Chene, Grégoire ULg; Calvo Del Castillo, Helena ULg et al

Conference (2015, December 07)

The University of Liège has more than twenty years of experience in the use of ion beam analysis techniques for cultural heritage research. We will present here some of the recent developments. First, we ... [more ▼]

The University of Liège has more than twenty years of experience in the use of ion beam analysis techniques for cultural heritage research. We will present here some of the recent developments. First, we have developed a high energy extracted beamline up to 20 MeV on our cyclotron with a good energy resolution of a few keV. These last years Ion Beam Analysis users show an interest in High Energy Alpha beam. These beams can be used for on-site analysis by means of radioactive sources e.g. for space application but they also offer a powerful combination of properties for the analysis of thick layers (about 10 to 20 µm). This kind of layers are often met in cultural heritage applications but can be also present on new materials. Contrary to this kind of materials where the principal information needed is the in-depth profiles as the sample are of known composition, for cultural heritage materials the combination of elemental analysis and their in-depth distribution is essential as the nature of the material is a-priori not known. We will also present the development around our first extracted beamline. We have indeed improved the automatic scanning system for macro-PIXE. Some examples will be shown. Finally we will show other non-invasive analysis developments related to cultural heritage. [less ▲]

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See detailLaparoscopic management of a traumatic lumbar hernia: about a case
Vandermeulen, morgan; DETRY, Olivier ULg

Conference (2015, December 07)

Traumatic Lumbar hernia (TLH) is a very rare clinical entity with about 100 cases reported worldwide. It is a difficult challenge when encountered and there is no consensus on the best management: early ... [more ▼]

Traumatic Lumbar hernia (TLH) is a very rare clinical entity with about 100 cases reported worldwide. It is a difficult challenge when encountered and there is no consensus on the best management: early or delayed, open or laparoscopic. We report the clinical case of a 28-year-old man who suffered from a TLH after a 6- meter-high fall. The diagnosis was based on CT imaging showing a defect in the postero-lateral abdominal wall by disinsertion of the lumbar origin of transverse, internal and external oblique muscles. A few months after the trauma, it became gradualy more painful, the hernia was clinically increased with a large swelling on the right flank majored by valsalva. CT imaging showed herniation of the right colic flexure through the defect. Eight months after the trauma, we performed an intra-abdominal laparoscopic approach. Herniated structures were reduced and we opened the peritoneum. The defect was repaired by placing a pre-peritoneal polypropylene mesh fixed by laparoscopic staples before closing the peritoneum. The patient had an uneventful recovery. Ten weeks after the surgery the result was clinically very good. The CT scanner showed a good recovery of parietal continuity. [less ▲]

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See detailLes relations entre universités et entreprises comme vecteurs d'innovation
Artige, Lionel ULg

Conference given outside the academic context (2015)

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See detailIdentification of the concepts at stake during a consultation. Clinical exercises
Jamoulle, Marc ULg

E-print/Working paper (2015)

During a consultation between a patient and a doctor, symptoms, process and health problems are at stake and could be identified and retrieved through the use of ICPC.(refer to www.ph3c.org) Specific ... [more ▼]

During a consultation between a patient and a doctor, symptoms, process and health problems are at stake and could be identified and retrieved through the use of ICPC.(refer to www.ph3c.org) Specific training and managerial competences of the doctor could be identified and explained through the Q-Codes Together ICPC and Q-Codes form 3CGP ; Core Content Classification in General Practice/ Family Medicine The concepts identified in ICPC and Q-Codes could be useful to understand and teach the content of consultation in family medicine. [less ▲]

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See detailFraming the Concept of Citizenship in a Contested Nation-State: Reflections on Kosovo
Mazur Kumric, Nives ULg

in Pécs Journal of International and European Law (2015), (II), 70-88

Since the inception of the Republic of Kosovo in February 2008, the contouring of its statehood has been predominantly affected by four interwoven factors: the partial recognition of its sovereignty ... [more ▼]

Since the inception of the Republic of Kosovo in February 2008, the contouring of its statehood has been predominantly affected by four interwoven factors: the partial recognition of its sovereignty, perplexed inter-ethnic relations, profound international interference and parallel jurisdictions with the Republic of Serbia. The efforts put forth to conceptualise the meaning and scope of Kosovo citizenship in such a sensitive socio-political environment have proved particularly challenging. This paper aims to provide an analytical framework for determining essential elements of Kosovo citizenship, with particular emphasis on its practical and ideological implications for the multicultural, yet ethnically divided society. This is done through an assessment of the key nation-constituting legal norms as well as the deep-rooted ethnic tensions sparked by conflicting perceptions of Kosovo's statehood by the majority (Kosovo Albanian) and minority (Kosovo Serbian) population. By formal definition, Kosovo is an indivisible state of all citizens, however, polarised majority-minority interests have impinged the constitutionally guaranteed civic spirit of the entity, thereby threatening not only national, but also wider international security and integrity. With the purpose of determining and delineating labyrinthine intersections of a contested nation-state, citizenship, 'communities' and security, the paper offers a comprehensive theoretical analysis of the respective quadrilateral nexus. [less ▲]

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See detailInfluence of process operating conditions on solvent thermal and oxidative degradation in post-combustion CO2 capture
Léonard, Grégoire ULg; Crosset, Cyril; Toye, Dominique ULg et al

in Computers & Chemical Engineering (2015), 83

The CO2 post-combustion capture with amine solvents is modeled as a complex system interconnecting process energy consumption and solvent degradation and emission. Based on own experimental data ... [more ▼]

The CO2 post-combustion capture with amine solvents is modeled as a complex system interconnecting process energy consumption and solvent degradation and emission. Based on own experimental data, monoethanolamine degradation is included into a CO2 capture process model. The influence of operating conditions on solvent loss is validated with pilot plant data from literature. Predicted solvent consumption rates are in better agreement with plant data than any previous work, and pathways are discussed to further refine the model. Oxidative degradation in the absorber is the largest cause of solvent loss while thermal degradation does not appear as a major concern. Using a single model, the process exergy requirement decreases by 10.8% and the solvent loss by 11.1% compared to our base case. As a result, this model provides a practical tool to simultaneously minimize the process energy requirement and the solvent consumption in post-combustion CO2 capture plants with amine solvents. [less ▲]

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See detailIdentités et stéréotypes postcoloniaux
Dony, Christophe ULg; Ledent, Bénédicte ULg; Munos, Delphine ULg et al

Conference given outside the academic context (2015)

Detailed reference viewed: 15 (6 ULg)
See detailCOP21, la conférence des Nations Unies à Paris, et ses enjeux
Ozer, Pierre ULg

Speech/Talk (2015)

Nous recevons cette semaine le climatologue Pierre Ozer, chargé de recherche au département des sciences et gestion de l'environnement de l'ULg, Il apporte son éclairage sur la COP21, la conférence des ... [more ▼]

Nous recevons cette semaine le climatologue Pierre Ozer, chargé de recherche au département des sciences et gestion de l'environnement de l'ULg, Il apporte son éclairage sur la COP21, la conférence des Nations Unies à Paris, et ses enjeux. [less ▲]

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See detailThe lessons of the first reconstruction in Belgium : Canon Lemaire's "La restauration des monuments anciens" (1938).
Houbart, Claudine ULg

Conference (2015, December 05)

Contrairement à la seconde reconstruction qui reste aujourd’hui largement inexplorée, la première reconstruction en Belgique a fait l’objet de nombreuses recherches et publications. Et pourtant, une ... [more ▼]

Contrairement à la seconde reconstruction qui reste aujourd’hui largement inexplorée, la première reconstruction en Belgique a fait l’objet de nombreuses recherches et publications. Et pourtant, une figure essentielle n’a que très peu retenu l’attention des chercheurs : le chanoine Raymond A.G. Lemaire. Professeur d’archéologie et de restauration à l’université de Louvain, chantre du néogothique dans le sillage de Joris Helleputte, il participe activement aux débats de la reconstruction, non seulement à Louvain, où il est membre de la Commissie voor Stedenschoon, mais dans tout le pays, en tant que membre correspondant de la Commission royale des monuments et des sites et conseiller de l’archevêché de Malines. Auteur de nombreux articles, il synthétise les débats dans “La restauration des monuments anciens”, publiée à Anvers en 1938, tout en développant une approche personnelle se nourrissant de la théorie des valeurs d’Aloïs Riegl et s’approchant de la théorie du “cas par cas” développée à la même époque, en Italie, par Ambroggio Annoni. Bien que les rapports entre les deux hommes ne soient pas documentés dans les archives belges, les nombreux parallèles entre leurs approches, ainsi que le fait que le chanoine Lemaire enverra son neveu, Raymond M. Lemaire, se former chez Annoni en 1943, laissent entendre qu’ils devaient exister. A travers notre participation à la conférence, nous espérons découvrir des éléments susceptibles d’alimenter la poursuite des recherches en ce sens. [less ▲]

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See detailThérapie familiale avec les famille LG: défis et ressources pour le thérapeute
D'Amore, Salvatore ULg

Scientific conference (2015, December 05)

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See detailPoint(s) de rupture : Sartre, Merleau-Ponty, la psychanalyse existentielle
Cormann, Grégory ULg

Conference (2015, December 05)

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See detailFéminiser la voix
Morsomme, Dominique ULg; Remacle, Angélique ULg

Scientific conference (2015, December 04)

Dans cet Atelier, nous présenterons la voix du point de vue du genre. En effet, l’Unité Logopédie de la Voix (www.logopedie-voix.be) s’intéresse entre autres à la féminisation vocale chez les personnes ... [more ▼]

Dans cet Atelier, nous présenterons la voix du point de vue du genre. En effet, l’Unité Logopédie de la Voix (www.logopedie-voix.be) s’intéresse entre autres à la féminisation vocale chez les personnes transidentitaires, en processus de changement de genre. Ces personnes ne s’identifiant pas au sexe et au genre qui leur ont été attribués à la naissance, elles éprouvent un désir profond de vivre comme une personne du sexe opposé à leur sexe biologique. Lors du processus de transition où ont lieu les transformations nécessaires au changement de genre, l'orthophonie a pour but d’améliorer la cohérence entre l’apparence de la personne et sa voix. Ainsi, notre recherche se focalise sur ce qui distingue la voix féminine de la voix masculine. Nous visons à développer des stratégies de féminisation vocale, portant sur des paramètres tels que la fréquence fondamentale de la voix, les formants, les contours intonatifs, le débit de parole, le rythme, ou encore le vocabulaire choisi. Féminiser une voix, c’est chercher à comprendre ce qui permet d’en identifier le genre, mais également participer à la construction de l’identité de la personne à part entière. [less ▲]

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See detailThe Belgian Judicial Actors and the Establishment of the Repression and the Civic Purge in the East Cantons
Brüll, Christoph ULg; Van Haecke, Lawrence

Conference (2015, December 04)

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See detailLA RENONCIATION, L’ABDICATION ET LA RUPTURE DU CONTRAT DE TRAVAIL
Kéfer, Fabienne ULg

in LA RUPTURE DU CONTRAT DE TRAVAIL : ENTRE HARMONISATION ET DISCRIMINATION (2015, December 04)

L’étude, limitée au contexte de la dissolution du contrat de travail, aborde, dans une première partie, la possibilité pour les parties au contrat de travail de renoncer au bénéfice d’une disposition ... [more ▼]

L’étude, limitée au contexte de la dissolution du contrat de travail, aborde, dans une première partie, la possibilité pour les parties au contrat de travail de renoncer au bénéfice d’une disposition, possibilité liée au caractère impératif ou d’ordre de la disposition en cause. Est particulièrement étudié le lien entre le rapport de subordination et la faculté d’abdiquer un droit. Le document effectue ensuite une incursion dans la question de la preuve de la renonciation. La troisième partie passe en revue un large éventail de droits auxquels les parties pourraient être tentées de renoncer : clauses d’écolage, clauses de stabilité d’emploi, renonciation au droit d’invoquer la rupture du contrat de travail en cas d’acte équipollent à rupture ou de préavis nul, renonciation à la durée du préavis ou à l’indemnité en tenant lieu, renonciation au reclassement professionnel, aux droits découlant d’une convention collective, renonciation par un délégué du personnel, renonciation par la voie d’une convention collective, etc. Si la matière reste incertaine à bien des égards, elle est aussi en évolution, tant par l’effet de la jurisprudence que par l’action de la loi, et notamment celle du 26 décembre 2013 dite « statut unique », qui a modifié de manière sensible le champ de la licéité des renonciations au délai ou à l’indemnité compensatoire de préavis. [less ▲]

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See detailLe fonctionnement exécutif dans le vieillissement normal: Quel rôle accorder aux variables attentionnelles ?
Gilsoul, Jessica ULg; Simon, Jessica ULg; Collette, Fabienne ULg

Conference (2015, December 04)

Introduction. Selon Miyake et al. (2000), le fonctionnement exécutif serait sous-tendu par trois fonctions distinctes - l’inhibition, la flexibilité et la mise à jour - alors que d’autres auteurs (Fisk ... [more ▼]

Introduction. Selon Miyake et al. (2000), le fonctionnement exécutif serait sous-tendu par trois fonctions distinctes - l’inhibition, la flexibilité et la mise à jour - alors que d’autres auteurs (Fisk & Sharp, 2004) suggèrent qu’elles seraient au nombre de quatre (coordination de tâche double). On sait aujourd’hui que l’avancée en âge s’accompagne d’un déclin exécutif. Toutefois, peu d’études ont étudié l’impact de variables non-exécutives (et plus particulièrement attentionnelles) sur la variabilité des performances exécutives dans le vieillissement. Méthode. 114 participants jeunes et 65 participants âgés ont réalisé un ensemble de tâches cognitives évaluant les quatre aspects du fonctionnement exécutif : l’inhibition (Stroop, Anti-saccade, Stop-Signal), la flexibilité (Plus et Moins, Chiffres-Lettres, Global-Local), la mise à jour (Mise à jour sonore, Mise à jour sémantique, Mise à jour de consonnes) et la coordination de tâche double (PASAT, Brown-Peterson, Attention divisée (TEA)). Par ailleurs, nous avons mesuré la vitesse de traitement de l’information (Comparaison de lettres, Stop-signal contrôle, Alerte tonique, Vitesse articulatoire), le fonctionnement attentionnel dans ses aspects d’alerte phasique, d’orientation visuelle externe (Balayage visuel, Motilité oculaire) et d’attention soutenue (Détection d’irrégularités visuelles, Détection de cibles), ainsi que le niveau d’empan. Nous avons tout d’abord comparé les performances des deux groupes sur chacune des tâches exécutives. Pour celles où nous avons observé une différence entre les groupes, nous avons tenté de déterminer si certaines variables non-exécutives pourraient expliquer une part de la variance des performances de nos participants âgés. Résultats. Les comparaisons entre groupes révèlent que les sujets jeunes ont toujours (sauf pour la tâche Stop-Signal) des performances exécutives supérieures à celles des âgés (p<0.01). Lorsque les différentes variables attentionnelles et non-attentionnelles sont introduites dans un modèle de régression multiple stepwise pas à pas, nous observons que les variables attentionnelles expliquent une part significative de la variance pour la tâche Chiffres-Lettres (alerte), la tâche de Mise à jour sémantique (orientation visuelle externe), la tâche de Mise à jour de consonnes (orientation visuelle externe) et la tâche d’attention divisée (alerte et orientation visuelle externe). Discussion. En accord avec de précédentes études, le fonctionnement exécutif décline avec l’âge. Nos résultats indiquent que le déclin de certaines fonctions (mais pas toutes) serait modulé par les capacités attentionnelles. Cette modulation attentionnelle ne serait toutefois pas un processus général, mais dépendrait des caractéristiques propres à chaque tâche. [less ▲]

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See detailParticipation à la table ronde consacrée au financement de la recherche
Cormann, Grégory ULg

Diverse speeche and writing (2015)

Detailed reference viewed: 20 (1 ULg)