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See detailLa mise en œuvre du droit de plainte en Belgique francophone. Observation des processus de médiation en soins de santé
Dubois, Christophe ULg; Vandeninden, Elise ULg

in Revue Française des Affaires Sociales (2017), 1(1), 79-96

This article concerns the treatment of patients’ rights cases in French‐speaking Belgian hospitals by the “mediator”, that is, the person who has the legal duty of dealing with grievances arising from the ... [more ▼]

This article concerns the treatment of patients’ rights cases in French‐speaking Belgian hospitals by the “mediator”, that is, the person who has the legal duty of dealing with grievances arising from the application of this right of complaint. What happens to a patient’s complaint? This is the question that this article attempts to answer through a report on the “local” organization of mediation ser‐ vices within the hospital. It thus clari es the links and divergences between the formal discourses accompanying the implementation of the mediation function in health care on the one hand, and, on the other hand, the actual practices of media‐ tion determined by the work of mediators in the hospital. [less ▲]

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See detailMachine Learning of Real-time Power Systems Reliability Management Response
Duchesne, Laurine ULg; Karangelos, Efthymios ULg; Wehenkel, Louis ULg

in PowerTech Manchester 2017 Proceedings (2017)

In this paper we study how supervised machine learning could be applied to build simplified models of real-time (RT) reliability management response to the realization of uncertainties. The final ... [more ▼]

In this paper we study how supervised machine learning could be applied to build simplified models of real-time (RT) reliability management response to the realization of uncertainties. The final objective is to import these models into look-ahead operation planning under uncertainties. Our response models predict in particular the real-time reliability management costs and the resulting reliability level of the system. We tested our methodology on the IEEE-RTS96 benchmark. Among the supervised learning algorithms tested, extremely randomized trees, kernel ridge regression and neural networks appear to be the best methods for this application. Furthermore, by using feature “importances” computed by tree-based ensemble methods, we were able to extract the most relevant variables to predict the response of real-time reliability management, and thus obtain a better understanding of the system properties. [less ▲]

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See detailMicrostructural and functional correlates of glutamate concentration in the posterior cingulate cortex.
Arrubla Martinez, Jorge Andres ULg; Farrher, Ezequiel; Strippelmann, Johanna et al

in Journal of Neuroscience Research (2017)

Glutamate is the major excitatory neurotransmitter in the human brain and has a central role in both intrinsic and stimulus-induced activity. We conducted a study in a cohort of healthy, male volunteers ... [more ▼]

Glutamate is the major excitatory neurotransmitter in the human brain and has a central role in both intrinsic and stimulus-induced activity. We conducted a study in a cohort of healthy, male volunteers in which glutamate levels were measured in the posterior cingulate cortex (PCC) using 1H magnetic resonance spectroscopy at 3T. The advantages of simultaneous electroencephalography and magnetic resonance imaging (EEG-MRI) were exploited and the subjects were measured in the same session and under the same physiological conditions. Diffusion tensor imaging (DTI), functional MRI (fMRI) and EEG were measured in order to investigate the functional and microstructural correlates of glutamate. The concentration of glutamate (institute units) was calculated and those values were tested for correlation with the metrics of resting state fMRI, DTI, and EEG electrical sources. Our results showed that the concentration of glutamate in the PCC had a significant negative correlation with the tissue mean diffusivity in the same area. The analysis of resting state networks did not show any relationship between the concentration of glutamate and the intrinsic activity of the resting state networks. The concentration of glutamate showed a positive correlation with the electrical generators of alpha-1 frequency and a negative correlation with the generators of alpha-2 and beta-1 electrical generators. (c) 2017 Wiley Periodicals, Inc. [less ▲]

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See detailFlux penetration in a superconducting film partially capped with a conducting layer
Brisbois, Jérémy ULg; Gladilin, V. N.; Tempere, J. et al

in Physical Review B (2017)

The influence of a conducting layer on the magnetic flux penetration in a superconducting Nb film is studied by magneto-optical imaging. The metallic layer partially covering the superconductor provides ... [more ▼]

The influence of a conducting layer on the magnetic flux penetration in a superconducting Nb film is studied by magneto-optical imaging. The metallic layer partially covering the superconductor provides an additional velocity-dependent damping mechanism for the flux motion that helps protecting the superconducting state when thermomagnetic instabilities develop. If the flux advances with a velocity slower than w = 2/µ0σt, where σ is the cap layer conductivity and t is its thickness, the flux penetration remains unaffected, whereas for incoming flux moving faster than w, the metallic layer becomes an active screening shield. When the metallic layer is replaced by a perfect conductor, it is expected that the flux braking effect will occur for all flux velocities. We demonstrate this effect by investigating Nb samples with a thickness step. Some of the observed features, namely the deflection and the branching of the flux trajectories at the border of the thick centre, as well as the favoured flux penetration at the indentation, are reproduced by time-dependent Ginzburg-Landau simulations. [less ▲]

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See detailTumor host-interface in metastatic dissemination and adaptation to treatment
Sounni, Nor Eddine ULg

Scientific conference (2017)

Detailed reference viewed: 17 (2 ULg)
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See detailMethylglyoxal-Mediated Stress Correlates with High Metabolic Activity and Promotes Tumor Growth in Colorectal Cancer.
Chiavarina, Barbara ULg; Nokin, Marie-Julie ULg; Bellier, Justine ULg et al

in International Journal of Molecular Sciences (2017), 18(1),

Cancer cells generally rely on aerobic glycolysis as a major source of energy. Methylglyoxal (MG), a dicarbonyl compound that is produced as a side product during glycolysis, is highly reactive and ... [more ▼]

Cancer cells generally rely on aerobic glycolysis as a major source of energy. Methylglyoxal (MG), a dicarbonyl compound that is produced as a side product during glycolysis, is highly reactive and induces the formation of advanced glycation end-products that are implicated in several pathologies including cancer. All mammalian cells have an enzymatic defense against MG composed by glyoxalases GLO1 and GLO2 that converts MG to d-lactate. Colorectal cancer (CRC) is one of the most frequently occurring cancers with high morbidity and mortality. In this study, we used immunohistochemistry to examine the level of MG protein adducts, in a series of 102 CRC human tumors divided into four clinical stages. We consistently detected a high level of MG adducts and low GLO1 activity in high stage tumors compared to low stage ones suggesting a pro-tumor role for dicarbonyl stress. Accordingly, GLO1 depletion in CRC cells promoted tumor growth in vivo that was efficiently reversed using carnosine, a potent MG scavenger. Our study represents the first demonstration that MG adducts accumulation is a consistent feature of high stage CRC tumors. Our data point to MG production and detoxification levels as an important molecular link between exacerbated glycolytic activity and CRC progression. [less ▲]

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See detailThe role of parental anxiety sensitivity and learning experiences in children's anxiety sensitivity.
Stassart, Céline ULg; Dardenne, Benoît ULg; Etienne, Anne-Marie ULg

in British Journal of Developmental Psychology (2017)

This study evaluated the impact of the mother’s and father’s anxiety sensitivity (AS) andlearning experiences on children’s AS, and the influence of two moderators: the children’sfemininity orientation and ... [more ▼]

This study evaluated the impact of the mother’s and father’s anxiety sensitivity (AS) andlearning experiences on children’s AS, and the influence of two moderators: the children’sfemininity orientation and the children’s emotional intelligence (EI). The samplecomprised 200 non-clinical children, aged 9–13 years, and their parents (mothers andfathers). Results revealed that the effect of parental AS on children’s AS is moderated bythe children’s EI for maternal AS and by their femininity traits for paternal AS. Learningexperiences following somatic sensations influenced the children’s level of AS. Morespecifically, special attention by parents following a child’s somatic sensations (reinforce-ment and transmission of information) was associated with high AS in children. Parentalreactions of fear following a parent’s somatic sensations (modelling) seem to predicthigher scores for AS when the link is moderated by the child’s femininity orientation. Theimplications of these findings are discussed. [less ▲]

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See detailGlobal disorders of consciousness.
Stender, Johan; Laureys, Steven ULg; Gosseries, Olivia ULg

in Velmans, Max; Schneider, Susan (Eds.) The Blackwell Companion to Consciousness (2017)

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See detailPotential uses of pumped urban groundwater. A case study in Sant Adrià del Besòs (Spain)
Jurado Elices, Anna ULg; vázquez-Suñé, Enric; Pujades, Estanislao ULg

in Hydrogeology Journal (2017)

Urban groundwater has been over-exploited during the past, mainly for industrial uses, and it now tends to be reduced or abandoned due to pollution and/or changes in land use. The use and the subsequent ... [more ▼]

Urban groundwater has been over-exploited during the past, mainly for industrial uses, and it now tends to be reduced or abandoned due to pollution and/or changes in land use. The use and the subsequent disuse of groundwater resulted in rising water tables that damage underground structures (e.g., building basements and underground car parks and tunnels), leading to additional pumping in urban areas. This is the case of the underground parking lot of Sant Adrià del Besòs (NE Spain), where large amounts of urban groundwater are pumped to avoid seepage problems. The question that arises here is if this pumped groundwater can be used for other purposes (e.g., drinking water and urban irrigation) instead of wasting this valuable resource. To answer this question, it is necessary to quantify the groundwater recharge and to assess the evolution of ground-water quality in order to properly identify its potential uses. The limiting factor to define the uses of this resource is the groundwater quality because ammonium and some metals (iron and manganese) are present at high concentrations. Hence, further treatment would be needed to meet drinking water requirements. The pumped groundwater could also be used for supplying the ecological river flow and/or for mitigating seawater intrusion problems. Currently, only a small amount of this urban groundwater is used for cleaning public areas and watering public gardens. This situation highlighted the urgent need to manage this resource in a responsible and more efficient manner, especially in moments of high water demand such as drought periods. [less ▲]

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See detailMono- and bimetallic manganese-carbonyl complexes and clusters bearing imidazol(in)ium-2-dithiocarboxylate ligands
Beltran Alvarez, Tomás Francisco ULg; Zaragoza, Guillermo; Delaude, Lionel ULg

in Dalton Transactions (2017), 46

Five complexes with the generic formula fac-[MnBr(CO)3(S2C[middle dot]NHC)] were obtained by reacting [MnBr(CO)5] with a set of representative imidazol(in)ium-2-dithiocarboxylate zwitterions. These ... [more ▼]

Five complexes with the generic formula fac-[MnBr(CO)3(S2C[middle dot]NHC)] were obtained by reacting [MnBr(CO)5] with a set of representative imidazol(in)ium-2-dithiocarboxylate zwitterions. These ligands are the adducts of N-heterocyclic carbenes (NHCs) and carbon disulfide. The mononuclear Mn(i) derivatives were coupled with Na[Mn(CO)5] to afford bimetallic [Mn2(CO)6(S2C[middle dot]NHC)] clusters. Yet, the most convenient strategy to access these dinuclear Mn(0) products implied a direct carbonyl substitution from the [Mn2(CO)10] dimer. The molecular structures of three monometallic and four bimetallic compounds were elucidated by single crystal X-ray diffraction analysis. In the monometallic complexes, the NHC[middle dot]CS2 ligands exhibited a bidentate [small kappa]2-S,S[prime or minute] coordination mode with an S-C-S bite angle of about 116[degree]. In the dinuclear clusters, the CS2- unit acted as a chelate toward one manganese center and as a pseudoallylic ligand toward the other one. The S-C-S bite angle was reduced to ca. 104[degree]. Thus, the zwitterions displayed a remarkable flexibility, which also permitted a staggered arrangement of the carbonyl groups in the bimetallic systems. Examination of the [small nu, Greek, macron]CO absorption bands on IR spectroscopy helped identify the presence of fac-Mn(CO)3 or Mn2(CO)6 motifs, while the 13C NMR chemical shift of the CS2- moiety was a reliable indicator for monitoring its hapticity. Whereas the dinuclear clusters were air- and moisture-stable crystalline solids, mononuclear halido derivatives displayed only a limited stability under aerobic conditions. Both types of compounds underwent rather unselective, extensive fragmentations in the gas phase, in sharp contrast with the analogous rhenium derivatives that led to clean sequential decarbonylation processes upon collision-induced dissociation. [less ▲]

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See detailAssessment of the entering stock, migration dynamics and fish pass fidelity of european eel in the belgian meuse river
Nzau Matondo, Billy ULg; Benitez, Jean-Philippe ULg; Dierckx, Arnaud ULg et al

in River Research & Applications (2017), 33

Migration dynamics of incoming eels in Belgium via Lixhe in the Meuse River were investigated using two fish passes with different configurations— net traps and automatic detection stations—as tools to ... [more ▼]

Migration dynamics of incoming eels in Belgium via Lixhe in the Meuse River were investigated using two fish passes with different configurations— net traps and automatic detection stations—as tools to distinguish resident and migrating eels. From April to September 2013, 435 eels (P50 length, 403 mm; range, 196–836 mm) were caught (daily maxima catch, 90 eels per day), 90% between 13 June and 1 August (50 days) and P50 on 19 July. Eels migrated mostly at 19–26 °C (P50, 24.4 °C), river discharge 65–314m3 s 1 (P50, 84m3 s 1), during the dark at 00:00–05:00 h and during both the waxing and waning phases of moonlight. From 396 eels tagged and released 0.3 km downstream of the Lixhe dam, 6.8% of them were recaptured, and 37.4% were detected. Migration flux was estimated at 7184 eels (0.863 t) using the markrecapture method and decreased to 1156 eels (0.139 t) using automatic transponder detection. Most eels probably migrated through a sluice located downstream of Lixhe to reach the upper Meuse via the Albert Canal. Eels moved almost independently to the configuration of the fish passes and their location, but most eels displayed fidelity to the fish pass where they were captured. Migrant eels showed a wide range of size and life stages, with a higher proportion of eels (80%) belonging to the yellow eel stage. A lower proportion of eels (6%) had a larger size and presented an advanced continental silvering process corresponding to the migrating stage before their transatlantic migration. Copyright © 2016 John Wiley & Sons, Ltd. [less ▲]

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See detailExtracting oscillating components from nonstationary time series: A wavelet-induced method
Deliège, Adrien ULg

E-print/Working paper (2017)

This paper consists in the description and application of a new method named Wavelet-Induced Mode Extraction (WIME) in the context of time-frequency analysis. WIME aims to extract the oscillating ... [more ▼]

This paper consists in the description and application of a new method named Wavelet-Induced Mode Extraction (WIME) in the context of time-frequency analysis. WIME aims to extract the oscillating components that build amplitude modulated-frequency modulated signals. The essence of this technique relies on the successive extractions of the dominant ridges of wavelet-based timefrequency representations of the signal under consideration. Our tests on simulated examples indicate strong decomposition and reconstruction skills, trouble-free handling of crossing trajectories in the time-frequency plane, sharp performances in frequency detection in the case of mode-mixing problems and a natural tolerance to noise. These results are compared with those obtained with the Empirical Mode Decomposition. We also show that WIME still gives meaningful results with real-life data, namely the Oceanic Niño Index. [less ▲]

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See detailMeta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci
Jones, Gregory; Tromp, Gerard; Kuivaniemi, Helena et al

in Circulation Research (2017)

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See detailA novel SMAD3 mutation caused multiple aneurysms in a patient without osteoarthritis symptoms
Courtois, Audrey ULg; Coppieters, Wouter ULg; BOURS, Vincent ULg et al

in European Journal of Medical Genetics (2017)

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See detailL’indemnité de procédure, l’appel de la partie civile et l’acquittement du prévenu : la croix et la bannière ?
Michiels, Olivier ULg; Falque, Géraldine ULg

in Revue de Droit Pénal et de Criminologie (2017), 2017/1

En ce qu’il ne permet pas au juge répressif d’accorder au prévenu acquitté et au civilement responsable une indemnité de procédure d’appel à charge de la partie civile succombante qui, en l’absence de ... [more ▼]

En ce qu’il ne permet pas au juge répressif d’accorder au prévenu acquitté et au civilement responsable une indemnité de procédure d’appel à charge de la partie civile succombante qui, en l’absence de tout recours du ministère public, a interjeté appel d’un jugement d’acquittement statuant sur une action intentée par le ministère public, l’article 162bis, alinéa 2, du Code d’instruction criminelle viole les articles 10 et 11 de la Constitution. [less ▲]

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See detailEffects of non-invasive vagus nerve stimulation on attack frequency over time and expanded response rates in patients with chronic cluster headache: a post hoc analysis of the randomised, controlled PREVA study
Gaul, Charly; MAGIS, Delphine ULg; Liebler, Eric et al

in Journal of Headache and Pain (2017), 18

Background: In the PREVention and Acute treatment of chronic cluster headache (PREVA) study, attack frequency reductions from baseline were significantly more pronounced with non-invasive vagus nerve ... [more ▼]

Background: In the PREVention and Acute treatment of chronic cluster headache (PREVA) study, attack frequency reductions from baseline were significantly more pronounced with non-invasive vagus nerve stimulation plus standard of care (nVNS + SoC) than with SoC alone. Given the intensely painful and frequent nature of chronic cluster headache attacks, additional patient-centric outcomes, including the time to and level of therapeutic response, were evaluated in a post hoc analysis of the PREVA study. Findings: After a 2-week baseline phase, 97 patients with chronic cluster headache entered a 4-week randomised phase to receive nVNS + SoC (n = 48) or SoC alone (n = 49). All 92 patients who continued into a 4-week extension phase received nVNS + SoC. Compared with SoC alone, nVNS + SoC led to a significantly lower mean weekly attack frequency by week 2 of the randomised phase; the attack frequency remained significantly lower in the nVNS + SoC group through week 3 of the extension phase (P < 0.02). Attack frequencies in the nVNS + SoC group were significantly lower at all study time points than they were at baseline (P < 0.05). Response rates were significantly greater with nVNS + SoC than with SoC alone when response was defined as attack frequency reductions of ≥25%, ≥50%, and ≥75% from baseline (≥25% and ≥50%, P < 0.001; ≥75%, P = 0.009). The 100% response rate was 8% with nVNS + SoC and 0% with SoC alone. Conclusions: Prophylactic nVNS led to rapid, significant, and sustained reductions in chronic cluster headache attack frequency within 2 weeks after its addition to SoC and was associated with significantly higher ≥25%, ≥50%, and ≥75% response rates than SoC alone. The rapid decrease in weekly attack frequency justifies a 4-week trial period to identify responders to nVNS, with a high degree of confidence, among patients with chronic cluster headache. [less ▲]

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See detailLegal Mobilization Within the Bureaucracy: Disability Rights and the Implementation of Antidiscrimination Law in Sweden
Lejeune, Aude ULg

in Law and Policy (2017)

This paper argues that the analysis of legal mobilization needs to give more attention to the state and its relationship with social movements in order to examine how the state either sustains social ... [more ▼]

This paper argues that the analysis of legal mobilization needs to give more attention to the state and its relationship with social movements in order to examine how the state either sustains social movements' demands or is a field of contention for those demands. Focusing on how disability bureaucrats and activists mobilize antidiscrimination law in Sweden, this article shows that two main factors shape legal mobilization within the bureaucracy and alter the state's ability to become a legal mobilization actor: (1) the institutional relationships between social movement organizations and government agencies; and (2) the profiles and careers of bureaucrats and activists. It concludes by suggesting several lines for further research on law and social movements in nonpluralist countries. [less ▲]

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See detailEU Competition Law Analysis of FRAND Disputes
Petit, Nicolas ULg

in Jorge L Contreras (Ed.) The Cambridge Handbook of Technical Standardization Law (2017)

This paper describes the degree of obligation created by a FRAND commitment on the holders of a Standard Essential Patent (“SEP”) from an EU competition law perspective. It shows that the EU courts case ... [more ▼]

This paper describes the degree of obligation created by a FRAND commitment on the holders of a Standard Essential Patent (“SEP”) from an EU competition law perspective. It shows that the EU courts case-law does not seem supportive of the reading of FRAND as a distributional, pricing commitment. Instead, it views FRAND as a soft commitment device, designed to promote cooperation and exchange amongst independent firms. This is apparent in the Huawei v ZTE judgment, which conveys an invitation on both SEP holders and unlicensed implementers to follow basic procedural requirements in licensing talks. In addition, the paper contributes to the debate on the legal applicability of Article 102 TFEU to SEP holders other than practicing entities. Last, the paper discusses if Standard Setting Organizations (“SSOs”) ex ante specifications of FRAND terms can constrain the conduct of SEP holders under EU competition law. [less ▲]

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See detailSignificant Impediment to Industry Innovation: A Novel Theory of Harm in EU Merger Control?
Petit, Nicolas ULg

Report (2017)

A novel theory of harm is crystallising in European Union (“EU”) merger control. Under this theory, the EU Commission (“Commission”) can intervene in mergers that it considers generally reduce innovation ... [more ▼]

A novel theory of harm is crystallising in European Union (“EU”) merger control. Under this theory, the EU Commission (“Commission”) can intervene in mergers that it considers generally reduce innovation incentives in an industry as a whole. This theory of harm can be referred to as the Significant Impediment to Industry Innovation (“SIII”) theory. This policy paper first attempts to describe the content and extent of the SIII theory (I). Second, it shows that the SIII theory marks a departure from established EU merger control practice (II). Third, it discusses the economic foundations of the SIII theory (III). Finally, it puts forward best practices for the assessment of mergers in R&D intensive industries (IV). With this, the present paper hopes to assist the development of sound merger control policy in innovative markets, and undermine crude conjectures on the relationship between market structure, patent statistics and industry innovation theory. [less ▲]

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See detailFamilial history of migraine influences habituation of visual evoked potentials
Lisicki Martinez, Marco ULg; Ruiz-Romagnoli, Emiliano; D'Ostilio, Kevin ULg et al

in Cephalalgia : An International Journal of Headache (2017)

Background: Lack of habituation of visual evoked potentials (VEP) is a common finding in migraine patients between attacks. Previous studies have suggested an electrophysiological familial aggregation ... [more ▼]

Background: Lack of habituation of visual evoked potentials (VEP) is a common finding in migraine patients between attacks. Previous studies have suggested an electrophysiological familial aggregation pattern associated with migraine. The aim of this study was to evaluate the influence of a positive familial history of migraine on VEP amplitude and habituation. Methods: We recorded six blocks of 100 VEP during continuous pattern-reversal stimulation in 30 patients with migraine between attacks (MO) and in 30 healthy volunteers, of whom 15 had a first-degree relative suffering from migraine (HVm) and 15 had not (HV). Results: Both MO and HVm had a significant deficit of VEP habituation and similarly reduced N1-P1 first block amplitudes, compared to HV (habituation slope: MO ¼ 0.033, HVm ¼ 0.021, HV ¼ 0.025, HV vs. MO p ¼ 0.002, HV vs. HVm p ¼ 0.036; mean N1-P1 amplitude in the first block: MO ¼ 9.08 mV, HVm ¼ 9.29 mV, HV ¼ 12.19 mV. HV vs. MO p ¼ 0.041, HV vs. HVm p ¼ 0.076). The first block N1-P1 amplitude was negatively correlated with the habituation slope for both MO (r ¼ .44, p ¼ 0.015) and HVm (r ¼ .56, p ¼ 0.031) while no significant correlation was found in HV (r ¼ .17, p ¼ 0.53). There were no differences in VEP latencies between the groups. Conclusions: Our study suggests that lack of habituation of visual evoked potentials is probably a genetically determined endophenotypic trait that is associated with both migraine and migraine susceptibility. We hypothesize that genetic diversity of populations could account for some of the discrepancies between electrophysiological studies performed in migraine and for interindividual variations among the subgroups. [less ▲]

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