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See detailInfluence of the inter‐stage coupling flexibility on the dynamics of multi‐stage rotors
Nyssen, Florence ULg; Golinval, Jean-Claude ULg

in Proceedings of the ASME Turbo Expo 2016 (2016, June)

In this work, a characterization of the inter-stage coupling in a one-piece multi-stage bladed structure is performed. More particularly, the effect of the inter-stage coupling flexibility on the mode ... [more ▼]

In this work, a characterization of the inter-stage coupling in a one-piece multi-stage bladed structure is performed. More particularly, the effect of the inter-stage coupling flexibility on the mode-shapes is evaluated. To this purpose, the MAC matrix between the mono-stage and multi-stage modes is computed for different drum Young’s modulus of the inter-stage coupling. In parallel, the strain energy located in the blades and in the connecting structure is computed for different levels of inter-stage coupling. This enables to establish a criterion to determine when a multi-stage finite element analysis is necessary instead of only computing the different mono-stage models separately. This criterion is based on the localization of the energy in the structure. Numerical analyses are performed on a two-stages academic bladed structure. [less ▲]

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See detailShedding Light on the Dark Side of Customer Participation: Investigating Customer Participation Stress
Treger, Stephanie; Büttgen, Marion; Schumann, Jan Hendrik et al

Conference (2016, June)

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See detailL'importance de l'appartenance ethnique en RDC
Kabamba, Bob ULg

Scientific conference (2016, June)

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See detailDefects do Catalysis: CO Monolayer Oxidation and Oxygen Reduction Reaction on Hollow PtNi/C Nanoparticles
Dubau, Laetitia; Nelayah, Jaysen; Moldovan, Simona et al

in ACS Catalysis (2016)

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See detailStein's method, many interacting worlds and quantum mechanics
McKeague, Ian; Peköz, Erol; Swan, Yvik ULg

E-print/Working paper (2016)

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See detailShedding Light on the Dark Side of Customer Participation: Investigating Customer Participation Stress
Treger, Stephanie; Büttgen, Marion; Schumann, Jan Hendrik et al

Conference (2016, June)

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See detailUnderstanding Usage Behaviour in a Peer-to-Peer Task Community
Deliège, Fanny ULg; Ates, Zelal ULg; Benoit, Sabine et al

Conference (2016, June)

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See detailCareer development for international researchers
Halleux, Isabelle ULg

Diverse speeche and writing (2016)

This talk as invited speaker aims to express how and why the stakeholders opinions converge on the competences required from researchers and the needs for their career assessment. Inspiring tools and very ... [more ▼]

This talk as invited speaker aims to express how and why the stakeholders opinions converge on the competences required from researchers and the needs for their career assessment. Inspiring tools and very good practices exist that be shared to help employers as well as the researchers themselves. [less ▲]

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See detailDental ceramics: classification and indications
Mainjot, Amélie ULg

in Esthetics in Dentistry (2016)

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See detailMyoclonin-1 modulates the post-translational modification of microtubules
Medard, Laurie ULg; Coumans, Bernard ULg; Lakaye, Bernard ULg et al

Poster (2016, June)

Juvenile myoclonic epilepsy is one of the most common forms of generalized genetic epilepsy. Genetic studies have shown that heterozygous mutations in Myoclonin1 are responsible for 3-9% of clinical cases ... [more ▼]

Juvenile myoclonic epilepsy is one of the most common forms of generalized genetic epilepsy. Genetic studies have shown that heterozygous mutations in Myoclonin1 are responsible for 3-9% of clinical cases worldwide. This protein contains three DM10 domains of unknown function and an EF-hand domain. We have previously demonstrated that Myoclonin1 is a microtubule-associated protein involved in cell division and radial migration during neocortex development. In cells, this protein co-localized with specific structures rich in microtubules (MTs) such as the centrosome, the poles of the mitotic spindle or the motile cilia but not with cytoplasmic MTs. This suggests post-translational modifications (PTM) of MTs may be important for the interaction between Myoclonin1 and MTs. We have co-express the different enzymes catalyzing PTM of MTs with Myoclonin1 in U2OS cell line. With one of these enzymes, we observed a strong increase in PTM in the presence of Myoclonin-1. This suggests that Myoclonin1 may interact with and modulate the activity of this enzyme. By using luciferase complementation assay and pull down experiments, we could demonstrate that it is indeed the case. Interestingly, the effect is observed even when a DM10 domain alone is co-expressed with the enzyme, suggesting for the first time a role for this domain. In conclusion our data suggest myoclonin-1 modulates specific PTM of MTs. This is of prime importance for microtubule dynamic and notably for neuroblast precursor migration during neocortex development. This could be the mechanism that explains why pathological forms of myoclonin-1 affect brain development. [less ▲]

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See detailGuidance Document on the Estimation of LOD and LOQ for Measurements in the Field of Contaminants in Food and Feed
Wenzl, Thomas; Haedrich, Johannes; Schaechtele, Alexander et al

Report (2016)

The European Union Reference Laboratory (EURL) for Polycyclic Aromatic Hydrocarbons (EURL PAH), the EURL for Heavy Metals in Feed and Food (EURL HM), the EURL for Mycotoxins (EURL Mycotoxins), and EURL ... [more ▼]

The European Union Reference Laboratory (EURL) for Polycyclic Aromatic Hydrocarbons (EURL PAH), the EURL for Heavy Metals in Feed and Food (EURL HM), the EURL for Mycotoxins (EURL Mycotoxins), and EURL for Dioxins and PCBs in Feed and Food aim to provide with this document guidance to official food control in the EU on the estimation of the limit of quantification of analytical methods for the determination of individual substances in the field of contaminants in feed and food. The document focusses on estimation of the limit of detection (LOD) and/or limit of quantification (LOQ) of polycyclic aromatic hydrocarbons (PAHs), heavy metals (HM), mycotoxins, and polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs) and polychlorinated biphenyls (PCBs). The concept presented here consists of two major routes: The first route responds to the requirements for determination of PAHs, HMs and Mycotoxins. The second route corresponds to PCDD/F and PCB analysis, where results are calculated as sumparameters and expressed in toxic equivalents (TEQs), converting thereby congener concentrations together with estimated LOQs using toxic equivalency factor (TEFs) into TEQs. Due to the nature of this more complex procedure, emphasis is put in the area of PCDD/F and PCB analysis on the LOQs, while LODs are of minor consequence. Terminology in this guidance document was adapted to the chemical analysis of contaminants in feed and food; hence, some of the general terms defined and used in international standards were replaced by more specific terms applicable to analytical chemistry. The presented statistical-mathematical approach is based on elements taken mainly from DIN 32645:2008-11 (DIN 2008) and ISO 11843-2:2000 (ISO 2000). This document covers only quantitative methods of analysis. The authors believe that LOD and LOQ values derived from the application of the presented experimental methodologies converge to a certain degree. Estimation of LOD/LOQ values based on blank measurements, and from calibration data is described. Signal-to-noise ratios are applied in the area of PCDD/Fs and PCBs. Mathematical terms and statistical background are presented as well. This guide document shall be applied systematically if measurement results are used for monitoring purposes and exposure modelling. However, authors are aware that precise knowledge of LOD/LOQ may not be required when assessing compliance with maximum levels exceeding LOD/LOQ. This guidance document shall be applied if maximum levels and analysis results are close to the expected LOQ. The authors acknowledge that the presented approach has its limitations and may not be generally applicable to all cases. [less ▲]

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See detail“The Sweet Smell of Chemistry” - Characterization of volatile mixtures from Life Sciences
Stefanuto, Pierre-Hugues ULg

Doctoral thesis (2016)

From a Separation Science standpoint, Life Sciences represent a broad source of complex compound mixtures that require powerful analytical strategies to be considered when characterization is aimed. The ... [more ▼]

From a Separation Science standpoint, Life Sciences represent a broad source of complex compound mixtures that require powerful analytical strategies to be considered when characterization is aimed. The depiction of the complex volatile organic compound (VOC) component of these mixtures is an important part of such characterization. The aim of this doctoral work was to develop a versatile analytical approach to resolve such VOC samples. For the characterization of complex VOC mixtures, comprehensive two-dimensional gas chromatography (GC×GC) is the method of choice. The combination of two GC separation columns offers higher peak capacity than single dimension GC (1D GC). Moreover, the hyphenation of GC×GC to a mass spectrometer provides an extra dimension of identification, especially when high-resolution (HR) time-of-flight mass spectrometers (TOFMS) is used. However, the optimization of the GC×GC conditions is not straightforward. Currently, there are no defined strategies to obtain the best capabilities these instruments, not only in terms of the optimization of the separation itself, but also mainly in terms of data processing efficiency. The first section of this work was devoted to the evaluation of theoretical aspects and the definition of a specific optimization strategy for GC×GC separation. The first part dealt with the heavily debated concept of ‘orthogonality’ was specifically investigated by means of a metric calculation, the Orthogonality Index (OI), linked to a new nomenclature describing the separation space usage. The second part was focused on the development of an optimization strategy for the sampling and the chromatographic separation of VOCs, as well as the processing of large sets of GC×GC data. This was conducted on complex beer aroma headspace replicates for sampling method selection, peak dispersion optimization, and robust multivariate statistical treatment. The third part of this theoretical investigation relied on the implementation of fast-GC conditions for GC×GC separation. The idea was to evaluate the effect of combining short columns, fast modulation, high temperature ramping, and high flow on GC×GC efficiency for explosive headspace analyses. In the second section, the focus was directed to challenging applications in the area of thanatochemistry, i.e. the chemistry of death, especially considering the volatile fraction of cadaveric decomposition, a complex chemical process releasing numerous VOCs. In this context, soil surrounding decomposing remains, headspace of cadavers, and more “specific” matrices (i.e. synthetic solutions and internal gas from decomposition) were analyzed by GC×GC TOFMS. Major attention was dedicated to the development of an analytical and data mining procedures for these complex VOC samples with emphasis on the study of the impact of different parameters on the cadaveric decomposition process. [less ▲]

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See detailNovel application assigned to toluquinol: inhibition of lymphangiogenesis by interfering with VEGF-C/VEGFR-3 signaling pathway.
Garcia-Caballero, Melissa; BLACHER, Silvia ULg; Paupert, J. et al

in British Journal of Pharmacology (2016), 173(12), 1966-87

BACKGROUND AND PURPOSE: Lymphangiogenesis is an important biological process associated with the pathogenesis of several diseases, including metastatic dissemination, graft rejection, lymphedema and other ... [more ▼]

BACKGROUND AND PURPOSE: Lymphangiogenesis is an important biological process associated with the pathogenesis of several diseases, including metastatic dissemination, graft rejection, lymphedema and other inflammatory disorders. The development of new drugs blocking lymphangiogenesis has become a promising therapeutic strategy. In this study, we aim at investigating the ability of toluquinol, a 2-methyl-hydroquinone isolated from the culture broth of the marine fungus Penicillium sp. HL-85-ALS5-R004, to inhibit lymphangiogenesis in vitro, ex vivo and in vivo. EXPERIMENTAL APPROACH: We used human lymphatic endothelial cells (LEC) to analyze the effect of toluquinol in 2D and 3D in vitro cultures, and in the ex vivo mouse lymphatic ring assay. For in vivo approaches, the transgenic Fli1:eGFPy1 zebrafish, the mouse ear sponges and cornea models were used. Western-blotting and apoptosis analyses were carried out to search for drug targets. KEY RESULTS: Toluquinol inhibited LEC proliferation, migration, tubulogenesis and sprouting of new lymphatic vessels. Furthermore, toluquinol induced LEC apoptosis after 14 h of treatment in vitro, blocked the thoracic duct development in zebrafish, and reduced the VEGF-C-induced lymphatic vessel formation and corneal neovascularization in mice. Mechanistically, we are providing evidence that this drug abrogates the VEGF-C-induced VEGFR-3 phosphorylation in a dose-dependent manner, and represses Akt and ERK1/2 phosphorylations. CONCLUSIONS AND IMPLICATIONS: Based on these findings, we propose toluquinol as a new candidate with pharmacological potential for the treatment of lymphangiogenesis-related pathologies. Notably, its ability to suppress corneal neovascularization paves the way for applications in vascular ocular pathologies. This article is protected by copyright. All rights reserved. [less ▲]

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See detailCompte rendu de Voltaire, Œuvres complètes, vol. 51A : Recueil des facéties parisiennes, éd. dirigée par Nicholas Cronk
Daubercies, Laurence ULg

in COnTEXTES : Revue de Sociologie de la Littérature (2016)

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See detailCerebral metabolism before and after external trigeminal nerve stimulation in episodic migraine
MAGIS, Delphine ULg; D'Ostilio, Kevin ULg; Thibaut, Aurore ULg et al

in Cephalalgia : An International Journal of Headache (2016)

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See detailTranscranial magnetic stimulation in sleep consciousness
Gosseries, Olivia ULg; Niemienen, Jaakko; Jason, Samaha et al

Poster (2016, June)

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See detailEducation of instructors of a physical activity program for cancer patients and survivors: planning and evaluation of a poster presentation session
Rompen, Jérôme ULg; Korycki, Marta ULg; Ortmans, Sabine et al

Poster (2016, June)

Introduction The Belgian Foundation against Cancer proposes an adapted physical activity (APA) program for cancer patients and survivors, called Raviva (http://www.cancer.be/raviva-bouger-pour-se-sentir ... [more ▼]

Introduction The Belgian Foundation against Cancer proposes an adapted physical activity (APA) program for cancer patients and survivors, called Raviva (http://www.cancer.be/raviva-bouger-pour-se-sentir-mieux).The activities are supervised by instructors with inconstant trainings and experiences. Contrary to other countries, Belgian APA instructors do not necessarily need to follow specific education programs such those proposed by the ACSM (Schmitz et al., 2010).We were involved in the implementation of a specific training day for in-service Raviva instructors. As it is the case in sport coaches’ education (Erickson et al., 2008), interacting with colleagues seemed to be an appropriate method to improve APA instructors’ skills. Therefore, interactive methods were proposed to be used in order to increase the participants’ interest. The aim of this paper was to describe and analyse a poster presentation session as well as to identify good practices. Methods As part of the training day, the poster presentation session consisted to create groups of 4 to 5 persons and to ask them to imagine and share solutions to specific problems linked with psycho-emotional aspects of the instruction process with Raviva groups. Three methods were used to collect the data: interviews of the organizers (n=4), a questionnaire for all trainees (n=35) and participant observation. Results Examples of good practices were listed and exchanged between the participants. All trainees considered that the poster presentation session was interesting and most of them (94%) reported that appropriate themes were discussed. Moreover, 88.2% of the participants mentioned that they were able to share their experiences. Three expressed negative opinions about the organization. These opinions were supported by all organizers as well as by the observation. Conclusions This educational tool seems to be interesting. However, organizers should plan enough time for such activity. Moreover, the time allocation between each part of the session should be better prepared and controlled. [less ▲]

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See detailEducation of instructors of a physical activity program for cancer patients and survivors: planning and evaluation of interactive adapted physical activity working groups
Rompen, Jérôme ULg; Korycki, Marta ULg; Ortmans, Sabine et al

Conference (2016, June)

Introduction Raviva is a Belgian adapted physical activity (APA) program for cancer patients and survivors, developed by the Belgian Foundation against Cancer (http://www.cancer.be/aide-aux-patients/la ... [more ▼]

Introduction Raviva is a Belgian adapted physical activity (APA) program for cancer patients and survivors, developed by the Belgian Foundation against Cancer (http://www.cancer.be/aide-aux-patients/la-fondation-votre-service/raviva-bouger-pour-se-sentir-mieux). Activities supported by this foundation are supervised by instructors with inconstant trainings and experiences. Indeed, in Belgium, APA instructors do not necessarily follow specific training programs such those proposed by the ACSM (Schmitz et al., 2010). As it is the case in sport coaches’ education (Erickson et al., 2008), interacting with colleagues and sharing knowledge could be an interesting way to improve APA instructors’ competencies. The aim of this study was to plan and analyse interactive APA working groups, as part of a training day intended for all Raviva instructors. Methods As part of this training, we proposed three practical physical activity working groups, each one concerning a specific activity: fitness, relaxation and aqua-aerobics. They were designed to generate some good practices in intervention with Raviva groups and had to be interactive: all participants had the opportunity to present their own practices and to discuss and comment the practices of the others. Three methods were used to analyse the activities: interviews of the organizers (n=4), a questionnaire for all trainees (n=35) and participant observation. Results Many examples of practical situations and good practices have been identified.79.4% of the trainees considered that the proposed method was interesting and 88.3% mentioned that they have been actively involved. The organizers were less convinced as they highlighted a lack of ideas sharing as well as low active participation and dynamism. Observations confirmed the organizers’ opinions. Conclusions Participants appeared to be globally satisfied with the practical activities. However, further research is needed to measure the impact of such methods on their future practices. [less ▲]

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