Last 7 days
Bookmark and Share    
Full Text
Peer Reviewed
See detailStrand-specific, high-resolution mapping of modified RNA polymerase II
Milligan, Laura; Huynh-Thu, Vân Anh ULg; Delan-Forino, Clémentine et al

in Molecular Systems Biology (2016), 12(6), 874

Reversible modification of the RNAPII C-terminal domain links transcription with RNA processing and surveillance activities. To better understand this, we mapped the location of RNAPII carrying the five ... [more ▼]

Reversible modification of the RNAPII C-terminal domain links transcription with RNA processing and surveillance activities. To better understand this, we mapped the location of RNAPII carrying the five types of CTD phosphorylation on the RNA transcript, providing strand-specific, nucleotide-resolution information, and we used a machine learning-based approach to define RNAPII states. This revealed enrichment of Ser5P, and depletion of Tyr1P, Ser2P, Thr4P, and Ser7P in the transcription start site (TSS) proximal ~150 nt of most genes, with depletion of all modifications close to the poly(A) site. The TSS region also showed elevated RNAPII relative to regions further 3′, with high recruitment of RNA surveillance and termination factors, and correlated with the previously mapped 3′ ends of short, unstable ncRNA transcripts. A hidden Markov model identified distinct modification states associated with initiating, early elongating and later elongating RNAPII. The initiation state was enriched near the TSS of protein-coding genes and persisted throughout exon 1 of intron-containing genes. Notably, unstable ncRNAs apparently failed to transition into the elongation states seen on protein-coding genes. [less ▲]

Detailed reference viewed: 11 (4 ULg)
Full Text
See detailDes mini-jeux pour apprendre - Retour d'expérience dans un cours de chimie à l'université
le Maire, Nathalie ULg; Colaux, Catherine ULg; Fauconnier, Marie-Laure ULg et al

Conference (2016, June)

Dans le champ éducatif, les jeux ont régulièrement fait l’objet de réflexions et d’expérimentations visant à en exploiter leur potentiel au service de la compréhension, la motivation, la créativité ... [more ▼]

Dans le champ éducatif, les jeux ont régulièrement fait l’objet de réflexions et d’expérimentations visant à en exploiter leur potentiel au service de la compréhension, la motivation, la créativité, l’esprit critique etc. des étudiants. De la tortue LOGO aux jeux de simulation, l’exploitation du jeu dans l’enseignement a revêtu de multiples formes. Récemment la notion de gamification a enrichi cette ligne de recherche sur le jeu. Le concept de « gamification » désigne l’application d’éléments, de mécanismes, de processus ludiques à des situations, des contextes, des visées non ludiques. En la matière, Candy Crush, Farm Ville, Clash of Clans, etc. sont autant de jeux commerciaux qui remportent un grand succès aujourd’hui et peuvent fournir une source d’inspiration pour la création de mini-jeux pédagogiques. La présente communication relate la mise en place de « World of Chemistry », un parcours ludique mis en place de septembre à décembre 2015 en complément des supports de cours traditionnels. Ce parcours était composé de quatre mini-jeux portant sur des savoirs et des compétences identifiés comme difficiles en chimie et conçus explicitement pour incorporer des éléments de gamification issus de mini-jeux commerciaux variés. Cette expérimentation avait pour objectif d’étudier dans quelle mesure et à quelles conditions ces mini-jeux étaient susceptibles d’augmenter la fréquentation de la matière de chimie par les étudiants. A la lumière de l’usage fait des mini-jeux par 159 étudiants de première année d’université et de questionnaires de feedback qui leur ont été adressés, la communication évaluera la valeur de cette initiative pédagogique. [less ▲]

Detailed reference viewed: 76 (14 ULg)
Full Text
Peer Reviewed
See detailA review of glucosamine for knee osteoarthritis: why patented crystalline glucosamine sulfate shoulf be differentiated from the other glucosamines to maximize clinical outcomes
Kucharz, E.J.; Kovalenko, V.; Szanto, S. et al

in Current Medical Research & Opinion (2016), 32(6), 997-1004

The European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) treatment algorithm for knee osteoarthritis (OA) recommends symptomatic slow-acting drugs for ... [more ▼]

The European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) treatment algorithm for knee osteoarthritis (OA) recommends symptomatic slow-acting drugs for osteoarthritis (SYSADOAs) first line for the medium to long term management of OA, due to their ability to control pain, improve function, and delay joint structural changes. Among SYSADOAs, glucosamine is probably the most widely used intervention. In the present review of glucosamine for knee OA, we have investigated whether the evidence is greater for the patented crystalline glucosamine sulfate (pCGS) preparation (Rottapharm/Meda) than for other glucosamine formulations. Glucosamine is actually widely available in many forms, as the prescription-grade pCGS preparation, generic and over-the-counter formulations of glucosamine sulfate (GS) and food supplements containing glucosamine hydrochloride (GH), which vary substantially in molecular form, pharmaceutical formulation and dose regimens. Only pCGS is given as a highly bioavailable once daily dose (1500mg) with a proven pharmacological effect. pCGS consistently reaches the plasma levels of around 10 lM required to inhibit interleukin-1 induced expression of genes involved in the pathophysiology of joint inflammation and tissue destruction, compared with sub-therapeutic levels achieved with GH. It is evident, from careful consideration of the evidence base, that only the pCGS formulation of glucosamine reliably provides an effect size on pain that is higher than that of paracetamol and equivalent to that provided by non-steroidal antiinflammatory drugs. In comparison, the effect size on pain of non-crystalline GS preparations and GH from randomized controlled trials is repeatedly demonstrated to be zero. In addition, there is evidence that chronic administration of pCGS has disease-modifying effects, with a reduction in the need for total joint replacement surgery lasting for at least 5 years after treatment cessation. Consequently, the pCGS preparation (Rottapharm/Meda) is the logical choice, with demonstrated medium-term control of pain and lasting impact on disease progression. [less ▲]

Detailed reference viewed: 15 (5 ULg)
Full Text
Peer Reviewed
See detailALERBLOT: Interest of 2D Immunoblot for the diagnosis of allergy to wheat
BERTHOLET, Catherine ULg; GADISSEUR, Romy ULg; quinting, birgit et al

in Allergy (2016, June), 71

Detailed reference viewed: 13 (1 ULg)
Peer Reviewed
See detailHow to enhance citizenship and reduce dysfunctional patient behavior during service interactions: An empirical study in the nursing context
Lerch, Jennifer; Schmitz, Gertrud; Büttgen, Marion et al

Conference (2016, June)

Detailed reference viewed: 24 (1 ULg)
Full Text
Peer Reviewed
See detailPolar interface phonons in ionic toroidal systems
Nguyen, Ngoc Duy ULg; Evrard, Roger ULg; Stroscio, Michael

in Journal of Physics : Condensed Matter (2016), 28(34), 345301

We use the dielectric continuum model to obtain the polar (Fuchs–Kliewer like) interface vibration modes of toroids made of ionic materials either embedded in a different material or in vacuum, with ... [more ▼]

We use the dielectric continuum model to obtain the polar (Fuchs–Kliewer like) interface vibration modes of toroids made of ionic materials either embedded in a different material or in vacuum, with applications to nanotoroids specially in mind. We report the frequencies of these modes and describe the electric potential they produce. We establish the quantum-mechanical Hamiltonian appropriate for their interaction with electric charges. This Hamiltonian can be used to describe the effect of this interaction on different types of charged particles either inside or outside the torus. [less ▲]

Detailed reference viewed: 8 (1 ULg)
Peer Reviewed
See detailModeling, sensitivity analysis and parameter identification of a twin screw extruder
Grimard, Jonathan; Dewasme, Laurent; Thiry, Justine ULg et al

Conference (2016, June)

Detailed reference viewed: 27 (2 ULg)
Full Text
Peer Reviewed
See detailA Gaussian mixture approach to model stochastic processes in power systems
Gemine, Quentin ULg; Cornélusse, Bertrand ULg; Glavic, Mevludin ULg et al

in Proceedings of the 19th Power Systems Computation Conference (PSCC'16) (2016, June)

Probabilistic methods are emerging for operating electrical networks, driven by the integration of renewable generation. We present an algorithm that models a stochastic process as a Markov process using ... [more ▼]

Probabilistic methods are emerging for operating electrical networks, driven by the integration of renewable generation. We present an algorithm that models a stochastic process as a Markov process using a multivariate Gaussian Mixture Model, as well as a model selection technique to search for the adequate Markov order and number of components. The main motivation is to sample future trajectories of these processes from their last available observations (i.e. measurements). An accurate model that can generate these synthetic trajectories is critical for applications such as security analysis or decision making based on lookahead models. The proposed approach is evaluated in a lookahead security analysis framework, i.e. by estimating the probability of future system states to respect operational constraints. The evaluation is performed using a 33-bus distribution test system, for power consumption and wind speed processes. Empirical results show that the GMM approach slightly outperforms an ARMA approach. [less ▲]

Detailed reference viewed: 104 (25 ULg)
Full Text
See detailReshaping Diplomacy / Réinventer la diplomatie. Networks, Practices and Dynamics of Socialization in European Diplomacy since 1919 / Sociabilités, réseaux et pratiques diplomatiques en Europe depuis 1919
Genin, Vincent ULg; Osmont, Matthieu; Raineau, Thomas

Book published by P.I.E.-Peter Lang (2016)

After the First World War, reshaping the art of diplomacy is a necessity. International lawyers, merchant bankers, academics, journalists and senior officials became key-figures of a new International ... [more ▼]

After the First World War, reshaping the art of diplomacy is a necessity. International lawyers, merchant bankers, academics, journalists and senior officials became key-figures of a new International order in which the diplomats have lost their monopoly over foreign affairs. New diplomatic arenas emerged such as the League of Nations, the precursor of today’s multilateral organizations. In that series of ten case studies, the European continent appears as a fertile ground where new diplomatic practices have emerged along the whole 20th century. This book brings together the edited proceedings of the RICHIE International Conference organized in Brussels on 20 and 21 March 2015, under the title «Networks, Dynamics of Socialization and Practices in European Diplomacy since 1919». [less ▲]

Detailed reference viewed: 15 (1 ULg)
Full Text
Peer Reviewed
See detailWASP-121 b: a hot Jupiter close to tidal disruption transiting an active F star
Delrez, Laetitia ULg; Santerne, A.; Almenara, J.-M. et al

in Monthly Notices of the Royal Astronomical Society (2016), 458(4), 4025-4043

We present the discovery by the WASP-South survey of WASP-121 b, a new remarkable short-period transiting hot Jupiter. The planet has a mass of 1.183_{-0.062}^{+0.064} MJup, a radius of 1.865 ± 0.044 RJup ... [more ▼]

We present the discovery by the WASP-South survey of WASP-121 b, a new remarkable short-period transiting hot Jupiter. The planet has a mass of 1.183_{-0.062}^{+0.064} MJup, a radius of 1.865 ± 0.044 RJup, and transits every 1.274 9255_{-0.000 0025}^{+0.000 0020} days an active F6-type main-sequence star (V = 10.4, 1.353_{-0.079}^{+0.080} M⊙, 1.458 ± 0.030 R⊙, Teff = 6460 ± 140 K). A notable property of WASP-121 b is that its orbital semimajor axis is only ˜1.15 times larger than its Roche limit, which suggests that the planet is close to tidal disruption. Furthermore, its large size and extreme irradiation (˜7.1 109 erg s-1 cm-2) make it an excellent target for atmospheric studies via secondary eclipse observations. Using the TRAnsiting Planets and PlanetesImals Small Telescope, we indeed detect its emission in the z'-band at better than ˜4σ, the measured occultation depth being 603 ± 130 ppm. Finally, from a measurement of the Rossiter-McLaughlin effect with the CORALIE spectrograph, we infer a sky-projected spin-orbit angle of 257.8°_{-5.5°}^{+5.3°}. This result may suggest a significant misalignment between the spin axis of the host star and the orbital plane of the planet. If confirmed, this high misalignment would favour a migration of the planet involving strong dynamical events with a third body. [less ▲]

Detailed reference viewed: 24 (2 ULg)
Full Text
See detailLa Présidence de la Fédération Internationale des Professeurs de Français
Defays, Jean-Marc ULg

in Vivre le Français : Revue de l'Association Belge des Professeurs de Français (2016), 249

Detailed reference viewed: 6 (0 ULg)
See detailA quoi sert un astrophysicien?
Stiepen, Arnaud ULg

Conference given outside the academic context (2016)

Detailed reference viewed: 11 (3 ULg)
Full Text
See detailAux astres, citoyens! Oufti! Liège dans l'espace!
Stiepen, Arnaud ULg

Article for general public (2016)

Detailed reference viewed: 7 (1 ULg)
Full Text
Peer Reviewed
See detailBenchmarking for Bayesian Reinforcement Learning
Castronovo, Michaël ULg; Ernst, Damien ULg; Couëtoux, Adrien ULg et al

in PLoS ONE (2016)

In the Bayesian Reinforcement Learning (BRL) setting, agents try to maximise the col- lected rewards while interacting with their environment while using some prior knowledge that is accessed beforehand ... [more ▼]

In the Bayesian Reinforcement Learning (BRL) setting, agents try to maximise the col- lected rewards while interacting with their environment while using some prior knowledge that is accessed beforehand. Many BRL algorithms have already been proposed, but even though a few toy examples exist in the literature, there are still no extensive or rigorous benchmarks to compare them. The paper addresses this problem, and provides a new BRL comparison methodology along with the corresponding open source library. In this methodology, a comparison criterion that measures the performance of algorithms on large sets of Markov Decision Processes (MDPs) drawn from some probability distributions is defined. In order to enable the comparison of non-anytime algorithms, our methodology also includes a detailed analysis of the computation time requirement of each algorithm. Our library is released with all source code and documentation: it includes three test prob- lems, each of which has two different prior distributions, and seven state-of-the-art RL algorithms. Finally, our library is illustrated by comparing all the available algorithms and the results are discussed. [less ▲]

Detailed reference viewed: 391 (32 ULg)
Full Text
Peer Reviewed
See detailFreeze-dried mucoadhesive polymeric system containing pegylated lipoplexes: Towards a vaginal sustained released system for siRNA
Furst, Tania ULg; Dakwar, George R.; Zagato, Elisa et al

in Journal of Controlled Release (2016)

Topical vaginal sustained delivery of siRNA presents a significant challenge due to the short residence time of formulations. Therefore, a drug delivery system capable to adhere to the vaginal mucosa is ... [more ▼]

Topical vaginal sustained delivery of siRNA presents a significant challenge due to the short residence time of formulations. Therefore, a drug delivery system capable to adhere to the vaginal mucosa is desirable, as it could allow a prolonged delivery and increase the effectiveness of the therapy. The aim of this project is to develop a polymeric solid mucoadhesive system, loaded with lipoplexes, able to be progressively rehydrated by the vaginal fluids to form a hydrogel and to deliver siRNA to vaginal tissues. To minimize adhesive interactions with vaginal mucus components, lipoplexes were coated with different derivatives of polyethylene glycol: DPSE-PEG2000, DPSE-PEG750 and ceramide-PEG2000. Based on stability and diffusion properties in simulated vaginal fluids, lipoplexes containing DSPE-PEG2000 were selected and incorporated in hydroxyethyl cellulose (HEC) hydrogels. Solid systems, called sponges, were then obtained by freeze-drying. Sponges meet acceptable mechanical characteristics and their hardness, eformability and mucoadhesive properties are not influenced by the presence of lipoplexes. Finally, mobility and stability of lipoplexes inside sponges rehydrated with vaginal mucus, mimicking in situ conditions, were evaluated by advanced fluorescence microscopy. The release rate was found to be influenced by the HEC concentration and consequently by the viscosity after rehydration. This study demonstrates the feasibility of entrapping pegylated lipoplexes into a solid matrix system for a prolonged delivery of siRNA into the vagina. [less ▲]

Detailed reference viewed: 32 (18 ULg)
Full Text
Peer Reviewed
See detail(Re)producing others: diversity and discrimination in the discourse of Northern League
Mazzola, Alessandro ULg; Mandin, Jérémy ULg

in Jamin, Jérôme (Ed.) L'extrême droite en Europe (2016)

Detailed reference viewed: 26 (3 ULg)
Full Text
Peer Reviewed
See detailDevelopment of a semi-analytical model of volumetric expander for system-level simulation.
Oudkerk, Jean-François ULg

in Proceedings of ECOS 2016 (2016, June)

Organic Rankine cycles are particularly well suited for recovering energy from low-grade heat sources, such as industrial waste, engine exhaust gas or solar concentrated power. In ow-capacity systems ... [more ▼]

Organic Rankine cycles are particularly well suited for recovering energy from low-grade heat sources, such as industrial waste, engine exhaust gas or solar concentrated power. In ow-capacity systems, volumetric expanders are often preferred to turbomachines because of their reliability, robustness, low rotational speed and their ability to handle high pressure ratios… Different types of machines have been investigated and successfully tested by the uthors and tools have been developed in order to analyse experimental data. Semi-empirical odel was built to analyse losses, detect potential improvement and simulate performances. This paper present a simple and fastcomputing semi-analytical model useful for simulate dynamic system integrating volumetric expander. This model is validated on experimental data and compare to black-box model. [less ▲]

Detailed reference viewed: 16 (5 ULg)
Full Text
See detailDu programme d'origine à la restauration des charpentes et couvertures
Hoffsummer, Patrick ULg

in Monumental : Revue Scientifique et Technique des Monuments Historiques (2016), 2016 1(1), 6-11

Les toitures des monuments historiques en France représentent un patrimoine pour l'histoire de l'architecture et l'histoire de la construction. Leur typologie dépend de nombreux facteurs: type de bâtiment ... [more ▼]

Les toitures des monuments historiques en France représentent un patrimoine pour l'histoire de l'architecture et l'histoire de la construction. Leur typologie dépend de nombreux facteurs: type de bâtiment, contexte historique, géographique. Leur conservation exige une analyse profonde de leur état et impose certains choix au moment de la restauration en fonction de leur réaffectation. [less ▲]

Detailed reference viewed: 9 (3 ULg)