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See detailPEGylation of lipoplexes: The right balance between cytotoxicity and siRNA effectiveness
Lechanteur, Anna ULg; Furst, Tania ULg; Evrard, Brigitte ULg et al

in European Journal of Pharmaceutical Sciences (2016), 93

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See detailHigh selfing rate, limited pollen dispersal and inbreeding depression in the emblematic African rain forest tree Baillonella toxisperma - Management implications
Duminil, Jérôme; Mendene Abessolo, D. T.; Ndiade Bourobou, D. et al

in Forest Ecology & Management (2016), 379

Mating system and gene flow are major influencing factors of species population dynamics and evolution. These factors are often not characterized in tropical tree species, yet they constitute basic ... [more ▼]

Mating system and gene flow are major influencing factors of species population dynamics and evolution. These factors are often not characterized in tropical tree species, yet they constitute basic information that must be considered to implement sustainable management practices. In particular, as logging implies a reduction of the density of congeneric mates, the connectivity through pollination between individuals has to be well characterized (selfing versus outcrossing rates, distances between mates). We conducted a genetic-based analysis (using 10 nuclear microsatellites) to determine the mating system and gene flow characteristics of an emblematic timber tree species from lowland rain forests of the Congo Basin, Baillonella toxisperma (Sapotaceae). The species, which is frequently exploited for its wood and for a number of non-timber forest products, naturally occurs at low densities (ca. 0.01–0.1 individuals/ha). It is supposedly an entomophilous species whose seeds are probably dispersed by mammals. We have shown that the species presents a mixed-mating system (about 20–40% of selfing depending on analysis method). However, the comparison of inbreeding parameters among cohorts suggests that inbred individuals die between seedling and mature tree stages. The mean pollen dispersal distance was relatively low for such a low-density population species (estimated to be 690 or 777 m depending on analysis method) and, together with a low mean number of pollen donors (NEP = 2.76), it suggests a pattern of nearest-neighbour mating where allo-pollen could be a limiting factor. However, B. toxisperma presents a relatively weak genetic structure (Sp statistic = 0.0095) indicative of long gene dispersal distance (rg = 3–5 km according to the assumed effective population density). Overall, this would indicate that gene flow occurs mainly by extensive seed dispersal in this species. These results suggest that mammals and local populations involved in the dispersal of the species play a key role by lowering biparental inbreeding effects. Sustainable population management might require assisted regeneration using unrelated planting material. [less ▲]

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See detailStatistically Bundled Shewhart Control Charts for Monitoring Delivery Chains Systems
Foster, Earnest; Faraz, Alireza ULg; Heuchenne, Cédric ULg

in European Journal of Industrial Engineering (2016)

Continuous monitoring of Delivery Time variables by means of control charts in a delivery chain is a very recent application of Statistical Process Control (SPC) to the service sector. The aim of the ... [more ▼]

Continuous monitoring of Delivery Time variables by means of control charts in a delivery chain is a very recent application of Statistical Process Control (SPC) to the service sector. The aim of the proposed method is to provide supply chain decision makers with an easy to be managed tool monitoring the current functioning state of the delivery chain. The implementation of SPC control charts makes it possible to limit over-corrections to false alarm conditions and to maintain at an acceptable level the safety stock, with a consequent reduction of the overall management costs of the delivery chain. An illustrative example shows the proposed control chart implementation in a real delivery chain. [less ▲]

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See detailHeart Team Session
PIERARD, Luc ULg; LANCELLOTTI, Patrizio ULg; PETERMANS, Jean ULg et al

Conference (2016, August)

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See detailEntretien avec Céline Letawe - ULg
Letawe, Céline ULg

in Chambre Belge des Traducteurs et Interprètes (Ed.) Le Linguiste (2016)

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See detailImpact of vertical and horizontal advection on nutrient distribution in the southeast Pacific
Barceló-Llull, Barbara; Mason, Evan; Capet, Arthur ULg et al

in Ocean Science (2016), 12(4), 1003-1011

An innovative approach is used to analyze the impact of vertical velocities associated with quasi-geostrophic (QG) dynamics on the redistribution and uptake of nitrate in the southeast Pacific (SEP). A ... [more ▼]

An innovative approach is used to analyze the impact of vertical velocities associated with quasi-geostrophic (QG) dynamics on the redistribution and uptake of nitrate in the southeast Pacific (SEP). A total of 12 years of vertical and horizontal currents are derived from an observation based estimate of the ocean state. Horizontal velocities are obtained through the application of thermal wind balance to weekly temperature and salinity fields. Vertical velocities are estimated by integration of the QG omega equation. Seasonal variability of the synthetic vertical velocity and kinetic energy associated with the horizontal currents is coincident, with peaks in austral summer (November–December) in accord with published observations. The impact of vertical velocity on SEP nitrate uptake rates is assessed by using two Lagrangian particle tracking experiments that differ according to vertical forcing (ω = ωQG vs. ω = 0). From identical initial distributions of nitrate-tagged particles, the Lagrangian results show that vertical motions induce local increases in nitrate uptake reaching up to 30 %. Such increases occur in low uptake regions with high mesoscale activity. Despite being weaker than horizontal currents by a factor of up to 10−4, vertical velocity associated with mesoscale activity is demonstrated to make an important contribution to nitrate uptake, hence productivity, in low uptake regions. [less ▲]

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See detailRelease of cardiac biomarkers during a cycling race
LE GOFF, Caroline ULg; Kaux, Jean-François ULg; D'OTREPPE DE BOUVETTE, Stéphanie ULg et al

in World Journal of Cardiovascular Diseases (2016), 6(8), 285-294

Objectives: Over the past two decades, a large interest in cardiac marker elevations has developed in endurance sports events. The intense effort is not without risk. We aim to see if the relatively ... [more ▼]

Objectives: Over the past two decades, a large interest in cardiac marker elevations has developed in endurance sports events. The intense effort is not without risk. We aim to see if the relatively cardiospecific biomarkers could show the damage on cardiac muscle cells. Methods: Fourteen cyclists were recruited for an international race (177km). We studied the release of injury related cardiac markers, risk related cardiac markers, renal function markers and blood cytology. The subjects were submitted to three blood test: one before (T0), one just after (T1) and the last one 3 hours after the race (T3). Results: Blood cytology markers, namely erythrocytes, hemoglobin, hematocrit, and average hemoglobin concentration, were found to evolve in a similar way. Renal function markers, such as creatinin, cystatin C and uric acid, showed a post effort increase that might be related to renal blood flow depletion during exercise. Cardiac and muscular markers were all increased at T1. Conclusions: Physiological stress induced by an international cycling race certainly has consequences on cardiac muscle cells. Fortunately, those blood concentration variations are more representative of a transitional state, due to an imbalance created by an intense aerobic effort maintained during several hours, rather than an irreversible injury. [less ▲]

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See detailPhonological acquisition in CLIL- and non-CLIL education
Rasier, Laurent ULg

Conference (2016, August)

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See detailDu côté de chez...Godefroid Kurth. Réflexions personnelles
Genin, Vincent ULg

in Bulletin Trimestriel de l'Institut Archéologique du Luxembourg Arlon (2016), 92(3/4), 99-107

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See detailMicroorganisms and semiochemicals to manipulate aphidophagous predators
Verheggen, François ULg

Conference (2016, August)

Semiochemicals provide a powerful way for organisms to communicate and coordinate their behaviors. But they also represent opportunities for other organisms to intercept and exploit such signals. There ... [more ▼]

Semiochemicals provide a powerful way for organisms to communicate and coordinate their behaviors. But they also represent opportunities for other organisms to intercept and exploit such signals. There are now numerous examples of natural enemies eavesdropping the intraspecific communication of their prey to better locate them. Aphid natural enemies, including predators and parasitoids, frequently exhibit innate responses to chemical cues reliably associated with aphids, and there is also abundant evidence that learning of profitable chemical cues frequently occurs. Thenceforth, the efficiency of aphid natural enemies to locate their prey is mainly based on their ability to perceive and orientate toward aphid-associated semiochemicals. Aphid predators were shown to respond to different groups of aphid-related semiochemicals, including aphid-induced plant volatiles; aphid pheromones and the more recently identified bacteria-produced honeydew volatiles. These laboratory studies suggest potentially promising avenues for the deployment of aphid-associated semiochemicals for the management of these pest species. While laboratory experiments are invaluable tools for revealing mechanisms, additional field studies are however needed to test ecological relevance of the observed effects. Although it is now possible to attract naturally occurring aphid predators in a crop field using semiochemicals, future work should more fully explore the broader ecological context in which signaling occurs. The information gained from a deeper understanding of the chemical ecology of aphid-natural enemy interaction will enhance our understanding of the chemical biology and ecology of aphids, and may facilitate the design of novel control strategies. [less ▲]

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See detailLa légation des Pays-Bas en cour de Rome au temps de l’agent Laurent du Blioul (1573-1598): Une légation au cœur des réseaux de la monarchie de Philippe II
Regibeau, Julien ULg

in Actes du neuvième congrès de l'Association des Cercles francophones d'Histoire et d'Archéologie de Belgique (2016, August)

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See detailThe dual action of neuroestrogens on sexual behavior
Cornil, Charlotte ULg

Conference (2016, August)

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See detailPostmortem Internal Gas Reservoir Monitoring Using GCxGC-HRTOFMS
Stefanuto, Pierre-Hugues ULg; Perrault, Katelynn ULg; Grabher, Silke et al

in separations (2016), 3(24),

Forensic investigations often require postmortem examination of a body. However, the collection of evidence during autopsy is often destructive, meaning that the body can no longer be examined in its ... [more ▼]

Forensic investigations often require postmortem examination of a body. However, the collection of evidence during autopsy is often destructive, meaning that the body can no longer be examined in its original state. In order to obtain an internal image of the body, whole body postmortem computed tomography (PMCT) has proven to be a valuable non-destructive tool and is currently used in medicolegal centers. PMCT can also be used to visually locate gas reservoirs inside a cadaver, which upon analysis can provide useful information regarding very volatile compounds that are produced after death. However, the non-targeted profiling of all potential volatile organic compounds (VOCs) present in these reservoirs has never been attempted. The aim of this study was to investigate the VOC profile of these reservoirs and to evaluate potential uses of such information to document circumstances surrounding death, cause of death and body taphonomy. Comprehensive two-dimensional gas chromatography coupled to time-of-flight high-resolution mass spectrometry (GC GC-HRTOF-MS) was used for VOC measurements. This study demonstrated that the chemical composition of VOCs within the gas reservoirs differed between locations within a single body but also between individuals. In the future, this work could be expanded to investigate a novel, non-destructive cadaver screening approach prior to full autopsy procedures. [less ▲]

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See detailCollaborative Care regarding major depressed patients: A review of guidelines and current practices
Van den Broeck, Kris; Remmen, Roy; Vanmeerbeek, Marc ULg et al

in Journal of Affective Disorders (2016), 200

Major Depressive Disorder (MDD) is a severe and common mental disorder. A growing body of evidence suggests that stepped and/or collaborative care treatment models have several advantages for severely ... [more ▼]

Major Depressive Disorder (MDD) is a severe and common mental disorder. A growing body of evidence suggests that stepped and/or collaborative care treatment models have several advantages for severely depressed patients and caretakers. However, despite the availability of these treatment strategies and guidance initiatives, many depressive patients are solely treated by the general practitioner (GP), and collaborative care is not common. In this paper, we review a selected set of international guidelines to inventory the best strategies for GPs and secondary mental health care providers to collaborate when treating depressed patients. Additionally, we systematically searched the literature, listing potential ways of cooperation, and potentially supporting tools. We conclude that the prevailing guidelines only include few and rather vague directions regarding the cooperation between GPs and specialised mental health practitioners. Inspiring recent studies, however, suggest that relatively little efforts may result in effective collaborative care and a broader implementation of the guidelines in general. [less ▲]

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See detailGuided group purchases of energy renovation services and works in deprived urban neighbourhoods
Ruelle, Christine ULg; Teller, Jacques ULg

in Energy Efficiency (2016), 9(4), 861-874

The energy retrofitting of housings is progressing very slowly in Wallonia (Belgium) despite individual fiscal measures and subsidies offered by public authorities to support households engaging in this ... [more ▼]

The energy retrofitting of housings is progressing very slowly in Wallonia (Belgium) despite individual fiscal measures and subsidies offered by public authorities to support households engaging in this process. This paper explores the use of a method called ‘Guided Group Purchases’ (GPPs), i.e. an approach combining support, guidance and group purchasing of energy renovation services and works, as a possible method to accelerate the retrofitting of the existing housing stock. It reports on an action research experiment conducted in the context of the Interreg project ‘SUN’ (Sustainable Urban Neighbourhoods). The results of this experiment are quite promising. Within a few months, some 80 energy retrofitting interventions (energy audits or insulation works) were implemented in one neighbourhood of the city of Liège. Our evaluation of the experiment showed that the prospect of achieving cost reductions was one of the main initial expectations of participants to the GGPs. Still the participants rather insisted on other benefits after taking part to the initiative. These benefits were mostly related to the guidance they received, to the facilitation with contractors and to the social dynamics generated by the initiative. Several weaknesses were also identified by participants, like the lack of follow-up during and after the works. Our evaluation also highlighted that the main landlords did not participate in the initiative and that the influence of GGPs on costs was limited to specific types of interventions. Despite observed limitations and possible improvements, such a neighbourhood-based approach certainly constitutes a promising avenue for public authorities to support and accelerate the energy retrofitting of private residential buildings in urban neighbourhoods. [less ▲]

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See detailThymectomy in myasthenia gravis: removal of the defective 'sick' organ?
Geenen, Vincent ULg

E-print/Working paper (2016)

As evidenced by this randomized trial, thymectomy clearly improved clinical status of patients with nonthymomatous myasthenia gravis (MG) and this study ends a very long controversy about the interest of ... [more ▼]

As evidenced by this randomized trial, thymectomy clearly improved clinical status of patients with nonthymomatous myasthenia gravis (MG) and this study ends a very long controversy about the interest of this surgical procedure mainly based on previous empirical observations. Although they are not discussed in this important paper, a series of experimental arguments reviewed in joint references argue for the idea that the clinical benefit of thymectomy is primarily due to the removal of the organ primarily implicated in MG pathophysiology. The thymus plays a central role in programming central immunological self-tolerance [1,2], and a thymus dysfunction is a primary event in the development of organ-specific autoimmunity [3,4]. It is therefore not surprising that the surgical removal of the primary 'sick' organ contributes to improve clinical outcomes and to reduce immunosuppressive therapy in MG patients. References: 1. Kamradt T, Mitchison NA. N Engl J Med 2001; 344:655-64. 2. Kyewski B, Klein L. Annu Rev Immunol 2006; 24:571-606. 3. Giraud M, Taubert R, Vandiedonck C, et al. Nature 2007; 448:934-7. 4. Geenen V, Bodart G, Henry S, et al. Front Neurosc 2013; 7:art 187. [less ▲]

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See detailBiologie moléculaire: exercices et méthodes
Thiry, Marc ULg; Bourmeyster, Nicolas; Dommes, Jacques ULg et al

Book published by Dunod (2016)

Cet ouvrage constitue une méthode progressive et efficace pour comprendre et appliquer les concepts fondamentaux de la biologie moléculaire. Il propose : des rappels de cours sous forme de fiches, des ... [more ▼]

Cet ouvrage constitue une méthode progressive et efficace pour comprendre et appliquer les concepts fondamentaux de la biologie moléculaire. Il propose : des rappels de cours sous forme de fiches, des exercices pour s'évaluer (QCM, questions Vrai/Faux, exercices de synthèse...), des corrigés détaillés. Des exercices d’entraînement supplémentaires sont téléchargeables sur le site dunod.com. [less ▲]

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See detailLongterm results of liver transplantation from donation after circulatory death.
Blok, Joris J.; DETRY, Olivier ULg; Putter, Hein et al

in Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society (2016), 22(8), 1107-14

Donation after circulatory death (DCD) liver transplantation (LT) may imply a risk for decreased graft survival, caused by posttransplantation complications such as primary nonfunction or ischemic-type ... [more ▼]

Donation after circulatory death (DCD) liver transplantation (LT) may imply a risk for decreased graft survival, caused by posttransplantation complications such as primary nonfunction or ischemic-type biliary lesions. However, similar survival rates for DCD and donation after brain death (DBD) LT have been reported. The objective of this study is to determine the longterm outcome of DCD LT in the Eurotransplant region corrected for the Eurotransplant donor risk index (ET-DRI). Transplants performed in Belgium and the Netherlands (January 1, 2003 to December 31, 2007) in adult recipients were included. Graft failure was defined as either the date of recipient death or retransplantation whichever occurred first (death-uncensored graft survival). Mean follow-up was 7.2 years. In total, 126 DCD and 1264 DBD LTs were performed. Kaplan-Meier survival analyses showed different graft survival for DBD and DCD at 1 year (77.7% versus 74.8%, respectively; P = 0.71), 5 years (65.6% versus 54.4%, respectively; P = 0.02), and 10 years (47.3% versus 44.2%, respectively; P = 0.55; log-rank P = 0.038). Although there was an overall significant difference, the survival curves almost reach each other after 10 years, which is most likely caused by other risk factors being less in DCD livers. Patient survival was not significantly different (P = 0.59). Multivariate Cox regression analysis showed a hazard ratio of 1.7 (P < 0.001) for DCD (corrected for ET-DRI and recipient factors). First warm ischemia time (WIT), which is the time from the end of circulation until aortic cold perfusion, over 25 minutes was associated with a lower graft survival in univariate analysis of all DCD transplants (P = 0.002). In conclusion, DCD LT has an increased risk for diminished graft survival compared to DBD. There was no significant difference in patient survival. DCD allografts with a first WIT > 25 minutes have an increased risk for a decrease in graft survival. Liver Transplantation 22 1107-1114 2016 AASLD. [less ▲]

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See detailEffects of aging on task- and stimulus-related cerebral attention networks
Kurth, Sophie ULg; Majerus, Steve ULg; Bastin, Christine ULg et al

in Neurobiology of Aging (2016), 44

Interactions between a dorsal attention (DAN) and a ventral attention cerebral network (VAN) have been reported in young participants during attention or short term memory (STM) tasks. Since it remains an ... [more ▼]

Interactions between a dorsal attention (DAN) and a ventral attention cerebral network (VAN) have been reported in young participants during attention or short term memory (STM) tasks. Since it remains an under-investigated question, age effects on DAN and VAN activity and their functional balance were explored during performance of a STM task. Older and young groups showed similar behavioral patterns of results. At the cerebral level, DAN activation increased as a function of increasing STM load in both groups, suggesting preserved activity in DAN during healthy aging. Age-related over-recruitment in regions of the DAN in the higher task load raised the question of compensation attempt versus less efficient use of neural resources in older adults. Lesser decrease of VAN activation with increasing load and decreased stimulus-driven activation in the VAN, especially in the higher load, in older participants suggested age-related reduced response in the VAN. However, functional connectivity measures showed that VAN was still functionally connected to the DAN in older participants. [less ▲]

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See detailA MACRO-ELEMENT FOR THE NONLINEAR ANALYSIS OF DEEP BEAMS BASED ON A THREE-PARAMETER KINEMATIC MODEL
Liu, Jian ULg; Mihaylov, Boyan ULg

in the 11th fib International PhD Symposium in Civil Engineering (2016, August)

This paper presents a computationally-effective macro element capable of predicting the complete shear response of RC deep beams in analogy with beam elements for slender beams. The element stems from a ... [more ▼]

This paper presents a computationally-effective macro element capable of predicting the complete shear response of RC deep beams in analogy with beam elements for slender beams. The element stems from a three-parameter kinematic theory (3PKT) for the shear strength and deformation capacity of deep beams subjected to double curvature. The macro element is composed of two rotational springs and one transverse spring to simulate the nonlinear flexural and shear behaviour of the shear span. The element has two nodes (end sections) with two DOFs per node, which enables it to be easily connected to other elements of the same or different types to model structures with deep beams. The numerical implementation of the element is based on the secant stiffness approach which provides robust convergence properties. Validation studies are performed by using thirteen tests from the literature showing excellent results for the complete shear response. The obtained peak load experimental-to-predicted ratios have an average of 1.10 with a coefficient of variation of 14.2%, while these values for the mid-span deflection are 1.16 and 17.0%. [less ▲]

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