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See detailChemical constituents from Erythrina droogmansiana (Fabaceae), radical scavenging and antibacterial potential of some extracts and compounds
Talla, Emmanuel; Yaya Gbaweng, Joël; Mokale, Laurel et al

in Natural Products : An Indian Journal (2016), 12(1), 12-20

A new ceramide, droogmansiamide (1), was isolated from methanolic extract of roots wood of Erythrina droogmansiana, with eight known compounds namely 3-(3’,4’-methylenedioxyphenyl)-2,3-epoxypropanol (2 ... [more ▼]

A new ceramide, droogmansiamide (1), was isolated from methanolic extract of roots wood of Erythrina droogmansiana, with eight known compounds namely 3-(3’,4’-methylenedioxyphenyl)-2,3-epoxypropanol (2), erythrinasinate A (3), erythrinasinate B (4), abyssinone-IV-4'-methylether (5), erythrabyssin (6), phaseollidin (7), 4’-methoxylicoflavanone (8) and abyssinone-V-4'-methylether (9) respectively from methanolic extract of roots wood and EtOAc extract of roots bark of the same plant. Their structures were elucidated using spectroscopic methods (MS, NMR and IR) and by comparison with some data found in literature. Free radical scavenging (DPPH) and antibacterial potentials of extracts and compounds were also evaluated in this work. For radical scavenging, results showed that it is phaseollidin (7) which is responsible of radical scavenging potential in the ethyl acetate extract of roots barks with value of 1.31 mg/ml; for antibacterial, one of the tested compounds abyssinone-IV-4'-methylether (5) exhibited antibacterial activities against two strains: Providencia stuartiiATCC 29916 and Enterobacter aerogenes ATCC 13048 with MIC values of 25μg/ml. [less ▲]

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See detailReconstruction of the Schmallenberg virus epidemic in Belgium: Complementary use of disease surveillance approaches
Poskin, A; Theron, Léonard ULg; Hanon, JB et al

in Veterinary Microbiology (2016), 183

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See detailMétamémoire, fonctions exécutives et performance mnésique
Geurten, Marie ULg

Conference (2016)

L’objectif de cette recherche est d’examiner le développement des habiletés métacognitives au cours de l’enfance, en prêtant une attention particulière aux variables et processus impliqués dans ... [more ▼]

L’objectif de cette recherche est d’examiner le développement des habiletés métacognitives au cours de l’enfance, en prêtant une attention particulière aux variables et processus impliqués dans l’acquisition des connaissances concernant le fonctionnement général de la cognition. Précisément, le but de cette étude est de démontrer l’impact des atteintes exécutives résultant d’un traumatisme crânien sur le développement des connaissances explicites des enfants en métamémoire. Dans ce but, 22 enfants (âgés de 7 à 14 ans) ayant subi un traumatisme crânien modéré à sévère ont été recrutés et divisés en deux groupes en fonction de la gravité de leurs atteintes exécutives (déterminée par le score obtenu à une épreuve d’inhibition, de flexibilité et de mémoire de travail). Au total, dix enfants constituaient le groupe ne montrant pas d’altération du fonctionnement tandis que douze enfants constituaient le groupe montrant des altérations significatives du fonctionnement exécutif. Les deux groupes de patients étaient équivalents à tous les autres niveaux du fonctionnement cognitif. Chaque patient a également été apparié à deux enfants contrôles (n = 44) en fonction de l’âge et du niveau socio-économique. Conformément à l’hypothèse généralement avancée dans la littérature concernant le rôle des fonctions exécutives dans l’apprentissage des connaissances métacognitives au cours de l’enfance, les résultats montrent une différence significative entre les deux groupes de patients au niveau des scores à l’échelle de métamémoire. De même, de moins bonnes performance à l’échelle de métamémoire sont observées pour le groupe de patients démontrant une atteinte exécutive comparativement au groupe d’enfants contrôles. Aucune différence n’était observée entre le groupe de patients ne démontrant pas d’atteinte exécutive et le groupe contrôle. Ces différents résultats suggèrent l’implication des fonctions exécutives dans l’acquisition des connaissances en métamémoire au cours de l’enfance. L’implication de ces résultats pour la prise en charge des patients souffrant de déficits exécutifs sera discutée. [less ▲]

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See detailAlain au prisme de l’ontologie phénoménologique. Relectures croisées d'Alain et de Sartre
Cormann, Grégory ULg

in Depraz, Natalie (Ed.) Alain philosophe rouennais (2016)

Parmi les grands représentants de la « génération 1905 », selon l’expression de J.-F. Sirinelli, Sartre passe pour celui qui a refusé l’enseignement d’Alain alors que des penseurs aussi différents qu’Aron ... [more ▼]

Parmi les grands représentants de la « génération 1905 », selon l’expression de J.-F. Sirinelli, Sartre passe pour celui qui a refusé l’enseignement d’Alain alors que des penseurs aussi différents qu’Aron, Canguilhem ou Hyppolite acceptaient, au moins pour un temps, l’enseignement du maître. Cette appréciation expéditive ne fait droit ni à ce qu’on sait aujourd’hui des premières tentatives philosophiques de Sartre ni au travail inlassable de relecture d’Alain que Sartre aura mené, en sous-main, tout au long de sa trajectoire intellectuelle. Dans cet article, on procédera dès lors, d’une part, au repérage de l’influence d’Alain dans une série de textes, souvent posthumes, qui passent pour des textes préparatoires aux grandes œuvres. On montrera, d’autre part, que cette influence d’Alain s’insinue jusqu’au cœur de l’ontologie phénoménologique de Sartre, dans L’être et le néant, puis dans les prolongements que Sartre y a donnés dans ses psychanalyses existentielles. Au total, on montrera que la plupart des interprétations récentes de Sartre (Coorebyter, Breeur, Gély, Giovannangeli, J. Simont, etc.), depuis une dizaine d’années, se resserrent autour de la relation largement insoupçonnée que l’ontologie phénoménologique sartrienne entretient avec la pensée d’Alain. [less ▲]

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See detailHosios - A Semantic Study of Greek Piety
Peels, Saskia ULg

Book published by Brill, Mnemosyne Supplements (2016)

In HOSIOS – A Semantic Study of Greek Piety Saskia Peels elucidates the semantics of the Ancient Greek adjective hosios and its cognates. Traditionally rendered as ‘piety’, hosios was a key notion in ... [more ▼]

In HOSIOS – A Semantic Study of Greek Piety Saskia Peels elucidates the semantics of the Ancient Greek adjective hosios and its cognates. Traditionally rendered as ‘piety’, hosios was a key notion in Classical Greek religion and reflected a core value in Athenian democracy. Since antiquity, its meaning and usage have puzzled many. This study sets out to resolve various scholarly debates on the semantics of hosios by focusing on the idea of lexical competition. It illuminates the semantic relationship between hosios and its near-synonyms eusebês and dikaios, and the connection to the notion of the ‘sacred’. Using insights from modern linguistic theory, the book also aims to improve methods for research into the lexical semantics of a dead language. [less ▲]

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See detailInvolvement of Executive Functions in Children’s Metamemory
Geurten, Marie ULg; Catale, Corinne ULg; Meulemans, Thierry ULg

in Applied Cognitive Psychology (2016), 30(1), 70-80

This experiment examined how knowledge of memory strategies and of memory functioning improves during childhood and what variables are involved in this development. Three main aspects of metamemory were ... [more ▼]

This experiment examined how knowledge of memory strategies and of memory functioning improves during childhood and what variables are involved in this development. Three main aspects of metamemory were assessed based on the performance of a group of 100 children (aged 4, 6, 9 and 11 years) on a battery of executive tasks. At the same time, the influence of variables such as intelligence, vocabulary and parental education level was also investigated. Results of mediation analyses reveal that the relation between children’s age and internal strategy knowledge was partially mediated by working memory skills but that executive functions did not mediate the impact of chronological age on children’s knowledge of external strategies or of memory functioning. Additionally, verbal fluency predicted internal and external strategy knowledge. Implications for general learning theories in childhood are discussed [less ▲]

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See detailDe la thérapeutique à la cosmétique : le verbe στιμμίζειν dans les écrits médicaux grecs
Marganne, Marie-Hélène ULg

in Boudon-Millot, Véronique; Labonnelie-Pardon, Muriel (Eds.) Le teint de Phrynè. Thérapeutique et cosmétique dans l'Antiquité. Paris, Maison de la Recherche, 14-15 janvier 2016 (2016)

Depuis quand et dans quel(s) contexte(s) le substantif στίμμι (ou στῖμι ou στῖβι) désignant une substance de couleur noire dont le nom est d'origine égyptienne, et le verbe στιμμίζειν (ou στιμίζειν ou ... [more ▼]

Depuis quand et dans quel(s) contexte(s) le substantif στίμμι (ou στῖμι ou στῖβι) désignant une substance de couleur noire dont le nom est d'origine égyptienne, et le verbe στιμμίζειν (ou στιμίζειν ou στιβίζειν, ainsi que le composé ὑποστιμμίζειν) décrivant son application dans la région des yeux, sont-ils attestés dans les écrits médicaux grecs ? C'est à ces questions que l'on s'efforcera de répondre en relevant en outre les justifications thérapeutiques de cette pratique par les médecins. [less ▲]

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See detail"Des Heilands schwarzes Haupt im Dornenstrauch". Celan-Stilisierung und Autorinszenierung in Jean Daives Erzählung "Sous la coupole"
Viehöver, Vera ULg

in Shchyhlevska, Natalia; Waldschmidt, Christine (Eds.) Celan-Referenzen: Prozesse einer Traditionsbildung in der Moderne (2016)

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See detailLes codices médicaux grecs de petit format en parchemin dans l'Egypte byzantine
Marganne, Marie-Hélène ULg

in Davoli, Paola; Pellé, Natascia (Eds.) Studi in omaggio a Mario Capasso (2016)

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See detailRole of the Retinoblastoma protein, Rb, during adult neurogenesis in the olfactory bulb
Naser, Rayan; Vandenbosch, Renaud ULg; Omais, Saad et al

in Scientific Reports (2016)

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See detailDe l'obscurité comme censure. Proust, Muhlfeld, Mallarmé
Durand, Pascal ULg

in Leclerc, Yvan; Macé, Laurence; Poulouin, Claudine (Eds.) Censure et Critique (2016)

Proust’s paper « Contre l’obscurité » [“Against Obscurity”], published in 1896 by La Revue blanche, has been paid back with to rather rough answers : Lucien Muhlfeld’s paper « Sur la clarté » [“About ... [more ▼]

Proust’s paper « Contre l’obscurité » [“Against Obscurity”], published in 1896 by La Revue blanche, has been paid back with to rather rough answers : Lucien Muhlfeld’s paper « Sur la clarté » [“About Clarity”] and « Le Mystère dans les Lettres » by Mallarmé. One of the very few polemical texts of the poet, the latter paper deals with mechanisms of poetical meaning and reciprocal adjustment of both the literary text and his reader. Three kinds of censorship are at stake here. Censorship by the obscurity (Proust). Censorship of the obscurity (Muhlfeld). Censorship with and for the sake of obscurity (Mallarmé). The whole controversy being placed under the very sign of reading and critical evaluation. [less ▲]

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See detailDecitabine improves progression-free survival in older high-risk MDS patients with multiple autosomal monosomies: results of a subgroup analysis of the randomized phase III study 06011 of the EORTC Leukemia Cooperative Group and German MDS Study Group
Lübbert, Michael; Suciu, Stefan; Hagemeijer, Anne et al

in Annals of Hematology (2016), 95

In a study of elderly AML patients treated with the hypomethylating agent decitabine (DAC), we noted a surprisingly favorable outcome in the (usually very unfavorable) subgroup with two or more autosomal ... [more ▼]

In a study of elderly AML patients treated with the hypomethylating agent decitabine (DAC), we noted a surprisingly favorable outcome in the (usually very unfavorable) subgroup with two or more autosomal monosomies (MK2+) within a complex karyotype (Lübbert et al., Haematologica 97:393-401, 2012). We now analyzed 206 myelodysplastic syndrome (MDS) patients (88 % of 233 patients randomized in the EORTC/GMDSSG phase III trial 06011, 61 of them with RAEBt, i.e. AML by WHO) with cytogenetics informative for MK status.. Endpoints are the following: complete/partial (CR/PR) and overall response rate (ORR) and progression-free (PFS) and overall survival (OS). Cytogenetic subgroups are the following: 63 cytogenetically normal (CN) patients, 143 with cytogenetic abnormalities, 73 of them MKnegative (MK−), and 70 MK-positive (MK+). These MK+ patients could be divided into 17 with a single autosomal monosomy (MK1) and 53 with at least two monosomies (MK2+). ORR with DAC in CN patients: 36.1 %, in MK−patients: 16.7 %, in MK+ patients: 43.6 % (MK1: 44.4 %, MK2+ 43.3 %). PFS was prolonged by DAC compared to best supportive care (BSC) in the CN (hazard ratio (HR) 0.55, 99 % confidence interval (CI), 0.26; 1.15, p=0.03) and MK2+ (HR 0.50; 99%CI, 0.23; 1.06, p=0.016) but not in the MK−, MK+, and MK1 subgroups. OS was not improved by DAC in any subgroup. In conclusion, we demonstrate for the first time in a randomized phase III trial that high-risk MDS patients with complex karyotypes harboring two or more autosomal monosomies attain encouraging responses and have improved PFS with DAC treatment compared to BSC. [less ▲]

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See detailMethods of ex vivo expansion of human cord blood cells: challenges, successes and clinical implications
Baron, Frédéric ULg; Ruggeri, A.; Nagler, A.

in Expert Review of Hematology (2016), 21

More than 40,000 unrelated cord blood transplantations (UCBT) have been performed worldwide as treatment for patients with malignant or non-malignant life threatening hematologic disorders. However, low ... [more ▼]

More than 40,000 unrelated cord blood transplantations (UCBT) have been performed worldwide as treatment for patients with malignant or non-malignant life threatening hematologic disorders. However, low absolute numbers of hematopoietic stem and progenitor cells (HSPCs) within a single cord blood unit has remained a limiting factor for this transplantation modality, particularly in adult recipients. Further, because UCB contains low numbers of mostly naïve T cells, immune recovery after UCBT is slow predisposing patients to severe infections. Other causes of UCBT failure has included graft-versus-host disease (GVHD), and relapse of the underlying disease. In this article, we first review the current landscape of cord blood engineering aimed at improving engraftment. This includes approaches of UCB-HSPCs expansion and methods aimed at improving UCB-HSCPs homing. We then discuss recent approaches of cord blood engineering developed to prevent infection (generation of multivirus-specific cytotoxic T cells (VSTs) from UCB), relapse (transduction of UCB-T cells with tumor-specific chimeric receptor antigens (CARs)) and GVHD (expansion of regulatory T cells from UCB). Although many of these techniques of UCB engineering remain currently technically challenging and expensive, they are likely to revolutionize the field of UCBT in the next decades. [less ▲]

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See detailThe Rexinoids LG100268 and LG101506 Inhibit Inflammation and Suppress Lung Carcinogenesis in A/J Mice.
Cao, Martine ULg; Royce, Darlene B.; Risingsong, Renee et al

in Cancer prevention research (Philadelphia, Pa.) (2016), 9(1), 105-14

LG101506 was originally synthesized to overcome some of the undesirable side effects of rexinoids. We compared the anticarcinogenic action of LG101506 and LG100268 and for the first time showed that both ... [more ▼]

LG101506 was originally synthesized to overcome some of the undesirable side effects of rexinoids. We compared the anticarcinogenic action of LG101506 and LG100268 and for the first time showed that both drugs are useful for prevention of lung cancer in A/J mice. These molecules markedly reduced tumor number, tumor size, and total tumor burden, when chronically administered to A/J mice that had been initiated with the mutagenic carcinogen, vinyl carbamate. Moreover, LG100268 synergized with the histone deacetylase inhibitor, vorinostat, for prevention of experimental lung cancer and enhanced the effect of carboplatin/paclitaxel for treatment of experimental lung cancer. Both rexinoids diminished the percentage of high-grade, highly malignant adenocarcinomas found at autopsy. In cell culture studies, the rexinoids exhibited potent anti-inflammatory properties at nanoMolar concentrations. These drugs suppressed the ability of lipopolysaccharide to stimulate the synthesis and secretion of nitric oxide and inflammatory cytokines and chemokines, such as IL6, IL1beta, CXCL2, and CSF3, in macrophage-like RAW264.7 cells. The present results suggest that LG100268, LG101506, or a related rexinoid may have useful clinical applications in the field of oncology. Cancer Prev Res; 9(1); 105-14. (c)2015 AACR. [less ▲]

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See detailAn integrated framework for forecasting travel behavior using Markov Chain Monte-Carlo simulation and profile Hidden Markov Models
Saadi, Ismaïl ULg; El Saeid Mustafa, Ahmed Mohamed ULg; Teller, Jacques ULg et al

in Proceedings of the 95th Annual Meeting of the Transportation Research Board (2016)

Recent advances in agent-based micro-simulation modelling have further underlined the importance of a thorough full synthetic population procedure to guarantee a correct characterization of the true ... [more ▼]

Recent advances in agent-based micro-simulation modelling have further underlined the importance of a thorough full synthetic population procedure to guarantee a correct characterization of the true population. We propose an integrated approach including Markov Chain Monte Carlo (MCMC) simulation and profiling based methods to catch the complexity and the diversity of agents of the true population through representative micro samples. The population synthesis method is capable of building the joint distribution of a given population with its corresponding marginal distributions (e.g. age, gender, socio-professional status etc.) using complete, partial conditional probabilities or both of them at the same time. Particularly, the estimation of socio-demographic variables and characterization of daily activity-travel patterns are included within the framework. Data stemming from the 2010 Belgian Household Daily Travel Survey (BELDAM) are used to calibrate the modelling framework. We illustrate that this framework catches in an efficient way the behavioral heterogeneity of travelers. Furthermore, we show that the proposed framework is adequately adapted to build large scale micro-simulation scenarios of transportation and urban systems. [less ▲]

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See detailDe la grammaire pure logique à la grammaire philosophique. La grammaire des concepts chez Wittgenstein
Gauvry, Charlotte ULg

in Bulletin d'Analyse Phénoménologique (2016)

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See detailParsimonious time series clustering using P-splines
Iorio, Carmela; Frasso, Gianluca ULg; D’Ambrosio, Antonio et al

in Expert Systems with Applications (2016)

Abstract We introduce a parsimonious model-based framework for clustering time course data. In these applications the computational burden becomes often an issue due to the large number of available ... [more ▼]

Abstract We introduce a parsimonious model-based framework for clustering time course data. In these applications the computational burden becomes often an issue due to the large number of available observations. The measured time series can also be very noisy and sparse and an appropriate model describing them can be hard to define. We propose to model the observed measurements by using P-spline smoothers and then to cluster the functional objects as summarized by the optimal spline coefficients. According to the characteristics of the observed measurements, our proposal can be combined with any suitable clustering method. In this paper we provide applications based on non-hierarchical clustering algorithms. We evaluate the accuracy and the efficiency of our proposal by simulations and by analyzing two real data examples. [less ▲]

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See detailHigh resolution characterization of the soil organic carbon depth profile in a soil landscape affected by erosion
Jague, Emilien; Sommer, Michael; Saby, Nicolas et al

in Soil & Tillage Research (2016), 156

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See detailCompte rendu, La mise en scène des produits et des marques. Représentations,significations, publics
Duchesne, Caroline ULg

in Questions de Communication (2016), 28

Actes d’un colloque interdisciplinaire organisé en juillet 2013 à l’Institut universitaire de technologie Nancy-Charlemagne, le volume rassemble douze contributions envisageant, en trois temps ... [more ▼]

Actes d’un colloque interdisciplinaire organisé en juillet 2013 à l’Institut universitaire de technologie Nancy-Charlemagne, le volume rassemble douze contributions envisageant, en trois temps, l’évolution stratégique de la mise en scène des marques, la place symbolique occupée par celles-ci dans l’espace social et l’interpénétration grandissante des registres commerciaux et culturels présidant à leur positionnement stratégique. [less ▲]

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See detailEconomic assessment of energy storage for load shifting in Positive Energy Building
Dumont, Olivier ULg; Carmo, carolina; Georges, Emeline ULg et al

Conference (2016)

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