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See detailUne charte en six principes pour guider la mise en œuvre des programmes visant le développement de compétences dans l’enseignement supérieur
Poumay, Marianne ULg; Scheffers, Patricia ULg; Georges, François ULg

Conference (2016, June 08)

Dans l’enseignement supérieur, les programmes se structurent de plus en plus autour de référentiels de compétences, que ces derniers constituent des prescrits légaux ou des choix institutionnels. Mais la ... [more ▼]

Dans l’enseignement supérieur, les programmes se structurent de plus en plus autour de référentiels de compétences, que ces derniers constituent des prescrits légaux ou des choix institutionnels. Mais la cohérence entre le référentiel et le programme est parfois mince. Il arrive en effet que les contraintes de terrain prennent le pas sur les intentions de changement, rendant impossible une réelle « approche visant le développement de compétences » (APC). Force est aussi de constater combien il est complexe de dériver un programme cohérent au départ d’un référentiel de compétences. Pour aider les équipes enseignantes, lors de la refonte d’un programme, à garder le cap sur la notion de compétence telle que définie par Tardif (2006), le LabSET a élaboré une charte en six principes. Cette charte a été utilisée par une dizaine d’équipes libanaises et égyptiennes dans le projet ADIP, lors de la construction de quatre Masters. Les six principes y ont été assortis de recommandations qui président à leur mise en œuvre concrète et serviront de points de repères lors de l’évaluation des programmes. Notre communication partira de ces six principes et de leurs fondements théoriques. Elle explicitera ensuite leur adaptation aux programmes de banque-finance de deux universités libanaises, à travers leur traduction en recommandations concrètes. Elle les illustrera enfin par le cas des architectes de l’ULg, soulignant notamment parmi ces principes ceux qui semblent les plus complexes à mettre en œuvre. [less ▲]

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See detailEnthalpy-Entropy Compensation in the Binding of Modulators at Ionotropic Glutamate Receptor GluA2
Krintel, Christian; Francotte, Pierre ULg; Pickering, Darryl S. et al

in Biophysical Journal (2016), 110

The 1,2,4-benzothiadiazine 1,1-dioxide type of positive allosteric modulators of the ionotropic glutamate receptor A2 (GluA2) are promising lead compounds for the treatment of cognitive disorders, e.g ... [more ▼]

The 1,2,4-benzothiadiazine 1,1-dioxide type of positive allosteric modulators of the ionotropic glutamate receptor A2 (GluA2) are promising lead compounds for the treatment of cognitive disorders, e.g., Alzheimer’s disease. The modulators bind in a cleft formed by the interface of two neighboring ligand binding domains and act by stabilizing the agonist-bound open- channel conformation. The driving forces behind the binding of these modulators can be significantly altered with only minor substitutions to the parent molecules. In this study, we show that changing the 7-fluorine substituent of modulators BPAM97 (2) and BPAM344 (3) into a hydroxyl group (BPAM557 (4) and BPAM521 (5), respectively), leads to a more favorable binding enthalpy (DH, kcal/mol) from 4.9 (2) and 7.5 (3) to 6.2 (4) and 14.5 (5), but also a less favorable binding entropy ( TDS, kcal/mol) from 2.3 (2) and 1.3 (3) to 0.5 (4) and 4.8 (5). Thus, the dissociation constants (Kd, mM) of 4 (11.2) and 5 (0.16) are similar to those of 2 (5.6) and 3 (0.35). Functionally, 4 and 5 potentiated responses of 10 mM L-glutamate at homomeric rat GluA2(Q)i receptors with EC50 values of 67.3 and 2.45 mM, respectively. The binding mode of 5 was examined with x-ray crystallography, showing that the only change compared to that of earlier compounds was the orientation of Ser-497 pointing toward the hydroxyl group of 5. The favorable enthalpy can be explained by the formation of a hydrogen bond from the side-chain hydroxyl group of Ser-497 to the hydroxyl group of 5, whereas the unfavorable entropy might be due to desolva- tion effects combined with a conformational restriction of Ser-497 and 5. In summary, this study shows a remarkable example of enthalpy-entropy compensation in drug development accompanied with a likely explanation of the underlying structural mechanism. [less ▲]

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See detailIntegrated and systemic management of storm damage by the forest-based sector and public authorities
Riguelle, Simon ULg; Hebert, Jacques ULg; Jourez, Benoît ULg

in Annals of Forest Science : a Multidisciplinary and International Journal (2016)

The paper’s goals are to identify key challenges in the currentwindthrow management framework and present a blueprint for howto progress in the settlement of regional strategies.SWOT analyses are used to ... [more ▼]

The paper’s goals are to identify key challenges in the currentwindthrow management framework and present a blueprint for howto progress in the settlement of regional strategies.SWOT analyses are used to highlight relevant issues and opportunities in classical approaches from both the forest-based sector and public authorities’ perspectives. Despite the large body of knowledge that allows decision-makers to react promptly after huge storms, strategic responses still suffer from too individual and fragmented decisions and a lack of holistic economic assessments. To tackle these issues, the paper suggests using systemic and integrated risk management approaches. It also presents the ways to enhance the forest-based sector’s resistance and resilience towards economic shock and supports decision-making with the help of systemic analysis. This shift of paradigm is one of the key requirements in optimizing the way of dealing with storm damage, but public authorities should concur with it more actively by improving decisional and administrative frameworks. Contribution of the co-authors Co-authors are PhD thesis’ supervisors and have thoroughly reviewed the paper. [less ▲]

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See detailMultifractal analysis of the divergence of wavelet series
Esser, Céline ULg

Conference (2016, June 07)

In this talk, we study pointwise divergence properties of wavelet expansions of functions in a given Besov space. We obtain deterministic upper bounds for the Hausdorff dimensions of the sets of points ... [more ▼]

In this talk, we study pointwise divergence properties of wavelet expansions of functions in a given Besov space. We obtain deterministic upper bounds for the Hausdorff dimensions of the sets of points where a given rate of divergence is observed, and we show that these bounds are generically (in the sense of Baire's categories) optimal. This gives a complement to the works done by F. Bayart and Y. Heurteaux in the case of Fourier series and by J.M. Aubry. [less ▲]

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See detailBoltzmann Transport Calculations in Systems with Electron-phonon Coupling
Pike, Nicholas ULg

Scientific conference (2016, June 07)

Recent experimental and theoretical calculations point to a complex interplay between the electron and phonon baths in a wide variety of materials [1,2]. We propose a method of coupling the Boltzmann ... [more ▼]

Recent experimental and theoretical calculations point to a complex interplay between the electron and phonon baths in a wide variety of materials [1,2]. We propose a method of coupling the Boltzmann equations for the electron and phonon baths within the relaxation time approximation to describe the changes in the electron and phonon distributions and thus calculate the thermoelectric transport coefficients. Our model for the coupled system will include tight-binding and ${\bf k \cdot p}$ Hamiltonians for both the electron and phonon energies and analytic calculations for the electron and phonon relaxation mechanisms. From these calculations we hope to better understand the role and interplay of electron-phonon and phonon-phonon interactions on the thermoelectric transport coefficients. [1] - Phys. Rev. Lett. ${\bf 114}$, 115901 (2015). [2] - PNAS ${\bf 112}$, 14777-14782 (2015). [less ▲]

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See detailUniversal amorphous-amorphous transition in GexSe100−x glasses under pressure
Yildirim, Can ULg; Micoulaut, Matthieu; Boolchand, Punit et al

in Scientific Reports (2016), 6

Pressure induced structural modifications in vitreous GexSe100−x (where 10 ≤ x ≤ 25) are investigated using X-ray absorption spectroscopy (XAS) along with supplementary X-ray diffraction (XRD) experiments ... [more ▼]

Pressure induced structural modifications in vitreous GexSe100−x (where 10 ≤ x ≤ 25) are investigated using X-ray absorption spectroscopy (XAS) along with supplementary X-ray diffraction (XRD) experiments and ab initio molecular dynamics (AIMD) simulations. Universal changes in distances and angle distributions are observed when scaled to reduced densities. All compositions are observed to remain amorphous under pressure values up to 42 GPa. The Ge-Se interatomic distances extracted from XAS data show a two-step response to the applied pressure; a gradual decrease followed by an increase at around 15–20 GPa, depending on the composition. This increase is attributed to the metallization event that can be traced with the red shift in Ge K edge energy which is also identified by the principal peak position of the structure factor. The densification mechanisms are studied in details by means of AIMD simulations and compared to the experimental results. The evolution of bond angle distributions, interatomic distances and coordination numbers are examined and lead to similar pressure-induced structural changes for any composition. [less ▲]

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See detailAménorhhée primaire : le point de vue endocrinien
VALDES SOCIN, Hernan Gonzalo ULg

Scientific conference (2016, June 07)

Aménorhhée primaire : le point de vue endocrinien Dr Hernan Valdés-Socin Chef de Clinique. Service d’Endocrinologie. CHU de Liège Résumé L’alternance de la phase folliculaire et lutéale ovarienne ... [more ▼]

Aménorhhée primaire : le point de vue endocrinien Dr Hernan Valdés-Socin Chef de Clinique. Service d’Endocrinologie. CHU de Liège Résumé L’alternance de la phase folliculaire et lutéale ovarienne, s’accompagne d’une variation de la sécrétion oestroprogestative déterminant le cycle menstruel de l’utérus. Les différentes perturbations pouvant toucher les circuits hypothalamiques (neurones à kisspeptines, neurones a GnRH), le fonctionnement hypophysaire et son contrôle des différentes glandes endocrines, les anomalies acquises et génétiques des ovaires (syndrome de Turner, insuffisance ovarienne primaire,etc) et de l’utérus (syndrome d’Asherman, Syndrome de Rokytanski, etc) peuvent déterminer selon les cas une aménorrhée primaire ou secondaire. L’aménorrhée primaire est définie par l’absence de ménarche chez une fille arrivée à l’âge de 16 ans alors que l’aménorrhée secondaire est l’absence de menstruation depuis plus de 3 mois, chez une patiente antérieurement bien réglée. Nous discutons et résumons ici les différentes étiologies d’aménorrhée primaire et secondaire, ainsi que leur prise en charge. La disponibilité récente au CHU de Liège d’un panel de 16 gènes responsables d’hypogonadisme hypogonadotrope nous a permis d’approfondir la recherche sur les causes du syndrome de Kallmann et de l’hypogonadisme hypogonadotrope normosmique. Références H. Valdes-Socin , F.G. Debray, A.S. Parent, M.C. Lebrethon, J.P. Bourguignon, V. Bours A. Beckers. Comment je diagnostique un hypogonadisme hypogonadotrope congénital isolé? Rev Med Liège 2010 Nov;65(11):634-41 Valdes-Socin H, Rubio Almanza M, Tomé Fernández-Ladreda M, Debray FG, Bours V, Beckers A. Reproduction, Smell and Neurodevelopmental disorders: Genetic defects in different hypogonadotropic hypogonadal syndromes. Frontiers in Endocrinology 2014 (5) 109 1-8. Valdes-Socin H, Beckers A. El síndrome de Pasqualini. Medicina (B Aires). 2015;75(1):53-8. B. González Aguilera, P. Syrios, R. Gadisseur, F. Luyckx, E. Cavalier, A. Beckers, H. Valdes-Socin. Persistent low levels of serum hCG due to heterophilic mouse antibodies: an unrecognized pitfall in the diagnosis of trophoblastic disease. Gynecology Endocrinology 2015 Jun;32(6):439-41. H. Valdes-Socin, Fg. Debray, C. Libioulle, A. Pintiaux, As. Parent, V. Corman, K. Gellner, V. Geenen, L. Vroonen, V. Dideberg, V. Bours, A. Beckers. Caractérisation clinique, neuroendocrinienne, génétique et résultats thérapeutiques dans le syndrome de Kallmann et de l’hypogonadisme normosmique idiopathique: expérience liégeoise. Annales d'Endocrinologie - 32ème congrès de la société Française d'Endocrinologie 2016. Bordeaux. France. H. Valdes-Socin (Dr), A. Verloesb , Fg. Debrayc , C. Libioullec , A. Pintiauxd , P. Maquet, A. Beckers) Le Syndrome de De Morsier : une cause congénitale méconnue d’hypopituitarisme. Annales d'Endocrinologie - 32ème congrès de la société Française d'Endocrinologie 2016. Bordeaux. France [less ▲]

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See detailCohesive band model: a triaxiality-dependent cohesive model for damage to crack transition in a non-local implicit discontinuous Galerkin framework
Leclerc, Julien ULg; Wu, Ling ULg; Noels, Ludovic ULg et al

Conference (2016, June 07)

Numerical modelling of the complete ductile failure process is still a challenge. On the one hand, continuous approaches, described by damage models, succeed in the initial diffuse damage stage but are ... [more ▼]

Numerical modelling of the complete ductile failure process is still a challenge. On the one hand, continuous approaches, described by damage models, succeed in the initial diffuse damage stage but are still unable to represent physical discontinuities. On the other hand, discontinuous approaches, such as the cohesive zone models, are able to represent the crack propagation behaviour. They are suited for local damaging processes as crack initiation and propagation, and so, fail in diffuse damage prediction of ductile materials. Moreover, they do not usually capture triaxiality effects, mandatory for accurate ductile failure simulations. To describe the ductile failure process, the numerical scheme proposed here combines both approaches [1] in order to beneficiate from their respective advantages: a non-local damage model combined with an extrinsic cohesive law in a discontinuous Galerkin finite element framework. An application example of this scheme is shown on the attached figure. The initial diffuse damage stage is modelled by an implicit nonlocal damage model as suggested by [2]. Upon damage to crack transition, a cohesive band [3] is used to introduce in-plane stretch effects inside the cohesive law or in other words, a triaxiality-dependent behaviour. Indeed, these in-plane strains play an important role during the ductile failure process and have to be considered. Concretely, when crack appears in the last failure stage, all the damaging process is assumed to occur inside a thin band ahead of the crack surface. Thanks to the small but finite numerical band thickness, the strains inside this band can be obtained from the in-plane strains and from the cohesive jump. Then, the stress-state inside the band and the cohesive traction forces on the crack lips are deduced from the underlying continuum damage model. The band thickness is not a new material parameter but is computed to ensure the energetic consistency during the transition. [1] Wu L, Becker G, Noels L. Elastic damage to crack transition in a coupled non-local implicit discontinuous Galerkin/extrinsic cohesive law framework. Comput. Methods Appl. Mech. Eng. 279 (2014): 379–409 [2] Peerlings R., de Borst R., Brekelmans W., Ayyapureddi S. Gradient-enhanced damage for quasi-brittle materials, Int. J. for Num. Methods in Eng. 39 (1996): 3391-3403 [3] Remmers J. J. C., de Borst R., Verhoosel C. V., Needleman A. The cohesive band model: a cohesive surface formulation with stress triaxiality. Int. J. Fract. 181 (2013): 177–188 [less ▲]

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See detailDe l'avatar au personnage : regards croisés entre game studies et études littéraires
Dozo, Björn-Olav ULg; Delbouille, Julie ULg

Conference (2016, June 07)

Si les game studies se sont développées en prenant appui, dans un premier temps, sur les études littéraires et en particulier sur la narratologie (Ryan 2004, Atkins et Krzywinska 2007) pour interroger la ... [more ▼]

Si les game studies se sont développées en prenant appui, dans un premier temps, sur les études littéraires et en particulier sur la narratologie (Ryan 2004, Atkins et Krzywinska 2007) pour interroger la notion de récit appliquée au jeu vidéo, elles ont ensuite fait appel à d’autres disciplines (psychologie et sociologie en particulier) pour construire leur approche de certaines notions, dont celle d’avatar qui nous paraît utile dans le cadre de recherches sur le personnage en littérature. Confrontées à des objets irréductibles à leur textualité (l’étude de la composante « play » du jeu a pris le pas sur celle du « game », surtout en francophonie – voir à ce sujet Triclot, 2011), les game studies se sont dotées d’outils et de théories propres, réélaborant pragmatiquement certaines notions à partir de théories antérieures (les « univers fictionnels », voir Barnabé, 2014) ou forgeant des concepts spécifiques (l’« impératif d’action », voir Genvo, 2005). Dans cette communication, nous souhaitons mobiliser une série de réflexions récentes sur la notion d’avatar vidéoludique pour les étendre à l’étude des personnages au sein de la littérature contemporaine. [less ▲]

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See detailSet theory and foundational mereology as logical tools for descriptive psychology
Leclercq, Bruno ULg

Conference (2016, June 07)

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See detailL’abus de droit et le manque de réelle substance économique : Belgique
Bourgeois, Marc ULg

Conference given outside the academic context (2016)

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See detailPolitique internationale de la culture: patrimoine culturel et industries culturelles
Vlassis, Antonios ULg

Scientific conference (2016, June 06)

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See detailMOISTURE CONTENT DETERMINATION OF FREEZE-DRIED PRODUCTS BY NEAR-INFRARED SPECTROSCOPY: A CASE STUDY FOR UNIVERSAL REGRESSION MODEL
Clavaud, Matthieu ULg; Roggo, Yves; Degardin, Klara et al

Poster (2016, June 06)

Karl Fischer titration is the reference method for moisture content determination in the pharmaceutical industry. Near-infrared spectroscopy is considered the most suitable alternative technique. Indeed ... [more ▼]

Karl Fischer titration is the reference method for moisture content determination in the pharmaceutical industry. Near-infrared spectroscopy is considered the most suitable alternative technique. Indeed, NIRS is a safe and fast method which does not require sample preparation. Nevertheless, the development and validation phases are time-consuming. In addition, the NIRS methods presented so far were mostly product specific. The main objective of this study is to highlight that an universal calibration model can be validated for several freeze-dried products in order to speed up the validation time. This objective was led in two steps. A universal model was first evaluated. A calibration set and a validation set were built up with three freeze-dried products. An antibody drug conjugate, a large molecule and a small molecule all packed in sealed vials were used to introduce more variability. Regression methods were then compared in order to optimize the prediction values. [less ▲]

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See detailImprinting superconducting vortex footsteps in a magnetic layer
Brisbois, Jérémy ULg; Motta, Maycon; Avila Osses, Jonathan ULg et al

in Scientific Reports (2016), 6

Local polarization of a magnetic layer, a well-known method for storing information, has found its place in numerous applications such as the popular magnetic drawing board toy or the widespread credit ... [more ▼]

Local polarization of a magnetic layer, a well-known method for storing information, has found its place in numerous applications such as the popular magnetic drawing board toy or the widespread credit cards and computer hard drives. Here we experimentally show that a similar principle can be applied for imprinting the trajectory of quantum units of flux (vortices), travelling in a superconducting film (Nb), into a soft magnetic layer of permalloy (Py). In full analogy with the magnetic drawing board, vortices act as tiny magnetic scribers leaving a wake of polarized magnetic media in the Py board. The mutual interaction between superconducting vortices and ferromagnetic domains has been investigated by the magneto-optical imaging technique. For thick Py layers, the stripe magnetic domain pattern guides both the smooth magnetic flux penetration as well as the abrupt vortex avalanches in the Nb film. It is however in thin Py layers without stripe domains where superconducting vortices leave the clearest imprints of locally polarized magnetic moment along their paths. In all cases, we observe that the flux is delayed at the border of the magnetic layer. Our findings open the quest for optimizing magnetic recording of superconducting vortex trajectories. [less ▲]

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See detailOn the α-polarization of bacterial suspensions: SIP measurements on four bacterial strains
Pilawski, Tamara ULg; Tappe, Wolfgang; Zimmermann, Egon et al

Poster (2016, June 06)

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See detailA Stochastic Multi-scale Model For Predicting MEMS Stiction Failure
Hoang Truong, Vinh ULg; Paquay, Stéphane; Golinval, Jean-Claude ULg et al

in Proceedings of the SEM XIII International Congress and Exposition on Experimental and Applied Mechanics. (SEMXIII 2016) (2016, June 06)

Adhesion is an important phenomenon in the context of MEMS for which the surface forces become dominant in comparison with the body forces. Because the magnitudes of the adhesive forces strongly depend on ... [more ▼]

Adhesion is an important phenomenon in the context of MEMS for which the surface forces become dominant in comparison with the body forces. Because the magnitudes of the adhesive forces strongly depend on the surface interaction distances, which in turn evolve with the roughness of the contacting surfaces, the adhesive forces cannot be determined in a deterministic way. To quantify the uncertainties on the structural stiction behavior of a MEMS, this work proposes a “stochastic multi-scale methodology”. The key ingredient of the method is the evaluation of the random meso-scale apparent contact forces, which homogenize the effect of the nano-scale roughness and are integrated into a numerical model of the studied structure as a random contact law. To obtain the probabilistic behavior at the structural MEMS scale, a direct method needs to evaluate explicitly the meso-scale apparent contact forces in a concurrent way with the stochastic multi-scale approach. To reduce the computational cost, a stochastic model is constructed to generate the random meso-scale apparent contact forces. To this end, the apparent contact forces are parameterized by a vector of parameters before applying a polynomial chaos expansion in order to construct a mathematical model representing the probability of the random parameters vector. The problem of miro-beam stiction is then studied in a probabilistic way. [less ▲]

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See detailMéthodes historiques de recherche en architecture
Frankignoulle, Pierre ULg

Scientific conference (2016, June 06)

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See detailL’hypothèse d’une Pax Persiana. L’Iran et ses rapports avec l’Occident des années 1850 à 2016
Genin, Vincent ULg

Conference given outside the academic context (2016)

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See detailScreening study of SFC critical method parameters for the determination of pharmaceutical compounds
Dispas, Amandine ULg; Lebrun, Pierre ULg; Sacre, Pierre-Yves ULg et al

in Journal of Pharmaceutical & Biomedical Analysis (2016), 125

Nowadays, supercritical fluid chromatography is commonly presented as a promising alternative technique in the field of separation sciences. Nevertheless the selection of chromatographic conditions and ... [more ▼]

Nowadays, supercritical fluid chromatography is commonly presented as a promising alternative technique in the field of separation sciences. Nevertheless the selection of chromatographic conditions and sample preparation of pharmaceutical compounds remain a challenge and peak distortion was previously highlighted. The main objective of the present work was to evaluate the impact of different critical method parameters (CMPs), i.e. stationary phase, mobile phase composition and injection solvent nature. The experiments were performed considering two groups of antimalarial molecules: one group with neutral/apolar compounds and the other one with salt form of polar compounds. In this context, another objective was to propose a suitable sample solvent for quantitative analysis. The interest of new generation stationary phase to obtain good peak shape and the interest to tune the mobile phase composition were demonstrated. During this study, design of experiments and desirability function approach enabled to highlight optimal chromatographic conditions in order to maximise peak capacity and to get acceptable value of symmetry factor. Regarding sample injection solvent composition, some counterintuitive results were observed: solvents closer to the mobile phase polarity (i.e heptane or 2-propanol/heptane mixture) did not provide best results in terms of peak symmetry. In addition, acetonitrile and short aliphatic alcohols offered an interesting alternative as injection solvent: toxicity of solvents used is clearly reduced and better quantitative performances could be expected while keeping high peak capacity and symmetric sharp peaks. Finally, the quantitative performances were evaluated by the method validation for the quantitative determination of quinine sulfate in a pharmaceutical formulation. These better understandings on critical method parameters led SFC to be an even more promising technique in the field of the analysis of pharmaceutical compounds. [less ▲]

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