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See detailResponse to the discussion on “Reconstruction of the envelope of non-Gaussian structural responses with principal static wind loads by N. Blaise, T. Canor and V. Denoël”
Blaise, Nicolas; Canor, Thomas; Denoël, Vincent ULg

in Journal of Wind Engineering & Industrial Aerodynamics (2017)

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See detailL'image de marque des villes wallonnes
Scatton, Loïc; Schmitz, Serge ULg

in Belgeo (2017), 2016(1),

City branding practices have become widespread but few studies measure their effects on medium-sized cities. Through an analysis of the practices of city branding and internal and external images of the ... [more ▼]

City branding practices have become widespread but few studies measure their effects on medium-sized cities. Through an analysis of the practices of city branding and internal and external images of the cities of Liege and Charleroi, this article points out the relative strengths and weaknesses of the images of each of the Walloon cities, among their businessmen, vis-a vis those of the other Walloon city. The images of these two cities are composites and branding policies are still in their infancy. These policies have followed a top-down approach which may explain the limited use of the two brands even if they use ideas shared by local entrepreneurs. However the research underlines the absence of opinions on certain characteristics of the cities or a negative view which often requires works in the field but also better communication. [less ▲]

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See detailRecent Advances in Small Clusters and Polymetallic Assemblies Based on Transition Metals and Dithiocarboxylate Zwitterions Derived from N-Heterocyclic Carbenes
Beltran Alvarez, Tomás Francisco ULg; Delaude, Lionel ULg

in Journal of Cluster Science (2017), 28(2), 667-678

N-Heterocyclic carbenes (NHCs) react readily with carbon disulfide to form stable, crystalline, zwitterionic adducts. In this review, we outline the various strategies that were applied to synthesize ... [more ▼]

N-Heterocyclic carbenes (NHCs) react readily with carbon disulfide to form stable, crystalline, zwitterionic adducts. In this review, we outline the various strategies that were applied to synthesize transition metal clusters based on such NHC•CS2 ligands. We also briefly survey their most salient structural features and catalytic properties. Because this research field is still in its infancy, only a limited number of structures containing metals from Group 7 (Mn and Re) and 8 (Fe and Ru) have been described so far. Homo- and heterobimetallic manganese and rhenium carbonyl clusters with the generic formula [MM'(CO)6(mu-kappa2-S,S'-kappa3-S,C,S'-S2C•NHC)] (MM' = Mn2, MnRe, or Re2) were most thoroughly investigated. Isolated examples of dinuclear iron and tetranuclear ruthenium compounds, in which the dithiocarboxylate unit underwent fragmentation, were also reported. Other related polymetallic entities recently elaborated through the use of azolium-2-dithiocarboxylate zwitterions and Group 11 metals (Cu and Au) include copper-based coordination polymers, gold nanoparticles, and self-assembled monolayers. [less ▲]

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See detailSequential crystallization of high and low melting waxes to improve oil structuring in wax-based oleogels
Tavernier, Iris; Doan, Chi Diem; Van de Walle, Davy et al

in RSC Advances (2017), 7

Themain objective of this study was to investigate the effect of combining a high-melting wax (sunflower wax or rice bran wax)with a low-melting wax (berrywax or BEW) on the crystallization and gelation ... [more ▼]

Themain objective of this study was to investigate the effect of combining a high-melting wax (sunflower wax or rice bran wax)with a low-melting wax (berrywax or BEW) on the crystallization and gelation behavior of the corresponding wax-based oleogels in rice bran oil (RBO). Sunflower wax (SW) and rice bran wax (RBW) have a similar chemical composition but a very different crystallization behavior. Therefore, SWand RBW were also combined in a wax-based oleogel to examine the occurrence of co-crystallization and/or crystal coexistence. The thermal and gelation behavior of the binary blends in rice bran oil (5% w/w total concentration of wax) were investigated with differential scanning calorimetry (DSC) and rheological measurements, showing sequential crystallization and gelation for the SW/RBW : BEW wax-based oleogels and simultaneous crystallization and gelation for the SW : RBW wax-based oleogels. Oscillatory shear and hardness measurements revealed the reinforcement of the high-melting wax crystal network with the addition of the low-melting berry wax. X-ray diffraction (XRD) measurements in both the long-spacing and the short-spacing region showed the occurrence of crystal co-existence, rather than co-crystallization, which was confirmed with polarized light microscopy (PLM). Two different crystal morphologies could be discerned for all three combinations (RBW : SW, SW : BEW and RBW : BEW). We hypothesized that the improved rheological properties could be attributed to sintering, a process in which the low-melting BEW crystals form solid bonds between the crystals of the high-melting waxes. As such, a cohesive network is formed, resulting in an increased hardness of the bi-wax-based oleogels. This research provides the opportunity to minimize the amount of wax necessary in creating semi-solid materials with a wide variety in rheological and textural properties. [less ▲]

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See detailTracking dynamic interactions between structural and functional connectivity: a TMS/EEG-dMRI study
Amico, Enrico; Bodart, Olivier ULg; Rosanova, Mario et al

in Brain connectivity (2017)

Transcranial magnetic stimulation (TMS) in combination with neuroimaging techniques allows to measure the effects of a direct perturbation of the brain. When coupled to high density electroencephalography ... [more ▼]

Transcranial magnetic stimulation (TMS) in combination with neuroimaging techniques allows to measure the effects of a direct perturbation of the brain. When coupled to high density electroencephalography (TMS/hd-EEG), TMS pulses revealed electrophysiological signatures of different cortical modules in health and disease. However, the neural underpinnings of these signatures remain unclear. Here, by applying multimodal analyses of cortical response to TMS recordings and diffusion magnetic resonance imaging (dMRI) tractography, we investigated the relationship between functional and structural features of different cortical modules in a cohort of awake healthy volunteers. For each subject we computed directed functional connectivity interactions between cortical areas from the source reconstructed TMS/hd- EEG recordings and correlated them with the correspondent structural connectivity matrix extracted from dMRI tractography, in three different frequency bands (alpha, beta, gamma) and two sites of stimulation (left precuneus and left premotor). Each stimulated area appeared to mainly respond to TMS by being functionally elicited in specific frequency bands, i.e. beta for precuneus and gamma for premotor. We also observed a temporary decrease in the whole-brain correlation between directed functional connectivity and structural connectivity after TMS in all frequency bands. Notably, when focusing on the stimulated areas only, we found that the structurefunction correlation significantly increases over time in the premotor area contralateral to TMS. Our study points out the importance of taking into account the major role played by different cortical oscillations when investigating the mechanisms for integration and segregation of information in the human brain. [less ▲]

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See detailMT4-MMP and EGFR expression levels are key biomarkers for breast cancer patient response to chemotherapy and erlotinib.
Yip, Cassandre ULg; Foidart, Pierre ULg; Somja, Joan ULg et al

in British Journal of Cancer (2017)

BACKGROUND: Triple-negative breast cancers (TNBC) are heterogeneous cancers with poor prognosis. We aimed to determine the clinical relevance of membrane type-4 matrix metalloproteinase (MT4-MMP), a ... [more ▼]

BACKGROUND: Triple-negative breast cancers (TNBC) are heterogeneous cancers with poor prognosis. We aimed to determine the clinical relevance of membrane type-4 matrix metalloproteinase (MT4-MMP), a membrane type matrix metalloproteinase that interacts with epidermal growth factor receptor (EGFR) overexpressed in >50% of TNBC. METHODS: We conducted a retrospective immunohistochemical analysis on human TNBC samples (n=81) and validated our findings in in vitro and in vivo assays. RESULTS: Membrane type-4 matrix metalloproteinase and EGFR are produced in 72.5% of TNBC samples, whereas those proteins are faintly produced by healthy tissues. Unexpectedly, tumour relapse after chemotherapy was reduced in samples highly positive for MT4-MMP. Mechanistically, this is ascribed to a higher sensitivity of MT4-MMP-producing cells to alkylating or intercalating chemotherapeutic agents, as assessed in vitro. In sharp contrast, MT4-MMP expression did not affect tumour cell sensitivity to paclitaxel that interferes with protease trafficking. Importantly, MT4-MMP expression sensitised cancer cells to erlotinib, a tyrosine kinase EGFR inhibitor. In a pre-clinical model, the growth of MT4-MMP overexpressing xenografts, but not of control ones, was reduced by epirubicin or erlotinib. The combination of suboptimal drug doses blocked drastically the growth of MT4-MMP-producing tumours. CONCLUSIONS: We demonstrate that MT4-MMP defines a sub-population of TNBC sensitive to a combination of DNA-targeting chemotherapeutic agents and anti-EGFR drugs.British Journal of Cancer advance online publication 14 February 2017; doi:10.1038/bjc.2017.23 www.bjcancer.com. [less ▲]

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See detailReconstructing Cenozoic vegetation from proxy data and models – A NECLIME synthesis (Editorial)
François, Louis ULg; Bruch, A. A.; Utescher, T. et al

in Palaeogeography, Palaeoclimatology, Palaeoecology (2017), 467

[No abstract available]

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See detailIn Memoriam Léon Lacroix (1909-2016)
Rochette, Bruno ULg

in Antiquité Classique (2017), 86

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See detailA Comparison of Micro-objective Non-parametric Statistical Matching Techniques for the Integration of Different Survey Data
Eftekhar, Hamed ULg; Cools, Mario ULg

in Proceedings of the 96th Annual Meeting of the Transportation Research Board (2017)

Lack of information is often reported as one of the main study limitations in transport research. Other data sources provide an important opportunity, as the information from these data sources might be ... [more ▼]

Lack of information is often reported as one of the main study limitations in transport research. Other data sources provide an important opportunity, as the information from these data sources might be fully exploited when they are integrated using an appropriate mathematical framework. This paper determines which data integration techniques can be adopted in the context of road safety, and which criteria should be used to assess the quality of the integrated dataset. The paper contributes to the literature by providing a comparison of different techniques that allow the tabulation of the joint micro-data. To compare the suitability of different Statistical Matching techniques, data from the 2012 Belgium Road Safety Institute (BRSI) Attitude Survey and data from the 2010 Belgian National Household Travel Survey (BELDAM) are integrated. In particular, the socio-economic factor "Income" is being matched to the BRSI Attitude Survey data. The paper discusses and compares different non-parametric micro-objective Statistical Matching techniques, in which the “Income” variable from the BELDAM survey was added to the BRSI Attitude Survey. Based on similarity/dissimilarity measures, the Rank hot-deck Statistical Matching yielded the best result, which is in line with the existing literature. Moreover, from the results, it can be concluded that statistical data matching is a practically applicable technique, which can help overcome the lack of additional information. Further research should focus on using the integrated datasets with an attempt of expanding the scope of variables, and explicitly testing for omitted variable bias. [less ▲]

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See detailProteomic signatures reveal a dualistic and clinically relevant classification of anal canal carcinoma
Herfs, Michael ULg; Longuespée, Rémi ULg; Quick, Charles et al

in Journal of Pathology (The) (2017), 241

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See detailAnnexe A : Benchmark / Benchmark et analyse des écarts pour la planification d'urgence externe relative au risque Seveso
Verhaegen, Marlies; Fallon, Catherine ULg; Thiry, Aline ULg et al

Report (2017)

Ce rapport de recherche – annexe A du rapport final - présente les résultats du benchmark pour les cinq pays suivants : l’Allemagne, le Danemark, la France, la Hollande et la Suisse. L’objectif de ce ... [more ▼]

Ce rapport de recherche – annexe A du rapport final - présente les résultats du benchmark pour les cinq pays suivants : l’Allemagne, le Danemark, la France, la Hollande et la Suisse. L’objectif de ce deuxième volet de la recherche a été de fournir une vue globale de la manière dont la planification d’urgence Seveso externe est organisée dans les pays voisins que ce soit au niveau de la planification d’urgence stratégique, de la formation et des exercices, du matériel et de la communication. Une étude de la littérature (règlementation, littérature scientifique, rapports d’évaluation, etc.) a été complétée par des entretiens téléphoniques. Le premier objectif de cette phase de la recherche a été de mettre en évidence des exemples de bonnes pratiques dans les domaines où des difficultés/manquements ont été identifiés en Belgique. Pour ce faire, ce deuxième volet s’est déroulé de manière transversale par rapport à l’enquête menée en Belgique (Mesydel – voir annexe B). Cette phase internationale a permis d’ouvrir l’horizon d’analyse en incluant une dimension comparative entre les pratiques relatives à la planification d’urgence externe en matière de risques Seveso en Belgique et les pratiques relatives au même domaine dans cinq pays voisins. [less ▲]

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See detailAnnexe B: analyse du Mesydel / Benchmark et analyse des écarts pour la planification d'urgence externe relative au risque Seveso
Thiry, Aline ULg; Verhaegen, Marlies; Fallon, Catherine ULg et al

Report (2017)

Ce rapport de recherche – annexe du rapport final intégré - présente l’analyse des réponses aux deux tours du questionnaire en ligne Mesydel. Sur base des éléments récoltés lors des entretiens ... [more ▼]

Ce rapport de recherche – annexe du rapport final intégré - présente l’analyse des réponses aux deux tours du questionnaire en ligne Mesydel. Sur base des éléments récoltés lors des entretiens exploratoires avec des personnes ressources (premier volet de la recherche), l’équipe de recherche a réalisé un Mesydel - questionnaire en ligne selon la méthodologie Delphi - avec divers acteurs industriels et acteurs publics en Wallonie, en Flandre et à Bruxelles. Un des objectifs de cette phase participative a été de permettre aux acteurs directement concernés de s’exprimer sur le mode de l’écrit et donc de favoriser la prise en compte des connaissances, idées, expériences et appréciations de ceux-ci. Les questions ont été rédigées par les chercheurs sur base des résultats obtenus lors des entretiens. Ce travail de rédaction des questions est un travail de conceptualisation important qui a été réalisé par l’équipe de recherche. Le questionnaire a abordé les différentes dimensions : la planification d’urgence, la formation et les exercices, le matériel et la communication envers le public. Les questions essentiellement qualitatives invitent les participants à se positionner par rapport aux éléments, tout en laissant la possibilité d’ouvrir la discussion à de nouvelles dimensions importantes. Un des objectifs est de mettre en évidence les difficultés/manquements identifiés par ces différents acteurs en Belgique et d’envisager les solutions éventuelles. Le second tour du questionnaire a eu pour objectif de valider les éléments récoltés lors du premier tour. [less ▲]

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See detailDepth-speci c Fluctuations of gene expression and protein abundance modulate the photophysiology in the seagrass Posidonia oceanica
Procaccini, Gabriele; Ruocco, Miriam; Marin-Guirao, Lazaro et al

in Scientific Reports (2017), 7(42890), 1-14

We present the results of a multiple organizational level analysis conceived to identify acclimative/ adaptive strategies exhibited by the seagrass Posidonia oceanica to the daily uctuations in the light ... [more ▼]

We present the results of a multiple organizational level analysis conceived to identify acclimative/ adaptive strategies exhibited by the seagrass Posidonia oceanica to the daily uctuations in the light environment, at contrasting depths. We assessed changes in photophysiological parameters, leaf respiration, pigments, and protein and mRNA expression levels. The results show that the diel oscillations of P. oceanica photophysiological and respiratory responses were related to transcripts and proteins expression of the genes involved in those processes and that there was a response asynchrony between shallow and deep plants probably caused by the strong di erences in the light environment. The photochemical pathway of energy use was more e ective in shallow plants due to higher light availability, but these plants needed more investment in photoprotection and photorepair, requiring higher translation and protein synthesis than deep plants. The genetic di erentiation between deep and shallow stands suggests the existence of locally adapted genotypes to contrasting light environments. The depth-speci c diel rhythms of photosynthetic and respiratory processes, from molecular to physiological levels, must be considered in the management and conservation of these key coastal ecosystems. [less ▲]

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See detailIntentionalisme et phénoménologie de l'intentionnalité
Seron, Denis ULg

in Etudes Phénoménologiques - Phenomenological Studies (2017), 1

This paper presents an argument in favor of a “phenomenological” approach to intentionality. This approach, as I see it, involves the view that intentional facts are better expressed with the help of ... [more ▼]

This paper presents an argument in favor of a “phenomenological” approach to intentionality. This approach, as I see it, involves the view that intentional facts are better expressed with the help of appearance words (“seems”, “appears”, “is similar to”, etc.). By contrast, what I call the “intentionalist approach” assumes that intentional facts are better expressed by intentional verbs. The argument is as follows. First, it is well-known that the use of intentional verbs to express typically intentional facts generates anomalies with respect to existential generalization, substitution of identicals, and the principle of excluded middle. Secondly, I argue that the use of appearance words does not generate the same anomalies, which suggests that appearance words are more appropriate to describe intentional facts. This, I conclude, is an argument for preferring the phenomenological to the intentionalist approach to intentionality. [less ▲]

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See detailPrès de 20 ans après sa grave crise sanitaire, où en est la hêtraie ardennaise?
Claessens, Hugues ULg; Claessens, Laureline ULg; Longrée, Charlotte et al

in FORÊT.NATURE (2017), 142(Janvier-Février-Mars), 30-36

La "maladie du hêtre", apparue au début des années 2000 suite au coup de froid de 1998, détruisit plus d'un million de mètres cubes de bois. Un suivi d'une vingtaine d'années a permis de faire le point ... [more ▼]

La "maladie du hêtre", apparue au début des années 2000 suite au coup de froid de 1998, détruisit plus d'un million de mètres cubes de bois. Un suivi d'une vingtaine d'années a permis de faire le point sur son évolution et son impact actuel, et de proposer quelques recommandations pour la gestion de la hêtraie. [less ▲]

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See detailRIP3 antagonizes a TSC2-mediated pro-survival pathway in glioblastoma cell death.
Fettweis, Grégory ULg; Di Valentin, Emmanuel ULg; L'homme, Laurent et al

in Biochimica et Biophysica Acta (2017)

Glioblastomas are the deadliest type of brain cancer and are frequently associated with poor prognosis and a high degree of recurrence despite removal by surgical resection and treatment by chemo- and ... [more ▼]

Glioblastomas are the deadliest type of brain cancer and are frequently associated with poor prognosis and a high degree of recurrence despite removal by surgical resection and treatment by chemo- and radio-therapy. Photodynamic therapy (PDT) is a treatment well known to induce mainly necrotic and apoptotic cell death in solid tumors. 5-Aminolevulinic acid (5-ALA)-based PDT was recently shown to sensitize human glioblastoma cells (LN-18) to a RIP3 (Receptor Interacting Protein 3)-dependent cell death which is counter-acted by activation of autophagy. These promising results led us to investigate the pathways involved in cell death and survival mechanisms occurring in glioblastoma following PDT. In the present study, we describe a new TSC2 (Tuberous Sclerosis 2)-dependent survival pathway implicating MK2 (MAPKAPK2) kinase and 14-3-3 proteins which conducts to the activation of a pro-survival autophagy. Moreover, we characterized a new RIP3/TSC2 complex where RIP3 is suggested to promote cell death by targeting TSC2-dependent survival pathway. These results highlight (i) a new role of TSC2 to protect glioblastoma against PDT-induced cell death and (ii) TSC2 and 14-3-3 as new RIP3 partners. [less ▲]

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See detailRecovery of fibers and biomethane from banana peduncles biomass through anaerobic digestion
AwedemWobiwo, Florent; Korangi Alleluya, Virginie; Happi Emaga, Thomas et al

in Energy for Sustainable Development (2017), 37

Detailed reference viewed: 31 (3 ULg)