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See detailSécurité intérieure, compétitivité, protection sociale, intégration, modèle institutionnel : La Belgique fédérale - cinq défis d'avenir pour notre pays
Behrendt, Christian ULg

Conference given outside the academic context (2016)

Allocution prononcée lors de la réception solennelle donnée à l'occasion du 90e anniversaire du Rotary Club de Liège-Centre, Liège, le 17 novembre 2016.

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See detailEpidemiology and reporting of candidaemia in Belgium
Trouvé, Charlotte; Blot, Stijn; HAYETTE, Marie-Pierre ULg et al

in European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology (2016)

The primary aim of this study was to collect national epidemiological data on candidaemia and to determine the reporting time of species identification and antifungal susceptibility in clinical practice ... [more ▼]

The primary aim of this study was to collect national epidemiological data on candidaemia and to determine the reporting time of species identification and antifungal susceptibility in clinical practice. During a 1-year period (March 2013 until February 2014), every first Candida isolate from each episode of candidaemia was included prospectively from 30 Belgian hospitals. Identification and susceptibility testing were performed according to local procedures and isolates were sent to the National Reference Center for Mycosis. Species identification was checked by matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry (MALDI-TOF MS) and internal transcribed spacer (ITS) sequencing in case no reliable identification was obtained by MALDI-TOF MS. Antifungal susceptibility testing was performed according to the European Committee on Antimicrobial Susceptibility Testing (EUCAST) methodology. A total of 355 isolates were retrieved from 338 patients. The mean incidence rate of candidaemia was 0.44 (range: 0.07 to 1.43) per 1000 admissions or 0.65 (range: 0.11 to 2.00) per 10,000 patient days. Candida albicans was most frequently found (50.4 %), followed by C. glabrata (27.3 %) and C. parapsilosis sensu lato (9.8 %). The overall resistance to fluconazole was 7.6 %, ranging from 3.9 % in C. albicans to 20.0 % in C. tropicalis. Only one C. glabrata isolate was resistant to the echinocandins. Four days after blood culture positivity, 99.7 % of the identifications and 90.3 % of the antifungal profiles were reported to the treating clinician. Candidaemia incidence rates differed up to 20-fold among Belgian hospitals; no clear factors explaining this difference were identified. The overall antifungal resistance rates were low but high azole resistance rates were recorded in C. tropicalis. [less ▲]

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See detailOnze thèses pour sortir du mur. Populisme, démocratie, citoyenneté
Delruelle, Edouard ULg

Conference given outside the academic context (2016)

Après l’élection de Donald Trump aux États-Unis, et avant l’élection (fort possible) de Marine Le Pen en France, nous ressentons tous l’urgence de repenser à la fois nos cadres d’analyse de la société et ... [more ▼]

Après l’élection de Donald Trump aux États-Unis, et avant l’élection (fort possible) de Marine Le Pen en France, nous ressentons tous l’urgence de repenser à la fois nos cadres d’analyse de la société et nos modes d’action sur la société. Urgence, car il devient de plus en plus évident que nous ne vivons pas une « crise » (par essence passagère), mais un dérèglement généralisé (dérèglement économique, social, climatique, politique et géopolitique) qui débouche aujourd’hui sur une mise à l’épreuve de la démocratie elle-même. Selon une image que j’emprunte à Patrick Viveret : nous n’allons pas dans le mur, nous sommes dans le mur. Tous les équilibres économiques, sociaux et culturels s’effondrent.Mais en même temps, si nous sommes dans le mur, il y a peut-être autre chose à faire que de nous lamenter et désespérer : nous demander comment en sortir ! Comment sortir du mur ? Je voudrais formuler à ce sujet onze thèses. Elles tentent d’expliquer comment nous en sommes arrivés là, et comment nous pouvons opposer au populisme et au « welfare - chauvinisme » une conception renouvelée de la démocratie et de la citoyenneté sociale et laïque. [less ▲]

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See detailCarbon dioxide and vegetable oil for the synthesis of biobased polymer precursors
Alves, Margot ULg

Doctoral thesis (2016)

Although it is a thermodynamically and kinetically stable molecule, carbon dioxide can be converted into five- and six-membered cyclic carbonates by coupling with epoxides or oxetanes, respectively, using ... [more ▼]

Although it is a thermodynamically and kinetically stable molecule, carbon dioxide can be converted into five- and six-membered cyclic carbonates by coupling with epoxides or oxetanes, respectively, using appropriate catalysts. Cyclic carbonates are used as green solvents, electrolytes for Li-ion batteries or intermediates for the synthesis of polymers. However, the catalytic performance must be further enhanced in particular for the coupling of CO2 with epoxidized vegetable oils or oxetanes. In this context, we developed a new highly efficient bicomponent homogeneous organocatalyst composed of an ammonium salt as the catalyst and fluorinated single or double hydrogen bond donors as co-catalysts. First, a screening of onium-based catalysts and hydrogen-bond donors was performed. Performances of the catalysts and optimization of the reaction was realized through detailed kinetics studies using in-situ FTIR/Raman spectroscopy under pressure. We demonstrated that fluorinated alcohols showed unexpected co-catalytic activity due to synergisms between the onium salt and fluorinated co-catalysts enabling the fast and selective addition of CO2 onto model epoxides and epoxidized vegetable oils under solvent-free and mild experimental conditions. The use of this powerful dual catalyst was then extended to the first organocatalytic coupling of CO2 with less reactive oxetanes to produce hydroxyl telechelic oligocarbonates that were used as precursor of CO2-based polyurethanes by chain-extension with a diisocyanate. In addition, a fine comprehension of the mechanisms was investigated by DFT calculations highlighting that the co-catalytic performance of the onium salt/fluorinated alcohol binary catalyst arose from the strong stabilization of the intermediates and transitions states by hydrogen-bonding. To date, through comparative studies, we evidenced that this new catalyst is one of the most performing and versatile system enabling the coupling of CO2 both with epoxides or oxetanes. [less ▲]

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See detailLimited impact of imatinib in a murine model of sclerodermic chronic graft-versus-host disease
Belle, Ludovic; Fransolet, Gilles ULg; SOMJA, Joan ULg et al

Poster (2016, November 17)

Background: Graft-versus-host disease (GVHD) remains one of the major complications following haematopoietic stem cell transplantation (HSCT). Approximately 15% of the patients with chronic GVHD develop ... [more ▼]

Background: Graft-versus-host disease (GVHD) remains one of the major complications following haematopoietic stem cell transplantation (HSCT). Approximately 15% of the patients with chronic GVHD develop the sclerodermatous form of the disease characterized by multiple organ fibrosis and loss of skin elasticity. Several studies have shown the potential benefits of imatinib, a tyrosine kinase inhibitor, as a treatment of fibrosis in cGVHD due to its ability to inhibit simultaneously PDGF-R and c-Abl pathways which are both involved in fibrosis mechanisms. This work investigates the possible benefits of imatinib on fibrosis in a murine model of sclerodermatous chronic GVHD (sclcGVHD). Methods: Lethally irradiated Balb/cJ mice (7 Gy TBI) were injected i.v. with 10.106 bone marrow cells and 70.106 splenocytes from B10.D2 donnor mice. Mice were then treated with sterile water or imatinib (150 mg/kg/day) by oral gavage from day +7 to day +52 following transplantation. GVHD severity was assessed three times/week with a scoring system encompassing 5 criteria (mice posture, weight loss, activity, hair loss, skin integrity ; 0-1-2 point(s)/criteria). Results: Our results show that imatinib failed to prevent/improve GVHD with a similar evolution of the GVHD severity with no differences between groups. Histological analyses indicate a significant reduction of the phosphorylation level of the PDGR receptor (p = 0,033) and a trend to a decreased level of phosphorylated c-Abl (p = 0,1854). In vivo cell proliferation assay with CFSE were also performed and showed a reduced proliferation of T cells and subsets (CD4, CD8 and Tregs) in spleen, lymph nodes, bone marrow and blood after imatinib treatment. Finally, FACS analyses performed on days +21 and +35 after transplantation did not show any differences in the absolute T-cell counts. Conclusion: Although we have observed a decreased phosphorylation level of PDGR receptor and less proliferation of T cells and subsets in vivo, imatinib failed to alleviate scl-cGVHD in a murine model of severe scl-cGVHD. [less ▲]

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See detailNon-contact emerging nondestructive techniques for aerospace composite inspection
Georges, Marc ULg

Scientific conference (2016, November 17)

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See detailDiscutante du panel 'cohésion sociale et participation sociale'
Gavray, Claire ULg

Conference (2016, November 17)

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See detailTrouble déficitaire de l’attention avec ou sans hyperactivité ( ADHD – TDA/H – THADA )
SCHOLL, Jean-Marc ULg

Conference given outside the academic context (2016)

Le diagnostic d'un Trouble de l'attention avec ou sans hyperactivité est réalisé à partir de l'anamnèse et de la description de l'enfant dans ses différents milieux de vie. Cette présentation donne une ... [more ▼]

Le diagnostic d'un Trouble de l'attention avec ou sans hyperactivité est réalisé à partir de l'anamnèse et de la description de l'enfant dans ses différents milieux de vie. Cette présentation donne une sémiologie précise permettant de reconnaître les signes et symptômes chez l'enfant et chez l'adulte. Il est également important de systématiquement rechercher s'il n'y a pas d'autres difficultés et comorbidités s'ajoutant à ce premier diagnostic. Le module de formation ici présenté donne divers points de repères : 1) Données générales : Différentes dénominations ; Différentes formes ; Prévalence et Sex-ratio ; Évolution développementale ; Fondement clinique du diagnostic ; Composantes dimensionnelles du diagnostic 2) Le déficit d'attention : Déficit du traitement automatique ; Deux formes qualitatives de l’attention ; Attention divergente chez l’enfant et chez l’adulte ; Attention convergente chez l’enfant et chez l’adulte ; Fluctuations temporelles 3) L'hyperactivité : Fonctionnement pluriel ; Cours développemental ; Signes cliniques chez l’enfant ; Signes cliniques chez l’adulte 4) L'impulsivité : Fonctionnement ; Impulsivité simple chez l’enfant et chez l’adulte ; Troubles du comportement 5) L'ADHD : Fréquence des différentes formes d’ADHD ; Propositions d’aide et de traitements ; Pronostic de l’évolution ; Suspecter d’autres difficultés présentes ! 6) De l'ADHD aux comorbidités : Comorbidités comme règle ; Toutes les associations possibles 7) L'ADHD au quotidien. [less ▲]

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See detailLes indices de détection de patron de réponse inapproprié de type carré-moyens non-pondérés: à manipuler avec précaution!
Beland, Sebastien; Raiche, Gilles; Magis, David ULg et al

Conference (2016, November 17)

Le carré-moyen non-pondéré U comme indice de détection (unweighted mean square statistics) (Wright & Stone, 1979) et sa version standardisée ZU (Wright, 1980) sont parmi les indices de détection de ... [more ▼]

Le carré-moyen non-pondéré U comme indice de détection (unweighted mean square statistics) (Wright & Stone, 1979) et sa version standardisée ZU (Wright, 1980) sont parmi les indices de détection de patrons de réponse inappropriés paramétriques les plus connus. On retrouve l’un et/ou l’autre de ces indices dans des logiciels commerciaux ou gratuits tels que RUMM2030, FACETS ou la librairie R eRm en plus d’en faire mention dans les articles les plus cités sur le sujet (Karabatsos, 2003; Meijer et Sijtsma, 2001). Durant les dernières décennies, quelques voix se sont élevées afin de sensibiliser les utilisateurs aux problèmes que présentent U et ZU (Karabatsos, 2000; Smith, 1991). Ils semblent, en effet, présenter des scores extrêmes qui rendraient leur utilisation inadéquate dans certaines situations. Cette présentation aura comme objectif d’étudier les limites des indices U et ZU. Nous utiliserons une étude de simulation et différents modèles de réponses à l’item dichotomiques afin de soutenir notre propos. Les auteurs de l’étude concluront leur présentation en discutant de l’importance de manipuler ces indices avec précaution. [less ▲]

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See detailAnalysis of the interactions of fatty acyds hydroperoxides with biomimetic membranes by complementary biophysical approaches
Deboever, Estelle ULg; Nasir, Mehmet Nail ULg; Deleu, Magali ULg et al

Poster (2016, November 16)

In the actual context, biopesticides have emerged as a main alternative to conventional agriculture1. Hence, elicitors are metabolites naturally produced by microorganisms, pathogenic or not, and plants ... [more ▼]

In the actual context, biopesticides have emerged as a main alternative to conventional agriculture1. Hence, elicitors are metabolites naturally produced by microorganisms, pathogenic or not, and plants which are able to induce the natural resistance of plants. Also, they have proved to be excellent candidates for biological control. In this context, the lipoxygenase pathway leads to the formation of fatty acid degradation products, called oxylipins, which appear to be crucial agents in plant defence mechanisms2,3. Moreover, with their broad spectrum of action and their possible inducibility, oxylipins appear to be promising candidates for their use as elicitors4. This work focuses on two hydroperoxy-derived oxylipins, the 13(S)-hydroperoxy-octadecadienoic acid (13-HPOD) and the 13(S)-hydroperoxy-octadecatrienoic acid (13-HPOT). The study of the interaction of such compounds with representative plant plasma membrane lipids is essential to understand plant resistance mechanisms. Several in silico and experimental techniques of biophysics showed that acyl-hydroperoxides have significant adsorption capacity and a strong affinity for model membranes. They may also penetrate biological membrane but no permeabilisation effect was observed in this work. Slight conformational differences seem to have a significant impact on their ability to interact with plant plasma membranes. Based on these results, further investigation of the interactions of fatty acids hydroperoxides, even more on the 9-forms, with plant plasma membranes and eventually in the presence of phytopathogenic species, would allow a better understanding of the innate immunity and, on the longer term, could lead to the development of new elicitors with biological mechanisms potentially independent of membrane protein receptors. [less ▲]

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See detailPolyphenol content and antioxidant capacity in various commercial juices
Matute Matute, Alexis Fernando ULg; Tabart, Jessica; CHERAMY-BIEN, Jean-Paul ULg et al

Poster (2016, November 16)

Antioxidants are enzymes, non-enzymatic proteins, minerals micronutrients, vitamins, phenolic compounds, pigments and others. Polyphenols have the ability to reduce or prevent damage caused by free ... [more ▼]

Antioxidants are enzymes, non-enzymatic proteins, minerals micronutrients, vitamins, phenolic compounds, pigments and others. Polyphenols have the ability to reduce or prevent damage caused by free radicals promoting positive effects on human health due to their antioxidant capacity. In this study we evaluated the content of polyphenols from several commercial biological (n = 6) and conventional juices (n = 6 ) (orange, blackcurrant, apple, grapes, tomato, carrot, pomegranate, lemon, grapefruit juices) and we determined the antioxidant effect by inhibition of the superoxide anion production measured by chemiluminescence technology. Conventional juices (orange, apple, tomato, pomegranate, lemon, grapefruit juices) showed more total polyphenolics (+ 32%), more flavan-3-ols (+ 67%) and more flavonols (+ 42%) than the same biological juices. The presence of anthocyanins was reported in juices made with blackcurrant, pomegranate and grapes only, with values above 50 µg/mL, regardless of their nature. Surprisingly, chemiluminescence results showed an inhibition in superoxide anion production by 51% for biological juices vs 23% in conventional ones. The correlation between total polyphenol content and antioxidant capacity of all the juices was r = 0.83 (r2 = 0.7). The fact that there is less polyphenols and higher antioxidant activity in bio juices could be related to the concentration and the type of polyphenol present. [less ▲]

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See detailStudy of the evolution of the osteoarthritis pathology and the mechanical properties of cartilage in a spontaneous osteoarthritis model in the Dunkin-Hartley guinea pigs.
Legrand, Catherine ULg; Centonze, Prescilia ULg; Comblain, Fanny ULg et al

Poster (2016, November 16)

In animal models, the severity of cartilage damage is assessed by histological scores evaluating the structure, the proteoglycan content, the integrity of the tidemark, the cellularity, and osteophytes ... [more ▼]

In animal models, the severity of cartilage damage is assessed by histological scores evaluating the structure, the proteoglycan content, the integrity of the tidemark, the cellularity, and osteophytes. In parallel to these histological analyzes, we studied the mechanical properties of cartilage at different stages of disease progression in the Dunkin-Hartley guinea pigs. We also correlated the severity of histological lesions with the mechanical properties of cartilage. [less ▲]

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See detailZinc, iron and manganese interaction within the frd3 Arabidopsis mutant
Scheepers, Maxime ULg; Spielmann, Julien ULg; Goormaghtigh, Erik et al

Poster (2016, November 16)

Zinc and iron are two essential micronutrients for plants. The homeostasis networks of the two metals are intertwined. Arabidopsis halleri is a zinc- and cadmium-tolerant and zinc-hyperaccumulating ... [more ▼]

Zinc and iron are two essential micronutrients for plants. The homeostasis networks of the two metals are intertwined. Arabidopsis halleri is a zinc- and cadmium-tolerant and zinc-hyperaccumulating species, which also present adaptation of its iron homeostasis(1,4). Transcriptomic studies identified genes which are constitu-tively over-expressed in Arabidopsis halleri compared to Arabidopsis thaliana and which may have a role in metal tolerance or accumulation(2-4). Among them, a candidate gene encodes the FRD3 (FERRIC REDUCTASE DEFECTIVE 3) protein, a member of the MATE family of membrane transporters. FRD3 is a citrate transporter involved in iron homeostasis(5-7) and plays a role in zinc tolerance in A. thaliana(8). The FRD3 gene displays a complex regulation. In A. thaliana, alternative transcript initiation for FRD3 determines two transcripts, which dif-fer in their 5'UTRs and have differential translation efficiency. The two transcripts are selectively regulated under stress conditions: iron and zinc depletion, zinc excess or cadmium presence(9). In A. halleri, a single highly ex-pressed FRD3 transcript with high translation efficiency is present(9). [less ▲]

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See detailComment former à l'argumentation?
Scheepers, Caroline ULg; Delneste, Stéphanie

Conference (2016, November 16)

Confronté à des questions qui touchent à l'éthique, quelle conduite argumentative va mobiliser un petit groupe d'intervenants pour débattre des questions posées? Plus concrètement, quel sera le degré d ... [more ▼]

Confronté à des questions qui touchent à l'éthique, quelle conduite argumentative va mobiliser un petit groupe d'intervenants pour débattre des questions posées? Plus concrètement, quel sera le degré d'argumentativité du discours? Quelle est la visée des échanges : convaincre ou persuader? Quels types d'arguments seront convoqués? Sur quelles valeurs se fonderont-ils? Quels phénomènes de contre-argumentation émergeront? L'atelier, pratique, consiste à mettre en situation les participants (profs de philo au primaire, au secondaire ou au supérieur) de débattre ou d'analyser un débat. [less ▲]

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See detailErasurism, Peritext, Hypertext & Infratext
Delville, Michel ULg

Conference (2016, November 16)

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See detailDevelopment of a new method for arabidopsides extraction and purification
Genva, Manon ULg; Andersson, Mats X; Nasir, Mehmet Nail ULg et al

Poster (2016, November 16)

In the present work, a new method for arabidopsides extraction and purification was developed.

Detailed reference viewed: 37 (9 ULg)