Last 7 days
Bookmark and Share    
Full Text
Peer Reviewed
See detailReviews, opinions and insights for future clinical trials: an overview of PPCR journal
Thibaut, Aurore ULg

in Principles and Practice of Clinical Research (2015), 1(3),

Detailed reference viewed: 13 (0 ULg)
Full Text
See detailJoyaux cosmiques - 10/2015
Manfroid, Jean ULg

Article for general public (2015)

ESO 378-1 - Amas IC 4651 -Recyclage cosmique - M2-9

Detailed reference viewed: 9 (0 ULg)
Full Text
See detailL'astronomie dans le monde - 10/2015
Manfroid, Jean ULg

Article for general public (2015)

Fonction initiale demasse - Markarian 231 - Extinction globale - Supernovæ fuyantes - Pluton - Anneaux de Saturne

Detailed reference viewed: 13 (0 ULg)
Full Text
See detailL'année européenne du patrimoine architectural et ses répercussions au Grand-Duché de Luxembourg: une "procession d'Echternach" ?
Desseilles, François ULg; Langini, Alex

in Falser, Michael; Lipp, Wilfried (Eds.) Eine Zukunft für unsere Vergangenheit. Zum 40. Jubiläum des Europäischen Denkmalschutzjahres (1975–2015) (2015)

The contribution deals, mainly from parliamentary documents and legislation, with the encountering and embracing of the EAHY in the Grand Duchy of Luxembourg. The analysis concerns the preparation of ... [more ▼]

The contribution deals, mainly from parliamentary documents and legislation, with the encountering and embracing of the EAHY in the Grand Duchy of Luxembourg. The analysis concerns the preparation of activities and their achievement as well as the parliamentary discussions and the legal consequences of the EAHY. A positive effect of the campaign was the creation of a distinct built heritage service within the Ministry of Culture and the evolution of the legislation. Another positive effect was the advocacy work and the awareness of the people, a.o. thanks to a traveling exhibition on architecture in the Grand Duchy of Luxembourg. [less ▲]

Detailed reference viewed: 33 (12 ULg)
Full Text
Peer Reviewed
See detailFrom parents to siblings and peers: The wonderful story of social development.
Roskam, Isabelle; Stievenart, Marie ULg; Meunier, Jean-Christophe

in SAGE Open (2015)

The objective of the current research was to test the hypotheses arising from the epigenetic view of social development and from the wider perspective offered by the social network model with three ... [more ▼]

The objective of the current research was to test the hypotheses arising from the epigenetic view of social development and from the wider perspective offered by the social network model with three interactional systems, that is, child–parent, child–sibling, and child–peer. They were tested in two prospective longitudinal studies using a multi-informant and multimethod strategy. Study 1 was conducted among 83 children and their parents and Study 2 among 190 children. Attachment security with parents was assessed when the children were 4 years of age, relationships with siblings at 5 years of age, and relationships with peers at 6 years of age. Attachment to parent was found to explain a limited part of variations in later social relationships with siblings and peers. The sibling interactional system had a consistent and enduring effect on later peer relationships. With regard to the two theoretical backgrounds under consideration, neither was able to account for equivocal findings displayed in the two studies as well as in previous research. The wonderful story of social development seems to be a very complex process for which new models are needed. [less ▲]

Detailed reference viewed: 27 (2 ULg)
Full Text
Peer Reviewed
See detailFalciparum malaria molecular drug resistance in the Democratic Republic of Congo: a systematic review
Mvumbi, Dieudonné; Kayembe, Jean-Marie; Situakibanza, Hippolyte et al

in Malaria Journal (2015), 14

Background: Malaria cases were estimated to 207 million in 2013. One of the problems of malaria control is the emergence and spread of Plasmodium falciparum strains that become resistant to almost all ... [more ▼]

Background: Malaria cases were estimated to 207 million in 2013. One of the problems of malaria control is the emergence and spread of Plasmodium falciparum strains that become resistant to almost all drugs available. Monitoring drug resistance is essential for early detection and subsequent prevention of the spread of drug resistance by timely changes of treatment policy. This review was performed to gather all data available on P. falciparum molecular resistance in DR Congo, as baseline for future assessments. Methods: The search for this review was undertaken using the electronic databases PubMed and Google Scholar using the terms “malaria”, “Congo”, “resistance”, “molecular”, “antimalarial”, “efficacy”. Articles were classified based on year of collecting, year of publication, sample size and characteristics, molecular markers analysed and polymorphisms detected. Results: Thirteen articles were included and five genes have been analysed in these studies: pfcrt, pfdhps, pfdhfr, pfmdr1 and K13-propeller. The majority of studies included were not representative of the whole country. Conclusion: This systematic review demonstrates the lack of molecular resistance studies in DRC. Only 13 studies were identified in almost 15 years. The MOH must implement a national surveillance system for monitoring malaria drug resistance and this surveillance should be conducted frequently and country-representative. [less ▲]

Detailed reference viewed: 23 (2 ULg)
Full Text
Peer Reviewed
See detailLe médicament du mois. Humalog® 200 U/ml KwikPenTM
SCHEEN, André ULg

in Revue Médicale de Liège (2015), 70

Summary : Insulin lispro (Humalog®) was the first short-acting insulin analogue to be indicated for the treatment of diabetes mellitus requiring insulin therapy. After subcutaneous injection, insulin ... [more ▼]

Summary : Insulin lispro (Humalog®) was the first short-acting insulin analogue to be indicated for the treatment of diabetes mellitus requiring insulin therapy. After subcutaneous injection, insulin lispro has a more favourable pharmacokinetics/pharmacodynamics profile than human insulin, characterized by a faster resorption and a more rapid and less prolonged glucose-lowering activity. These properties allow a better control of postprandial hyperglycaemia and a reduction of the risk of delayed hypoglycaemia, especially at night. The patient’s quality of life is also improved because insulin lispro can be injected within the 15 minutes before meal and even possibly after meal when the amount of food intake is unpredictable. Already commercialized as Humalog® 100 U/ml, insulin lispro is now also available as Humalog® 200 U/ml. A pharmacokinetics/pharmacodynamics study confirmed the bioequivalence of the two formulations, based upon the analysis of both plasma free insulin concentrations and glucose infusion rates to maintain normoglycaemia. Humalog® 200 U/ml is available in a novel disposable 3 ml pen (KwikPenTM), with lower glide force and injection volume; thus this new pen is more convenient for the patient compared with the current pen used to inject Humalog® 100 U/ml. The new formulation Humalog® 200 U/ml is indicated in Europe for adult patients with type 1 or type 2 diabetes who require more than 20 units of prandial insulin per day to cover their meals. [less ▲]

Detailed reference viewed: 15 (3 ULg)
Full Text
Peer Reviewed
See detailL’ÉTUDE CLINIQUE DU MOIS TECOS : confirmation de la sécurité cardiovasculaire de la sitagliptine
SCHEEN, André ULg; PAQUOT, Nicolas ULg

in Revue Médicale de Liège (2015), 70

Summary : The cardiovascular safety of sitagliptin has been evaluated in TECOS («Trial Evaluating Cardiovascular Outcomes with Sitagliptin»). TECOS recruited patients with type 2 diabetes and a history of ... [more ▼]

Summary : The cardiovascular safety of sitagliptin has been evaluated in TECOS («Trial Evaluating Cardiovascular Outcomes with Sitagliptin»). TECOS recruited patients with type 2 diabetes and a history of cardiovascular disease who received, as add-on to their usual therapy, either sitagliptin (n = 7.257) or placebo (n = 7.266), with a median follow-up of 3 years. The primary cardiovascular outcome was a composite of cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for unstable angina. Sitagliptin was noninferior to placebo for the primary composite cardiovascular outcome (hazard ratio, 0.98; 95 % confidence interval, 0.88 to 1.09; P<0.001). Rates of hospitalization for heart failure did not differ between the two groups (hazard ratio, 1.00; 95 % CI, 0.83 to 1.20; P=0.98). The cardiovascular safety of sitagliptin, which was already shown in meta-analyses of phase II-III randomised controlled trials and in observational cohort studies in real life, is now confirmed in the landmark prospective cardiovascular outcome study TECOS. [less ▲]

Detailed reference viewed: 21 (1 ULg)
See detailNews about Nitric Oxide observed by MAVEN
Stiepen, Arnaud ULg

Scientific conference (2015, October)

Detailed reference viewed: 15 (0 ULg)
See detailIUVS periapse MUV observations overview
Stiepen, Arnaud ULg

Scientific conference (2015, October)

Detailed reference viewed: 13 (0 ULg)
See detailMAVEN overview
Stiepen, Arnaud ULg

Scientific conference (2015, October)

Detailed reference viewed: 7 (0 ULg)
See detailMars atmospheric escape constrained using MAVEN IUVS coronal observations
Chaffin; Deighan; Chauffray et al

Conference (2015, October)

Detailed reference viewed: 12 (0 ULg)
See detailNews about Nitric Oxide
Stiepen, Arnaud ULg

Scientific conference (2015, October)

Detailed reference viewed: 11 (0 ULg)
Full Text
Peer Reviewed
See detailEyes Open on Sleep and Wake: In Vivo to In Silico Neural Networks
Vanvinckenroye, Amaury ULg; Vandewalle, Gilles ULg; Phillips, Christophe ULg et al

in Neural Plasticity (2015)

Functional and effective connectivity of cortical areas are essential for normal brain function under different behavioral states. Appropriate cortical activity during sleep and wakefulness is ensured by ... [more ▼]

Functional and effective connectivity of cortical areas are essential for normal brain function under different behavioral states. Appropriate cortical activity during sleep and wakefulness is ensured by the balanced activity of excitatory and inhibitory circuits. Ultimately, fast, millisecond cortical rhythmic oscillations shape cortical function in time and space. On a much longer time scale, brain function also depends on prior sleep-wake history and circadian processes. However,much remains to be established on how the brain operates at the neuronal level in humans during sleep and wakefulness. A key limitation of human neuroscience is the difficulty in isolating neuronal excitation/inhibition drive in vivo. Therefore, computational models are noninvasive approaches of choice to indirectly access hidden neuronal states. In this review, we present a physiologically driven in silico approach, Dynamic Causal Modelling (DCM), as a means to comprehend brain function under different experimental paradigms. Importantly, DCM has allowed for the understanding of how brain dynamics underscore brain plasticity, cognition, and different states of consciousness. In a broader perspective, noninvasive computational approaches, such as DCM, may help to puzzle out the spatial and temporal dynamics of human brain function at different behavioural states. [less ▲]

Detailed reference viewed: 38 (7 ULg)
Full Text
See detailLa laïcité réactionnaire : une tentative de déconstruction
Jacquemain, Marc ULg

in Durand, Pascal; Sindaco, Sarah (Eds.) Le discours néréactionnaire (2015)

Le mot "laïcité" est revendiqué par des groupes d'extrême-droite ouvertement racistes et conspirationnistes comme "Riposte laïque". L'article montre que le même imaginaire conspirationniste, sous la même ... [more ▼]

Le mot "laïcité" est revendiqué par des groupes d'extrême-droite ouvertement racistes et conspirationnistes comme "Riposte laïque". L'article montre que le même imaginaire conspirationniste, sous la même structure narrative peut être retrouvé sous des formes débarrassée de leur racisme explicite dans des textes considérés comme "mainstream" au sein de la laïcité, en analysant un texte du Rappel. A partir de là, on tente de montrer que cette "dérivation conspirationniste" peut trouver des prises dans des formulations "progressistes" de la laîcité dès lors que ces formulations partent pour point de départ le point de vue à la fois holiste et idéaliste d'un "laos" toujours-dejà-là, comme chez Peña ruiz [less ▲]

Detailed reference viewed: 261 (12 ULg)
Full Text
Peer Reviewed
See detailHighlights of the 13th International Conference on Malignant Lymphoma
BONNET, Christophe ULg; BOSLY, A.

in Belgian Journal of Hematology (2015), 6(4), 173-178

A lot of interesting data were presented at the 13th International Conference on Malignant Lymphoma in Lugano, Switzerland. The authors summarise below those presentations/abstracts they found relevant ... [more ▼]

A lot of interesting data were presented at the 13th International Conference on Malignant Lymphoma in Lugano, Switzerland. The authors summarise below those presentations/abstracts they found relevant for daily practice, either now or in the near future. [less ▲]

Detailed reference viewed: 29 (0 ULg)
Full Text
Peer Reviewed
See detailWaldenström's macroglobulinaemia: Belgian Hematology Society guidelines
VAN HENDE, V.; BRON, D.; VAN DEN NESTE, E. et al

in Belgian Journal of Hematology (2015), 6(4), 142-151

Waldenström’s macroglobulinaemia is a B-cell disorder characterised by bone marrow infiltration with lymphoplasmacytic cells, along with demonstration of an IgM monoclonal gammopathy in the blood. This ... [more ▼]

Waldenström’s macroglobulinaemia is a B-cell disorder characterised by bone marrow infiltration with lymphoplasmacytic cells, along with demonstration of an IgM monoclonal gammopathy in the blood. This condition belongs to the lymphoplasmacytic lymphomas as defined by the World Health Organization classification (ICD-0 code 9671/3). Approximately one-fourth of patients are asymptomatic. Clinical features of the symptomatic patients are diverse and may relate to overall disease burden (such as peripheral blood cytopaenias, organomegaly and constitutional symptoms) or may be directly attributable to the IgM paraprotein. The latter include hyperviscosity syndrome, amyloidosis, peripheral neuropathy and cold haemagglutinin. Therapeutic options have traditionally involved alkylating agents, nucleoside analogues, and rituximab, either as single therapy or in combination. However, emerging new data on combination therapy as well as novel agents have shown encouraging results. This report provides the Belgian Hematology Society guidelines according to recent clinical studies. [less ▲]

Detailed reference viewed: 19 (0 ULg)
Full Text
Peer Reviewed
See detailÉcologie et gestion des espèces multi-usages du genre Erythrophleum (Fabaceae-Caesalpinioideae) en Afrique (synthèse bibliographique)
Gorel, Anaïs ULg; Fayolle, Adeline; Doucet, Jean-Louis ULg

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2015), 19

Littérature. Erythrophleum ivorense, E. suaveolens, E. africanum et E. lasianthum diffèrent morphologiquement et sont présentes dans des aires climatiques distinctes. Elles sont héliophiles non pionnières ... [more ▼]

Littérature. Erythrophleum ivorense, E. suaveolens, E. africanum et E. lasianthum diffèrent morphologiquement et sont présentes dans des aires climatiques distinctes. Elles sont héliophiles non pionnières (E. ivorense et E. suaveolens) ou pionnières (E. africanum). La dispersion primaire est ballochore. Les graines présentent une période de dormance et peuvent rester plusieurs années dans le sol. La phénologie est régulière et annuelle. La croissance annuelle moyenne varie entre les espèces, de la plus élevée pour E. ivorense (0,65 cm par an) à la plus faible pour E. africanum (0,16 cm par an). Elles sont largement utilisées dans la médecine traditionnelle. Seules E. ivorense et E. suaveolens sont exploitées pour le bois d’oeuvre et soumises à des normes d’exploitation et des tests sylvicoles. Conclusions. Les données sur l’écologie des espèces du genre Erythrophleum sont globalement mieux renseignées pour E. ivorense et E. suaveolens en raison de leur importance économique. Cette synthèse a permis de mettre en évidence certains manques de connaissances notamment sur la phénologie (relation avec le climat, périodes de fructifications), les diamètres minimums de fructification et les mécanismes de levée de dormance naturelle des graines. Remédier à ces lacunes contribuerait notablement à améliorer les méthodes de gestion des populations de ces espèces. [less ▲]

Detailed reference viewed: 44 (6 ULg)
Full Text
Peer Reviewed
See detailLymphotoxin-beta receptor in microenvironmental cells promotes the development of T-cell acute lymphoblastic leukaemia with cortical/mature immunophenotype.
Fernandes, Monica T.; Ghezzo, Marinella N.; Silveira, Andre B. et al

in British journal of haematology (2015)

Lymphotoxin-mediated activation of the lymphotoxin-beta receptor (LTbetaR; LTBR) has been implicated in cancer, but its role in T-cell acute lymphoblastic leukaemia (T-ALL) has remained elusive. Here we ... [more ▼]

Lymphotoxin-mediated activation of the lymphotoxin-beta receptor (LTbetaR; LTBR) has been implicated in cancer, but its role in T-cell acute lymphoblastic leukaemia (T-ALL) has remained elusive. Here we show that the genes encoding lymphotoxin (LT)-alpha and LTbeta (LTA, LTB) are expressed in T-ALL patient samples, mostly of the TAL/LMO molecular subtype, and in the TEL-JAK2 transgenic mouse model of cortical/mature T-ALL (Lta, Ltb). In these mice, expression of Lta and Ltb is elevated in early stage T-ALL. Surface LTalpha1 beta2 protein is expressed in primary mouse T-ALL cells, but only in the absence of microenvironmental LTbetaR interaction. Indeed, surface LT expression is suppressed in leukaemic cells contacting Ltbr-expressing but not Ltbr-deficient stromal cells, both in vitro and in vivo, thus indicating that dynamic surface LT expression in leukaemic cells depends on interaction with its receptor. Supporting the notion that LT signalling plays a role in T-ALL, inactivation of Ltbr results in a significant delay in TEL-JAK2-induced leukaemia onset. Moreover, young asymptomatic TEL-JAK2;Ltbr-/- mice present markedly less leukaemic thymocytes than age-matched TEL-JAK2;Ltbr+/+ mice and interference with LTbetaR function at this early stage delayed T-ALL development. We conclude that LT expression by T-ALL cells activates LTbetaR signalling in thymic stromal cells, thus promoting leukaemogenesis. [less ▲]

Detailed reference viewed: 8 (0 ULg)