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See detailStudy of the evolution of the osteoarthritis pathology and the mechanical properties of cartilage in a spontaneous osteoarthritis model in the Dunkin-Hartley guinea pigs.
Legrand, Catherine ULg; Centonze, Prescilia ULg; Comblain, Fanny ULg et al

in Osteoarthritis and Cartilage (2017, April), 25

In animal models, the severity of cartilage damage is assessed by histological scores evaluating the structure, the proteoglycan con- tent, the integrity of the tidemark, the cellularity, and osteophytes ... [more ▼]

In animal models, the severity of cartilage damage is assessed by histological scores evaluating the structure, the proteoglycan con- tent, the integrity of the tidemark, the cellularity, and osteophytes. In parallel to these histological analyzes, we studied the mechanical properties of cartilage at different stages of disease progression in the Dunkin-Hartley guinea pigs. We also correlated the severity of histo- logical lesions with the mechanical properties of cartilage. [less ▲]

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See detailChemokine neutralization as an innovative therapeutic strategy for atopic dermatitis
Abboud, Dayana ULg; Hanson, Julien ULg

in Drug Discovery Today (2017), 22(4), 702-7011

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See detailThe Belgian Internment Policy as an Example of Hybrid Governance
Pans, Maurice; Darcis, Coralie ULg

in Tijdschrift voor Bestuurswetenschappen en Publiekrecht (2017, April), 4(4),

Het domein van de zorg voor geïnterneerde personen kent internationaal een omslag. Naast de “criminalisering” van personen met een psychiatrische stoornis die criminele feiten begaan, ontwikkelen er zich ... [more ▼]

Het domein van de zorg voor geïnterneerde personen kent internationaal een omslag. Naast de “criminalisering” van personen met een psychiatrische stoornis die criminele feiten begaan, ontwikkelen er zich nieuwe visies en zorgperspectieven op de kwaliteit van leven en de re-integratie in de maatschappij van zowel personen met psychische kwetsbaarheid als geïnterneerde personen.1 Tot zeer recent werden geïnterneerde personen bijna exclusief benaderd als personen die misdaden of misdrijven hebben gepleegd waar ze door hun psychische stoornis niet voor verantwoordelijk konden worden gesteld. De onderliggende logica van de aanpak was sterk geënt op een model waarbij opsluiting en isolatie van de maatschappij centraal stonden omwille van misdaad. Geïnterneerde personen werden om die reden opgesloten in een gevangenissysteem volgens een justitiële benadering. Het behandelings- en zorgperspectief raakte hierbij ondergesneeuwd. De “criminalisering” van personen met psychische stoornissen heeft in België historisch geleid tot inadequate aanpak en begeleiding van deze groep patiënten. Meerdere veroordelingen van de Belgische Staat door het Europees Hof voor de Rechten van de Mens (EHRM), overvolle gevangenissen, het gebrek aan somatische en psychiatrische gezondheidszorg binnen gevangenissen en psychiatrische annexen en aanbevelingen van het Europees Comité voor de Preventie van Foltering en Onmenselijke of Vernederende Behandeling of Bestraffing (CPT) zijn directe aanleidingen voor het Masterplan Internering (juni 2016)2 en de wet van 5 mei 2014 betreffende de internering van personen3. In deze bijdrage staan we stil bij het Masterplan Internering van 2016 en de nieuwe Interneringswet van 5 mei 2014. We proberen te duiden op welke manier in beide bronnen randvoorwaarden worden gecreëerd voor een hybride bestuursvorm in de sector. We staan kort stil bij beleidsmatige en juridische ontwikkelingen die vooraf gingen. [less ▲]

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See detailFair Trade and Co-operatives
Nicholls, Alex; Huybrechts, Benjamin ULg

in Michie, Jonathan; Blassi, Joseph; Borzaga, Carlo (Eds.) The Handbook of Co-operative and Mutual Businesses (2017)

The Fair Trade and co-operative movements have much in common. This chapter aims to examine the convergences and divergences between the two fields, highlighting what they can learn from each other and ... [more ▼]

The Fair Trade and co-operative movements have much in common. This chapter aims to examine the convergences and divergences between the two fields, highlighting what they can learn from each other and how practitioners and researchers in the two areas can better collaborate. Fair trade is an innovative approach to economic development that uses a market-driven approach to exploit the growing trend in ethical, or caused-based, consumption (Nicholls & Opal 2005). Fair Trade organizations aim to re-engineer the value chains between poor producers and artisans - typically in developing countries - and their wholesale buyers such that a greater proportion of the overall rents accrue to those who provide the inputs. Put simply, Fair Trade aims to ensure that the poorest actors in a supply chain benefit from more of the overall financial value creation as a development tool. Moreover, Fair Trade reconnects producers and consumers at the point of purchase such that consumption becomes a political – or, at least, life style – choice. This chapter is structured as follows. After this introduction, the second section describes the development of Fair Trade from its historical roots to the current organizational landscape and market organization. Next there is a discussion of several key issues and challenges that have emerged as Fair Trade has become increasingly institutionalized. Then, the fourth section explores the relationship between Fair Trade and the co-operative and mutual movements. Finally, conclusions serve to sum up the chapter. [less ▲]

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See detailSilica or Coal ? Design and Implementation of Dust Prevention in the Collieries in Western Economies, ca. 1930-1980
Geerkens, Eric ULg

in Rosental, Paul-André (Ed.) Silicosis. A World History (2017)

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See detailLe Good Lives Model : un modèle alternatif au modèle de prévention de la récidive
Corneille, Serge ULg; Henrard, Noémie ULg

in Dieu, Erwan (Ed.) Les innovations criminologiques (2017)

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See detailL’ABSP: 20 ans de science politique en Belgique francophone
Reuchamps, Min; Van Haute, Emilie; Dodeigne, Jérémy ULg et al

Book published by Academia-L’Harmattan (2017)

Depuis 1996, l'Association belge francophone de science politique fédère les chercheur·e·s en science politique dans les différents champs qui l'animent en Belgique francophone et au-delà. Cet ouvrage ... [more ▼]

Depuis 1996, l'Association belge francophone de science politique fédère les chercheur·e·s en science politique dans les différents champs qui l'animent en Belgique francophone et au-delà. Cet ouvrage, 20e volume de la collection « Science politique », marque le 20e anniversaire de l'ABSP. Ces deux décennies ont vu de véritables métamorphoses au niveau politique et de la science politique. Ce livre collectif, mobilisant de nombreuses personnalités de l'enseignement, de la recherche et du service à la société, offre un regard rétrospectif et prospectif sur l'état de la science politique en Belgique francophone. [less ▲]

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See detailDebating on ideal rural settlement: from the classroom to the field
Schmitz, Serge ULg

Conference (2017, April)

Since 2007, I organize sessions with students or politicians aiming for a better understanding of land use and country planning. Within working groups of four to six, the participants elaborate their ... [more ▼]

Since 2007, I organize sessions with students or politicians aiming for a better understanding of land use and country planning. Within working groups of four to six, the participants elaborate their ideal village. The exercise informs about decision in planning, representations and desires regarding the countryside and rural villages. [less ▲]

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See detailHigh concordance of Pfdhfr and Pfdhps genotypes between matched peripheral and placental isolates of delivered women in Bobo-Dioulasso, Burkina Faso
Cissé, Mamoudou; Awandare, Gordon; Some, Fabrice et al

in Annals of Parasitology (2017), 63(2), 111-116

Whether maternal peripheral parasites constitute a representative sample of the overall population infecting the individual, remains unknown in Burkina Faso. We therefore compared Pfdhfr and Pfdhps ... [more ▼]

Whether maternal peripheral parasites constitute a representative sample of the overall population infecting the individual, remains unknown in Burkina Faso. We therefore compared Pfdhfr and Pfdhps génotypes between matched peripheral and placental isolates. PCR-restriction fragment length polymorphism (PCR-RFLP) analysis of polymorphic codons of the Pfdhfr gene (51, 59, 108 and 164) and the Pfdhps gene (437 and 540) was performed in 18 matched peripheral and placental dried blood spots of delivered women in Bobo-Dioulasso. Both Pfdhfr and Pfdhps genes were successfully genotyped in 94.4% (17/18) of the matched samples. Only 8.8% (3/34) of génotypes were of the wild type, while 20.6% (7/34), 20.6% (7/34), 23.5% (8/34) and 26.5% (9/34) comprised one, two, three and four mutations, respectively. None of the samples carried both Pfdhfr I164L and Pfdhps K540E mutations. A concordance of 82.4% was observed in matched samples for both the Pfdhfr and Pfdhps genes. Setting placental allèles as the reference, a concordance of 100% was obtained with Pfdhfr mutation S108N, Pfdhfr mutation C59R+S108N, and Pfdhfr mutation N51I+C59R +S108N, respectively. Likewise, a concordance of 85.7% was observed with the Pfdhps mutation A437G. For epidemiological purposes, peripheral blood Pfdhfr and Pfdhps genotyping is sufficient for monitoring SP resistant molecular markers in pregnant women. [less ▲]

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See detailUsefulness of multi-breed models in genetic evaluation of direct and maternal calving ease in Holstein and Belgian Blue Walloon purebreds and crossbreds
Vanderick, Sylvie ULg; Gillon, Alain; Glorieux, Géry et al

in Livestock Science (2017), 198

The objective of this study was to verify the feasibility of a joint genetic evaluation system for calving ease trait of Belgian Blue (BBB) and Holstein (HOL) Walloon cattle based on data of purebred and ... [more ▼]

The objective of this study was to verify the feasibility of a joint genetic evaluation system for calving ease trait of Belgian Blue (BBB) and Holstein (HOL) Walloon cattle based on data of purebred and crossbred animals. Variance components and derived genetic parameters for purebred BBB and HOL animals were estimated by using single-breed linear animal models. This analysis showed clear genetic differences between breeds. Estimates of direct and maternal heritabilities (± standard error) were 0.34 (±0.02) and 0.09 (±0.01) for BBB, respectively, but only 0.09 (±0.01) and 0.04 (±0.01) for HOL, respectively. Moreover, a significant negative genetic correlation between direct and maternal effects was obtained in both breeds: −0.46 (±0.04) for BBB and −0.29 (±0.11) for HOL. Variance components and derived genetic parameters for purebred BBB and HOL and crossbred BBB ×× HOL cattle were then estimated by using two multi-breed linear animal models: a multi-breed model based on a random regression test-day model (Model MBV), and a multi-breed model based on the random regression multi-breed model (Model MBSM). Both multi-breed models use different functions of breed proportions as random regressions, thereby enabling modelling different additive effects according to animal's breed composition. The main difference between these models is the way in which relationships between breeds are accounted for in the genetic (co)variance structure. Genetic parameters differed between single-breed and multi-breed analysis, but are similar to the literature. For BBB, estimates of direct and maternal heritabilities (±SE) were 0.45 (±0.07) and 0.08 (±0.01) by using Model MBV, and 0.45 (±0.08) and 0.09 (±0.02) for Model MBSM, respectively. For HOL, these estimates were 0.18 (±0.04) and 0.05 (±0.01) using Model MBV, and 0.16 (±0.04) and 0.05 (±0.01) for Model MBSM, respectively. Reliability gains (up to 25%) indicated that the use of crossbred data in the multi-breed models had a positive influence on the estimation of genetic merit of purebred animals. A slight re-ranking of purebred sires and maternal grandsires was observed between single-breed and multi-breed models. Moreover, both multi-breed models can be considered as quasi-equivalent models because they performed almost equally well with respect to MSE and correlations, for purebred and crossbred animals. [less ▲]

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See detailLa réforme du crédit hypothécaire
Biquet, Christine ULg

in Leleu, Yves-Henri (Ed.) Chroniques notariales, Vol. 65 (2017)

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See detailDecrease in climatic conditions favouring floods in the south-east of Belgium over 1959-2010 using the regional climate model MAR
Wyard, Coraline ULg; Scholzen, Chloé ULg; Fettweis, Xavier ULg et al

in International Journal of Climatology (2017), 37(5), 27822796

The Ourthe River, in the south-east of Belgium, has a catchment area of 3,500 km2 and is one of the main tributaries of the Meuse River. In the Ourthe, most of the flood events occur during winter and ... [more ▼]

The Ourthe River, in the south-east of Belgium, has a catchment area of 3,500 km2 and is one of the main tributaries of the Meuse River. In the Ourthe, most of the flood events occur during winter and about 50% of them are due to heavy rainfall events combined to an abrupt melting of the snowpack covering the Ardennes massif during winter. This study aims to determine whether trends in extreme hydroclimatic events generating floods can be detected over the last century in Belgium, where a global warming signal can be observed. Hydroclimatic conditions favourable to floods were reconstructed over 1959- 2010 using the regional climate model MAR (“Modèle Atmosphérique Régional”) forced by the ERA-Interim/ERA-40, the ERA-20C and the NCEP/NCAR-v1 reanalyses. Extreme run-off events, which could potentially generate floods, were detected using run-off caused by precipitation events and snowpack melting from the MAR model. In the validation process, the MAR-driven temperature, precipitation and snow depth were successfully compared to daily weather data over the period 2008-2014 for 20 stations in Belgium. MAR also showed its ability to detect up to 90% of the hydroclimatic conditions which effectively generated observed floods in the Ourthe River over the period 1974- 2010. Conditions favourable to floods in the Ourthe River catchment present a negative trend over the period 1959-2010 as a result of a decrease in snow accumulation and a shortening of the snow season. This trend is expected to accelerate in a warmer climate. However, regarding the impact of the extreme precipitation events evolution on conditions favouring floods, the signal is less clear since the trends depend on the reanalysis used to force the MAR model. [less ▲]

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See detailKranzhugeln et seconde révolution urbaine en Haute Mésopotamie au IIIe millénaire av. J.-C.
Mas, Juliette ULg

Scientific conference (2017, April)

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See detailSize fractionation as a tool for separating charcoal of different fuel source and recalcitrance in the wildfire ash layer
Mastrolonardo, Giovanni ULg

in Science of the Total Environment (2017), 595

Charcoal is a heterogeneous material exhibiting a diverse range of properties. This variability represents a serious challenge in studies that use the properties of natural charcoal for reconstructing ... [more ▼]

Charcoal is a heterogeneous material exhibiting a diverse range of properties. This variability represents a serious challenge in studies that use the properties of natural charcoal for reconstructing wildfires history in terrestrial ecosystems. In this study, we tested the hypothesis that particle size is a sufficiently robust indicator for separating forest wildfire combustion products into fractions with distinct properties. For this purpose, we examined two different forest environments affected by contrasting wildfires in terms of severity: an eucalypt forest in Australia, which experienced an extremely severe wildfire, and a Mediterranean pine forest in Italy, which burned to moderate severity. We fractionated the ash/charcoal layers collected on the ground into four size fractions (>2, 2–1, 1–0.5, <0.5 mm) and analysed them for mineral ash content, elemental composition, chemical structure (by IR spectroscopy), fuel source and charcoal reflectance (by reflected-light microscopy), and chemical/thermal recalcitrance (by chemical and thermal oxidation). At both sites, the finest fraction (<0.5 mm) had, by far, the greatest mass. The C concentration and C/N ratio decreased with decreasing size fraction, while pH and the mineral ash content followed the opposite trend. The coarser fractions showed higher contribution of amorphous carbon and stronger recalcitrance. We also observed that certain fuel types were preferentially represented by particular size fractions. We conclude that the differences between ash/charcoal size fractions were most likely primarily imposed by fuel source and secondarily by burning conditions. Size fractionation can therefore serve as a valuable tool to characterise the forest wildfire combustion products, as each fraction displays a narrower range of properties than the whole sample. We propose the mineral ash content of the fractions as criterion for selecting the appropriate number of fractions to analyse. [less ▲]

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See detailAn innovative non-animal chitosan hydrogel is able to restore the rheology of osteoarthritis synovial fluid ex vivo
Henrotin, Yves ULg; Rocasalbas, Guillem; Chausson, Mickaël et al

in Osteoarthritis and Cartilage (2017, April)

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See detailHypercalcemie par mutation inactivatrice du CYP24A1. Etude d'un cas et revue de la litterature.
Seidowsky, Alexandre; Villain, Cedric; Vilaine, Eve et al

in Néphrologie & Thérapeutique (2017)

We present the case of a family whose members have high levels of serum calcium (hypercalcaemia) by loss of function of the enzyme vitamin D 24-hydroxylase due to bi-allelic mutations in the CYP24A1 gene ... [more ▼]

We present the case of a family whose members have high levels of serum calcium (hypercalcaemia) by loss of function of the enzyme vitamin D 24-hydroxylase due to bi-allelic mutations in the CYP24A1 gene: c.443 T>C (p.Leu148Pro) and c.1187 G>A (p.Arg396Gln). 24-VITD hydroxylase is a key player in regulating the circulating calcitriol, its tissue concentration and its biological effects. Transmission is recessive. The estimated prevalence of stones in the affected subjects is estimated between 10 and 15%. The loss of peripheral catabolism of vitamin D metabolites in patients with an inactivating mutation of CYP24A1 is responsible for persistent high levels of 1,25-dihydroxyvitamin D especially after sun exposure and a charge of native vitamin D. Although there are currently no recommendations (French review) on this subject, this disease should be suspected in association with recurrent calcium stones with nephrocalcinosis, and a calcitriol-dependent hypercalcaemia with adapted low parathyroid hormone levels. Resistance to corticosteroid therapy distinguishes it from other calcitriol-dependent hypercalcemia. A ratio of 25-hydroxyvitamin D/24.25 hydroxyvitamin D>50, is in favor of hypercalcemia with vitamin D deficiency 24-hydroxylase. Genetic analysis of CYP24A1 should be performed at the second step. The current therapeutic management includes the restriction native vitamin D supplementation and the limitation of sun exposure. Biological monitoring will be based on serum calcium control and modulation of parathyroid hormone concentrations. [less ▲]

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See detailPerspective and priorities for improvement of parathyroid hormone (PTH) measurement - A view from the IFCC Working Group for PTH.
Sturgeon, Catharine M.; Sprague, Stuart; Almond, Alison et al

in Clinica Chimica Acta (2017), 467

Parathyroid hormone (PTH) measurement in serum or plasma is a necessary tool for the exploration of calcium/phosphate disorders, and is widely used as a surrogate marker to assess skeletal and mineral ... [more ▼]

Parathyroid hormone (PTH) measurement in serum or plasma is a necessary tool for the exploration of calcium/phosphate disorders, and is widely used as a surrogate marker to assess skeletal and mineral disorders associated with chronic kidney disease (CKD), referred to as CKD-bone mineral disorders (CKD-MBD). CKD currently affects >10% of the adult population in the United States and represents a major health issue worldwide. Disturbances in mineral metabolism and fractures in CKD patients are associated with increased morbidity and mortality. Appropriate identification and management of CKD-MBD is therefore critical to improving clinical outcome. Recent increases in understanding of the complex pathophysiology of CKD, which involves calcium, phosphate and magnesium balance, and is also influenced by vitamin D status and fibroblast growth factor (FGF)-23 production, should facilitate such improvement. Development of evidence-based recommendations about how best to use PTH is limited by considerable method-related variation in results, of up to 5-fold, as well as by lack of clarity about which PTH metabolites these methods recognise. This makes it difficult to compare PTH results from different studies and to develop common reference intervals and/or decision levels for treatment. The implications of these method-related differences for current clinical practice are reviewed here. Work being undertaken by the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) to improve the comparability of PTH measurements worldwide is also described. [less ▲]

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